Conserved Protein Domain Family
B56

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pfam01603: B56 (This model is not part of the current CDD release)
Protein phosphatase 2A regulatory B subunit (B56 family)
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.
Statistics
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PSSM-Id: 514381
Aligned: 106 rows
Threshold Bit Score: 243.293
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5CQL1       250 SPNEILLLIKKKLIACCITFNFtNNTYSNL--KEKKRETLLELVEYINNndH-------IFQEEIIPDVLLMITSNIFRP 320 Cryptosporidium...
XP_001319782  95 ESSSFQGIFEKKIEACCQICPF-ADEELERvsIERKTTHLTKLYRLF----LgaipqstKLTDKNYELLYGMVMRNIVRR 169
XP_001309853  80 NNPEFKNIFLHKLNLGCQVF-----SDMDPnqRLAKRIVLHQVAECIITlgi-----gpFIDSEMTSKVYEMIYVNIKRP 149
XP_001300214  90 NDSQFKSILLKKLDLCKQLCDF-ENPCNDRqaKDIKKHTLIEINNSFTTlgl-----nsISDDEIKDTILDVIKINLLRP 163
XP_001301443  75 GDPSFKNIMMKKIELCKQMCDF-DNPNNDKdaKIIKANALQEISNRFSNlgi-----nsYIDEDIRVNLVQMIKTNLIRP 148
XP_051076457  20 lspalaTQFVEALQFCKTIVDFdNPQTINMr--sKKADYLTKIFNTVNNvhv-----frSLDESLRVELFDMIKVNILRE 92 
XP_001326792  78 PPKDCKLYFKIKCNECAKICDF-SNPNKDTqaKANKISLLRHIISSYQIphi-----arSLSQDLIQEFYNMISSNLFRE 151
XP_001322330  66 PQNEYAKLFLHKCKECSKLCDF-SDANIDGkaKVTKSILLKHLTQCFSMvgf-----mkILTAEMMTEFYKMVSTNLFRA 139
XP_001276915  64 DPKEYNTVFAQKVKECQKICDF-SIGVKDVvaKKTKSDLLKDIMTAFDSpei-----mhLLTPSSYEKYFKMVTKNICRP 137
XP_001307541  61 PPKDQQKLLLEKCHECCVICDF-SSANADAkaKQTKATLLKHIAAAFTIphl-----vrSMQTDTINEFLNMLSVNLFRP 134
Q5CQL1       321 FN-----QChanlNTGnsflqsnnasgnssiqssnsnnngsslngsvgnslsdSkddeqLLEPSWPHLLVIYEFFLRFVI 395 Cryptosporidium...
XP_001319782 170 LPtidplALen-yDVS-------------------------------------P-----FTEPSWPHLSIAYSILGKILA 206
XP_001309853 150 VPkfelnQFln-sDSG-------------------------------------C-----FSVPEWEHLEFVYTIFQIFYK 186
XP_001300214 164 LNkldelTLfn-pDVG-------------------------------------A-----FKEFDFEHMEYIYRMLNTLYR 200
XP_001301443 149 LSklddiSLff-sDIN-------------------------------------S-----FHLEDFQHTQHIYKILTFFFR 185
XP_051076457  93 IPpipltIIda-dSRI-------------------------------------P-----INTNSWLHLSTVHRILYSFVS 129
XP_001326792 152 FPpvkiiDLhd-gSIP-------------------------------------D-----VQDASWTHLSIIYEALNGMID 188
XP_001322330 140 LPrypeaVPvd-aKVS-------------------------------------------FYDNSWPHLSLVYQVLNASLS 175
XP_001276915 138 MPqikivSPld-vDDQ-------------------------------------------VQDTAWPHLFLVYKTLNTLME 173
XP_001307541 135 FPtipsvSPid-aHDS-------------------------------------------LSDASWPHLSLVYDSLLASLN 170
Q5CQL1       396 SP-QFSTkVAKKYIDNTFILKLIDLFQSFDPRERDYLKTILHRIYGKIMPRRSCIRKAMKHIFLRVIIDGEPYNG----- 469 Cryptosporidium...
