3TQT


Conserved Protein Domain Family
Dala_Dala_lig_N

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pfam01820: Dala_Dala_lig_N 
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D-ala D-ala ligase N-terminus
This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.
Statistics
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PSSM-Id: 460346
Aligned: 508 rows
Threshold Bit Score: 61.4662
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3TQT_A         6 HISVLCGGQSTEHEISIQSAKNIVNTLda------------------akYLISVIFIDHvgrwyliDQPEMFLAHSPDHL 67  Coxiella burnet...
CCK80974      10 KIAVVFGGQSTEHDASIFSFKNFYMDIqssivdeeievsstyyilqdgrVLVSPVDLKK-------PAAFYFDP------ 76 
Q8F4I2         3 KIAVFFGGSSTEHSISILTGCFICKTLht------------------mgHSVKPILLTKdg---gwVVPSEYRMSIPFEV 61  Leptospira inte...
B0SS77         5 KIALLFGGISGEHIISVRSSAFIFATIdr------------------ekYDVCPVYINPngk--fwIPTVSEPIYPDPSG 64  Leptospira bifl...
Q6ME77       366 KVHVLFGGKNAERQVSLMSGTNVWLKLlrs-----------------skYHPIPFFYGK-------NDLIWQLPYAYTLD 421 Candidatus Prot...
XP_024511745  10 NIAVVVGGYSGEYDVSISTGAAIYTNVdr------------------srYNLYKIVIPRdpk-aawYHLTDSSQEIPVDR 70 
WP_022544874   6 iVALIYGGDSSEAQVSVMSGKNIAANIdr------------------qrYEVYEILLKGse----wNVQLEGGKTIPIDK 63  Bacteroidales b...
CCY37591       8 iLAVVYGGYSSEFEISVKSGRSVAGWLrn------------------agRNVYEVIISRkg----wWALDPSADGQEQRW 65 
BAC43436     485 KVFVIFGGDTSERQVSVMSGTNVWVNLqry-----------------vdLNVTPCLLSP-------SLSNSLGASSNLDN 540 thale cress
XP_003056164 462 KVYVLFGGGTSERQVSLMSGTNVWLRLrey-----------------peYDVEPLLLEP-------TPIGCQLDKTYVWH 517 Micromonas pusi...
3TQT_A        68 VKEGSArpi---------------------------------------tiAFGDAAKPWQSLNGDGRRYSAD-------- 100 Coxiella burnet...
CCK80974      77 --------------------------------------------------------------GRTASCDIVDaffli-re 93 
Q8F4I2        62 SNSPDLf-------------------------------------------QEEFQKRYGVSRTNQIFSLDAD-------- 90  Leptospira inte...
B0SS77        65 KT----------------------------------------------------EIEFLQEFNKANAIVSPSepadisqm 92  Leptospira bifl...
Q6ME77       422 HTVEEIlhrclareas-------------------------nkklpnyfnSICEQLGIPYNFQETPSSMCLQdfyqlsas 476 Candidatus Prot...
XP_024511745  71 NDF-------------------------------------------------SVTLPSSSGSGENNQKIKFD-------- 93 
WP_022544874  64 SD---------------------------------------------------FSFVLPAGDSRVQSRINFD-------- 84  Bacteroidales b...
CCY37591      66 PI----------------------------------------------------DRNDFSFTPEGREKITFD-------- 85 
BAC43436     541 REVWVLpysvvlrhtaeevlaacleavepvralftsllqkqvmedlmdgfKNQSWFAGFDITDELPRKYSLKewikhake 620 thale cress
XP_003056164 518 LPYAAVlrhtveevlavakrtqn----------ptpgacaraiilllrtyGWLDDVEDSGTGITTAVRETISefaataaa 587 Micromonas pusi...
3TQT_A       101 ---CVFPMVHGTQGEDGALQGLLELLNLPYVGA 130 Coxiella burnetii RSA 493
CCK80974      94 nneFVYLMCDGPVGTDGRFVSIAENYGIK---G 123
Q8F4I2        91 ---IVFLGLHGGQGEDGTIQGFLEILGIPYTGS 120 Leptospira interrogans serovar Lai str. 56601
B0SS77        93 gflSAFLGLHGGAGEDGRIQGFLDTLGIPHTGS 125 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'
Q6ME77       477 nqaFVFIAMHGGEGENGILQKELEKNQLYYNGS 509 Candidatus Protochlamydia amoebophila UWE25
XP_024511745  94 ---LAYISIHGNPGENGVLQGYFDMLGLPYTSC 123
WP_022544874  85 ---IALIMIHGTPGENGMLQAYLEMVGMPHTTC 114 Bacteroidales bacterium CF
CCY37591      86 ---KVFITIHGDPGENGRLQAYFEMLGITFSGC 115
BAC43436     621 aqaTVFIAVHGGIGEDGTLQGLLEDEGVSYTGP 653 thale cress
XP_003056164 588 ekaIIFNAVHGGCGEDGTLQALFTEARASYTGS 620 Micromonas pusilla CCMP1545
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