6OD7,7BQT,6PPI,8HEU


Conserved Protein Domain Family
Herpes_UL6
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pfam01763: Herpes_UL6 (This model is not part of the current CDD release)
Herpesvirus UL6 like
This family consists of various proteins from the herpesviridae that are similar to herpes simplex virus type I UL6 virion protein. UL6 is essential for cleavage and packaging of the viral genome.
Links
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Statistics
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PSSM-Id: 514482
Aligned: 15 rows
Threshold Bit Score: 661.749
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6OD7_A  37 MLFrEILHGQLGYTEGQGVYNVVRSSEATTRQLQAAIFHALLNATTYRDLEADWLGHVAArglqpqrlVRRYRNaREADI 116 Human alphaherpesviru...
P52454  77 MTFiEMLHGHKNFFKGQTIHNALRDSAVLKKQIAYGVAQALLNSVSIQQIHDEWKRHVRSfpfhnkklS----------- 145 Human herpesvirus 6 s...
P09302  74 MLFrKILAGDFGYTDGQGIYSAVRSTETVIRQVQATVLMNALDATRYEDLAADWEHHIQQcnlhagalAERYGLcGESEA 153 Human herpesvirus 3 s...
Q9E6R0  56 M-FkEILAGRLGYTDGQGIYNSVRSTETAIRQIQNTILTLSLDAVRYDDLKNDWIRHADMrgmsakklARTYGMhSEAEA 134 Marek's disease herpe...
P10190  37 MLFrEILHGQLGYTEGQGVYNVVRSSEATTRQLQAAIFHALLNATTYRDLEADWLGHVAArglqpqrlVRRYRNaREADI 116 Human alphaherpesviru...
Q01029  20 HLF-EILQGKYAYVKGQTLHSSLRNPGVFSRQLFIHIYKTVLSSCTYDHVISDWHKYEDN--------IKTRWKnENFTS 90  Herpesvirus saimiri (...
F5HGK9  22 SLF-EILQGKYSYVRGQTLHCSLRNPGVFFRQLFIHLYKNALANCSYDHVLSDWRTYESS--------AKTRWPeKEAQW 92  Human herpesvirus 8 s...
Q66646  20 PLF-EILQGKYSYVKGQTLHSSLRNPGVFSRQLFVHLYKRALSRCTYDEVLSDWQLFEAG--------IRARWRgSRYES 90  Equid herpesvirus typ...
Q6UDH0  55 MGFrEVLLGAPAYSPGHGIYNAVRATSTVIRQVQASVLRNILDGVAFEDLADDWRAHISArgfapgdlAEKYWL-EPADA 133 Psittacid herpesvirus...
6PPI_A  22 sLF-EILQGKYSYVRGQTLHCSLRNPGVFFRQLFIHLYKNALANCSYDHVLSDWRTYESS--------AKTRWPeKEAQW 92  Human herpesvirus 8 s...

6OD7_A 117 AGVAERVFDTWRNTLRTTLLDFAHGL----VACFapGGPSGPSSFPKYIDWLTCLGLVPILRKRQEGG----VTQGLRAF 188 Human alphaherpesviru...
P52454 146 ---FQDYFSVWAHAIKQVILGDISNI----INFI--LQSIDNSHYNRYVDWICTVGIVPFMRTTPTAPnlynLLQQVSS- 215 Human herpesvirus 6 s...
P09302 154 VRLAHQVFETWRQTLQSSLLEFLRGI----TGCLytSGLNGRVGFAKYVDWIACVGIVPVVRKVRSEQn--gTPAPLNTY 227 Human herpesvirus 3 s...
Q9E6R0 135 VKVAENVFVTWRKTLQTTLINLARQL----ISCFt-TANINTSSFSKYIDWICCLGIVPVVRHDRSAR----ATSSIPTC 205 Marek's disease herpe...
P10190 117 AGVAERVFDTWRNTLRTTLLDFAHGL----VACFapGGPSGPSSFPKYIDWLTCLGLVPILRKRQEGG----VTQGLRAF 188 Human alphaherpesviru...
Q01029  91 DSFRKSTYQSWAQTMRMTIDQLVLNN----IYQI--IHSK-ITSYERYTDWVMALGLVPVVKQLPDEK----LIRQIQSQ 159 Herpesvirus saimiri (...
F5HGK9  93 GSYRRSTFDSWAQTMRMTLDHLLLNA----INRV--LYAKTQLSYERYVDWVVTVGMVPVVKHTPDHK----LVNSIQEQ 162 Human herpesvirus 8 s...
Q66646  91 GAFKASTFQSWVDTVKMTLDQLLLNN----IYHI--LHTRTNLSYERYVDWVVAVGLVPLFVSKPDRA----LVKSITSK 160 Equid herpesvirus typ...
Q6UDH0 134 VRVAENATETWSFLLRNLLLDFVRRVaeycIDGM--GGADGTAAYARYVDWLTCLGIVPVIREGDVADd--sAGKGTERF 209 Psittacid herpesvirus...
6PPI_A  93 GSYRRSTFDSWAQTMRMTLDHLLLNA----INRV--LYAKTQLSYERYVDWVVTVGMVPVVKHTPDHK----LVNSIQEQ 162 Human herpesvirus 8 s...

