3QD7,2ZQE


Conserved Protein Domain Family
Smr
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pfam01713: Smr 
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Smr domain
This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity. The full-length human NEDD4-binding protein 2 also has the polynucleotide kinase activity.
Links
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Statistics
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PSSM-Id: 426392
Aligned: 567 rows
Threshold Bit Score: 35.1302
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3QD7_X               51 NLLRQPVEECRKMVFSFIQQ---------------------------------------------ALA------------ 73   Escheri...
CBJ25871            797 DLHLLRRAEALNVLETVLHAirrragehtgvlvngprapkpsqqhkehpgvvaapgghtepsssgASYtppaaqqgeglq 876  Ectocar...
WP_014271323        239 DLHGMKVTEAETACANFLKE---------------------------------------------SAE------------ 261  Sphaero...
bosiu:SAR11G3_00403  51 DLHGYTIEESFRKIDQLFIF---------------------------------------------AKE------------ 73   Candida...
Q4FNT1               74 DLHGYTIEEANKAIEQFIQK---------------------------------------------CFD------------ 96   Candida...
Q74EE8              151 DLHGLTREEAVASLERFITG---------------------------------------------AHR------------ 173  Geobact...
ACH37400            145 DLHGLTREEALENLDRFVKG---------------------------------------------AYN------------ 167  Geobact...
jgi:Ppro_3354       151 DLHGLTREEALEALPRFLAS---------------------------------------------AAA------------ 173  Pelobac...
WP_012468594        155 DLHGLTREEAVASLGPFLQA---------------------------------------------ARN------------ 177  Geobact...
Q3A2X6              143 DLHGATREDARQKVRYFLED---------------------------------------------GVY------------ 165  Pelobac...

3QD7_X               74 --------DGLRNVLIIHGKGRddk--------shaNIVRSYVARWLTEF----DDVQAYCTALPHHGG--SGACYVAL 130  Escheric...
CBJ25871            877 hdrvmsvlK-FASLEVVVGRGAhsv--------agvPRLRPCVMGYLAGKgfraEAVe---------GDkgKGVVVVGL 937  Ectocarp...
WP_014271323        262 --------KHLQKISIIPGKGLhng--------ngvSLLKDVALSQIRLS----GVVREAYSPKACYGG--SGAIWIIL 318  Sphaeroc...
bosiu:SAR11G3_00403  74 --------NNVKKALIITGKGIhsnkendpyaskdlSLLRYAVPDYINKNy--sQNIISIETSPISLGG--EGSMIVTL 140  Candidat...
Q4FNT1               97 --------ENVTKIIVITGKGLrsknienpylskdlSILKYSVPEFIEKNisltQFIIETTDAKIEDGG--SGAFYIYL 165  Candidat...
Q74EE8              174 --------RGQKAVLVITGKGNnss---------gePVLQGAVLSWLRERg--kSMVAEFAPAPRDMGG--SGAVVVFL 231  Geobacte...
ACH37400            168 --------RGQKGVLVITGKGNnsa---------gePVLKSAVAGWLREKg--kGMVSEFIQAPNDMGG--SGAVVVFL 225  Geobacte...
jgi:Ppro_3354       174 --------HGEKAVLVITGKGNnsp---------vePVLQQAVLGWLRDAg--rKLVVEFAPAPREMGG--SGAFVVFL 231  Pelobact...
WP_012468594        178 --------AGEKGVLVITGKGNhsl---------egPVLQQVVAAWLRDQg--rELITEYAPAPAEMGG--SGAFVIFL 235  Geobacte...
Q3A2X6              166 --------QGYKTVLIITGRGKgsq---------qgPVLRDDMEKYLSREa--rAWVAEWGRAPARYGG--EGALVVFL 223  Pelobact...
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