1Y5V


Conserved Protein Domain Family
TGT

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pfam01702: TGT (This model is not part of the current CDD release)
Queuine tRNA-ribosyltransferase
This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine. It catalyzes the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues.
Statistics
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PSSM-Id: 514441
Aligned: 450 rows
Threshold Bit Score: 188.852
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1Y5V_A        21 Eg----kARTGTIEMKR-Gv--IRTP-AFMPVgTAATVKALKPETV-R-A--T-G--ADIILGNT-Y-----HLM--L-- 75  Zymomonas mobilis
XP_013024063   7 S------ARISSVSLKN-Kv--LQTPcFIFPT-SKGTIPHLTPDNI-NhN----E--VPVVYFGL-Ed----SLD--L-- 60 
XP_009648486  24 A------ARLGSLALPNrKv--IDTP-HFIAIsSRGTVPHVTPDIL--------S--KHATFGGA-Ym----ALEdfIek 79 
XP_006670831  30 A------ARLGRLALPGrAa--IDTP-NYTSVaSRGAVPHLTPDNM-TkS--VsPgpVYMALEDF-Ie----KTQ----- 87 
XP_008594165  30 T------ARLGRLALPGrAa--FDTP-NYTSVaSRGAVPHLTPDNM------T----RHMSPGST-Ym----ALEdfIek 85 
XP_007806818  28 Ca-----ARLGRLSIPGrRp--METP-SYTAItSRGAIPHLTPDNV-TrYtnCgA--AYMALEDF-VerkepPIY--N-- 91 
EPS34537      24 Ma-----PRVGTLALA--GrqaLATP-NLVPLtSRGTVPHISHDMVrKeTa---M--TSFYVGLEdF-----IER--Kh- 82 
Q0CE16        22 StasvltPRLGTLAFAGrKp--ISTP-NFVPLtSRGAVSHVSHDVM-ReQtaI-G--KRQEKKRT-V-----PIYn-I-- 85  Aspergillus ter...
Q5AU16        10 Saav-lsPRLGRLTIAGrKp--ILTP-HYIPLtSRGVVPHLAHDVM-RdN--T-------SIGSL-Yi----GLEd-F-- 67  Aspergillus nid...
1_pfamImport   1 Tapv-laPRVGKLAIPGrKt--LATP-HHVPLtSRGTVPHVAHDLM-RdH-------TEI------N-----SLY----- 52 
1Y5V_A        76 --------RPGAER-I--AKLGGLHSFMGWdrP-----ILTDSGGYQvmsls-sltkqSEEGVTFKSHLdGSrHMLSPER 138 Zymomonas mobilis
XP_013024063  61 --------LEKSPI-L--NADGEIDKWVAg-tPsq--sILI---APRrsspl-psvsaGPHHIQVLTSs-GL-RKLTNEV 120
XP_009648486  80 ksppilsaPPTLAR--------PLHAFTGFprD-----MVTIMGPRRctpvk-tpvgnGSQSLSIWTST-GA-STLPIDT 143
XP_006670831  88 --------PPIYKTpV--TRENRLHSFTAL--PlasatILA---ARRsqtvt-tptgnTAKSVTLFTST-GF-RGLSVPA 149
XP_008594165  86 ------kqPPIYRIpV--SRENRLHSFTGL--PlcnttILAARRSQAvttp----mgnTAKSVTLFTST-GF-RSLTIPE 149
XP_007806818  92 --------TPEHDT-L--RRL---HNFTALesD-----RATILGARRcpavv-tpmgnGAKAVTLFTST-GF-ASVNVSQ 149
EPS34537      83 -------pAPLYNV-PvaANESPLKKFICV--Rn---dDTVVLGPRRfpaia-cppnnTETSIAISTSV-GF-RQLESQK 146
Q0CE16        86 --------PTASHE-S------ALRKFTSFpdD-----FLLILGPRRvppip-capdnTPNSISILTSV-GF-RQLDANQ 142 Aspergillus ter...
Q5AU16        68 --------PTAPHE-S------ALRKFICAadD-----LLLVFGARReppia-sgpanTDTSIAVLTSV-GY-AQLEANE 124 Aspergillus nid...
