2ZQE,3QD7


Conserved Protein Domain Family
Smr
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pfam01713: Smr (This model is not part of the current CDD release)
Smr domain
This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity. The full-length Human NEDD4-binding protein 2 also has the polynucleotide kinase activity.
Links
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Statistics
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PSSM-Id: 514447
Aligned: 486 rows
Threshold Bit Score: 30.5269
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2ZQE_A         7 VDLRGLTVAEALLEVDQALEEARALGLSTLRLLHGKGT--------GALRQAIREALRRDKRVESFADAPPGEGGHGVTV 78  Thermus thermop...
WP_024269077  67 LDLHGMRAQAAEISLRHFIDESYRRGWKKVLIIHGKGNhst---dgPVLKDTVMQVVRAHPHAGRHGVPGRSLGGSGALW 143 Salinispira pac...
WP_013759210 138 VDLHGLTRDEAWARLDSFIGDCAHRGLRKVLIVHGKGNhssdkagdSVLSAMVRSFIECDKRLGISGHPDKKLGGTGATW 217 Treponema brenn...
WP_013700504 103 IDLHQLTREEAWDKLKIFVDSCYIRKLKKILIIHGKGNhsh--gtdPVLGQLVRLFIEQDKRLGTSGHPDRNHGGSGATW 180 Treponema
WP_013969766  91 VDLHGLTRDEAWDQLILFFNKAKNHGAEKVLIIHGKGNhse---geAVLKRTTLQFIEQCPYAGMHGHPPAEGGGSGATW 167 Gracilinema cal...
WP_015707017 123 IDLHGLTRDEAWLALESFFRVSQQQGFEKLLIIHGKGNhtd---geAVLKRSVRDFIERCHYAGESGYSPAVDGGTGSTW 199 Treponema primitia
WP_015712110  46 LDLHNMTQEEAWLALDAFFRAGQQQGFEKLLVIHGKGNhpg---sdAVLRDLTRKFIENCPFAGESGHSPAAAGGSGATW 122 Leadbettera azo...
Q73NA1        90 IDLHGMTCDEAEAALNVFFENSIRRGLKKILIIHGKGNhsg---ggAVLAPFVRSYLEKHKRAGECGHPKNADGGTGSTW 166 Treponema denti...
O83680       116 LDLHGMTCSEARSALDSFFAQARERLLQKVEIVHGKGHhsk---ggSVLAPSVKRYVQAHPHAGELFHPAERRGGKGTTW 192 Treponema palli...
WP_013253073  75 IDLHGMTRDEAVTALDRFFREAASRDLQKVLIIHGKGNhsg--rdgAVLPDVVREYLQYSPIAGESGQADRSLGGSGATW 152 Sediminispiroch...

2ZQE_A        79 VALR 82  Thermus thermophilus HB8
WP_024269077 144 Lvik 147 Salinispira pacifica
WP_013759210 218 VIIR 221 Treponema brennaborense
WP_013700504 181 VIIK 184 Treponema
WP_013969766 168 VCLK 171 Gracilinema caldarium
WP_015707017 200 VILK 203 Treponema primitia
WP_015712110 123 VLLK 126 Leadbettera azotonutricia
Q73NA1       167 VILK 170 Treponema denticola
O83680       193 VLLK 196 Treponema pallidum subsp. pallidum str. Nichols
WP_013253073 153 VILK 156 Sediminispirochaeta smaragdinae
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