6OD7_A 189 LKQH---------PLTRqlATVAEAAERAGPGFFELALAFDSTRVADYDRVYIYYNHRRGDWLVRdpISGQRGECLVLWP 259 Human alphaherpesviru...
P52454 216 -------------------KLIHDIVRHKQNIVTPILLGLSSVIIPDFHNIKIFRDRNSEQISCF--KNKKAIAFFTYST 274 Human herpesvirus 6 s...
P09302 228 MGQAa--------ELSQmlKVADATLARGAAVVTSLVECMQNVAIMDYDRTRLYYNYNRRLIMAKddVTGMKGECLVVWP 299 Human herpesvirus 3 s...
Q9E6R0 206 AGRStvfpnwafhDASSrlRVVDSVMARGKQIVNYLSNSMSAVSILEYDRTLIEYNFFKRELRVKdiLSGERGECIVIWR 285 Marek's disease herpe...
P10190 189 LKQH---------PLTRqlATVAEAAERAGPGFFELALAFDSTRVADYDRVYIYYNHRRGDWLVRdpISGQRGECLVLWP 259 Human alphaherpesviru...
Q01029 160 LSAAsk------iAAGNd-RVMRTILSALEYTVTDMLETLTSIYIPDYSEVTIDYRSKDQLFVGT--YKGKHIAVEVITR 230 Herpesvirus saimiri (...
F5HGK9 163 LMKDcq------rLASGe-KTIGRILTSVTQEISNLVSSLSALYIPGYSEVSIDYDCVKNTFVGL--YKQKRVHVEVITM 233 Human herpesvirus 8 s...
Q66646 161 FSADsv------gFSSDkyKTMKTVLMTFKRELTSVLETVTSIYIPDFSEVQLYFDGSTTAYFGV--YRGQRITVEVVNR 232 Equid herpesvirus typ...
Q6UDH0 210 VADTew-----dlSMQNrlRLAPAITRRGYDMLGCLERCFRAARVMNYDRTVVIMHSATRELRAYdvHTRERGGCVVAWD 284 Psittacid herpesvirus...
6PPI_A 163 LMKDcq------rLASGe-KTIGRILTSVTQEISNLVSSLSALYIPGYSEVSIDYDCVKNTFVGL--YKQKRVHVEVITM 233 Human herpesvirus 8 s...

6OD7_A 260 PLWTGDRLVFDSPVQRLFPEIVACHSLREHAHVCRLRNTASVKVLLGRKSDSergva-gaarVVNKVLGEDDETKAGSAA 338 Human alphaherpesviru...
P52454 275 PYVIRNRLMLTTPLAHLSPELKKHNSLRRHQKMCQLLNTFPIKVLTAAKTDV----------TNKKIMDMIEKEEKNSDA 344 Human herpesvirus 6 s...
P09302 300 PVVCGEGVVFDSPLQRLSGEVLACYALREHARVCQVLNTAPLRVLIGRRNEDdrsh---strAVDRIMGENDTTRAGSAA 376 Human herpesvirus 3 s...
Q9E6R0 286 PVMNDGGVIFDSPMQRIYKEIIECHDLRQHATLCRLVNTAPVKVLIAKRDDGckgva-gaqrVIDKVLGDQPENAASSAA 364 Marek's disease herpe...
P10190 260 PLWTGDRLVFDSPVQRLFPEIVACHSLREHAHVCRLRNTASVKVLLGRKSDSergva-gaarVVNKVLGEDDETKAGSAA 338 Human alphaherpesviru...
Q01029 231 PVI-AKNIFFDSPVQRLFQNIMSCYRTTEHAKLCQLLNTAPIKAICGASTQN----------VYKDILSHLEQNSQKSDP 299 Herpesvirus saimiri (...
F5HGK9 234 PAILAGRVIFDSPIQRMYTSIMSCHRTAEHAKLCQLLNTAPTKALVGSACNN----------VYKDIMTHLEQASQRTDP 303 Human herpesvirus 8 s...
Q66646 233 PIIFNGEVTFDSPVQRLFNTVMSCHRTAEHAKLCQLLNTSPMKAVVGSTSNN----------LYKDILNHLEQSSHKSDP 302 Equid herpesvirus typ...
Q6UDH0 285 PMLTERGIVFDSPMQRLYAAVLRTQAVREHAKLCQLANTAPVSVLVARREDKvaadpagvskLVDKALGEGAEEAGQSAA 364 Psittacid herpesvirus...
6PPI_A 234 PAILAGRVIFDSPIQRMYTSIMSCHRTAEHAKLCQLLNTAPTKALVGSACNN----------VYKDIMTHLEQASQRTDP 303 Human herpesvirus 8 s...

