Conserved Protein Domain Family
Folate_carrier

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pfam01770: Folate_carrier (This model is not part of the current CDD release)
Reduced folate carrier
The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.
Statistics
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PSSM-Id: 514487
Aligned: 17 rows
Threshold Bit Score: 394.347
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9BZV2        10 SSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGIS 89  human
Q9EQN9        28 ECWFLPTALLCAYGFFANLRPSEPFLTPYLLGPDKNLTERQVYNEIYPVWTYSYLLLLFPVFLATDYLRYKPVILLQGLS 107 house mouse
EDO34856       6 EFWQKATLLLCLYGFFKEMKPSEPFLTPYLRAPPKNITDEQLENEIYPVWTYSYLAALFFVFVFTDFLRYKPVIIIEGLA 85 
O45166         2 EQW-KVMVLICMYGAVKEFRPTEPYMYEYQHTV-LNMSEQTLNSQVYPIWTYSYLITLIPAFLLTDVFLYKPLLVFEAFS 79  Caenorhabditis ...
Q9VK64         2 KSWLKISLLLCTFGFFREFRPSEPYVTEYLASDYGNLTTDQIYQDVYPFGTYSVLAQLVIVFLITDLVRYKPVIVLSALA 81  fruit fly
Q9VGV5         2 KEWLKISCLLCVFGCIREIRPSEPYVTEYLLGPWRNITEQQLTHDVYPVGTYSYLVQLVFVFLITDFLRYKPLIITIGAA 81  fruit fly
Q9VGV6         2 ESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLITDLLRYKPVIIANATT 81  fruit fly
2_pfamImport   1 ENWKYPTFILCIYGFFSTVRPIEPFLFAYLTGPDKNLTAEELNNQIFPMSTYGNLAAQIPIFLLTDWLRYKPVVILECVA 80 
Q1LV16         4 SDWVFPTVLLSLYGFFANCRPAEPFLTPYLVGP-KNISEEVVTNYLFPIWTYSYLSLLCPVFLLTDLLRYKPLIVAQGLF 82  zebrafish
Q28C92        10 SGWKYPTILLCLFGFFADMRAVDPFTAQYFTGSYHNLTVEQVKNSVLPVWTYSYIALLIPVFLLTDYLRYKPIIVLQALG 89  tropical clawed...
Q9BZV2        90 FIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSY 169 human
Q9EQN9       108 LIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYTVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVVGWSL 187 house mouse
EDO34856      86 YLATRVLLIWASGVLAMQFMQLAYGIATGAEVAYYSYIYAVVDIEHYLKVTSYTRAAVLVGRMMSGVVGQLLVSFRVCDY 165
O45166        80 YFLCWVIFVFGKSVWSQQVLEVFYGWATATEIAYFAYIYVKVPKTEYKSATAFTRAALLVGRFLAYALAQLLIGLNWTSY 159 Caenorhabditis ...
Q9VK64        82 GITLFSMLIWTETVGMLQVAQVFFGTFTAAEVAYYTYMYAKVNKEQYQVVTGHTRAAILSGKFLGGLFAQILVSTDSMDY 161 fruit fly
Q9VGV5        82 GVIIWSMLIWTTSLLSLQILEFFFGTYMAAEVAYYTYIYAKVDKKYYARVTSHTRAAMFAGKLVSGITSQLMLNLELMNY 161 fruit fly
Q9VGV6        82 GICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPRVTSHTRAAMFVGKLVAGILAQMVIGMRWMNY 161 fruit fly
2_pfamImport  81 LFTTTALNLWTASVPGQQASEFFFGVATASEVAYYSYIYSMVPVNKYRKATSYVRSVQLLGYTVGAVLAQLIFSFKLLSF 160
Q1LV16        83 LVTNYIILSFANSLPALTYLQFNFAVVTSTEVAYFSYIYSVIPPERYQRATGYVRSAMLAGYTFGAILGQMLISLANTSY 162 zebrafish
Q28C92        90 LSISMLLMLITRGEAAMQGMEFAYAIFSSCDVAYYSYIYSMVDIVYYQRVTSYCRSITLVAATLGALLQQILMSFAGVSY 169 tropical clawed...
Q9BZV2       170 FYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKpsreikksssv---npvleethegeAPGCEEQKPTSEILsTSGKLNK 246 human
Q9EQN9       188 FSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIpsschgvnglkvqnggivtdtpaanHLPGWEDIESKIPL-NLDEPPV 266 house mouse
EDO34856     166 LTLNYISMASVCIAFIFTFLLPSATGNVFGVGQni---------------------pqNTDSKADGNCDDEIiVVHKLPG 224
O45166       160 STLNIISLVAMTIAVFLALILPGVEWKEAYEKK--------------------------------------LeDNNVQGN 201 Caenorhabditis ...
Q9VK64       162 RQLHYLSLATQLISLAVSLFLPSVPRSLYFYAG-------------------------------------------SEKI 198 fruit fly
Q9VGV5       162 KELNYITLGTQIIAMLWAFGLPRVDRSLYFHRE------------------------------QLSITEPQT-QLPGVGN 210 fruit fly
Q9VGV6       162 KQLFYITVTSQVAALLWAFFLPKVEKSLYFHNR-------------------------SEAIEGGTKSDGGNlEKGSEQP 216 fruit fly
2_pfamImport 161 NNIAILTLILLAIGLFTSFLLPVPQWSMFFHKKtkvtd---------------lefpgELNTKHVERTGEIKdKGEETAN 225
Q1LV16       163 FHVNTVTLSLMIVALCISLSLPMPQHGVFFKKK-------------------------QVEVSMDTMNEVADgGSSRDLE 217 zebrafish
Q28C92       170 FYLNILTLTSALVSLVCSMFLPVPSRSMFFHKKmpgdt----------------ilskQARSPKMETTEDTN-------M 226 tropical clawed...