1_pfamImport  53 ---------------V------GLEDSADM--P-----LIL---GPRrfppipcppanTSTSVALLTSV-GF-TQLSAHE 99 
1Y5V_A       139 SI-EIQHLLGSDIVMA-FDE---C----TPYPA-TPSRAASSMERSMRWAKRSR----D-AFDS------RKEQAenaaL 197 Zymomonas mobilis
XP_013024063 121 YV-KAITKLRPEIAIP-LND---N----PSNAP-GVKRKPKMIERSVTWTDELLtvlqN-KQL--------TEKVk---V 178
XP_009648486 144 YAaHIE-ALSPDIAIA-PAE---LfhtsVRPPA---KKLVRMADRTEEWVARFLkpsrR-EKLR-------ESGTa---V 204
XP_006670831 150 YV-EAVRLLRPDVVVP-LAD---LphtsTAPPA---KKLVRMVDRTEEWLDQFL----E-ATAAgt---dAAPTSa---V 210
XP_008594165 150 YV-EATALLRPDIVVP-LAD---LfhisTTPPS---KKLVRMVDRTEEWVDQFL----E-ATAPep---sAARQSa---V 210
XP_007806818 150 YV-AAVKSLQPDVVVP-LADslhT----SSTPA-S-KKLIKMVERTEEWVDDFL----R-QFEGra--hlEQLGIs---V 211
EPS34537     147 YI-EAIQKLKPDIAIG-LAD---L----VIGRApGLKRRGKMVDRTHAYTRDAL----ErLFGQsmt-edKKLGTk---Y 209
Q0CE16       143 YI-EAVQKLRPDIVVGmADL---V----LGKRA-GSKRQGKMVDRTHAYTMHGT----D-KLYAss---dSPSSAa---Y 202 Aspergillus ter...
Q5AU16       125 YVgAIQ-RLSPDIVVGlADL---L----VGQKP-GTKRRVKMVDRTHAFTTHAT----D-NLYGpqlsehSRSTAa---Y 187 Aspergillus nid...
1_pfamImport 100 YV-EAVQKLRPDIAVGmVD----L----ANKQP-GSKRRGKMVDRTHAWTRDAL----E-QLYGnavaerEKSKSa---F 161
1Y5V_A       198 FGIQQG------SVFENLRQQSADALA--E--IgFd--GYA--VGGl-aVGEGQDEMFRVl----D-FSVPML-PDDK-P 255 Zymomonas mobilis
XP_013024063 179 FFPIPN-----------VEAPFLNPLI--E--R-FrendYQqnISGlacYGN-----LQSi----P-SELSIY------P 226
XP_009648486 205 FAPIVG-------VPHHVQWQYLKQLSedE--Id----A----LVGl-aIYD-----VKLlpavlE-HYKPLV-PL---A 256
XP_006670831 211 FAPVLP------VEYP-LQWAYLQHLAddV--L-----G-S--LSGl-aIYDTR-LLGDIi------RNYAALgPL---P 262
XP_008594165 211 FAPVLA------VEYP-LQWAYLQHLA--EdvLe----S----LSGl-aLYD-----TQLl----T-DIIPNYaPLRKlP 262
XP_007806818 212 FAPVl-------PVEMPLQWDYLRHIAe---dI-V----NE--VSGl-aVYD--VNILPEl----KsY-EPLA---AL-P 262
EPS34537     210 FAPVLP-------LDNAEQSIYLDDL---EneFr---dR----ISGl-aLYE--SASLSFi----S-ESLGNL------P 258
Q0CE16       203 FAPVLPlentqqSLY--LEELEGDEL------Rp----H----VSGl-aLYD--TISLSIv----P-ETLGTL------P 252 Aspergillus ter...
Q5AU16       188 FAPILP-------LENTQQQLYLEDL---E--TdLr---PS--ISGl-aLYE--PTSLSIv----P-ESLGDL------P 236 Aspergillus nid...
