2O8F,2O8E


Conserved Protein Domain Family
MutS_I
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pfam01624: MutS_I 
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MutS domain I
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.
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Statistics
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PSSM-Id: 426350
Aligned: 53 rows
Threshold Bit Score: 98.4269
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2O8F_A      17 VGFVRFFQGMPEK-PTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKy------mGpagaknLQSVVLSKMNFESFV 89   human
O13396      13 HGFIRFYKSLPQL-GEEAIRIFDRGDWYTAHGDDATFIARTVYKTTSVIRq------lGrsdhtgLPSVTMTVTVFRQFL 85   Neurospora crass...
Q9XGC9      24 QGFISFFKKLPQ--DPRAVRLFDRRDYYTAHGENATFIARTYYHTMSALRqlgs-------ssdgILSASVSKAMFETIA 94   Zea mays
O24617      22 QGFLSFYKTLPN--DTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTTALRqlgs-------gsnaLSSVSISRNMFETIA 92   thale cress
P25336     133 TPLDKQVKDLKMH-HRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKltidesnpQdcnhrqFAYCSFPDVRLNVHL 211  Saccharomyces ce...
NP_998689   17 hGFLNFYFSMSDK-PDTTVRVFDRNDYYTVHGKDAIFAAKEVFKTNGVIKn-------LgsgnrrLESVVLSKMNFESFV 88  
Q38AW5      44 aAMERQYWEVKSK-HYDVVIFFKKGKFYELYDQDAAMAHREFGLKLVVDT--------Tnr--gkMRLAGVPEQTFSEWA 112  Trypanosoma brucei
Q38F29      38 TPLERQVVCLKESlPPDVILMVACGYRVKFYGRDSRVVSRRFGIMCIqa--------------tpFEYSSVPYTGVNIYV 103  Trypanosoma brucei
P26359     104 TPLEQQYLELKKN-YQETILAIEVGYKFRFFGKDAKIASEVLGI--------------ScyfehnFLNASVPSYRIDYHL 168  Schizosaccharomy...
O65607     105 TPLEQQVVELKSK-YPDVVLMVEVGYRYRFFGEDAEIAARVLGI--------------YahmdhnFMTASVPTFRLNFHV 169  thale cress

2O8F_A      90 KDLLL-VrQYRVEVYKNRAGNKAS--------K-------ENDWYLAYKASPGNLSQFE 132  human
O13396      86 REALF-KlGKRIEIWASPSG--------------------RMNWKVVKQASPGNLQDVE 123  Neurospora crassa OR74A
Q9XGC9      95 RNILLeRtDCTLELYEGS----------------------GSNWRLTKSGTPGNIGSFE 131  Zea mays
O24617      93 RDLLLeRnDHTVELYEGS----------------------GSNWRLVKTGSPGNIGSFE 129  thale cress
P25336     212 ERLVH-H-NLKVAVVEQAETSAIKkhdpgaskSs------VFERKISNVFTKATFGVNS 262  Saccharomyces cerevisiae S288C
NP_998689   89 RDLLL-VrQYRVEVYKNASKSSK-----------------EHDWQIAFKASPGNLTQFE 129 
Q38AW5     113 RLFVF-R-GYKVGRVEQMKEEGESskn--arpK-------VVPRELVEILTPGTITDpm 160  Trypanosoma brucei
Q38F29     104 RRLVA-M-GYRVAFADQE-SASIRsts--gnsKg------LFSREIGRVYSRGTMLPDe 151  Trypanosoma brucei
P26359     169 ERLIN-F-GLKVAVVRQTETAALK--------StsssrntLFDRRVARVLTKGTTLDDS 217  Schizosaccharomyces pombe 972h-
O65607     170 RRLVN-A-GYKIGVVKQTETAAIK--------ShganrtgPFFRGLSALYTKATLEAAE 218  thale cress
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