Conserved Protein Domain Family
HrcA

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pfam01628: HrcA 
HrcA protein C terminal domain
HrcA is found to negatively regulate the transcription of heat shock genes. HrcA contains an amino terminal helix-turn-helix domain, however this corresponds to the carboxy terminal domain.
Statistics
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PSSM-Id: 426353
Aligned: 584 rows
Threshold Bit Score: 69.8783
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_014760239 103 QDTLQRAARLLSHITGQVAVVA-SPSPakAKVLRVQIVPV-SStLLLIVVITGAGNVAQHTLalsp-qptDIT-LADVGS 178 Bifidobacterium...
CAT04849     106 EQTINEAVKIISEVAGATLIATtNDSF--EKLMSISLTIIsES-TGVVVLITSSGRVENKLInfn--nfiKKEdVKIAIR 180 Mycoplasma conj...
B3PN01       110 DATLEEAAAIVSEVAGVTVVATsNNAA--ETMKSIQLTTLsEL-SAIVVIVTSSGRVESKIFnfen-sdiSLEdLRVAIR 185 Mycoplasma arth...
WP_012855683 120 NTTLEEAANVVSQMAGFAVVATsNNES--ELLKSIQLTPLdEE-SAVVVIVTSSGNVQNKMFkfe--sgiELNdLRIAIR 194 Mycoplasma hominis
Q6KIH9       103 DVTLDEAAKAINEIIGLTLVTSsNVNT--EVLKSIQLIELnNY-SATIILVTSTGQVANKTIdltnfqdiKLEdVRIAIR 179 Mycoplasma mobi...
Q98R68       111 DETIELAAKSISEIVGLTMVTStENSF--ETLKSIQLVLLdKN-ESIIIIVLSSGKVISKKLamk--dsiVLDdLRIAVR 185 Mycoplasma pulm...
WP_011949717 109 ENTVEEAAKIITESIGVTLVTTeNNEN--ATLKNLQLVPLsDR-EGIVLITDSYNKTTTNNInink-emySMNdLAIATK 184 Mycoplasma agal...
Q8EWX9       106 DVVIEESCKIISESTKLPMIKIeNNTE--VLLKRIDMVEInKQ-SAMVIVITSDGNLTKNIIhfk--ddsILKdISICIR 180 Mycoplasma pene...
Q9PQ68       119 DEILNAAVSIINETTQLPAVVTkTSSD--ELLKRIDLVKInDN-SALVLIVTSSENILTHSIkld--kntKFNdLQTCFS 193 Ureaplasma parv...
P75351       105 DEIIELGVKFINEMVNLPVVLThFSSD--EVLKKIDLIMLdQS-CALLLLVSASGNVFKKTIsya--nqrQFEdIMVCVR 179 Mycoplasma pneu...
WP_014760239 179 VVNGACLGLTFAQAAER---VRSLKssrresva------------lleglaqVFeamgdnersseLYMAGASHLAHRRd- 242 Bifidobacterium...
CAT04849     181 LFQERLISLPIIEIATAiqiLNPILekqikhsedilkh--------------faenvfnfhikpdSKIYNKNSLILDRdi 246 Mycoplasma conj...
B3PN01       186 LFKERLVDTPLIHLANKaraLTPIFgqqlknyelilqk--------------fiknifvfeeettNKTFNKGAIVLSRni 251 Mycoplasma arth...
WP_012855683 195 LFKERLIDTPLINLAKKtesLAPILstqvkhfelimqk--------------fiknifcfeekleNKSFNKNVIILSEqi 260 Mycoplasma hominis
Q6KIH9       180 LFKERLINTSLINLREKalaLKPILskyiknyetilqs----------------fignvfefenknHVYGKSNIIKQEgi 243 Mycoplasma mobi...
Q98R68       186 IFKERLIDTKVSELHEKtlaLKPILkisiqnyedilqe--------------fiinifdfevsqtNNVYGKKNIILARdi 251 Mycoplasma pulm...
WP_011949717 185 VFNQRLVNSSLINLASSakaLWPILsesiknyetllee--------------yinqvfhfafvnkNNIYGRNNIILADei 250 Mycoplasma agal...
