Conserved Protein Domain Family
Ferric_reduct

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pfam01794: Ferric_reduct (485283 is an unknown moldel)
Ferric reductase like transmembrane component
This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.
Statistics
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PSSM-Id: 485283
Aligned: 127 rows
Threshold Bit Score: 30.3182
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q672J9        55 RASA-VCLNFNCMLIllpvsrnfISlVRGTSVCcrGPWRRQLDK-------NLn-FHKLVAYGIAVNSVIHIVAHLFNLE 125 house mouse
Q8XLV2        67 KGFV-STALFILVMF--------AG----AL-----SKKWGITK-------KLlrVRAEMAILASILILPHFIIYTYKFL 121 Clostridium per...
Q5EAM9       246 FPIV-SLILLALVYL--------PG-IIAAVLQ--LYRGTKYSRfpdwldkWMl-CRKQLGLVALAYAFLHAIYTLVMPI 312 tropical clawed...
Q0RIS3        13 SGTV-ALLLLTLTVV--------LGv--------vARSGRGLAGlp---gfAVaaVHRSAGLLAVVFVTLHVVTLLLDPY 72  Frankia alni AC...
Q9EX48        90 SGLLwAWGTVMLGLL--------LSg---PRPArlPVSRQALER-----------LHRTTSLTTMALMSAHALMFAAELV 147 Streptomyces co...
WP_011693745  75 AGLA-GMDLVLLMLL--------LA-ARIPLID----QSVGHDR-------ALe-FHRKLGKPSLYLLLGHGILIAIGYG 132 Arthrobacter sp...
Q82L18        83 AGLY-GALLMAFQLL--------LV-ARLPWLD----RRIGMDR-------LTs-WHRWTGFGILWTLLAHAVFITFGYA 140 Streptomyces av...
Q9L1A8        50 TGLL-AGYLMALVVL--------QM-ARVPALE----RRVGSDR-------VAr-WHAMTGRYTLCLVLAHVFLIMWGYA 107 Streptomyces co...
WP_011718889  61 TGLL-AGYVVIVVLA--------LM-ARVPAVE----RGVGADR-------LAr-WHAMGGRYLVGVAAAHTALIIWGYA 118 Acidothermus ce...
Q0RT78       120 AGLL-AAYLVLVELM--------LM-ARVPALE----RAIGFDR-------LAs-WHRGLGTNIVLLIGGHVLLTVWGYG 177 Frankia alni AC...
Q672J9       126 RYHlgqakdaegllaalsklgdAPNESYLNPVRTFDMgtttellmtvsgiTGLGISLALVFIMTSSTEFIR-RSSYELFW 204 house mouse
Q8XLV2       122 VRL-------------------FSGKPLSILYISFII-------------VGLIAFIIMIPLFITSFKKVRvTMSPSKWK 169 Clostridium per...
Q5EAM9       313 RYYvrwwsnnyiitqiktnntyEFLNHYAWLSDSYVA-------------LGILGFFFYVLLGITSLPSVSnAVNWREFR 379 tropical clawed...
Q0RIS3        73 ARLal---------------pdVVLPFGPGYRPLWVG-------------LGTVALDLLAAVMLTS--ALRrRVGARIWR 122 Frankia alni AC...
Q9EX48       148 RYEaqlawaerl--wagfadtfVPGWYDSGTGRIAIP-------------LGQGALYLAIPLGLLF--YVRhRIGANTWR 210 Streptomyces co...
WP_011693745 133 MAEgl---------------dpVSEAVSLWVLVPDMW-------------LAFISMALFIAVVVTSLVAVRrRFPYEFWY 184 Arthrobacter sp...
Q82L18       141 QSSsm---------------dpVNQLVDLAETVEGVL-------------RAVVALTIIVVVGAVSGRYARrRLAYETWH 192 Streptomyces av...
Q9L1A8       108 AQAgrgl------------gdiVAQTVDSVNQLPDMG-------------KAAIGTGLLVVVGLLSVGPVRrRIPYDTWY 162 Streptomyces co...
WP_011718889 119 VSAhe---------------glIRQTSDLLLHYPDVL-------------MATVALGLFVGIGIVSARALRrRLAYETWY 170 Acidothermus ce...
Q0RT78       178 LSAhe---------------qpLSELVTVITRYPDEW-------------EATIGALLFVAVGISSAWSLRaRISYEAWY 229 Frankia alni AC...
Q672J9       205 YTHHIFVFFFISLA 218 house mouse
Q8XLV2       170 MVQRWAYPFYFLVY 183 Clostridium perfringens
Q5EAM9       380 FVQSKLGYLTLVLC 393 tropical clawed frog
Q0RIS3       123 TVHWAAYGAWPVAV 136 Frankia alni ACN14a
Q9EX48       211 RLHRFVIVVYVLSV 224 Streptomyces coelicolor
WP_011693745 185 AVHLLTYAAVATSL 198 Arthrobacter sp. FB24
Q82L18       193 FIHLYTYVAVVLAF 206 Streptomyces avermitilis
Q9L1A8       163 HVHLLTYAAVFLTF 176 Streptomyces coelicolor
WP_011718889 171 YLHFYTYLAIALSF 184 Acidothermus cellulolyticus
Q0RT78       230 AVHLTVYAAVALTF 243 Frankia alni ACN14a
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