7PPR,4R7P,4R7P,5WEG,1JVG


Conserved Protein Domain Family
UDPGP

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pfam01704: UDPGP (This model is not part of the current CDD release)
UTP--glucose-1-phosphate uridylyltransferase
This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyzes the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle. Also within the family is UDP-N-acetylglucosamine or AGX1 and two hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete.
Statistics
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PSSM-Id: 514442
Aligned: 77 rows
Threshold Bit Score: 366.845
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7PPR_A        43 MDNFFALFRRFLND-KakgNVVNwDRINPPAPNQ----V----VD-YNDLg-aE--ASVEFL----NKLAVVKLNGGLGT 105 Aspergillus fum...
XP_003974070  47 iMGFFRKAMEMSSNsk--nEKMD-TRMEPVPREVlgsvT----RD-REGL---KtwEQSGLQciseSKVAVLLLAGGQGT 115
XP_056088088  46 LSLFLHIFQRYILEnTsitHDLDpNEIRLLSAEE----I----VE-FEDIq-nEelFDPALI----SKVAILKLDGKNNS 111
WP_015424819  19 irtFEAYYQKLVKge---kGLIGeDAIRPPSEKN----L----ID-YQQI---KhlSRTSIL----KNTVVIKLNGGLGT 79  Candidatus Cloa...
WP_015752000  24 iDLFREYYQQLASgh---tGKLSeAAIRPLDKANd---L----LH-QDDLtaeAgtNGRHTL----DQTVMIKLNGGLGT 88  Desulfohalobium...
WP_014760213  35 isQFRHAYHVWASEke--sAWIReDAVEPLHGVRs---F----HDvYKTI---DhdKAVHAF----AKTAFLKLNGGLGT 98  Bifidobacterium...
WP_014259044  39 inifkyyYSLLLSgs---qGKMAeADITPISPDD----L----KD-YLELd-aYeaAGRKAL----PKVAIIKLNGGLGT 101 Desulfocurvibac...
WP_015773692  36 intFKCYFNQFLYga---qVKLSdRDVMAVHDDE----L----AD-YDAMe-qFkdKGEKAL----GKTAVIKLNGGLGT 98  Desulfomicrobiu...
XP_016786673  45 LNFFFQKAIEGFNQ-SshqKNVD-ARMEPVPREVlgsaT----RD-QDQL---QawESEGLFqisqNKVAVLLLAGGQGT 114
1JVG_A        45 LNFFFQKAIEGFNQ-SshqKNVD-ARMEPVPREV----LgsatRD-QDQLqa---wESEGLFqisqNKVAVLLLAGGQGT 114 human
7PPR_A       106 SMGCVGPKSVIEVR----EGMSFLDLSVRQIE------HL------NRTYNVNVPFVLMNSFNTDQDTQSIIK--K--YQ 165 Aspergillus fum...
XP_003974070 116 RLGVSDPKGMYDVGl--pSHKTLFQIQAERILklqqlaGQ------KQKTKCCIPWYIMTSGRTMEATEHFFSkhD--YF 185
XP_056088088 112 IISKASP--LLEVK----NGKCSLDIIVQQTQ------NL------NTKWNSDVPLIFMTSLETESHTTNFLE--K--HY 169
WP_015424819  80 SMGLSKAKSLLPVK----NNLNFLDIISRQVL------TL------RSLSGYDVLLLFMNSFNTEADTLKYLE--K--YP 139 Candidatus Cloa...
WP_015752000  89 SMGMPYAKSLLEVK----QGNNFLDVIVMQCN------GC------DGQLQYSIPLALMDSFATHQETNDYLQ--Q--QG 148 Desulfohalobium...
WP_014760213  99 SMGLQCAKSLLPVRrhkaRQMRFLDIILGQVL------TA------RTRLNVPLPVTFMNSFRTSDDTMKALR--H--QR 162 Bifidobacterium...
WP_014259044 102 SMGLETAKSLLAIK----AETCFLDVIIEQVE------RL------RERYDIPVPLTLMNSFHTHSDSMLAIE--G--FD 161 Desulfocurvibac...
WP_015773692  99 SMGLESAKSLIPVK----EGLSFLDLILLQAS------TV------RTHYGVDFPQVFMNSFKTHMDTM--LKvgD--FH 158 Desulfomicrobiu...
XP_016786673 115 RLGVAYPKGMYDVGl--pSRKTLFQIQAERILklqqvaEK------YYGNKCIIPWYIMTSGRTMESTKEFFTkhK--YF 184
1JVG_A       115 RLGVAYPKGMYDVGl--pSRKTLFQIQAERIL------KLqqvaekYYGNKCIIPWYIMTSGRTMESTKEFFT--KhkYF 184 human
7PPR_A       166 G-HNVDI-ITFNQSRYPRIIKDSLLPAPKSFDap-lQDWYPPGHGDVFESLYNSGTLDKLLERGVEYIFLSNADN-LGAV 241 Aspergillus fum...
