3LWB,2I80,2PVP,7U56


Conserved Protein Domain Family
Dala_Dala_lig_N
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pfam01820: Dala_Dala_lig_N (This model is not part of the current CDD release)
D-ala D-ala ligase N-terminus
This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.
Links
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Statistics
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PSSM-Id: 514528
Aligned: 444 rows
Threshold Bit Score: 50.343
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3LWB_A        17 FGGRSNEHAISCVSAGSILRNLdsrrFDVIAVG------------------------------ITPagswvltDANPDAL 66  Mycobacterium t...
Q2LS09        15 MAGLSSEKEVSLESGRNIFSKIdrrkYSPIPIF------------------------------MDS-------DAALWEI 57  Syntrophus acid...
WP_016482346  14 MGGSSSERAVSLSSGQMILEALdpsrYDAVGAD------------------------------MDA-------LFYLASQ 56  Chthonomonas ca...
WP_014856449  12 VGGVSSERKVSKATGKSIYSALknlnYNVTVIDpayglsqpedvelffgaddifplsarnyidIIN-------SAL---- 80  Melioribacter r...
Q1QNT9         7 FGGSNKERLVSVASAQALHRALpeadlwfwdirddvhnvrse--vlldharpfedefvpggtsMP--------------- 69  Nitrobacter ham...
Q89FV0         9 FGGSNRERLVSVASAQALHQALpeadlwwwdvedrvhvvqsk--qlleharpfedefkpgtsgIP--------------- 71  Bradyrhizobium ...
WP_012029233   7 FGGSNKERLVSVASAKALHAALpeadlwfweaddtvqqasgp--alvahakpfeepftadgvrIGT-------------- 70  Bradyrhizobium ...
WP_012853777   7 FGGASSEREVSIASAAQVFTALrdrgHDVIAID----------------------------------------TAKGKLS 46  Thermomonospora
Q2S942         7 FGGTSEERDVSIASAAQIIPALrslgHEVFSVD----------------------------------------TATGQLS 46  Hahella chejuen...
Q9HWI0        12 FGGSSEERDVSIASGAQVIQALrsagHQVLAVD----------------------------------------TASGLLG 51  Pseudomonas aer...

3LWB_A        67 TITNRELPQVKSgsgtelalpA-------DPRRGGQLVSLPPGAGEVLESVD-----------VVFPVLHGPYGEDGTIQ 128 Mycobacterium t...
Q2LS09        58 PLKLLMRNCTRD------------------VEEDLAEEAVRVPYEELKTRVD-----------LVFLALHGKYGEDGCMQ 108 Syntrophus acid...
WP_016482346  57 HLVSLSETGVSL---------P--------GLEWLEKQRQRLLPASAVVRPD-----------VVFIALHGRNGEDGRVQ 108 Chthonomonas ca...
WP_014856449  81 -----------------------------------------------FDDVD-----------VAFLALHGKWGEDGRIQ 102 Melioribacter r...
Q1QNT9        70 --------------------------------------------------FEqaldraraegrVLVLGLHGGRAENGELQ 99  Nitrobacter ham...
Q89FV0        72 --------------------------------------------------LVqaldqakaedrVLVLGLHGGCAENGELQ 101 Bradyrhizobium ...
WP_012029233  71 --------------------------------------------------LAealdraraedrILVLGLHGGRAENGELQ 100 Bradyrhizobium ...
WP_012853777  47 PQEVEAFVSATV---------Aydp-pgvDDIPASEVTARLTAEDSELRGVD-----------VVFLALHGGSGEDGTLQ 105 Thermomonospora
Q2S942        47 GTDEMRLLQAGV---------ApeppstsVIADVRGRAIALSAEAFNIRDVD-----------VVFLALHGGAGEDGRIQ 106 Hahella chejuen...
Q9HWI0        52 AEEERRLLASKV---------Kevp-pdsDSLAIIRSGKQSLLSAGELAGVD-----------VFFLALHGGTGEDGTLQ 110 Pseudomonas aer...

3LWB_A       129 GLLELAGVPYVGA 141 Mycobacterium tuberculosis
Q2LS09       109 GLLELLKIPYTGS 121 Syntrophus aciditrophicus SB
WP_016482346 109 GLLDLLGIPYTGS 121 Chthonomonas calidirosea
WP_014856449 103 SLLEMRNLKYTGS 115 Melioribacter roseus
Q1QNT9       100 AMCELRGIPFTGS 112 Nitrobacter hamburgensis X14
Q89FV0       102 VMCEARGVPFTGS 114 Bradyrhizobium japonicum
WP_012029233 101 VMCEMRGVPFTGS 113 Bradyrhizobium sp. ORS 278
WP_012853777 106 ALLKAAGIPYTGS 118 Thermomonospora
Q2S942       107 AMLDLAGLAYTGS 119 Hahella chejuensis KCTC 2396
Q9HWI0       111 ALLDAGGFAYTGS 123 Pseudomonas aeruginosa PAO1
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