2QJG,7AG7


Conserved Protein Domain Family
DeoC
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pfam01791: DeoC (This model is not part of the current CDD release)
DeoC/LacD family aldolase
This family includes diverse aldolase enzymes. This family includes the enzyme deoxyribose-phosphate aldolase EC:4.1.2.4, which is involved in nucleotide metabolism. The family also includes a group of related bacterial proteins of unknown function. The family also includes tagatose 1,6-diphosphate aldolase (EC:4.1.2.40) is part of the tagatose-6-phosphate pathway of galactose-6-phosphate degradation.
Links
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Statistics
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PSSM-Id: 514506
Aligned: 15 rows
Threshold Bit Score: 146.383
Created: 13-Feb-2025
Updated: 25-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2QJG_A  27 TVIVPMDHGVSNGPIKGl------------IDIRKTVNDVAEG-------GANAVLLHKGIVRHGHRGYGK------DVG 81  Methanocaldococcus ja...
Q8TJ99  10 lMLFAGDQKVEHLNDDFfeegv----peddADPEHLFRIAARS-------KIGVFATQLGLIARYGMDYK-------DVP 71  Methanosarcina acetiv...
P0A991  68 lSILPVDQGVEHSAGASfaan------plyFDPKNIVELAIEA-------GCNCVASTYGVLASVSRRYAH------RIP 128 Escherichia coli K-12
Q19264  60 KVIQYIDLTTLNGDDTAs-------------KVVALAKRAINPvptdpsiHCGSVCVYPQRIADVKKFLASsklnsnITS 126 Caenorhabditis elegans
Q9L7R9  16 FAMLAVDQREAMRLMFAaagaktpvadsvlTDFKVNAAKILSP-------YASAVLLDQQFCYRQAVEQNAva---kSCA 85  Salmonella enterica s...
P0A011  21 ISALAFDQRGALKRMMAkhqtee-ptvaqiEQLKVLVAEELTQ-------YASSILLDPEYGLPASDARNK------DCG 86  Staphylococcus aureus...
P26425  21 ISALAFDQRGALKRLMAqyqtqe-ptiaqmEELKVLVAEELTP-------YASSMLLDPEYGLPAAKHLDK------NAG 86  Streptococcus mutans ...
Q92W65  18 CLDVAIDHGVCNEPSFLsg----------lENMETVVKALTAA-------APDAIQMNYGQADLLQDLPGKd-----KPA 75  Sinorhizobium meliloti
O30128  21 TVIVPMDHGVSMGPIEGl------------KNLAETVNAVAEG-------GANAVVLHKGVVGFGHRGYGK------DVG 75  Archaeoglobus fulgidu...
Q8YQT4  74 LSILPVDQGIEHSAGASfapn------piyFDPENIIRLAIAG-------GCNAVATTLGVLGSVSRKYAH------KIP 134 Nostoc sp. PCC 7120

2QJG_A  82 LIIHLSGGTAISPNPLKKVI------VTTVEEAIRMGADAVSIHVNV---GSDE-DWEAYRDLGMIAETCEYWGMPLIAM 151 Methanocaldococcus ja...
Q8TJ99  72 YLVKVNSKTHLVGTSQADPFsnlwydVDQVAEFKENSGLNILGVGYTiylGSEY-EAEMLVQAAQVVYDAHQHGMVSVLW 150 Methanosarcina acetiv...
P0A991 129 FLVKLNHNETLSYPNTYDQTl-----YASVEQAFNMGAVAVGATIYF---GSEE-SRRQIEEISAAFERAHELGMVTVLW 199 Escherichia coli K-12
Q19264 127 VAGGFPSGQYHLKSK-----------VLEVELSVADGATEIDIVISRasaLDED-WKTVHDEVLACKKACGSAHLKTILA 194 Caenorhabditis elegans
Q9L7R9  86 MIVAAD---DFIPGNGIPVDnvvldkKINAQAVKRDGAKALKLLVLWr--SDED-AQQRLNMVKEFNELCHSNGLLSIIE 159 Salmonella enterica s...
P0A011  87 LLLAYEKTGYDVNAKGRLPDcl---vEWSAKRLKEQGANAVKFLLYYdvdDAEEiNIQKKAYIERIGSECVAEDIPFFLE 163 Staphylococcus aureus...
P26425  87 LLLAYEKTGYDTTSTKRLPDcl---vEWSAKRLKKQGADAVKFLLYYdvdGDEEvNQQKQAYIERIGSECKAEDIPFFLE 163 Streptococcus mutans ...
Q92W65  76 LVMRIDMGNPYNRIRHRDMWavlqneAEPLIGALAMDAACVVVNLFMlpdEPDL-FRQCVQNIARVRADCDKYRMPLMIE 154 Sinorhizobium meliloti
O30128  76 LIIHLSASTSLAPDPNEKVL------VCTVEEAIKLGADAVSVHVNV---GSKT-EAYQLRKLGEISKIAGEWGMPLLAM 145 Archaeoglobus fulgidu...
Q8YQT4 135 FIAKLNHNELLTFPNQFDQVl-----FADVEQAWNLGAVAVGATIYF---GSEQ-STRQIQEISRAFKRAHELGMVTILW 205 Nostoc sp. PCC 7120