XP_003974070 186 GlDKKDI-IFFQQGMLPAMDYNGKILLERKGK----VSMAPDGNGGLYRALGRQGVLDDMERRGIELIHVYCVDNiLVKV 260
XP_056088088 170 SsDEVTW-KTIVQSCFPVIDKNRLLPIDLQANsnkeDLWYPCGTGNLTDTLYFSGELDNLIARGKEFLFVSNVNN-LGAT 247
WP_015424819 140 DlGKQDLpLSFLQNKFPRIRQDTLMPYENKETk---LMWNPPGHGDIYTAL--GDLLDKMIAKDYRYAFVSNADN-LGAV 213 Candidatus Cloa...
WP_015752000 149 IrLGQDV-FTFLQHKFPKIRQDTLEPATYPEDp--eLEWNPPGHGDIYAALETSGLLNQLLSDGYRYAFVSNSDN-LGAV 224 Desulfohalobium...
WP_014760213 163 KfKQTDIpLEIIQHQEPKIDAATGAPASWPTNp--dLEWCPPGHGDLFSTLWESGLLDTLLEHGFEYLFISNSDN-LGAR 239 Bifidobacterium...
WP_014259044 162 N-GRTRVpLAFIQHMYPKIMRDTFLPARWPKNp--eLEWNPPGHGDLYTAMVTSKTLKRLEESGFEYAFISNSDN-LGAV 237 Desulfocurvibac...
WP_015773692 159 N-GTTGIdLAFLQHRYPKIMAKDHSPASWPRNp--eLEWNPPGHGDIYTAMITSGILDALLDKGYLYAFISNSDN-LGAI 234 Desulfomicrobiu...
XP_016786673 185 GlKKENV-IFFQQGMLPAMSFDGKIILEEKNK----VSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNiLVKV 259
1JVG_A       185 GlKKENV-IFFQQGMLPAMSFDGKIILEEKn----kVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNiLVKV 259 human
7PPR_A       242 VDLRILQHMADTGAEYIMELTDKTKADVKGGTII--DYEGKARLLEIAQVpKEHVNEFKSIKKFKYFNTNNI---WMSLR 316 Aspergillus fum...
XP_003974070 261 ADPAFIGFCVQKGADCGAKVVEKTNPTEAVGVVC--KVDGSYQVVEYSEI-TLATAEKRSADGRLMFNAGNVanhFFTFS 337
XP_056088088 248 VDLNILSYMVSEKIDYLVEVVERTANDSNTGVLA--TYKNKLRLVDYDCL------SNESARNCRIVNTNNI---WIDLR 316
WP_015424819 214 VDTSIPAYMENNNIPFVMEVCLRSQMDKKGGHLCe-DKSGQLLLREIAQCpEEDLPRFQDIDYYKYFNTNNI---WIDLR 289 Candidatus Cloa...
WP_015752000 225 VDSRLLGAFADSGTPFMIEVCRRTGADTKGGHLAr-HKDGRLILREIAQCpDEELDAFQDVERFKYFNTNNI---WIDLQ 300 Desulfohalobium...
WP_014760213 240 PSRTLAQYFEDTGAPFMVEVANRTYADRKGGHIVrdTATGRLILREMSQVhPDDKDAAQDIAKHPYFNTNNI---WVRID 316 Bifidobacterium...
WP_014259044 238 MDLKILGYMASEDLPFLMEVAQRTPADKKGGHLCkvKESGRLALREVAQCpDEELAEFQNIEKYAFFNTNSI---WINLK 314 Desulfocurvibac...
WP_015773692 235 MNRRLLGYMVHHNLPFLMEVARRTEQDKKGGHLCrlKKNKQLALREVAQCpDNEMESFCDIEKYKFFNTNSI---WIDLR 311 Desulfomicrobiu...
XP_016786673 260 ADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVC--RVDGVYQVVEYSEI-SLATAQKRSSDGRLLFNAGNIanhFFTVP 336
1JVG_A       260 ADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVC--RVDGVYQVVEYSEI-SLATAQKRSSDGRLLFNAGNIanhFFTVP 336 human
7PPR_A       317 AIK-RVV-E--E-NELEMEI------IANE-KSIpadkkgE-ADQa---IYQLETAVGAAIRHF--------KNAHGVNV 372 Aspergillus fum...
