2PPQ,1ZYL


Conserved Protein Domain Family
APH

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pfam01636: APH (485067 is an unknown moldel)
Phosphotransferase enzyme family
This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.
Statistics
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PSSM-Id: 485067
Aligned: 138 rows
Threshold Bit Score: 52.1222
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2PPQ_A  26 SYKGIAEGVENSNFLLHTTK-D---PLILTL------------------------YEKR---VEKNDL-PFFLGLXQHlA 73   Agrobacterium fabrum...
Q92YB2 105 TVRRLSSERDE-TFLFTRSDgR---DFILKI------------------------ANPA---EDAAAL-EFQDGALLHlE 152  Sinorhizobium meliloti
Q87UB0  35 TLKTLGSQQDR-NFLLETDK-R---RYVLKI------------------------CHGA---YSTREL-MAQHAALQHlA 81   Pseudomonas syringae...
Q92MC9  35 DLTELGSQQDR-NYRVDTSE-G---PFVLKI------------------------ARAE---YARVEI-EAQNAALRHvA 81   Sinorhizobium meliloti
Q7NEE2  26 RLVRLQIGQIQQTWRLETTA-G---RYICQS------------------------LHLA----FAKAVtEDAQAVSAYlR 73   Gloeobacter violaceus
P73647  29 QIKPFGNGNINDTFLVDLDG-QtqtSFILQR------------------------INHQvfkNPAAVM-GNMVRVTTHiK 82   Synechocystis sp. PC...
Q8YVD8  28 NVQAFGSGNINDTFLVTVDS-LeaqHFVLQR------------------------INTQ----VFRQP-ELIMQNMRIfS 77   Nostoc sp. PCC 7120
Q8EJU3  13 KISALGNGHINDTLLVRWPT-G---ELVLQR------------------------INTQvfkTPQALV-RNADKISHHlC 63   Shewanella oneidensis
Q89ZY1  19 EIKPLGAGLINDTYKVNTQE-AdapDYVLQRinhaifqnvemlqsniaavtghirKKLT----EAGEA-DIDRKVLSFlA 92   Bacteroides thetaiot...
Q8G3W1  23 GIEPYGDGHINTTYLVTTDGp----RYILQQ------------------------MNTS---IFPDTV-NLMRNVELVtS 70   Bifidobacterium longum
2PPQ_A  74 AKGLscplP---------LPR-K-------Dgel-lgELSGR--------PAALISFleGXWLRKpea----------kh 117  Agrobacterium fabrum...
Q92YB2 153 AA-Apv-vP---------VPRlV-------Rtks-geQSHTLstad-gprVMRLLTFlrGELQYRtpasea----qsrnv 208  Sinorhizobium meliloti
Q87UB0  82 SHRAv---S---------VPGvIrandtepLlsv-dvDGQAV--------HVRLLEFidGQSLGHvghlshd---ivvgl 137  Pseudomonas syringae...
Q92MC9  82 TRPDa--pK---------VPEvV-------Sal--sgEEIVTaavreetyQFRLLTYldGTPLTRrrhlavetvaalgdv 141  Sinorhizobium meliloti
Q7NEE2  74 RQGF----V---------IPEfLtt----rAgel-hfEGEGG--------RWRVMTClpGVSHRTapdp---------vy 118  Gloeobacter violaceus
P73647  83 QKLQrqplErp-----wlMPEvI-------Ltk--nnQDHWDsgt---geFWRAISFiaGSESFDiltdpaqa-kevgta 144  Synechocystis sp. PC...
Q8YVD8  78 DH-VhqrlQyappnrrweVPRvLstk-dnhDyct-dtQGNF----------WRAISFisGSQSFdtmqdla----qaqei 140  Nostoc sp. PCC 7120
Q8EJU3  64 AKALqq-qY---------GLQvV-------Spcl-tqEGELAidlg-eqgFWRAISYlpHSLSIevvksea----qaema 120  Shewanella oneidensis
Q89ZY1  93 TEEG----------------KtY-------Wfd---gESYWR--------VMVFIPR--AKTYETvnpeysn---yagea 133  Bacteroides thetaiot...
Q8G3W1  71 TLKA----Q---------GKEtL-------DivpttsGATWAeid---ggAWRVYKFieHTVSYNlvpnpdvf-reagsa 126  Bifidobacterium longum
2PPQ_A 118 cREVGKALAAXHLA-------SEGFEIKRpNALSVDGWKVLWdksEERADEVEKglREEIRP------EIDYLAAHWPkd 184  Agrobacterium fabrum...
Q92YB2 209 gRALAALGLGLEDYr------GRPPAGKLmWDISHTLDLTAVv--DHVAPERRA----QAEA------VLAEFERALPai 270  Sinorhizobium meliloti
Q87UB0 138 gELCARVDLALADFe------HPGLERILqWDPRHAQALIKHl-lPVIKDADARacVIEAGEq-----AHRRLLPLIPs- 204  Pseudomonas syringae...
