1CJY


Conserved Protein Domain Family
PLA2_B

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pfam01735: PLA2_B 
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Lysophospholipase catalytic domain
This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain pfam00168. Phospholipase B enzymes catalyze the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.
Statistics
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PSSM-Id: 366778
Aligned: 15 rows
Threshold Bit Score: 625.164
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1CJY_A       190 VAILGSGGGFRAMVGFSGVMKALY-----------ESGILDCATYVAGLSGSTWYMSTL-----YSHPDFPEKgPEEINE 253
Q08108       105 IAVAVSGGGYRSMLTGAGVLAAMDnrteg-ayehgLGGLLQSTTYLSGASGGNWLVGTLalnnwTSVQDILNNmQNDDSI 183 Saccharomyces c...
Q9UWF6        88 IGLAFSGGGYRAMLTGAGEISSLDsrtkt--ntpvLAGILQASSYIAGLSGGSWLVGSLasnnlNSVDDMLS--QG---L 160 Candida albican...
O42790       121 VAIAISGGGYRALMNGAGFVAAADnriqnttgaggIGGLLQSSTYLAGLSGGGWLVGSLfsnnfSSIETLLS----ENKV 196 Neurospora cras...
XP_002562131 114 IGIAVSGGGWRALMNGAGAVKAFDsrtdnatatghLGGLLQSATYISGLSGGSWLLGSIyinnfTTVDKLQT--HEAGSV 191
O13857       134 LGLAFSGGGLRAMVHGGGVLNAFDsrng---ngssLAGILQSAMYIAGLSGGSWLVGSVavnnfANITYLRD------NV 204 Schizosaccharom...
Q9Y7N6       125 LGIAISGGGFPAMLTGAGAINAFDarng---nttsLGGILQSSMYLTGLSGGSWLVGSVavnnfANITFLHDD------V 195 Schizosaccharom...
Q9UTH5       114 LGIAVSGGGWRSMLFGGGALAALDsrsn----ettLGGLLQSAHYITGADGGSWLLSSLavnefRTIQNISK------SI 183 Schizosaccharom...
P78854       114 IGIALSGGGLRAMILGSGALSAMDarhd---nhtvLTGLLQASDYLVGTDGSAWTVGGIalnnfSTINDFSK-------L 183 Schizosaccharom...
P49147       190 IAVLGSGGGFRAMVGFAGVMKALY-----------ESGVLDCATYIAGLSGSTWYMSTL-----YSHPDFPEKgPKEINQ 253 chicken
1CJY_A       254 ELMKNVSHN-P--LLLLTP-QKVKRY---VESLWKKKSSGQPVTFTDIFGMLIGETLIH----NRMNTTLSSLK--EKVN 320
Q08108       184 WDLSDSIVT-P--GGINIF-KTAKRWdhiSNAVESKQNADYNTSLADIWGRALAYNFFPslnrGGIGLTWSSIRdfPVFQ 259 Saccharomyces c...
Q9UWF6       161 WELTHSFLS-Y--YGIEHPiKQVEEWvnvGNQVASKRNANFNVSLTDIYGRLLSYPLLTntedEGDAYLWSDVTsaSNFQ 237 Candida albican...
O42790       197 WDFENSIFKgPkeAGLSTV-NRIQYWsevAKEVAKKKDAGFETSITDYWGRALSYQLIGad-mGGPAYTFSSIAqtDNFQ 274 Neurospora cras...
XP_002562131 192 WQFGNSIIEgPdaGGIQLL-DSAGYYkdlADAVDGKKKAGFDTTLTDIWGRALSYQMFNas-nGGLSYTWSSIAdtPEFQ 269
O13857       205 WNLEHSVFA-P--HGDNVV-ENLAYYddlDDEIDQKKDAGFDTSLTDLWGRALSRKLVDat-qGGPNITFSSIRnqTWFQ 279 Schizosaccharom...
Q9Y7N6       196 WNLDHSLFA-P---YDDAF-ENFYIYqewFEQVLQKKNAGFNVSITDLWGRALALKLVNpl-tGGANTTFSSVTneTWFQ 269 Schizosaccharom...
Q9UTH5       184 WYTRLGIFF-I--EETHFG-DLKNYYtnvVDEVNQKAAAGFNVSLTDYWGRAIARHFVGql-rGGPNLTYSSVQnaSWFQ 258 Schizosaccharom...
P78854       184 WAFNHPLMY-P---KSAIV-FNAHFYssiMNEVAEKANAGFNISLSDYWGRVISRTLGDtt-yGFPNVSLSSITsqEWYR 257 Schizosaccharom...
P49147       254 ELMNSVSHN-P--LLLLTP-QKVKRY---IEALWNKKSSGQPVTFTDIFGMLIGETLIH----NRMDTTLSDMK--EKVS 320 chicken
1CJY_A       321 TAQCPLPLFTCLHVK----PDVSELMF-ADWVEFSPYEIG--MAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVW 393
Q08108       260 NAEMPFPISVADGRY----PGTKVINLnATVFEFNPFEMGswDPSLNSFANVKYLGTNVSNGVPLERGKCTAGFDNAGFI 335 Saccharomyces c...
