3ZZM,4EHI,7MGQ


Conserved Protein Domain Family
AICARFT_IMPCHas

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pfam01808: AICARFT_IMPCHas (This model is not part of the current CDD release)
AICARFT/IMPCHase bienzyme
This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalyzed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC:2.1.2.3 (AICARFT), this enzyme catalyzes the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate. This is catalyzed by a pair of C-terminal deaminase fold domains in the protein, where the active site is formed by the dimeric interface of two monomeric units. The last step is catalyzed by the N-terminal IMP (Inosine monophosphate) cyclohydrolase domain EC:3.5.4.10 (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP.
Statistics
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PSSM-Id: 514518
Aligned: 552 rows
Threshold Bit Score: 285.461
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ZZM_A        141 AAKNHPSAAVVTDPLGYHGVLAALRA-GgFTLAERKRLASLAFQHIAEYDIAVASWMQqtLApehpvaafPqwfGRSW-R 218 Mycobacterium ...
30_pfamImport   1 AAKNHGRVVILTDPNDYAGFLQELKA-GeISSESRNLYALKAFEHTADYDASISDFFR--KQy-------A----SNGvQ 66 
XP_003713530  136 AAKNHSRVTILSDPTDYAEFLKELDS-GeIKESSRKLYALKAFEHTADYDAAIADFFR--KQy-------A----SDGlQ 201
XP_001586294  135 AAKNHTRVTILTDPADYPEFLEELEK-GdVTERSRKLYALKAFEHTADYDASISDYFR--KQy-------A----GNGvQ 200
XP_024323783  133 AAKNHTRVTILSDPSDYPSFLEELEK-GeIKEQSRQMYALKAFGHTADYDAAISDFFR--KQy-------A----SNGvQ 198
Q0V3E1        135 AAKNHARVTIISDPNDYHDLLTELKKdGeVSEQSKQRYALKAFEQTAAYDSAISEFFR--KKy-------A----GDGnQ 201 Parastagonospo...
XP_003850639  134 AAKNHGRVTILSDPEDYHDFLQELEK-GeVTEKQRQLYALKAFTHTADYDAAISDFFR--KKy-------A----GDGnQ 199
XP_007780455  131 AAKNHARVTVVVSPHQYHDFLSELESkGeISQTTREKYALKAFEHTAAYDKAISDFFR--RKy-------Ac--SGDGmQ 199
XP_002584062  133 AAKNHARVTILSDPNDYTEFLNELKK-GdISERNRRLYALKAFEHTADYDEAISGFFR--KQy-------A----GDGaQ 198
XP_011120504  143 AAKNHSRVTILSDPRDYPAFLEELHSqGgVQESSRKQYALKAFEHTADYDAAISEFFR--KKy-------A----GNGvQ 209 Orbilia oligos...
3ZZM_A        219 RvAMLRYGENPHQQa-ALYgdptawpglaqAeQ---L--H---GkDMSYNNFTDADAAWRAAF---DheqtC----VA-I 281 Mycobacterium ...
30_pfamImport  67 Q-LELRYGANPHQKpaAAF-----------T-KlgsMpfKvisG-SPGYINLLDALHGWPLVKelkA----AlgfaAAaS 128
XP_003713530  202 H-LTLRYGANPHQKpaAAF-----------A-KegkLpfKvlcG-SPGYINLLDALNAWPLVKelkA----AlglpAAaS 263
XP_001586294  201 Q-LALRYGANPHQKpaQAY-----------V-SegpMpfKvlcG-SPGYINLLDALNAWPLVKelkA----AlghpAAaS 262
XP_024323783  199 Q-LALRYGANPHQKpaAAY-----------V-KsgeLpfKvlcG-APGYINLLDALNAWPLVKelkE----AlghpAAaS 260
Q0V3E1        202 F-LPLRYGANPHQKpaTVA-----------M-PekpLpfKvlgG-APGYINLLDALNAWPLVQelsQ----AlnypAAaS 263 Parastagonospo...
XP_003850639  200 Q-LSLRYGTNPHQKpaSAY-----------V-SegpLpfKvlsG-SPGYINLLDALNAWPLVKelsE----AlqypAAaS 261
XP_007780455  200 H-LSLRYGTNPHQKpaSAF-----------T-RgepLpfKvlsG-AAGYINLLDALNAWGLVKelrA----AldvpAAaS 261
XP_002584062  199 Y-LALRYGANPHQKpaAAF-----------M-EqnkLpfKvlnG-SPGYINLLDSLNAWPLVKelkQ----AlgypAAaS 260
XP_011120504  210 Q-LTLRYGANPHQKpaQAY-----------T-PlgnLpfKvlaG-APGYINLLDALNAWPLVKelkQ----SlglpAAaS 271 Orbilia oligos...
3ZZM_A        282 IK-----HANPCGIAI----------------------SSvsVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTI 334 Mycobacterium ...