Q92MC9 142 aGRLAVALRDF-DHpg----lERELQWDLrRAGPVALHLLSA----MSDVDLRKr-IAEAMVg-----AMRRVQPLMPd- 205  Sinorhizobium meliloti
Q7NEE2 119 lRQAGQVAGKMHRL-------LAGFEHSFrFQLPNFHNTPQIh-rQLQACPCDS----KVEA------EWAYLLESVPal 180  Gloeobacter violaceus
P73647 145 lGIFHQLLSDLSPSq-----lVDTLPGFHhTPIYLQQYQRALaqnPKLTGSLGPe-INHCQRv-----IKTWLDQCGVle 213  Synechocystis sp. PC...
Q8YVD8 141 gYALGMFHNLISDLspekladTLPGFHITpLYLRHYEQVLATa-kPQPSPELDYclQFVSDRq-----SYACILENAKaa 214  Nostoc sp. PCC 7120
Q8EJU3 121 aKAFGHFACALSDFdateledVIPQFHHLpGRMEMLRQAVQQd-kAKRLESCRQw-VDYALSqqslldELAEISPQLP-- 196  Shewanella oneidensis
Q89ZY1 134 fGNFQAMLADIPETlg----eTIPDFHNMeFRLKQLRDAVAAn-aAGRVAEVQYy-LDEIEKr-----ADEMCKAERLfr 202  Bacteroides thetaiot...
Q8G3W1 127 fGDFQNFLSEFDASql---teTIARFHDTpHRFEDFKAALAAd-kLGRAAACQP----EIDF------YLSHADQYAVvm 192  Bifidobacterium longum
2PPQ_A 185 -------lPAGVIHADLFQDNVFFL-----GDELs--gLIDFYFACNDLLAYDVSICL----NAw-cFEKD--------G 237  Agrobacterium fabrum...
Q92YB2 271 t----glkRRQIIHNDFNPHNVLLDps--sPTTVv--gIIDFGDMVHAPLINDLAVAL----SYhlgTENW--------A 330  Sinorhizobium meliloti
Q87UB0 205 -------lPIQAVHLDITEHNVVWLrdsqrQWQMq--gLIDFGDLVSTWRVADLSVTCaa-lLHh--AEGD--------P 264  Pseudomonas syringae...
Q92MC9 206 -------lRLQAIHQDVTDDNVVSRad--rSGRLipdgVIDFGDVLKGWVVADLAVTCasllHHaggDPFQ--------I 268  Sinorhizobium meliloti
Q7NEE2 181 ll--paglPRQIIHGDLKLTNFLFDe----rGGVv--gIVDLDTFMYHSLYVELGDAL----RSw--cTAG--------E 238  Gloeobacter violaceus
P73647 214 takaqgqlPLRLMHGDPKVNNILFDrq---sGKAv--sVIDLDTTKPGLIHYDLGDCL----RS------G--------C 270  Synechocystis sp. PC...
Q8YVD8 215 g-----elPLRLMHGDPKINNIMFDtf-thKAVS----VIDLDTVKPGLVHYDIGDCL----RSg-cNPAGeetehwesV 279  Nostoc sp. PCC 7120
Q8EJU3 197 ---------LRICHNDTKINNMLFDk---rDMSSm--aIIDLDTCMKGHLMYDFGDMVr---TFcspEEED--------S 251  Shewanella oneidensis
Q89ZY1 203 e----gklPKRVCHCDTKVNNMMFDe----DGKVl--cVIDLDTVMPSFIFSDYGDFL-----Rt-gANTG--------D 258  Bacteroides thetaiot...
Q8G3W1 193 dglrdgsiPLRVTHNDTKLNNILMDa---tTGKAr--aIIDLDTIMPGSMLFDFGDSI-----R-----FG--------A 249  Bifidobacterium longum
2PPQ_A 238 AYNVTKGKALl-----------EGYQSVRPL 257  Agrobacterium fabrum str. C58
Q92YB2 331 ARTGSFLEGFhsv-------raLEPGEIEVL 354  Sinorhizobium meliloti
Q87UB0 265 LYILPAIRAYh----------aLNPLKREEL 285  Pseudomonas syringae pv. tomato
Q92MC9 269 LPAVKAFHAVc----------pLTDAELKAL 289  Sinorhizobium meliloti
Q7NEE2 239 TFNLQLLEASl-----------SGYAQSGAC 258  Gloeobacter violaceus
P73647 271 NLLGEETENWsa--------veFDLDLCRAI 293  Synechocystis sp. PCC 6803
Q8YVD8 280 AFDTDLCQGIl----------qGYLSVAKEF 300  Nostoc sp. PCC 7120
Q8EJU3 252 TALENVKVRQsif-------aaICRGYLSEL 275  Shewanella oneidensis
Q89ZY1 259 EDDKDLNRVN------------FNMEIFKAF 277  Bacteroides thetaiotaomicron
Q8G3W1 250 STALEDEKDLskvhfstelfraYTEGFVGEL 280  Bifidobacterium longum
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