Conserved Protein Domain Family
Adeno_E1B_19K
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pfam01691: Adeno_E1B_19K (This model is not part of the current CDD release)
Adenovirus E1B 19K protein / small t-antigen
This family consists of adenovirus E1B 19K protein or small t-antigen. The E1B 19K protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen. E1B 19K blocks apoptosis by interacting with and inhibiting the p53-inducible and death- promoting Bax protein. The E1B region of adenovirus encodes two proteins E1B 19K the small t-antigen as found in this family and E1B 55K the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis.
Links
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Statistics
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PSSM-Id: 514434
Aligned: 14 rows
Threshold Bit Score: 145.526
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4KSL0        27 MD----VWTILADFSKTRRLVEDSSDGCSGFWRHwFGTPLSRLVYTVKKDYNEEFENLFADCSGLLDSLNLGHQSLFQER 102 Human adenoviru...
Q9WA49         1 MDy--qLLAKLTNVNYLRKVIVQGSQNCPWWKKI-FSDRFIKVVAEARRQYGQELIEIFVEGERGFGPEFLREGGLYEEA 77  Porcine adenovi...
Q994F2         3 LElslkLCKTLCDFKNLTRVVYYASDRPGWLSRYfFGGRLAQLVYKAKVDYHQTLTELFEDDQSFWCLLESGRTLGFEAK 82  Porcine adenovi...
P04886         1 MD----FLKPFCQYKVLKSVVVGASNQSSVVSRF-FGPKITKLIYSTKVSNRDQFLDSLPR--GYLDGLASGDFSKID-L 72  Tree shrew aden...
Q64843         1 MD----HLSVLLDLKLLRSIVAGASNRTGVWKRRlWLGRLTQLVHDTCVENESIFLNSLPGNEAFLRLLRSGYFEVFDVF 76  Bovine adenovir...
P35984         1 MD----PLKICENYLTFRSIIKGSTFSPGVFRRWrFHG-LADVVGNIVEREEGRFWEIVPETHTLWAVFRGGFTVAPFTE 75  Canine adenovir...
Q6WQ37         1 ME----AWECLEDFSAVRNLLEQSSNSTSWFWRFlWGSSQAKLVCRIKEDYKWEFEELLKSCGELFDSLNLGHQALLQEK 76  Human adenovirus 5
Q6QPB7         1 ME----IWTVLEDFHQTRQLLENSSEGVSYLWRFcFGGPLAKLVYRAKQDYKDQFEDILRECPGIFDSLNLGHQSHFNQS 76  Simian adenovir...
1_pfamImport   1 MD----LLGDLREFGVVRRLLELASDRTSKFWRFcFGSTLSNVLYRVKKEQETQFARLLADTPGVFVALDLGHHSLFQEK 76 
P04492         1 ME----LETVLQSFQSVRQLLQYTSKNTSGFWRYlFGSTLSKVVNRVKEDYREEFENILADCPGLLASLDLCYHLVFQEK 76  Human adenoviru...

Q4KSL0       103 VLHSLDFSSPGRTTAGVAFVVFLVDKWS-QDTQ---LSRGYILDFAAMHLWRAWirqrgQRILNY 163 Human adenovirus 46
Q9WA49        78 VLKELDFSTLGRTVASVALVCFIFEKLQ-KHSG---WTDEGILSLLVPPLCSLL-----EARMMA 133 Porcine adenovirus 3
Q994F2        83 VVPWLDFSSTGRVVSSLSLLAYLVDHLD-CHTD---FSKDYNLEVICAPVCCRL-----KTLVEI 138 Porcine adenovirus 5
P04886        73 LVEQLDFTSAGRLTASLSLLVLVVEEWS-ARSC---VSFDILTELLLVPAWRKI-----IATAWK 128 Tree shrew adenovirus 1
Q64843        77 VVPELHLDTPGRVVAALALLVFILNDLD-ANSAssgFDSGFLVDRLCVPLWLKA-----RAFKIT 135 Bovine adenovirus 3
P35984        76 ILTSLQLENRGRQLAFLAFLSFLLRNWP-SDSV---VSEDARLDLVCAPAWSRIqi-wsQAARLI 135 Canine adenovirus 1 strain Glaxo
Q6WQ37        77 VIKTLDFSTPGRAAAAVAFLSFIKDKWS-EETH---LSGGYLLDFLAMHLWRAVvr--hKNRLLL 135 Human adenovirus 5
Q6QPB7        77 ILRALDFSTPGRTTAAVAFFAFILDKWS-QETH---FSRDYRLDCLAVALWRTWrcqrlNAISGY 137 Simian adenovirus 24
1_pfamImport  77 IIKNLTFTSPGRTVASAAFITYILDQWSnSDSH---LSWEYMLDYMAMALWRAMlr---rRVCIY 135
P04492        77 VVRSLDFSSVGRTVASIAFLATILDKWS-EKSH---LSWDYMLDYMSMQLWRAWlk---rRVCIY 134 Human adenovirus 12
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