6OB7


Conserved Protein Domain Family
Nucleoside_tran

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pfam01733: Nucleoside_tran 
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Nucleoside transporter
This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways. Also in this family is mouse and human nucleolar protein HNP36, a protein of unknown function; although it has been hypothesized to be a plasma membrane nucleoside transporter.
Statistics
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PSSM-Id: 396340
Aligned: 7 rows
Threshold Bit Score: 281.235
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6OB7_A 145 MIKIVLINS-FGAILQGSLFGLAGLFPASYTAAIMSGQGLAGFFASVAMI-CAIASGSE----LSESAFGYF---ITACA 215 human
Q19495 137 LGMATSINF-SNGLYENSVYGVFADFPHTYIGALLIGNNICGLLITVVKIgVTYFLNDE----PKLVAIVYF---GISLV 208 Caenorhabditis elegans
Q21145 434 LGTIVVLNA-ANGLFQNSMFGLASPFPFKYTNAVIIGQNFCGTAVTVLSM-LTKAASDD----VQMRASLFF---GLSSV 504 Caenorhabditis elegans
Q14542 131 MASVCFINS-FSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAML-LSMASGVD----AETSALGYFitpCVGIL 204 human
O54698 144 MIKIVLINS-FGAILQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMI-CAVASGSK----LSESAFGYF---ITACA 214 Norway rat
P31381 180 IMMLVVISSmGTAMTQNGIMAIANVFGSEYSQGVMVGQAVAGVLPSLVLFaLAFIENSSv--sTTGGILLYF---FTTTL 254 Saccharomyces cerevis...
Q8VXY7 167 SAAVALSGL-GDALMQGGLIGVAGEMPERYMQAVVAGTAGSGVLVSLLRI-LTKAVYPQdpdgLRKSANLYF---AVGIV 241 thale cress
6OB7_A 216 VIILTIICYLGLPRLEFYRYYQQLKle----------------------------------gpTNES------------- 248 human
Q19495 209 ILLVCAIALFFITKQDFYHYHHQKGmeirekaetd-------------------rpspsilwtTFTN------------- 256 Caenorhabditis elegans
Q21145 505 AVVVCFILLNFLKRLAFYKKFGILRtssqsdeeg--------------------isswesvklAFEK------------- 551 Caenorhabditis elegans
Q14542 205 MSIVCYLSLPHLKFARYYLANKSSQaqaqeletkaellqs---------dengipsspqkvalTLDLdlekepesepdep 275 human
O54698 215 VVILAILCYLALPWMEFYRHYLQLNlagpaeqetkldlis---------egeeprggreesgvPGPN------------- 272 Norway rat
P31381 255 VVTICVVMFSVSKISRKVNENWNVEdghitdvllgslrsneeeirivgridqmededhrrtngTRDD------------- 321 Saccharomyces cerevis...
Q8VXY7 242 VMVICAVFYNVAHKLPVIKFHEERKneelireks---------------------eekgsltgLAWR------------- 287 thale cress
6OB7_A 249 H----------SIKAILKKISVLAFSVCFIFtITIGMFPAVtve-vksSiagsstwER-YFIpvSCFLTFNIFDWLGRSL 316 human
Q19495 257 Cygqlf-nvwfCFAVTLTIFPVMMTVTTRGDsGFLNKIMSE-------N-------DE-IYTllTSFLVFNLFAAIGSIV 320 Caenorhabditis elegans
Q21145 552 Skmqfa-nifvLFFVTLALFPNVCMYVKDAKkGELHSFVVP---------------EK-YFMdvVTFLNFNLFAFLGSLM 614 Caenorhabditis elegans
Q14542 276 Qkpgkp-----svftVFQKIWLTALCLVLVFtVTLSVFPAItam-vtsStsp--gkWSqFFNpiCCFLLFNIMDWLGRSL 347 human
O54698 273 Slpanr---nqsiKAILKSIWVLALSVCFIFtVTIGLFPAVtae-vesSiagtspwKNcYFIpvACFLNFNVFDWLGRSL 348 Norway rat
P31381 322 NdegeelqlkvPFEVLFAKLKYLVLSIFTTF-VVTLVFPVFasatyvtGlp---lsNAqYIP--LIFTLWNLGDLYGRVI 395 Saccharomyces cerevis...
Q8VXY7 288 T----------TLWDIVTKVKSHGFGIVLLYmVTLSIFPGYitedvhsEllt--dwYPi-----LLIAAYNVFDLVGKCL 350 thale cress
6OB7_A 317 TAVFMWPg--kDSRWLPSLVLARLVFVPLLLLCNIKPR---R---YLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGP 388 human
Q19495 321 ASKIHWP----TPRYLKFAIILRALFIPFFFFCNYRVQt--R---AYPVFFESTDIFVIGGIAMSFSHGYLSALAMGYTP 391 Caenorhabditis elegans
Q21145 615 ANWIRFPg--pNTVWICVA--ARFWFMFYFPAANYHPMdfpR---AYPVLFESTWLFAFNICIFALTSGYLSSLIMMYAP 687 Caenorhabditis elegans
Q14542 348 TSYFLWPd--eDSRLLPLLVCLRFLFVPLFMLC-HVPQr-sR----LPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAP 419 human
O54698 349 TAICMWPg--qDSRWLPVLVACRVVFIPLLMLCNVK-Qh--H---YLPSLFKHDVWFITFMAAFAFSNGYLASLCMCFGP 420 Norway rat
P31381 396 ADWPMFRdqkfTPRKTFIYSLLRVAAIPLFLMFTAITSs-sSgdeEHNGSVIVDLCYMLLQFLFGVTNGHVISMSFMKVP 474 Saccharomyces cerevis...
Q8VXY7 351 TAVFMLE----DEKIAVGGSIARLLFYPLFWGCLHG-----------PMFLRTEIPVTILTCLLGLTNGYLTSVLMILAP 415 thale cress
6OB7_A 389 KKVK-PAEAETAGAIMAFFLCLGLALGAVFSFLFRA 423 human
Q19495 392 NVVP-SHYSRFAAQLSVCTLMVGLLTGGLWAVVIEH 426 Caenorhabditis elegans
Q21145 688 RSHEdPKIQRMAGMIASFFLIFGIVAGLVFSWQIRL 723 Caenorhabditis elegans
Q14542 420 RQVL-PHEREVAGALMTFFLALGLSCGASLSFLFKA 454 human
O54698 421 KKVK-PAEAETAGNIMSFFLCLGLALGAVLSFLLRA 455 Norway rat
P31381 475 EQLDnDDEKEAAGGFTNIFVSTGLALGSIISYVFVF 510 Saccharomyces cerevisiae S288C
Q8VXY7 416 KSVP-LRHSETAGIVTVMFLVVGLASGSVIAWFWVI 450 thale cress
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