XP_001319782 207 EFpNAPF------FDFKTLSNILLVAGSADGRERQQIVIFISRFISLNQQFNDPLIQKFASIIENYLD------Smhnpf 274
XP_001309853 187 TFpKLEF------WTTQFFESLIPLISSRDTLERDRLAIILSTYY----INNPILLHGFALKLAKIIE---NHFItpdpc 253
XP_001300214 201 DMpKYKG------FNIDLLVQLLPVLSSKDKRERELIIQFYVNVL----TAKPKLFPEIFPKLIRILI---SDYFdpdpc 267
XP_001301443 186 DFpKYEI------FDIKFMKELIPVLSSRDIRERDMIIAFMVSLI----QAKNNLFNQILPSLIKIID---HHFVdidpc 252
XP_051076457 130 NSeISAL---QNLLTKDFLTRYITLLESPDPKEIQAVESFILLVFDTVSGYRQIIFQIILRQLLKYRDNYMLYPC----- 201
XP_001326792 189 ISnAPDF-------PPNFIANIARNFYSFDSRERQQVCNTLIAISNKFPQCRVHIRKRIVDILSSNYC------------ 249
XP_001322330 176 SH-------FAANITPTFIYKIISNGLSIDPSERVAVRDFLHSYYSRFMGQRVMIRTDIFGLFSMGQA------------ 236
XP_001276915 174 SN------NVPTCNNKNLVQALVSNCCGPDDRERFACKDILRKMYSKCPNLQQLILRAVVSQFQTKQC------------ 235
XP_001307541 171 CP------LIQNSITTSFLYKLIGNCVSPDDREKAVVRDILHALYTKFIHLREIVRSNIAYQFSNNIC------------ 232
Q5CQL1       470 -IAELLEIFVSIVNG-FTIPLKEEHKIFLETALIPLHKAKYISSFHQQLIYCLIQYIEKDTKLSVPIIEGVLKYWPITNS 547 Cryptosporidium...
XP_001319782 275 iILTILTTFVAIIRDlGEIP--PLFSRFFRHFIVRLLSDIHLPFYDQIMCTIIDLYIEDDSRNSICVVHQVLRHWPYTKL 352
XP_001309853 254 aVYTALTIFSNIIAS--SIENRNMAFNLCNNLCIQLIQNQYLSIFISPFSNLLKMILPLSETLTLILLNGIVKYWPVSDP 331
XP_001300214 268 gIYSALSIIYSCQQS--NNNLKDIIKPYYHSHFLPLIRHEHFGVFYFPLLQLLKMFFTNNYSNTNEFVRLIINIWPISKP 345
XP_001301443 253 gVYSALGIMKGVIKE--IPSFWRVIQPMFQTHLLNLLRYDCLRVYADPLSEIFSLFYNNNSIYSKNTIELLVSIWPVSNP 330
XP_051076457 202 -VAPCLRFLHHFLKA-QTLPLKPPFFTLYKTIIFPLISSQMSSEFFGPFNQLAEFFESQDGTISTWTLYELVKHWPKTDT 279
XP_001326792 250 -ASAILDWMLSYANG-LSIPLKQDSIDMFMKVLLPLHTLPNFCDYSKQIQVLMYTFIVKQPELFAYVANFIIVHWPIANV 327
XP_001322330 237 -SLELLDFFSSIVQG-FNPPLKADHVKFFNQALLPLYTYSELNRYSKALTSCVCKFCEKNFNLISVAFDYLYKHWPLQDS 314
XP_001276915 236 -SADLLEFFGKVVAG-YQAPLTAEQISTYKNAVLFLHSSPNFLKFCLNLLQVINQHIKLDPSLYEPTIEYIISHWPSLSI 313
XP_001307541 233 -SSELMEFFLSIVSG-FNAPLKQDHVDFYYKYVLPLHCTQKYSSIQRPFVQCTVKFIQKSILLFTPTVMYIAKHWPCSDR 310
Q5CQL1       548 SKQILFLNELEELFEITPTNYIEPILIPIFERLASCIQSPHFHVAERVLYLWNNDIIVNLINEYKYEIYPVLIKALSCnG 627 Cryptosporidium...