Q9BZV2       247 GQLNSLKPs--nVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYK-APSQDSSIYNGAVEAIA 323 human
Q9EQN9       267 EEPEEPKP----DRLRVFRVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYAQGLWEKV-MPSQNADIYNGGVEAVS 341 house mouse
EDO34856     225 S--LNNCGrlynSWKLSLLNMWHDFKVCYSNKELLKWSLWWSFGTCGEFQVENFIQNLWEVIyPSMSHRKIYNGGVTAIS 302
O45166       202 LKEIVDQSsymdYLRMFFVGLRHNLMAIYRNPLILKWSVWSALSSCIFYQVTNYTQTLWGTL---PESANRYNGITEALV 278 Caenorhabditis ...
Q9VK64       199 TIADGEETspkfSFANACRLLWYHLVSSYSNPVVLQWSIWWALATCGQVQVISYIQFLWKEV--APNKLSVYNGGVEAVA 276 fruit fly
Q9VGV5       211 LAEMDQQQentqKQPGALSLLWLHFRNAYTNPRVVQWSLWYAIGLAGYLQVTYYVQVLWKVI--EPEPVIAWNGAVDAVL 288 fruit fly
Q9VGV6       217 SN----EEasqeKKIPALQLLWSHFRSAYTNPLVIQWSLWYAISLAGFLQITTYMQVVWKSF--ENEPTIAWNGAVDVAL 290 fruit fly
2_pfamImport 226 TTEDPQELaveqTCGKVLLKMIRDSRDSFSSRKLLYWSLWWVMATCGFTQIVSFVQSLWEHV-QPSQNASIYNGGVEAVS 304
Q1LV16       218 KEVTGRSVkiceYIKTSGKQMWESLKESYSSRRLVQWSLWWALATAGYGQVFNYVQLMWDHI-EPSSTSSVYNGGVEAVC 296 zebrafish
Q28C92       227 LKGCEAERasntNFFNVIWLLCKEVKECYWSRKILYWSLWWAFATPIYNLLVNYSQLLWVYV-EPSGKINAYNSAVDAAS 305 tropical clawed...
Q9BZV2       324 TFGGAVAAFAVGYVKVN--WDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVE 401 human
Q9EQN9       342 TLLGASAVFAVGYIKLS--WSTWGEMTLFLCSLLIAAAVYVMDTVQSIWVCYASYVVFRIIYMVLITIATFQIAANLSME 419 house mouse
EDO34856     303 HLFCVGVALLLSRLNVN--WSIFGEVVLGIVCVADAFVLYISAHTSSLWLAYLMYILFRVAYTFLITIASFQIAKNVGLS 380
O45166       279 PLLGIPADLITRQLNVN--WNRWGDLLLAVGSIGQAGLLFWMSQSHHIVVLYLSYIFYRVIYQLTTTIAQSTLAFSLDSR 356 Caenorhabditis ...
Q9VK64       277 TLLGAIGAILAGLLNSNkrRGSY-MMGISICAAALGALLIYAAKTQLIWVAYVNYVLFCTVFFFIITVAGAVVAENLVED 355 fruit fly
Q9VGV5       289 TALAALSALAAGYLHTGrlRPRASLLILGILSAVEGGCVLICCWTQDIYWSYAGFVLFGALYGFTITVASAEVARNLEEE 368 fruit fly
Q9VGV6       291 TLLSAVFALLAGYFHAGrlNTRSSLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSELASSLEED 370 fruit fly
2_pfamImport 305 NLLSAATVYAIGYKEDR--WERWEELALGAFSGLCSGALFVMTFSNNIWVCYVSFVIFKCLYMVLMTLAMFHIAIGLTME 382
Q1LV16       297 ALVGAAAAFSVGYIQVQ--WGVWGELSLGVFSAVGAGCVFLMGLTNSIWLSYAGYAIFKASYMFLITITMFQIAVNLSME 374 zebrafish
Q28C92       306 TFLGAILSMGAGFVKVD--CELFGEAALTCLSIIDAGVLLFMGFSRTVWISYAGYLIFKSSYMLLITIATFNIAVNLSME 383 tropical clawed...
Q9BZV2       402 RYALVFGINTFIALVIQTIMTVIVVD-QRGLNLPVSIQFLV 441 human
Q9EQN9       420 RYALVFGVNTFIALALQTLLTLIVVD-ARGLGLCITTQFLI 459 house mouse
EDO34856     381 RFALVFGCNMFAALALQTILTTIVAD-KSGLDLNIIEQFVV 420
O45166       357 LFGLLFGINTFVALLLQSILTAVVID---WQKLDIRPQFVV 394 Caenorhabditis elegans
Q9VK64       356 SFGLIFGINTLVGLILQTILTVAVVE-RVGFALEPRDQYVV 395 fruit fly
Q9VGV5       369 SFGLVFGVNTFVALIFQSLLTIIFVT-DTGFELDPVGQYTA 408 fruit fly
Q9VGV6       371 SFALVFGFNTFVGLLLQCILTFVVVSeKANLNLNVFQQFSV 411 fruit fly
2_pfamImport 383 RYALVFGANNFSAVVLQTILTSIVVD-KGGLGLSIIPQFIV 422
Q1LV16       375 CYALTFGINSFVALTLQTILTAIVVD-NTALGLDIATQGLY 414 zebrafish
Q28C92       384 RYALLFGFNTLVALFIQTLLT-VVVD-HRRLGLDLITQFLV 422 tropical clawed frog
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