30_pfamImport 129 FK-----HVSPAGAAIgvpltpeeckvymvedieglgeSQ--LAQAYARARGADRMSSFGDMIALSDIVDVPTARIISKE 201
XP_003713530  264 FK-----HVSPAGAAIgtplsadeqkvymvegiegiesSA--LAQAYARARGADRMSSFGDMIALSDVVDLPTAQIISKE 336
XP_001586294  263 FQacltcRVLPFGvpltpderkvy----mvddiaglenSP--LAQAYARARGADRMSSFGDMIALSDIVDVPTAKIISRE 336
XP_024323783  261 FK-----HVSPAGAAIavpltaeerkvyfvddiegletSP--LAQAYARARGADRMSSFGDMIALSDTVDVPTAKIISRE 333
Q0V3E1        264 FK-----HVSPAGAAIgvplsegerkvymvddiegienSG--LAQAYARARGADRMSSFGDMIALSHEVDLPTAKIISRE 336 Parastagonospo...
XP_003850639  262 FK-----HVSPAGAAIgvplnevekkvymvediegidsSG--LAQAYARARGADRMSSFGDVIALSHEVDVPTAKIIGKE 334
XP_007780455  262 FK-----HVSPAGAAIgvplhdaerkvymvddieglenSA--LAQAYARARGADRMSSFGDMIALSDVCDVPTAKIISRE 334
XP_002584062  261 FK-----HVSPAGAAIgiplndkekkvymvediagideSG--LAQAYARARGADRMSSFGDVIALSDVVDVPTAKIISRE 333
XP_011120504  272 FK-----HVSPAGAAVgvplsdvekkvyfvddivgideSK--VATAYARARGADRMSSFGDWIAISDEVDLPTAKIINRE 344 Orbilia oligos...
3ZZM_A        335 FTEVIVAPGYAPGALDVL-ARK-KNIRVLVAAEPLAgGS--ELRP-IsgGL-LIQQSDQLDahgDNPaNW--TLATG--- 403 Mycobacterium ...
30_pfamImport 202 VSDGVIAPGFEDAALEILkRKKgGRYLVLQIDPDYT-PApqDSRTvF--GItLTQHRNDIE---ISK-KSfnSVITPkd- 273
XP_003713530  337 VSDGVIAPGYDAAALEVLkKKKgGRYLVLQMDADYV-PSpqELRTvY--GVsLAQHRNDVE---VSP-ASfsTVLVPkd- 408
XP_001586294  337 VSDGVIAAGYEDAALEILkKKKgGKYLVLQMDPDFT-PStqETRTvY--GInLSQRRNDIV---ISP-KSfsSIITPkd- 408
XP_024323783  334 VSDGVIAPGYEDAALEILkKKKgGRYLVLQIDPEYV-PNpqETRTvY--GItMAQHRNDVV---ISP-ASfsSIITPke- 405
Q0V3E1        337 VSDGVIAPSYSAEALDILkKKKgGKYLVLQMDPEYV-PAteETRTvF--GItLKQHRNDAK---IVPsDTfnHVIVPkn- 409 Parastagonospo...
XP_003850639  335 VSDGVIAPGYHPEALEILsKKKgGKYLVLQMDPNYS-PPaqEHRTlF--GVhLTQRRNDAQ---ISPqNTfnTIITPkd- 407
XP_007780455  335 VSDGIIAPGYDSEALEILrKKKaGRYLVIQMDPEHEpAAlqEVRTvR--GIsMSQHRNDAR---ISPkDTfnAIMTQkek 409
XP_002584062  334 VSDGVIAPGYEPEALALLaKKKgGKYLVLEMDDNYT-PPgeETRTvY--GVqLRQNRNDAV---ISPnSTfgTIITPkd- 406
XP_011120504  345 VSDGIIAPGYTPEALQILkAKKgGKYTILEIDESYI-PGpvETRTvY--GVtLSQQRNDVK---ITS-RTfsNIHTPn-- 415 Orbilia oligos...
3ZZM_A        404 ----S-PaDPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVER 457 Mycobacterium tuberculosis H37Rv
30_pfamImport 274 ---sGpL-PDTALRDLTVATISLKYTQSNSVCYALNGQVIGLGAGQQSRIHCTRLAGDK 328
XP_003713530  409 ---gPaL-PESALRDLTVATIALKYTQSNSVCYAANGQVIGLGAGQQSRIHCTRLAGDK 463
XP_001586294  409 ---sApL-SESAVRDLTVATIALKYTQSNSVCYALNGQVIGLGAGQQSRIHCTRLAGDK 463
XP_024323783  406 ---gAaL-SDSALRDLTVATIALKYTQSNSVCYALNGQVVGLGAGQQSRIHCTRLAGDK 460
Q0V3E1        410 ---sGtL-PESAQRDLTVATIALKYTQSNSVCYALNGQIIGLGAGQQSRIHCTRLAGDK 464 Parastagonospora nodorum SN15
XP_003850639  408 ---sMpL-PESALRDLTVATIALKFTQSNSVCYALNGQVIGLGAGQQSRIHCTRLAGDK 462
XP_007780455  410 ykdgQaL-PESAMRDLTVATIALKYTQSNSVCYALNGQVIGLGAGQQSRIHCTRLAGDK 467
XP_002584062  407 ---lKsL-PESALRDLTVATIALKYTQSNSVCYAVNGQVVGLGAGQQSRIHCTRLAGDK 461
XP_011120504  416 ---aEpL-PESALIDLTVATIALKFTQSNSVCYAKNGMVVGLGAGQQSRIHCTRLAGDK 470 Orbilia oligospora ATCC 24927
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