2QJG_A 152 -MYPRGKHIQNER-------DPELVAHAARLGAE--LGADIVKTSYT-------------------GDIDSFRDVVKGCP 202 Methanocaldococcus ja...
Q8TJ99 151 -IYPRGAAVKDEK-------DPHLIAGATGVGAC--LGTDFVKVNYPkke--------------geKSAEIFKEAIKAAg 206 Methanosarcina acetiv...
P0A991 200 -AYLRNSAFKKDGvdy--hvSADLTGQANHLAAT--IGADIVKQKMAennggyk------ainygyTDDRVYSKLTSENP 268 Escherichia coli K-12
Q19264 195 tGELKTLS---------------NVYRASWASIL--AGSDFIKTSTGkesv-----------natlEVAYVMCTAIKRWH 246 Caenorhabditis elegans
Q9L7R9 160 -PVVRPPRCGDKFd------REQAIIDAAKELGD--SGADLYKVEMPlygk-----------garsDLLTASQRLNGHIN 219 Salmonella enterica s...
P0A011 164 -VLTYDDNIPDNGsvefakvKPRKVNEAMKLFSEprFNVDVLKVEVPvnmkyvegfaegevvytkeEAAQHFKDQDAATH 242 Staphylococcus aureus...
P26425 164 -ILAYDETITDAAsveyakvKPHKVLDAMKVFSDerFGIDVLKVEVPvnmkyvegfgdgpivhtqdQAANFFKQQDQATP 242 Streptococcus mutans ...
Q92W65 155 pLVMQPVTEHGGYmv---dgDADKIVTLTRLARE--MGADIVKADPT-------------------NDVDEFHRVVEAAR 210 Sinorhizobium meliloti
O30128 146 -MYPRGDGI-NQF-------DEKAVALAARVGAE--LGADIIKTNFT-------------------GDVESFRRVVDGCP 195 Archaeoglobus fulgidu...
Q8YQT4 206 -CYLRNNAFKQDKdy---hlAADLTGQANHLGVT--IEADIIKQKLPennngygavakatgqsygkTHEKVYTDLTTDHP 279 Nostoc sp. PCC 7120

2QJG_A 203 AP---------------VVVAGGPktnTDEEFLQMIKDAM---EAGA--------------AGVAVGRNIFQH 243 Methanocaldococcus jannaschii
Q8TJ99 207 r--------------tkVVCAGGSs-dEAEAFLKKLHDQIh--ISRA--------------QGNATGRNIHQK 248 Methanosarcina acetivorans
P0A991 269 IDlvryqlancymgragLINSGGAa-gGETDLSDAVRTAVinkRAGG--------------MGLILGRKAFKK 326 Escherichia coli K-12
Q19264 247 ELtgk---------kvgFKPAGGI---------KTVDEALsyvALVKdilgdewlnphlfrIGASSLLDDCLK 301 Caenorhabditis elegans
Q9L7R9 220 MPw--------------VILSSGV---DEKLFPRAVRVAM---EAGA--------------SGFLAGRAVWSS 258 Salmonella enterica subsp. e...
P0A011 243 LPy--------------IYLSAGV---SAELFQETLKFAH---EAGAk------------fNGVLCGRATWSG 283 Staphylococcus aureus subsp....
P26425 243 LPy--------------IYLSAGV---SAKLFQDTLVFAK---ESGAn------------fNGVLCGRATWAG 283 Streptococcus mutans UA159
Q92W65 211 CP---------------VLVRGG----GKEDLRSVLDKSAalmKQGA--------------MGMVYGRNIYQH 250 Sinorhizobium meliloti
O30128 196 VP---------------VVVAGGPkmgSDEDILRMVRMAM---DAGA--------------RGVAIGRNIFQA 236 Archaeoglobus fulgidus DSM 4304
Q8YQT4 280 IDltryqvlncycgragLINSGGAs--GKNDFAEAVRTAVinkRAGG--------------TGLISGRKAFQR 336 Nostoc sp. PCC 7120
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