6OD7_A 339 SR-LVRLIINMKGMRHVGDINDTVRAYLDEAGGHLID-APAvdgtlpgFGKGGNsrgsagqdqggraPQLRQAFRTAVVN 416 Human alphaherpesviru...
P52454 345 KKsLIKFLLNLSDSKSKIGIRDSVEGFIQEITPSIIDqNKLmln-rgqFRKRSAi------------DTGERDVRDLFKK 411 Human herpesvirus 6 s...
P09302 377 SR-LVKLIVNLKNMRHVGDITETVRSYLEETGNHILEgSGSvdtsqpgFGKANQsfngg---amsgtTNVQSAFKTSVVN 452 Human herpesvirus 3 s...
Q9E6R0 365 SR-LVKLIIGLKGMRHVGDITDTVRDYLEETSGHLLD-AASidtsqpgFGQSNRaqsstteetrrntIKIRDAFHSSVVT 442 Marek's disease herpe...
P10190 339 SR-LVRLIINMKGMRHVGDINDTVRSYLDEAGGHLID-APAvdgtlpgFGKGGNsrgsagqdqggraPQLRQAFRTAVVN 416 Human alphaherpesviru...
Q01029 300 KReLLSLLVKLAENKTVSGVTDVVEEFITDVSQNIVDkNKL-------FGSQ---------------ESTTQGLKKHVSN 357 Herpesvirus saimiri (...
F5HGK9 304 KReLLNLLMKLAENKTVSGVTDVVEDFVTDVSQNIVDkNKL-------FGTGQ--------------ETTTQGLRRQVSN 362 Human herpesvirus 8 s...
Q66646 303 KReMLQLLIKLAENKTVSGITDVVEDFVTDVSQNIVDrNKL-------FGGGGGgp---------saESTAQGLKKQVSG 366 Equid herpesvirus typ...
Q6UDH0 365 AK-LIKFIIDMQNMRKVGDVAEVVDAYLRESGGPAIDkTFSldpgragFGGNGKsaqgll-gqqgqpNQPKDGVASVMRD 442 Psittacid herpesvirus...
6PPI_A 304 KReLLNLLMKLAENKTVSGVTDVVEDFVTDVSQNIVDkNKL-------FGTGQ--------------ETTTQGLRRQVSN 362 Human herpesvirus 8 s...

6OD7_A 417 NINGVLEGYINNLFGTIERLRETNAGLATQLQERDRELRRATAGALe---RQQRAADLAAESVTG--------------- 478 Human alphaherpesviru...
P52454 412 QIIKCMEEQIQTQMDEIETLKTTNQMFERKIKDLHSLLETN------------NDCDRYNPDLDH--------------- 464 Human herpesvirus 6 s...
P09302 453 SINGMLEGYVNNLFKTIEGLKDVNSDLTERLQFKEGELKRLREERVkikpSKGSHITMAEETRIA--------------- 517 Human herpesvirus 3 s...
Q9E6R0 443 SINEMLEGYVNKLFNTVEGLKAANKDLLAKLCSKELELDRVRTEHLi---SKQAHTDMGNSQYSP--------------- 504 Marek's disease herpe...
P10190 417 NINGVLEGYINNLFGTIERLRETNAGLATQLQERDRELRRATAGALe---RQQRAADLAAESVTG--------------- 478 Human alphaherpesviru...
Q01029 358 NVFKCLTSQINEQFDTINKLEKERELYLGKINQIETQLLHLTQDEKq----SVSPDNVLVSDTFC--------------- 418 Herpesvirus saimiri (...
F5HGK9 363 SVFKCLTNQINEQFDTITQLEKERELCMKRLKCIETQLSHQQPGDAk----GPGSVNLLTANTFQ--------------- 423 Human herpesvirus 8 s...
Q66646 367 TVFKCLTNQINEQFDTIHKLEKERDMMLRKVHTLETHLSQCRAEDKrlgeVSITS-SLLTTDTLK--------------- 430 Equid herpesvirus typ...
Q6UDH0 443 AVNTSVGKVVNNLFKAVSDLKSANADLTRRNAHIAKELTESRRRIGaltsAAARDNSNGSSRYDApdawrvldekdarwe 522 Psittacid herpesvirus...
6PPI_A 363 SVFKCLTNQINEQFDTITQLEKERELCMKRLKCIETQLSHQQPGDAk----GPGSVNLLTANTFQ--------------- 423 Human herpesvirus 8 s...