Q9UWF6       238 SHQMPFPILISDGRA----PDTTIINLnSTVIELTPYEFGswDPSLNEFVDTRYLGTKLDNGRPT--GKCYNGFDNAGFF 311 Candida albican...
O42790       275 KAETPFPILVADGRA----PGDTIISLnATNYEFNPFETGswDPTVYGFAPTKYLGANFSNGVIPSGGKCVEGLDQAGFV 350 Neurospora cras...
XP_002562131 270 DGDYPMPFVVADGRN----PGELVIGSnSTVYEFNPWEFGtfDPTIFGFVPLEYLGSKFEGGSLPSNESCIRGFDSAGFV 345
O13857       280 NADYPYPIIISDSRL----EEEKAIPAnTSIFEFTPYEFGtwDNGIKAFLPMEYVGTHLKNGVPP-DHKCIRNYDNAGFV 354 Schizosaccharom...
Q9Y7N6       270 DGEFPFPIIIADNVI----EGETVIPLnDTVFEFTPIEFGtwDTGVESFIPMEYTGTHLINGIPL-NESCVRNFDNAGFL 344 Schizosaccharom...
Q9UTH5       259 TAEYPYPLIVTQGLTgglpDGSNGTATnSSIYEISPYYLTsfDNNVRSYTPTQYLGTNYSNGTAV-DGKCVTQFDNVGFL 337 Schizosaccharom...
P78854       258 NANFPYPIITFATQN----YGEDISNVnTTFFEASPNVFGtfDHGINSFIPTEYLGTTLNNGASS-NGSCVINYDNFGFM 332 Schizosaccharom...
P49147       321 EAQCALPLFTCLHVK----PDVSELMF-ADWVEFSPYEIG--MAKYGTFMSPDLFGSKFFMGTVVKKYSENPLHFLMGVW 393 chicken
1CJY_A       394 GSAFSILFNRVLGV-SGSQSrgstmEEELENITTKHIVS-NDSSDSD-DESHEPkGTENEDAGSD-YQSDNQaswihrmi 469
Q08108       336 MGTSSTLFNQFLLR-INSTH-----LPSFITRLARHFLK-DLSQDFN-DIAVYS-PNPFKDTKFL-DSDYTT-------- 397 Saccharomyces c...
Q9UWF6       312 MGTSSALFNEAVLS-ITEAN-----IPSFLKDIIDDILV-DPILKSNiDVSAYN-PNPFFKSS-----GSNT-------- 370 Candida albican...
O42790       351 MGTSSTLFNQFLLAnISSYDg----VPDVLIEAVTSVLK-EIGAKRD-DVSQII-PNPFLDWN-----NRTN-------- 410 Neurospora cras...
XP_002562131 346 IGTSSSLFNQFLLQ-INTTS-----LPSFIKDVFNGILF-DLDKSQN-DIASYD-PNPFYKYN-----EHSS-------- 403
O13857       355 MGTSATLFNTFLLE-WSQEVt----SNSTLYDIIHKVFE-KLSEDQN-DIAPYP--NPYQNFTTT-NTTVKN-------- 416 Schizosaccharom...
Q9Y7N6       345 MGTSSNVFSGILPA-TNASLt---aSNNTFNNAVLSFLE-MLAEDQL-DVGLYP--NPYQGYGNAsNTTTTN-------- 408 Schizosaccharom...
Q9UTH5       338 VGTSSTRYNEALID-VSLRQsr--mS-RRLGFTLRHMRI-NGSS-----VSFYP--NPYTDATDI-AGNATAvs------ 398 Schizosaccharom...
P78854       333 MGASSTYFNKIMRN-FNDSS-------TKNGRIIQQYLKgNFSENGQ-QIISIP--NPFQGVESA-NSDAAN-------- 392 Schizosaccharom...
P49147       394 GSAFSILFNRVLGV-SNSQNkgptmEEELENIRLKHLVS-NDSSDSE-DESQHPkGTENSEANEE-YQNSSQeswvqrml 469 chicken
1CJY_A       470 mALVSDSALFNTREGRAGkvHNFMLGLNLNTSYPLSPLSDFATQD-SFDDDELDaAVADPDEFERIYEp---LDV-KSKK 544
Q08108       398 -SIVDSDSLFLVDGGEDD--ENVPVLPLIQKERDVDIIFAVDNSA-DMRLAWPD-GSSLVHTYERQFV----KQG-QGMS 467 Saccharomyces c...
Q9UWF6       371 -AISQSKNLYLVDGGEDG--QNIPISPLLH--RNVSAIFAFDNSN-DVLN-WPD-GTSLVKTYERQFS----SQG-NGIA 437 Candida albican...
O42790       411 -PNADTLELDLVDGGEDL--QNIPLNPLTQPVRAVDVIFAVDSSA-DVTN-WPN-GTALRATYERTFG----SIS-NGTL 479 Neurospora cras...