1_pfamImport 162 FAPILP-------LDNAQQSLYLDDL---E--SeFr---WD--VSGl-aLYQ--SASLGFv----P-ESLANL------P 210
1Y5V_A       256 HY-LMGVG-KPDDIVGAVERGIDMFDCVLPTRSGRNGQAFT----------------W--D-----G------------- 297 Zymomonas mobilis
XP_013024063 227 KL-FLRPLlTPLAILQSIHQGADIVMADLVNQASDAGIVFT-------------------F-----Sfpppvedlqnrkl 281
XP_009648486 257 RLsLHTVT-SPQQILEQIAAGVDICAVPFLNTTSDAGIALDftf-----------ppP--E-----Gpheh-------pl 310
XP_006670831 263 RLsLDAPK-TPQQVLQQVALGVDVCVLPFINAVSDSGVAFTftfpapa--ssvaapqP--L-----G------------- 319
XP_008594165 263 RLsLDPPE-TPHEVLKQIALGVDVCVLPFINTVSDAGVALTftfpatsc-ssasapqP--L-----G------------- 320
XP_007806818 263 KL-SFDQPkSPHDVLRQVSLGVDICALPFVNGVSDAGVALTftf-----------paPevEtpqpmG------------- 317
EPS34537     259 RL-LLSEPsSPHEVLREISLGADLLTVPFLQTCSDAGIALDftfpvssavsaqseaqS--L-----G------------- 317
Q0CE16       253 RV-LFDEPaSPHDILRQVALGADLVTIPFLGAVSDAGIALDfvfp---------pppHssD-----Gptpk-------dq 310 Aspergillus ter...
Q5AU16       237 RLlFSGPR-TPHDLLREVELGADLLTIPFLADSSDAGMAFT-------------------FsfpapSdtasasn-pstep 295 Aspergillus nid...
1_pfamImport 211 RL-LFSEPeTPHTILSDISLGADLLTTPLLGAASDGGIAMEfvfpapat-lqegkseP--Lp---lG------------- 270
1Y5V_A       298 --PI-NIRNARFSEDLKPLDSECHCAVC-QKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISE--G--RF 369 Zymomonas mobilis
XP_013024063 282 elAW-DMWHNRFATDLSSLQPGCNCNIC-QSYSRAYVHHLLQTRELVGWIMVQQHNIHVFHNFFCGIRDSIAA--G--SF 355
XP_009648486 311 alGT-SMWSPEHVTSVTPLAPGCQCYACtK-HHRAYIHHLLNANEMLAWTLLQIHNHHVVGEFFAGIRAAFAA--GptRF 386
XP_006670831 320 ---T-NMWLEEHATALRPLSAGCSCYAC-TTHHRAYLRHLLNAKEMLGWSLLQIHNHCAMSRFFDGVRAALRD--G--TF 390
XP_008594165 321 ---T-NMWSEEHATALQPLRAGCKCYVC-TTHHRAYLRHLLNAKEMLGWSLLQIHNHRVMDDFFEGVRAALRD--G--TF 391
XP_007806818 318 ---I-NMWSTDHSVAVVPLQEGCECNAC-TNHHRAYLQHLLNAKEMLGWNLLQIHNHHVIDTFFQGIRDELRKglD--HF 390
EPS34537     318 ---F-DLWAPEYTQDTSPLVESCECYAC-RKHHRSYFNHLLRAKEMAAWALLQMHNHHVMERLFAGARASIAR--G--TF 388
Q0CE16       311 plAF-DLWSSEYKTDIAPLQQDCGCYAC-RSHHRAYINHLLHAKEMLAWTLLQLHNYHVMDRFFAAIRESIQR--G--TF 384 Aspergillus ter...
Q5AU16       296 lpLAdDLWSRSNTTNTGPLSESCACYAC-QSHHRAYIHHLLSAKEMLAWTLLQIHNYYTMDLFFANVRKSIER--G--TF 370 Aspergillus nid...
1_pfamImport 271 ---V-DLWTGSHATDVSPLCDGCECYAC-KNYHRAYIHHLLLAKEMTAWALLQVHNFHIMDKFFAGVRKSIQR--G--SF 341
1Y5V_A       370 SQFAQDFRArYFA 382 Zymomonas mobilis
XP_013024063 356 LEDTERFERiYAP 368
XP_009648486 387 EELSEQFVAtYEA 399
XP_006670831 391 GAAAERFAAaYEA 403
XP_008594165 392 GVAAERFAQvYVA 404
XP_007806818 391 EEQRKRFLAaYLP 403
EPS34537     389 DQDMQNFNRaYAS 401
Q0CE16       385 EADVQAFQRtYAS 397 Aspergillus terreus NIH2624
Q5AU16       371 EADVRTFQQtYVA 383 Aspergillus nidulans
1_pfamImport 342 EQDVETFARfYAS 354
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