pfam01693: Cauli_VI (This model is not part of the current CDD release)
Ribonuclease H1 N-terminal domain
This domain is found at the N-terminal of ribonuclease H1 from human, its fungal orthologues and in various caulimovirus viroplasmin proteins. This domain consists of three-stranded antiparallel beta-sheet and two short alpha-helices that pack onto opposite faces of the beta-sheet and is structurally similar to ribosomal protein L9 which binds to 23 S ribosomal RNA. RNase H1 belong to the family of ribonuclease H enzymes that recognise RNA:DNA hybrids and degrade the RNA component. The viroplasmin protein is encoded by gene VI and is the main component of viral inclusion bodies or viroplasms. Inclusions are the site of viral assembly, DNA synthesis and accumulation. Two domains exist within gene VI corresponding approximately to the 5' third and middle third of gene VI, these influence systemic infection in a light-dependent manner.
Jiyao W et al.(2023). "The conserved domain database in 2023.",