2OZB,6RXV,7AJT,6ND4,3ICX,5ZWM


Conserved Protein Domain Family
Nop

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pfam01798: Nop (This model is not part of the current CDD release)
snoRNA binding domain, fibrillarin
This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.
Statistics
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PSSM-Id: 514512
Aligned: 288 rows
Threshold Bit Score: 176.869
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2OZB_B        27 TVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTV-KELGn------SLDKCKNNE------NLQQi-LTNATIM 92  human
XP_001327582  34 llkLRKQ---LHSILTNTFHERFADLASVVTDYKPYAILAkHLATh------NEIESEDIrk----------fLTSQQIV 94 
Q5CQM4       110 VGIIDSKVSEKYECVKALYKDHFGELASIIINKIDYLEVVkRIIThenfedvKLNDI----------------LPNSTIM 173 Cryptosporidium...
XP_002140900  73 LGNIDKIIEILHKNVINLYRPKFGELSSIIINPIQYLEVVkRCIHvsditqvQFNDI----------------LPNSIAM 136
XP_051623196 102 VQEIDNEIINIYNYVRDIYSKRFPKLESIVYSPLDYIAVV-RRAQn------E-MDFTKV--------TLSdiLPNTMVM 165
EFJ08312       1 ---mEKEIESLYDFVKTMYGRRFKELELMVRDPLDYARLV-KKIGn------K-MDLSEVs--------LEd-LPAPTAL 60 
XP_003291242 155 AQEIQHEIYLIHKFVRDRYSKKFPELESSVQNALDYINVV-KRIKn------E-NDLSSVe--------LNdlLPKSTIM 218
XP_004356258 161 IQDIQHEIYLIHKYVKEKYSTKFPSLSNTIQNPLDYILVV-KRIGn------Q-DDLINIn--------LSdlLPKATIM 224
XP_020436859 133 VQDIQHEIYLIHKYVRERYSIKFPELDSTVQNPLDYINVV-KRIGn------Q-SDLTQVd--------LNdlLPKATIM 196
XP_002683293 145 TLSIDQDIDQLFIQLKLLYSEKFKDLESNIIDPMTFVNTV-LRIGn------GIPLVAPRGsqnftdIDLSdiLPPSTIM 217
2OZB_B        93 VVSVt----aSttQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNL 168 human
XP_001327582  95 ACTLsl--qqQ--LGPEI---ESKDFQEACDLQIAASDVSTQLSEICTKCVEMFAPNMCALVGPEISAILITHAGGLKQL 167
Q5CQM4       174 TITIss--stS--KRNIPTLEKKESILKCIDFVNQINESKSKILEFLQFQIEAITPNLSALIGPEIAANLLCVSGGLKNL 249 Cryptosporidium...
XP_002140900 137 TISIaa--stN--TNANISNDTCINIENLIDDAFSLFKKKNELLKFVELEMDKIAPNLSSLVNPNLAAMLICSTNGLRNL 212
XP_051623196 166 AITVaa--ttS--SGSYLSSHVLKEVLAACNEGMILADFRNDILVYLETRMALLAPNVSAIIGTALAARLITQAGGLTTL 241
EFJ08312      61 AISMlf--stM--DMPTLEDSDLQRVLDACDRIIELTETRKEVLGFLESETSSAAPNLSAILGSSITAKLIEEAGGLVSL 136
XP_003291242 219 VLLVtl--ssT--TGKNLTEEDLKKVLDACEMGLELDSKKKRILNYLESRMSYIAPNLSVLLGSSIASKLIGIAGSIIQL 294
XP_004356258 225 V--Vim--ssG--TDKSLSDGELERINSACDMAIELDKTKKVILGYLESRMAFIAPNLSVLLGGSIAARLIGIAGSVSNL 298
XP_020436859 197 VLLVtf--ssT--TGKPLSEKNTDIILNGCDMALELDSNKKLILSYLESRMSFIAPNLSVLLGSSIAARLIGIAGGVQNL 272
XP_002683293 218 ILKVtaandgT--FKVNLSEDKWKKIEQICRDVILLDEHKEHILQYLSMRMSYVAPNLSLLVGTRIAAQLIGAAGGILLL 295
2OZB_B       169 SKMPACNIMLLGAQRktLsGFSsTS--V--------------------------------LPHTG--------------Y 200 human
XP_001327582 168 SQIPSCNIKTFGSNK----SALlGFssRn------------------------------iGNHQG--------------I 199
Q5CQM4       250 AEMPSQNIMVLGSLKn--------------------------------------------NKKNGhfstgpvrlellqsI 285 Cryptosporidium...
XP_002140900 213 AEMPSQNIMLLGSDRk--------------------------------------------SRKYGlyttgvlrielqqsY 248
XP_051623196 242 AKMPSQNIMLVGGNR--KgTVV-----------------------------------------PG--------------V 264
EFJ08312     137 ASMPACNVKLLGREE--IdDLL-GFssAt-------------------------------VKNNGm------------gH 170
XP_003291242 295 SVIPAGHLQTFGADK--K-SLA-GFsgInnrk-----------------------------fqsG--------------L 327
XP_004356258 299 AVIPAGNLQTFGADT--K-ALA-GFsgMgnrk-----------------------------fqmG--------------F 331
XP_020436859 273 SVIPAGNLQTFGASK--K-HLE-GFsgMtnrr-----------------------------fqsG--------------L 305
XP_002683293 296 SQTSADVIQCLGREK--K-KLE-GFstKtymgmlpkrkqtstdskdgnyllsytandfshMRYTG--------------F 357
2OZB_B       201 IYHSDIVQ-SlPP--DLRRKAARLVAAKCTLAARVD------SFHEsTEGKVGYELKDEIERKFD 256 human
XP_001327582 200 IYTSELVQ-QtDP--EYRDSIFRNLADKVALCCRVDa-----SKGN-PDGSFGEKSLFEIKEKLD 255
Q5CQM4       286 ISQSDIVR-NiQD--KYKKKAIRLVSLKCGLCARIDf-----SSTD-KSPDHGVNYRNYILNILE 341 Cryptosporidium parvum
XP_002140900 249 LSKCDIVL-GvPE--LFKKKALRLLSSKCSLCARLDl-----AKSN-KDGKYGKNWRDYIIKILN 304
XP_051623196 265 IYSCDIIQ-NaPS--AVKHRAVKLVSGKLSLAAKIDmf---kEA---TDGSMGAEYRNMIEQALQ 320
EFJ08312     171 VFECEIVQ-StPP--PLRNRACRLVCSKAALAARVDatttinST---KGGEIGRALREEILKTIN 229
XP_003291242 328 ISQCDIIK-QaPP--HLQVKAIRVLTCKVSLAARIDaq---qES-S-FYGEMGRQYRDKVLADIE 384
XP_004356258 332 ISQCDIVK-SaPV--YLQKQAIRAITGRVSIAARVDsc---qES-N-HYGELGQQYKEEIEAKIE 388
XP_020436859 306 ISQCEIVK-KaPP--YLQKKAIRVLTGKVSICARVDaq---qET-S-LYGETGRQFRDLVMAQIE 362
XP_002683293 358 VGLCDLVMeHtPPreKLRKKVARLVATKCALAARIDs-----CNSA-KNGSEGLHLREDIQMAIK 416
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