6OD7_A 479 ------GCGSRpAGADLLRadydiidVSKSMDDDTYVANSFQHPYIPSYAQDLERLSRLWEHELVRCFKILCHRNNQGQE 552 Human alphaherpesviru...
P52454 465 ------DLENLsLSRALNIvqr-lpfTSVSIDDTRSVANSFFSQYIPDTQYADKRIDQLWEMEYMRTFRLRKNVNNQGQE 537 Human herpesvirus 6 s...
P09302 518 ------------------DlnhevidLTGIIGDDAYIANSFQSRYIPPYGDDIKRLSELWKQELVRCFKLHRVNNNQGQE 579 Human herpesvirus 3 s...
Q9E6R0 505 ------TLETL-----ARDlkhdvidVGEVMDDDSYVANSFQSRYIPAYDVDLKRLSELWEQEMLRCFKLTRATNNQGHE 573 Marek's disease herpe...
P10190 479 ------GCGSRpAGADLLRadydiidVSKSMDDDTYVANSFQHPYIPSYAQDLERLSRLWEHELVRCFKILCHRNNQGQE 552 Human alphaherpesviru...
Q01029 419 ------SLQTL-QSSKLSM-------TSSDVPKGAAVLNSFFSQYVPPFRELNKDLTLLWESEIFHTFKLTPVVDPQGQR 484 Herpesvirus saimiri (...
F5HGK9 424 ------SLGRL-QDPSLQL-------TSSHIPSGSAVLNSFFSSYIPPVRESMKDLTNLWESEMFQTYKLAPVVDNQGQR 489 Human herpesvirus 8 s...
Q66646 431 ------SLLNI-HDSSLSL-------HAASVNKGDNVHNSFFSQYVPPFREVSQDLTSLWESEVFETFKLTPVIDNQGQR 496 Equid herpesvirus typ...
Q6UDH0 523 mgdtllSLGNLpESVTMNKv-----dLSGEMTEDQYVANSFFSRYVPPYLEEESRLSALWERELLRVFKMHRVTNNQGDE 597 Psittacid herpesvirus...
6PPI_A 424 ------SLGRL-QDPSLQL-------TSSHIPSGSAVLNSFFSSYIPPVRESMKDLTNLWESEMFQTYKLAPVVDNQGQR 489 Human herpesvirus 8 s...

6OD7_A 553 TSISYSSGAIAAFVAPYFESVLRAPRVGaPITGSDVILGEEELWDAVFKKTRLQTYLTDIAALF 616 Human alphaherpesvirus 1 strain KOS
P52454 538 ESITYSNYSIELLIVPFLRRLLNIYNLE-SIPEEFLFLSLGEILLAIYESSKIKHYLRLVYVRe 600 Human herpesvirus 6 strain Z29
P09302 580 ISVSYSNASISLLVAPYFSFILRATRLGfLVTQSEVHRSEEELCQAIFKKARTESYLSQIRILY 643 Human herpesvirus 3 strain Dumas
Q9E6R0 574 VSISYSNSAITLLLAPYFFSVLNIYDIGpIVTNHEVYKSEEELCNSVFEKTRIHVYLDDLALIF 637 Marek's disease herpesvirus type 1 st...
P10190 553 TSISYSSGAIAAFVAPYFESVLRAPRVGaPITGSDVILGEEELWDAVFKKTRLQTYLTDIAALF 616 Human alphaherpesvirus 1 strain 17
Q01029 485 LYVKYTQDTVTILIGPFTYSITKLHQME-LINDIFVSMSFNDIASYIYSTSRLAVYIADIGNKY 547 Herpesvirus saimiri (strain 11)
F5HGK9 490 LSVTYSQDTISILLGPFTYVIADLLQME-LISHSFVSSSLQDIAAYLYQTSRLFVYITDVGQKY 552 Human herpesvirus 8 strain GK18
Q66646 497 LYVKYSQDTVSVLLGPFTYVITKMYEME-LITDVYSSLSLNEIADGLYKSSRLYVYMQDVGAKY 559 Equid herpesvirus type 2 strain 86/87
Q6UDH0 598 VSISYSNSSISLIVGPFFHRVLKATRLGfLVADDEAYKSEEELCESLFKKSRVDAYLRDLKTTY 661 Psittacid herpesvirus 1 Amazon parrot...
6PPI_A 490 LSVTYSQDTISILLGPFTYVIADLLQME-LISHSFVSSSLQDIAAYLYQTSRLFVYITDVGQKY 552 Human herpesvirus 8 strain GK18
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