XP_001319782 353 AKQSIFLYLIIKCFPKLPNKEIQPNLTRILNILATSTDSECYRVAEAAFQMWTTHGFDRIINENIKLINHIFAVHVFNaR 432
XP_001309853 332 AKQVPMIKLIIAALFSNHSMNDGVILKKVFLLLGELCDTEFFKVADQACKCLQEEVILGLLSNNCREIVPYIMTHVRSsL 411
XP_001300214 346 AKEEMMLDFLVQSLEFARNIDYRLL-GRAFKIIGSLCDSPSFKVAEKANKIIISPVLMELISQASTKILPFLLVHIENaR 424
XP_001301443 331 SKEEIMINILSSALDF-PEAINNALLCHIVDIVAISIDSPSHKIAEAANRLFVQPSFTELVSKNRKTFTVKLLPHVENaR 409
XP_051076457 280 NKETAFLSHFSYLAPHLPPKDIESCGLIIFNILKESLDSLNFKTNISALNVITNKNFLIVFSSFSTKLVPIILKGVDRcS 359
XP_001326792 328 YKQVAFIDELDIIFSKYSQASQTQHFQMFFKFLCNLLSDQSYQVTDKVMTVLSNKGYYPIIKDHSNGIIFNLVTALLDtS 407
XP_001322330 315 KKQKIYIDSVKIILFSFDKFSDTS-LRRAFAILAEGVRSDNVDVAEIALDTLLAENLVLVYKQNPRLIFTTIFEKLYKsA 393
XP_001276915 314 RKQILMLSEVEGLFLGFPKLLNERSSKLVFTLLSELITQPNIDLSETSCNVIIGPALEEALLAFTPLAHKILDEQLLSvA 393
XP_001307541 311 RKQIDFLNELTTLLSTFELNVSPKVASTIFKIVGDCVESENTDVSEASVDFLMNPELASVIRTHSTIVFPIVIEPIYRaA 390
Q5CQL1       628 KKlHWNPTVHGLSFVVNKVLSDTDPELFSQ-IIEQYNDDSANIEIQKKEREE---YWKYIIELA 687 Cryptosporidium parvum
XP_001319782 433 EN-HWSPTVRNNANFVLSILMKKDP---------KFGNNFNQESTIDDADCKklrFWVYIAREA 486
XP_001309853 412 K--HWYAPLRETAQVTLRVLCQIC----------------QERRSDDIGLNVrtsNWVSIARTA 457
XP_001300214 425 N--HWSNTVRIAAEDSMTSISRLMGRSAN-----------RKKQEDLNNSKEklkSWASIARAA 475
XP_001301443 410 T--HWNEKIRSLGNESNLAILRMNPNIKSK----------KIQDATTDTNKTklkGWASIARAA 461
XP_051076457 360 A--HWNVVVSKAALDAARVLMSVNHDVGSRlEIG------RIESERNRAIQSkrrNWEVLVEev 415
XP_001326792 408 AN-HWSTDVRKKSCTSLALLESYDANSYKKsVEA----QKIMNTRRKAQLGLcksTWQRVIDEA 466
XP_001322330 394 KS-HWDEDIKTDSIAALQILSEIDPNIFGE-LNNAHKDKKNTKKAPVKEASAlktNWMQVFNLA 455
XP_001276915 394 RN-HWNDFVRDDSKLALQMMSDIDNDLLEEtLNN----SKDTKKRKKANNLIwktNWAKVFETA 452
XP_001307541 391 KH-HWDECTKTNAYVVLQVLSEIDNQTFNKaNDA----HKLMKAQKSASFAVfknNWTRIFENA 449
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