pfam01796: OB_ChsH2_C (This model is not part of the current CDD release)
ChsH2, C-terminal OB-fold domain
This domain is found at the C-terminal end of the probable enoyl -CoA hydratase alpha subunit from Thermomonospora curvata (ChsH2) and similar archaeal and bacterial proteins. ChsH2 is likely to be involved in bile acid degradation. The C-terminal region of this protein is organised into two domains: an N-terminal zinc finger domain (pfam12172) and an OB-fold domain (this entry) that consists of a five-stranded beta-barrel. This domain is also found in 3-oxo-4,17- pregnadiene-20-carboxyl-CoA hydratase alpha subunit from Mycobacterium tuberculosis that is involved in cholesterol side chain degradation. It is also found in Methanothermococcus thermolithotrophicus HMGCS, an enzyme complex comprising the thiolase and 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase, that catalyzes the second reaction in the mevalonate pathway-the exergonic condensation of acetoacetyl-CoA and acetyl-CoA to HMG-CoA.
Jiyao W et al.(2023). "The conserved domain database in 2023.",