2NRF,3ODJ


Conserved Protein Domain Family
Rhomboid

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pfam01694: Rhomboid 
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Rhomboid family
This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.
Statistics
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PSSM-Id: 426384
Aligned: 60 rows
Threshold Bit Score: 82.2699
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NRF_A        39 PTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRL-----GSGKLIVITLI-----SALLSGYVQQKFSGP--- 105 Escherichia coli
Q12270        47 SLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETH-----GTVYTGVFLNL-----SALFAGILYCLLGKLlyp 116 Saccharomyces c...
Q9M1B5        45 TAIEGHYWRMITSALSHISVLHLVFNMSALWSLGVV--EQLghvglGTAYYLHYTLVlv-vfSGVLVIGIYHLLIARfki 121 thale cress
O74926        50 LLQKRQLYEIITYVTLHLSMLHIVFNFVSLLPAMSQFEKKQ-----GTLACILVTVIpytlfPGIMHLIVYHFFLRKdy- 123 Schizosaccharom...
XP_014988788  54 ALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTV-----GTVRHCFFTVI-----FAIFSAIIFLSFEAVssl 123 Rhesus monkey
Q8LB17        58 IISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIM-----GSVRLLYLTVL-----LATTNAVLHLLIASLagy 127 thale cress
Q9RSX7        86 PRQVGTFWHVFTAPFLHAGFPHLIANTVPLAVLAFMTAVR------SVSRFLVATFL-----IALIGGGLVWLLGRSg-- 152 Deinococcus rad...
P9WM21        71 PLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLGFLMTLA------GLSRFVWATAI-----IWILGGLGTWLIGNVgss 139 Mycobacterium t...
P53426        83 LLKTDVLWGISFAPVLHANWQHLVANTIPLLVLGFLIALA------GLSRFIWVTAM-----VWIFGGSATWLIGNMgss 151 Mycobacterium l...
P74553        49 PRSLEGLRGIVFAPFLHADFGHLIANSVPFVVLAWLVMLQ------EVSDFWIVTII-----TMVVGGLGVWLIAPPn-- 115 Synechocystis s...
2NRF_A       106 ------------WFGGLSGVVYALMGYVWLRGERDPQSGIYLQRG------LIIFALIWIVAGWFDLFgm--sMANGAHI 165 Escherichia coli
Q12270       117 ----------eaLVAGASGWCFTLFAYYSFKESQIRPRTRIFRTDysiptlYTPLVLLVAIAVVIPGS------SFWGHF 180 Saccharomyces c...
Q9M1B5       122 dy------frrvTAVGYSCVVFGWMTILSVKQPSSKLNLFGLLSLpi---sFAPFESLIFTSIIVPQA------SFLGHL 186 thale cress
O74926       124 -----------vSIAGLSGWAFAFISASCVHSPQRLISFFNLFSIpa---yCFPIIYLIMTTILVPKA------SFIGHA 183 Schizosaccharom...
XP_014988788 124 sk-----lgeveDARGFTPVAFAMLGVTTVRSRMRRALVFGMVVPs----vLVPWLLLGASWLIp-------qTSFLSNV 187 Rhesus monkey
Q8LB17       128 npfyqydhlmneCAIGFSGILFSMIVIETSLSGVTSRSVFGLFNVpa---kLYPWILLIVFQLLMTn------VSLLGHL 198 thale cress
Q9RSX7       153 -----------sVHLGASELVFGYLAYLLGVGWWERTPLSVVIAV------IAFALYGGVLWGVLPSNp---aISWEAHL 212 Deinococcus rad...
P9WM21       140 c--------gptDHIGASGLIFGWLAFLLVFGLFVRKGWDIVIGL------VVLFVYGGILLGAMPVLgqcggVSWQGHL 205 Mycobacterium t...
P53426       152 f--------gptDHIGVSGLIFGWLAFLLVFGLFVRRGWDIIGCM-------VLFAYGGVLLGVMPVLgrcggVSWQGHL 216 Mycobacterium l...
P74553       116 -----------tVTVGASILIFGYLGFLLFRGWFQKNLASIVLSI------VVLVLYGSALWGLLPGRa---gVSWQGHL 175 Synechocystis s...
2NRF_A       166 AGLAVGLAMAFVDSLNA 182 Escherichia coli
Q12270       181 FGLCVGYAIGYKESWFN 197 Saccharomyces cerevisiae S288C
Q9M1B5       187 SGILVGYAISWGLIGGM 203 thale cress
O74926       184 SGAVMGYCTPFMLGSIP 200 Schizosaccharomyces pombe 972h-
XP_014988788 188 CGLSIGLAYgltycysi 204 Rhesus monkey
Q8LB17       199 CGILSGFSYSYGLFNFL 215 thale cress
Q9RSX7       213 FGFIGGLVAAALLHRKV 229 Deinococcus radiodurans
P9WM21       206 SGAVAGVVAAYLLSAPE 222 Mycobacterium tuberculosis H37Rv
P53426       217 CGAISGVVAAYLLSAPE 233 Mycobacterium leprae TN
P74553       176 FGFIGGAIAAWLIAREK 192 Synechocystis sp. PCC 6803
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