8VDO


Conserved Protein Domain Family
I_LWEQ
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pfam01608: I_LWEQ (This model is not part of the current CDD release)
I/LWEQ domain
I/LWEQ domains bind to actin. It has been shown that the I/LWEQ domains from mouse talin and yeast Sla2p interact with F-actin. I/LWEQ domains can be placed into four major groups based on sequence similarity: (1) Metazoan talin; (2) Dictyostelium TalA/TalB and SLA110; (3) metazoan Hip1p; and (4) yeast Sla2p. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks.
Links
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Statistics
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PSSM-Id: 514382
Aligned: 73 rows
Threshold Bit Score: 56.8266
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8VDO_A       2649 DGQ-WSQGLISAARMVAAATNNLCEAA-NAAVQgh---asQEKLISSAKQVAASTAQLLVACKVKADQDSEAMK---RLQ 2720 house mouse
XP_004993026 1394 SFA-RARGLVRQVQDVTDAVVWLCDSC-SLAAAgq---edLPQVMTRGQNLRTSAAHLQTAAEFKVGRLGRGQSlltAVK 1468
XP_654777    1267 DAN-WEEGLISAAKTVTGCIQYLVKAAnDQVIHnk---psEAMLVACAKSVAANAMQLQAASMVNLALDDPMRD---KLA 1339
XP_001318203 1379 PNLdNQTGMINTARNLVDSLDLIIVAA-EAIVKskk--daINKVLAACNIISSSIAHFQAECRQKEGSP--------ELN 1447
XP_006676075 2388 DGT-WNDGLVSAAKQVAASTSELCEAA-NEVVKgs---aqHDRVIVCARNVSSFTVQLLTAAAVRSDSSSQTQI---RLR 2459
XP_004342755  718 AVGvWSEGLVSAAREVAEYTSMLRAAA-EGLSNgt---rpLMDLPASARAVAAATMQLVLAGSTRNPNQAVQL----RLH 789 
NP_490886    2404 TYQ-WSEGLISAARVVVASVHKLCDAA-NTLMKgq---ttEERLISAAKQVSSSTAQLLVACNVRADPDSQANR---RLQ 2475
XP_004997176 2397 EAQ-WSASMVSAAKLVAFATQNLCEAA-NATVQgg---saDEKLVASAKSVANSTAQLMLACRAKMDAQSPTAK---RLL 2468
XP_001743668 1389 DENsTAADLVAAAKLVAHATQELCDGA-NASMRgd---lsQERLVAAAKSIAKSTAQLIMACKVKMPSNSGPMR---RLQ 1461
XP_003975000  450 TEQrYNKLKEKHTELVASHAELLRKSA-DTVRMlsatqqtQDEVERTKHQLSFEIDRVKQESDMKLEEQKFEME---KLR 525  torafugu

8VDO_A       2721 AAGNAVKRASDNLVKAAQKAAAFEDQe-nETVVV--KEK--MVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYK 2794 house mouse
XP_004993026 1469 GSISKVYSATAAFTKLCQEQLAKQTKqrasapavsiPDRgsAVARQRQIMEEQAAIMRLESELDQRRTTLHGLRRSHYN 1547
XP_654777    1340 STIKKITDSQSAFVKTVSQGADARSEva-------pPKArnAQQLRIMLMEASVNISNIEKELQQAQEELLRMRRARYG 1411
XP_001318203 1448 DVIQKITDQIQETIGHVRNFGETAQRketEELTKdvKQPtkALNKMVEKLNAEAKVIEAKRALEEAENKLKQIRQK--K 1524
XP_006676075 2460 AAGKAVTDATEQLVEAAKGNNTIQDNdmsa---vdaELFisPTKSKVLEMEAQMNILRMEKELERARVGLAAVRKGRYA 2535
XP_004342755  790 DAGAAVRHVCDKLSAAQLQQTISQMPads----apaMSAssLAAQRAAELEARSKVLQMERNLEKAREDLHSVHKAKYV 864 
NP_490886    2476 AAGQAVRNAAERLVQSAQQEM-IARDdr------niAISdrLVNGIAQVMDAQEEVLRKERELGEARHKLAHLNKARYE 2547
XP_004997176 2469 AAGSAVKKAADHLVESAKTALEEAQEad-------mSLDerPVQSMRQEIEAVEAVLKQERELEAAKRNLAKLRATKYK 2540
XP_001743668 1462 AAGSAVKKAAENLVRTVQAAPTDVEDs--------iQLDasRVHAMKQEIEAVEAIVKQERELEVAKRALAKIRANKYG 1532
XP_003975000  526 RELEEKMAEVTRIKANLQSSEKVSEQa--SSSMT--ALQaeKERLMRSVSEKEAELSSLRQAAQVQQSSLQQEQEKNTR 600  torafugu
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