XP_003974070 338 FLR-DVVqK--HePRLQHHV------AQKKiPHV------DaSGQ----LISPEKPNGIKMEKFvfdifqfaKKFVVYEV 398
XP_056088088 317 SLK-RLV-E--S-DGLNLPIrsfdakIIHNnREL------E--------CLQFRTQLADCIGCF--------SSAQAMKV 369
WP_015424819 290 ALEwQMIaN--E-GLMLLPL------IVNP-KVVdg-----------tpVYQLETAMGSAISVF--------NNSKALVV 340 Candidatus Cloa...
WP_015752000 301 QLR-DFIdA--H-GFPQLPI------IVNP-KTV------NpRDEnstpVFQIETAMGAAVAAF--------PGALAVQV 355 Desulfohalobium...
WP_014760213 317 VLR-DMLaE--HdGVLPLPV------IINN-KTV------DpTDPqspaVVQLETAMGAAIGLF--------EGAICVQV 372 Bifidobacterium...
WP_014259044 315 VLE-KVFaY--H-GMMPLDL------IANH-KTL------DpRDPdsppVIQVETAMGSAISAF--------HTAAAVRV 369 Desulfocurvibac...
WP_015773692 312 ILQ-SVFiS--H-RMMPLDL------IINP-KSL------DpRDPsspkVFQLETAMGSAITNF--------LNAQAVIV 366 Desulfomicrobiu...
XP_016786673 337 FLR-DVVnV--YePQLQHHV------AQKKiPYV------DtQGQ----LIKPDKPNGIKMEKFvfdifqfaKKFVVYEV 397
1JVG_A       337 FLR-DVV-NvyE-PQLQHHV------AQKKiPYV------D-TQGq---LIKPDKPNGIKMEKFvfdifqfaKKFVVYEV 397 human
7PPR_A       373 PR-RRFLPVKTCSD------------LLLVKSDLYRLEHGqlvmdpnrf--ggvpviklgSDFkkVSDFQKRIP-SIP-R 435 Aspergillus fum...
XP_003974070 399 LReDEFSPLKNADSqdgkdtpttarhALMSLHHRWVLNAG--------------------GHF--IDENGRRVP-AIP-S 454
XP_056088088 370 AR-SRFLPLTTCRD------------LFLLKSNLYDLDANgtfnlyplkf-gllpsiklgDEFanYETFRIGIP-HIP-D 433
WP_015424819 341 SR-ERFVPVKKTNE------------LLALWSDAYELNEQyqivlkrgve-kapvieldeKYYgkIEDLQKRFSkGIP-S 405 Candidatus Cloa...
WP_015752000 356 NR-DRFIPVKKTND------------LLAVWSDCYIFTPDcrivpnperrlgtivikldsTYFkkIEQLTERFQhGAP-S 421 Desulfohalobium...
WP_014760213 373 DR-MRFLPVKTTND------------LFIMRSDRFHLTDSyemedgnyi---fpnvdldpRYYknIEDFNERFPyNVP-S 435 Bifidobacterium...
WP_014259044 370 PR-TRFAPVKTSND------------LLNVMSDNFILSTDyeivpnpernrspvlvdldpTFYkkVDDFQDRFPeGVP-S 435 Desulfocurvibac...
WP_015773692 367 PR-KRFAPVKTTND------------LLLVMSDCFVRTERetiipnpdrstpmpsisldeNYFkkIDAFLARFPkNPP-S 432 Desulfomicrobiu...
XP_016786673 398 LReDEFSPLKNADSqngkdnpttarhALMSLHHCWVLNAG--------------------GHF--IDENGSRLP-AIPrS 454
1JVG_A       398 LReDEFSPLKNADSqngkdnpttarhALMSLHHCWVLNAG--------------------GHF--IDENGSRLP-AIPrS 454 human
7PPR_A       436 IVELDHLTITGAVnlgrNVTLK 457 Aspergillus fumigatus
XP_003974070 455 LKDGTDLPIKCEIsplvsygge 476
XP_056088088 434 ILELDYLDVMGNVffgrRVILR 455
WP_015424819 406 LSECKELKIYGDVsfgeDVIce 427 Candidatus Cloacimonas acidaminovorans
WP_015752000 422 LVACSSLTIHGDFafgpNVVcr 443 Desulfohalobium retbaense
WP_014760213 436 LAAANSVSIKGDWtfgrDVImf 457 Bifidobacterium bifidum
WP_014259044 436 LLNCTTFTVRGDVrfkggvacr 457 Desulfocurvibacter africanus
WP_015773692 433 LLKCDSLVIEGDVrfeeDVrcv 454 Desulfomicrobium baculatum
XP_016786673 455 ATNGKSETITADV----NHNLK 472
1JVG_A       455 ATNGKSETITADV----NHNLK 472 human
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