6R9T


Conserved Protein Domain Family
I_LWEQ

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pfam01608: I_LWEQ 
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I/LWEQ domain
I/LWEQ domains bind to actin. It has been shown that the I/LWEQ domains from mouse talin and yeast Sla2p interact with F-actin. I/LWEQ domains can be placed into four major groups based on sequence similarity: (1) Metazoan talin; (2) Dictyostelium TalA/TalB and SLA110; (3) metazoan Hip1p and (4) yeast Sla2p. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks.
Statistics
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PSSM-Id: 426343
Aligned: 82 rows
Threshold Bit Score: 57.2073
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6R9T_A       2385 DDGQ-WSQGLISAARMVAAATNNLCEAA-NAAVQgh---asQEKLISSAKQVAASTAQLLVACKVKADQDSEAMK---RL 2456 
XP_004993026 1393 KSFA-RARGLVRQVQDVTDAVVWLCDSC-SLAAAgq---edLPQVMTRGQNLRTSAAHLQTAAEFKVGRLGRGQSlltAV 1467 Salpingoeca r...
XP_654777    1266 RDAN-WEEGLISAAKTVTGCIQYLVKAAnDQVIHnk---psEAMLVACAKSVAANAMQLQAASMVNLALDDPMRD---KL 1338 Entamoeba his...
XP_655382     556 NNEV-WSEGLLSCAKKIVEWAQYISSALmNGe--------pDERILAGLKQFKSHCSQLLTAARVSMEDQSPLLQ---RL 623  Entamoeba his...
XP_003975000  449 ATEQrYNKLKEKHTELVASHAELLRKSA-DTVRMlsatqqtQDEVERTKHQLSFEIDRVKQESDMKLEEQKFEME---KL 524  torafugu
XP_004997176 2396 EEAQ-WSASMVSAAKLVAFATQNLCEAA-NATVQgg---saDEKLVASAKSVANSTAQLMLACRAKMDAQSPTAK---RL 2467 Salpingoeca r...
EDQ91246     1388 GDENsTAADLVAAAKLVAHATQELCDGA-NASMRgd---lsQERLVAAAKSIAKSTAQLIMACKVKMPSNSGPMR---RL 1460 Monosiga brev...
AAA74747     2403 GTYQ-WSEGLISAARVVVASVHKLCDAA-NTLMKgq---ttEERLISAAKQVSSSTAQLLVACNVRADPDSQANR---RL 2474 Caenorhabditi...
KJE98142      717 FAVGvWSEGLVSAAREVAEYTSMLRAAA-EGLSNgt---rpLMDLPASARAVAAATMQLVLAGSTRNPNQAVQL----RL 788  Capsaspora ow...
EGF83358     2387 SDGT-WNDGLVSAAKQVAASTSELCEAA-NEVVKgs---aqHDRVIVCARNVSSFTVQLLTAAAVRSDSSSQTQI---RL 2458 Batrachochytr...
6R9T_A       2457 QAAGNAVKRASDNLVKAAQKAAAFEEQenET---VVVKEK--MVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYK 2531 
XP_004993026 1468 KGSISKVYSATAAFTKLCQEQLAKQTKqrasapavsiPDRgsAVARQRQIMEEQAAIMRLESELDQRRTTLHGLRRSHYN 1547 Salpingoeca r...
XP_654777    1339 ASTIKKITDSQSAFVKTVSQGADARSEva-------pPKArnAQQLRIMLMEASVNISNIEKELQQAQEELLRMRRARYG 1411 Entamoeba his...
XP_655382     624 EKSLCSLMSQIQKIIQNILSREQEQRQeik----eqnKTQdnGIESKKELMESQVRVLQLQKELEKAQNHLYSLRKEEYN 699  Entamoeba his...
XP_003975000  525 RRELEEKMAEVTRIKANLQSSEKVSEQa-SS---SMTALQaeKERLMRSVSEKEAELSSLRQAAQVQQSSLQQEQEKNTR 600  torafugu
XP_004997176 2468 LAAGSAVKKAADHLVESAKTALEEAQEad-------mSLDerPVQSMRQEIEAVEAVLKQERELEAAKRNLAKLRATKYK 2540 Salpingoeca r...
EDQ91246     1461 QAAGSAVKKAAENLVRTVQAAPTDVEDs--------iQLDasRVHAMKQEIEAVEAIVKQERELEVAKRALAKIRANKYG 1532 Monosiga brev...
AAA74747     2475 QAAGQAVRNAAERLVQSAQQEM-IARDdr------niAISdrLVNGIAQVMDAQEEVLRKERELGEARHKLAHLNKARYE 2547 Caenorhabditi...
KJE98142      789 HDAGAAVRHVCDKLSAAQLQQTISQMPads----apaMSAssLAAQRAAELEARSKVLQMERNLEKAREDLHSVHKAKYV 864  Capsaspora ow...
EGF83358     2459 RAAGKAVTDATEQLVEAAKGNNTIQDNdmsa---vdaELFisPTKSKVLEMEAQMNILRMEKELERARVGLAAVRKGRYA 2535 Batrachochytr...
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