2YVX


Conserved Protein Domain Family
MgtE

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pfam01769: MgtE 
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Divalent cation transporter
This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)
Statistics
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PSSM-Id: 426419
Aligned: 891 rows
Threshold Bit Score: 34.7075
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2YVX_D         343 VPVLLGTGGNTGNQSATLIIRALATR------DLdlrdwr-rvflkeMGVGLLLGLT-------LSFLLVGK-VY--W-- 403 Thermus therm...
jgi:Tagg_0436  240 lPAFNALIGAGMGVLGNSLNVKLHLGvenslhKYvdd-----------skTIAIATF-------IAVLVSMLiVSglTlt 301 Thermosphaera...
jgi:Kcr_0881   256 YPAIIDTLGDCGAIFGSTSTTKLFTGlmepslSEissr------ineLAQIWIAGLIyyflyaiIGFSVGGS-------- 321 Candidatus Ko...
O28767         205 YPAVIGSIGNYGSIMVARTSTKLHLG------Elsvg------klsdAPYVFLTSVV-------IAPTIYVL-AS--L-- 260 Archaeoglobus...
WP_015589870   259 YPAILDSSGNYGSIIGAKTSTMLHLG------EIgkpldr--kivyeILIYSMTGIP-------LAVIMNSL-AT--L-- 318 Archaeoglobus...
Q8U1P8         256 YPAILDTTGNLGSIIGAKTSTKIHLG------EIektlnk--diafeIGVYTILAYP-------LALLSNGI-AV--L-- 315 Pyrococcus fu...
Q5JH39         263 YPAVLATTGNLGAIIGTKTSTRIHLG------ELegflnr--kilveILVYSAVGAL-------LGLLANII-AI--L-- 322 Thermococcus ...
jgi:Ferp_2521  251 YPAIIGSLGNFGGVVGARVSTKLHIG------EVerffek--dvlldILALTTLTLP-------LASIMYSS-GV--L-- 310 Ferroglobus p...
jgi:Arcpr_1246 250 YPAVLDSLGNYGCVIGSKTSTRLHLG------EIdklfdi--rsasdIVSLLSTSIP-------LSVIMYSL-GY--M-- 309 Archaeoglobus...
jgi:Mpet_1665  265 IPPFMGGCGSIGGILCSRLATGMHMG------ELspsviptrevfghFGQSYLYSFI-------LIPVLVLT-VY--Y-- 326 Methanolacini...
2YVX_D         404 -DGH------PLLLP-VVGVSLVlivfFANLV---GAMLPFLLRRLGVDPALVSNPLVATLSDVTGLLIYL 463 Thermus thermophilus HB8
jgi:Tagg_0436  302 sIQS------VGISVlIIGLSFPvlflISSLL---TFYLTQVSFKMGWNPDNLVFPLMTTFVDLNGPLIVS 363 Thermosphaera aggregan...
jgi:Kcr_0881   322 ------------LRS--FAIPLLvysiLFPLIslfTFSLAIVAFRKGLNPDNFIIPLETTMTDTITTVMLs 378 Candidatus Korarchaeum...
O28767         261 -FAStftgapFPEAK-DFLYFMIvylaLAAFVllfSTTLSIWLHRVGVDPDNGGIPLTTTLTDIVGTTAVV 329 Archaeoglobus fulgidus
WP_015589870   319 -IVKvt---lGKTVG-LVPIFLLlypiFLLFVmtiAHLIAIVSEKVGFDPDNTTVPVITTIADMIGTAFTV 384 Archaeoglobus sulfatic...
Q8U1P8         316 -VGRfl---lNKTMG-IIPEFVLlypiLAHLVmwfAYFIAIFAEKMRLDPDNVTVPTITTLADVFSTLFVV 381 Pyrococcus furiosus
Q5JH39         323 -VVKvt---lGARVG-LVKPFLVlypiLIFGVmwmAYFMAIIFDRTGLDPDNATVPTITTIADIISTLFIV 388 Thermococcus kodakaren...
jgi:Ferp_2521  311 -VAYfi---fGRVPG-IYYFFFPfymlTALFVmilGNLISVTFHKFGFDPDNVTVPAITTLADLIGTALTI 376 Ferroglobus placidus D...
jgi:Arcpr_1246 310 -ISIn----lGKSVN-INYAFFLlypiVVLVVmflGYLLAFVSYRFGLDPDNVTVPTITTLADLIGTTFTV 374 Archaeoglobus profundu...
jgi:Mpet_1665  327 -ASMmlgldsPPLSL-LMVICITtgllVITLVnfiGYFAASMSFRYGLDPDNFGIPVITSFIDLTGAALLV 395 Methanolacinia petrole...
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