Conserved Protein Domain Family
Folate_carrier

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pfam01770: Folate_carrier 
Reduced folate carrier
The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.
Statistics
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PSSM-Id: 426420
Aligned: 18 rows
Threshold Bit Score: 389.33
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9BZV2        10 SSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGIS 89  human
Q9EQN9        28 ECWFLPTALLCAYGFFANLRPSEPFLTPYLLGPDKNLTERQVYNEIYPVWTYSYLLLLFPVFLATDYLRYKPVILLQGLS 107 house mouse
EDO34856       6 EFWQKATLLLCLYGFFKEMKPSEPFLTPYLRAPPKNITDEQLENEIYPVWTYSYLAALFFVFVFTDFLRYKPVIIIEGLA 85  starlet sea ane...
O45166         2 EQW-KVMVLICMYGAVKEFRPTEPYMYEYQHTV-LNMSEQTLNSQVYPIWTYSYLITLIPAFLLTDVFLYKPLLVFEAFS 79  Caenorhabditis ...
Q9VGV5         2 KEWLKISCLLCVFGCIREIRPSEPYVTEYLLGPWRNITEQQLTHDVYPVGTYSYLVQLVFVFLITDFLRYKPLIITIGAA 81  fruit fly
Q9VGV6         2 ESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLITDLLRYKPVIIANATT 81  fruit fly
Q9VK64         2 KSWLKISLLLCTFGFFREFRPSEPYVTEYLASDYGNLTTDQIYQDVYPFGTYSVLAQLVIVFLITDLVRYKPVIVLSALA 81  fruit fly
1_pfamImport   1 QPWLRVSLLLCVFGFFRELRVSEPFVTEFLSGEWRDIEPEQLNRDVYPIGTYSQVALLVFMFLLTDVLRYKSIIVFSACL 80 
CAF91078       6 ENWKYPTFILCIYGFFSTVRPIEPFLFAYLTGPDKNLTAEELNNQIFPMSTYGNLAAQIPIFLLTDWLRYKPVVILECVA 85  spotted green p...
Q1LV16         4 SDWVFPTVLLSLYGFFANCRPAEPFLTPYLVGP-KNISEEVVTNYLFPIWTYSYLSLLCPVFLLTDLLRYKPLIVAQGLF 82  zebrafish
Q9BZV2        90 FIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSY 169 human
Q9EQN9       108 LIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYTVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVVGWSL 187 house mouse
EDO34856      86 YLATRVLLIWASGVLAMQFMQLAYGIATGAEVAYYSYIYAVVDIEHYLKVTSYTRAAVLVGRMMSGVVGQLLVSFRVCDY 165 starlet sea ane...
O45166        80 YFLCWVIFVFGKSVWSQQVLEVFYGWATATEIAYFAYIYVKVPKTEYKSATAFTRAALLVGRFLAYALAQLLIGLNWTSY 159 Caenorhabditis ...
Q9VGV5        82 GVIIWSMLIWTTSLLSLQILEFFFGTYMAAEVAYYTYIYAKVDKKYYARVTSHTRAAMFAGKLVSGITSQLMLNLELMNY 161 fruit fly
Q9VGV6        82 GICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPRVTSHTRAAMFVGKLVAGILAQMVIGMRWMNY 161 fruit fly
Q9VK64        82 GITLFSMLIWTETVGMLQVAQVFFGTFTAAEVAYYTYMYAKVNKEQYQVVTGHTRAAILSGKFLGGLFAQILVSTDSMDY 161 fruit fly
1_pfamImport  81 GIVIWSLLLWTESLAALQVVQVLYGAYMASEVAYYTYIYAKISREKYQQVTGNTRAAILLGRFLSGVISQVLVSTGAMNV 160
CAF91078      86 LFTTTALNLWTASVPGQQASEFFFGVATASEVAYYSYIYSMVPVNKYRKATSYVRSVQLLGYTVGAVLAQLIFSFKLLSF 165 spotted green p...
Q1LV16        83 LVTNYIILSFANSLPALTYLQFNFAVVTSTEVAYFSYIYSVIPPERYQRATGYVRSAMLAGYTFGAILGQMLISLANTSY 162 zebrafish
Q9BZV2       170 FYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKpsreikksssv---npvleethegeAPGCEEQKPTSEILsTSGKLNK 246 human
Q9EQN9       188 FSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIpsschgvnglkvqnggivtdtpaanHLPGWEDIESKIPL-NLDEPPV 266 house mouse
EDO34856     166 LTLNYISMASVCIAFIFTFLLPSATGNVFGVGQni---------------------pqNTDSKADGNCDDEIiVVHKLPG 224 starlet sea ane...
O45166       160 STLNIISLVAMTIAVFLALILPGVEWKEAYEKK--------------------------------------LeDNNVQGN 201 Caenorhabditis ...
Q9VGV5       162 KELNYITLGTQIIAMLWAFGLPRVDRSLYFHRE------------------------------QLSITEPQT-QLPGVGN 210 fruit fly
Q9VGV6       162 KQLFYITVTSQVAALLWAFFLPKVEKSLYFHNR-------------------------SEAIEGGTKSDGGNlEKGSEQP 216 fruit fly
Q9VK64       162 RQLHYLSLATQLISLAVSLFLPSVPRSLYFYAG-------------------------------------------SEKI 198 fruit fly
1_pfamImport 161 RDLNYITLGTQAVSLLWSFLLPPVKTSVYFYARdedtk----------------ptdgMVAYRTTPNNEPNEsVENGTAT 224
CAF91078     166 NNIAILTLILLAIGLFTSFLLPVPQWSMFFHKKtkvtd---------------lefpgELNTKHVERTGEIKdKGEETAN 230 spotted green p...