Q8EWX9       181 IFNDRLIDCPIKEIATKidsMKSIIkekvkeyefvlq---elierifqikskMI-----------KTVHGQSSLLAVPef 246 Mycoplasma pene...
Q9PQ68       194 VLDERLVDTKLSLISSKldlIVDIVrnkleeveyyfskivhrvfdfyaykpnID-----------SKTYGVKYLTKHSef 262 Ureaplasma parv...
P75351       180 IFNDRIIDTRFCDIAQHldvLKEIIrskvheyqyvideilfklfnfeefqqaR------------KQVYGIHYLAQQPef 247 Mycoplasma pneu...
WP_014760239 243 --iADMAPLFDALEEQivLM-KLMSALSEDtday-gvgV--AIGSEThtpelLHASVVTSgyGNspaSRtEPaesdaghe 316 Bifidobacterium...
CAT04849     247 -srQKLVQLLEIIEKK--SIwEILDENSQSede------tlKISIES-----KEASFISK--QFpksSNi---------- 300 Mycoplasma conj...
B3PN01       252 -srEEIANVLDLIEKH--SVwESIDNDLDEdn-------niKLDVSR-----PNLSIISK--KIdfsNEkNI-------- 306 Mycoplasma arth...
WP_012855683 261 -srEEIAKTLELIENH--SVwEAIENNLDEek-------niKLDFSH-----PNLNIISK--RIqfiNHkNI-------- 315 Mycoplasma hominis
Q6KIH9       244 -drLHLTQILDLIENN--SIwNMIESKVEEde-------tlKIDVRN-----SNISLISK--KIfvnNTt---------- 296 Mycoplasma mobi...
Q98R68       252 -krEDLTKIIKLIEST--SIwQTIEDNLEEee-------niKIEIRP-----DNSSFLSK--KIsidNKi---------- 304 Mycoplasma pulm...
WP_011949717 251 -srQDLLKILHKIENE--SIwEIIDSEISDqnr------niKIAICS-----DHSTFIAK--KLqnnKI----------- 303 Mycoplasma agal...
Q8EWX9       247 qdtEKLKEILQILEST--SIwEQIAFKQNQtgsntlitFgdEVSHED-------IVFAQT--DLninEQnK--------- 306 Mycoplasma pene...
Q9PQ68       263 edqQKLNDLLNLLEDS--TIwQQIALNKKTdgla-kimLgnEIGHEH-------LAIATT--QInlaNTn---------- 320 Ureaplasma parv...
P75351       248 anqERLTRILNLLEDT--SVwQQMAFMNQNnqtt-nitFgdKLGLEG-----EEVSVAST--LInttNEsK--------- 308 Mycoplasma pneu...
WP_014760239 317 dgggsalggaahantaqtgmagesritddadaepgkmddgdivampsldggsggsgessgpvAFVGSIGPT-HMDYA 392 Bifidobacterium bi...
CAT04849     301 --------------------------------------------------------------KEISFVGSTqKINYS 315 Mycoplasma conjunc...
B3PN01       307 --------------------------------------------------------------KEITVIGPN-NLDYG 320 Mycoplasma arthrit...
WP_012855683 316 --------------------------------------------------------------KEISILGPK-NLDve 329 Mycoplasma hominis
Q6KIH9       297 --------------------------------------------------------------KEISVIGSN-RMDYI 310 Mycoplasma mobile ...
Q98R68       305 --------------------------------------------------------------REISVVGSK-KMDYA 318 Mycoplasma pulmoni...
WP_011949717 304 --------------------------------------------------------------KEISLVGTN-RMNYA 317 Mycoplasma agalactiae
Q8EWX9       307 --------------------------------------------------------------TKLVMVAPT-RVDYS 320 Mycoplasma penetra...
Q9PQ68       321 --------------------------------------------------------------HQITVVGPT-RMDYA 334 Ureaplasma parvum ...
P75351       309 --------------------------------------------------------------HQLAIVGPT-RMDYQ 322 Mycoplasma pneumon...
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