XP_002562131 404 -PYAAQKLLDVVDGGEDG--QNVPLHPLIQPERHVDVIFAVDSSA-DTDYFWPN-GTSLVATYERSLNs--sGIA-NGTA 475
O13857       417 -PFERFDTIDLVDGGEDD--ENIPIWPLLHPQRFVDVIFAVDATY-DDSNGWPD-GSSIVTTYERIITynanKSV-DVRG 490 Schizosaccharom...
Q9Y7N6       409 -PLEPYPIIELIDGGSDS--EGIPFWPLLHPQRDVDVIFAIDGGYqSATSGWPD-GSSLVSTYERVLAt---NSS-GVRG 480 Schizosaccharom...
Q9UTH5       399 eDIVDTPYLDLFDGGYDG--QNIPIWPLLQPERKLDVVFAFDSSG-DTSNFWPN-GSSLVATYERVTQra-sDAVyDVED 473 Schizosaccharom...
P78854       393 -NLGSSSSLNLVDTFLTG--EKIPLWPLLQKGRDVDVIVAVDNGD-DSEWLWPN-GNSLVQTYERVVAaqaaGNT-NVKG 466 Schizosaccharom...
P49147       470 mALVGDSALFNTREGRAGkvHNFMLGLNLNSCYPLSPLADLLTQE-SVEEDELDaAVADPDEFERIYEp---LDV-KSKK 544 chicken
1CJY_A       545 IHVVDSGLTFNLpYPLILRP-QRGVDLIISFDFsarpsDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECyVF 623
Q08108       468 FPYVPDTNTFVN-LGLNKKPtFFGCDANNLTDL-----QYIPPLVVYLPNAEYSFNSNQSAFKLSYSESQRRSMIQN-GF 540 Saccharomyces c...
Q9UWF6       438 FPYVPDQYTFRN-LNLTSKPtFFGCDAKNLTSLtk--dIYDVPLVIYLANRPFTYWSNTSTFKLTYDDNERQGMISN-GF 513 Candida albican...
O42790       480 FPSIPDDWTFIN-LGLNNRPsFFGCDVKNFTLNa---nQKVPPLIVYVPNAPYTALSNVSTFDPSYTMSQRNDIIGN-GW 554 Neurospora cras...
XP_002562131 476 FPAVPDQNTFIN-LGLSTRPsFFGCDSSNQTGP--------SPLVVYIPNAPYSYHSNISTFQLSTDDAERDNIILN-GY 545
O13857       491 FPYIPDEDTIIS-LGLNTHPtFFGCDGRNTTAGnhtvdNNTPPLLVYFPNYPWVYYSNISTFTMSMNDTLSSGILEN-AA 568 Schizosaccharom...
Q9Y7N6       481 FPYIPDTNTFLA-LGLNTHPtFFGCDGRNTTAGnhtvnDDTPPLVVYFPNYPWTMYANVTTYTVQLEDTLSSGMIEN-AA 558 Schizosaccharom...
Q9UTH5       474 FVHVPTPETFVN-LGLNANPtFFGCDGRNTTRGdvpvdHNTPPLVVYMPNTPWTMKSNLVDHRYRIANSEIQALIQN-GF 551 Schizosaccharom...
P78854       467 FPYVPSQQSFVS-LHFNDRPvFFGCDGRNTTAGnhtvtRDTPPLVIYLPNVPYNYFTNISTDRTYYTEDMIQQLLTN-GL 544 Schizosaccharom...
P49147       545 IHIVDSGLTFNLpYPLILRP-QRGVDLIISFDFsarpsDSSPPFKEILLAEKWAKMNKLPFPKIDPNVFDREGLKECyVF 623 chicken
1CJY_A       624 KPKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETEEEKEIADFDIFDDP 674
Q08108       541 EIATRNNFTDDPEFMGCVGCAIIRRKQQALNITLPPECETCFKNYCWNGTL 591 Saccharomyces cerevisiae S288C
Q9UWF6       514 EIATRSSGSLDDEWAACVGCAIIRREQERQGIEQTEQCKRCFENYCWDGTI 564 Candida albicans SC5314
O42790       555 NSATQGNGTLDSEWPTCVACAVISRSLDRLGRQTPAACKTCFERYCWNGTV 605 Neurospora crassa OR74A
XP_002562131 546 EVATMANSTLDDNWTACVGCAILSRSFERTGTTLPDICSQCFDRYCWNGTV 596
O13857       569 LSATQNN---SDSFAVCLACAMIQRSLERKNMSTPSQCSSCFEQYCWNGTT 616 Schizosaccharomyces pombe 972h-
Q9Y7N6       559 VAATQNN---SDSFAVCVACALVQRSLERKNMSTPSQCASCFNQYCWNGTI 606 Schizosaccharomyces pombe 972h-
Q9UTH5       552 VATTQDN---STDFASCLACAVVQRSLERRNQSTSAACQQCFSQYCWNGTV 599 Schizosaccharomyces pombe 972h-
P78854       545 ISSTVDN---DTYFGQCFACAVVKRTLERNNITASPECQQCYYNYCWSGLY 592 Schizosaccharomyces pombe 972h-
P49147       624 KPKDTSSEKDCPTIIHFVLANINFRKYKAPGLPRESKEEKDFADFDIFDDP 674 chicken
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