Q1LV16       163 FHVNTVTLSLMIVALCISLSLPMPQHGVFFKKK-------------------------QVEVSMDTMNEVADgGSSRDLE 217 zebrafish
Q9BZV2       247 GQLNSLKPs--nVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYK-APSQDSSIYNGAVEAIA 323 human
Q9EQN9       267 EEPEEPKP----DRLRVFRVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYAQGLWEKV-MPSQNADIYNGGVEAVS 341 house mouse
EDO34856     225 S--LNNCGrlynSWKLSLLNMWHDFKVCYSNKELLKWSLWWSFGTCGEFQVENFIQNLWEVIyPSMSHRKIYNGGVTAIS 302 starlet sea ane...
O45166       202 LKEIVDQSsymdYLRMFFVGLRHNLMAIYRNPLILKWSVWSALSSCIFYQVTNYTQTLWGTL---PESANRYNGITEALV 278 Caenorhabditis ...
Q9VGV5       211 LAEMDQQQentqKQPGALSLLWLHFRNAYTNPRVVQWSLWYAIGLAGYLQVTYYVQVLWKVI--EPEPVIAWNGAVDAVL 288 fruit fly
Q9VGV6       217 SN----EEasqeKKIPALQLLWSHFRSAYTNPLVIQWSLWYAISLAGFLQITTYMQVVWKSF--ENEPTIAWNGAVDVAL 290 fruit fly
Q9VK64       199 TIADGEETspkfSFANACRLLWYHLVSSYSNPVVLQWSIWWALATCGQVQVISYIQFLWKEV--APNKLSVYNGGVEAVA 276 fruit fly
1_pfamImport 225 AKTIDAQPkarfSASRAVRLLWKHLISAYRQLPVVQWSLWWALAMAGFIQVQVYVQLLWHEI--DQQQGTLFNGGAEALL 302
CAF91078     231 TTEDPQELaveqTCGKVLLKMIRDSRDSFSSRKLLYWSLWWVMATCGFTQIVSFVQSLWEHV-QPSQNASIYNGGVEAVS 309 spotted green p...
Q1LV16       218 KEVTGRSVkiceYIKTSGKQMWESLKESYSSRRLVQWSLWWALATAGYGQVFNYVQLMWDHI-EPSSTSSVYNGGVEAVC 296 zebrafish
Q9BZV2       324 TFGGAVAAFAVGYVKVN--WDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVE 401 human
Q9EQN9       342 TLLGASAVFAVGYIKLS--WSTWGEMTLFLCSLLIAAAVYVMDTVQSIWVCYASYVVFRIIYMVLITIATFQIAANLSME 419 house mouse
EDO34856     303 HLFCVGVALLLSRLNVN--WSIFGEVVLGIVCVADAFVLYISAHTSSLWLAYLMYILFRVAYTFLITIASFQIAKNVGLS 380 starlet sea ane...
O45166       279 PLLGIPADLITRQLNVN--WNRWGDLLLAVGSIGQAGLLFWMSQSHHIVVLYLSYIFYRVIYQLTTTIAQSTLAFSLDSR 356 Caenorhabditis ...
Q9VGV5       289 TALAALSALAAGYLHTGrlRPRASLLILGILSAVEGGCVLICCWTQDIYWSYAGFVLFGALYGFTITVASAEVARNLEEE 368 fruit fly
Q9VGV6       291 TLLSAVFALLAGYFHAGrlNTRSSLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSELASSLEED 370 fruit fly
Q9VK64       277 TLLGAIGAILAGLLNSNkrRGSY-MMGISICAAALGALLIYAAKTQLIWVAYVNYVLFCTVFFFIITVAGAVVAENLVED 355 fruit fly
1_pfamImport 303 TLLGAMSALAAGYI-ANriFEQWALWILTVCSGLQGGLIFYSGFATNIWVAYVLYILFGTLYLFMVTMASAIVAKYLEED 381
CAF91078     310 NLLSAATVYAIGYKEDR--WERWEELALGAFSGLCSGALFVMTFSNNIWVCYVSFVIFKCLYMVLMTLAMFHIAIGLTME 387 spotted green p...
Q1LV16       297 ALVGAAAAFSVGYIQVQ--WGVWGELSLGVFSAVGAGCVFLMGLTNSIWLSYAGYAIFKASYMFLITITMFQIAVNLSME 374 zebrafish
Q9BZV2       402 RYALVFGINTFIALVIQTIMTVIVVD-QRGLNLPVSIQFLV 441 human
Q9EQN9       420 RYALVFGVNTFIALALQTLLTLIVVD-ARGLGLCITTQFLI 459 house mouse
EDO34856     381 RFALVFGCNMFAALALQTILTTIVAD-KSGLDLNIIEQFVV 420 starlet sea anemone
O45166       357 LFGLLFGINTFVALLLQSILTAVVID---WQKLDIRPQFVV 394 Caenorhabditis elegans
Q9VGV5       369 SFGLVFGVNTFVALIFQSLLTIIFVT-DTGFELDPVGQYTA 408 fruit fly
Q9VGV6       371 SFALVFGFNTFVGLLLQCILTFVVVSeKANLNLNVFQQFSV 411 fruit fly
Q9VK64       356 SFGLIFGINTLVGLILQTILTVAVVE-RVGFALEPRDQYVV 395 fruit fly
1_pfamImport 382 SFGLIFGINMFVAVGVQALLTLATIS-ERGLMLDPRDQFKV 421
CAF91078     388 RYALVFGANNFSAVVLQTILTSIVVD-KGGLGLSIIPQFIV 427 spotted green pufferfish
Q1LV16       375 CYALTFGINSFVALTLQTILTAIVVD-NTALGLDIATQGLY 414 zebrafish
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