6U7H


Conserved Protein Domain Family
CoV_S2

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pfam01601: CoV_S2 
Coronavirus spike glycoprotein S2
The coronavirus spike glycoprotein forms the characteriztic 'corona' after which the group is named. The Spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 pfam01600 and S2,. The S2 subunit normally contains multiple key components, including one or more fusion peptides (FP), a second proteolytic site (S2') and two conserved heptad repeats (HRs), driving membrane penetration and virus-cell fusion. The HRs can trimerize into a coiled-coil structure built of three HR1-HR2 helical hairpins presenting as a canonical six-helix bundle and drag the virus envelope and the host cell bilayer into close proximity, preparing for fusion to occur.
Statistics
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PSSM-Id: 460263
Aligned: 37 rows
Threshold Bit Score: 372.372
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6U7H_B        580 ANLSIPSNWTISVQVEYLQ----ITSTPIVVDCSTYVCNGNVRCVELLKQYT--SACKTIEDALRNSARLESADVSEMLT 653  Human coronav...
ADN95979      701 GYASTPIYSGYLTHTEVISkppfCTSFTSLPSCAELICGSNSLCYTKLTEFGklNMCTALGDAISV-------------- 766 
ASF90450      587 SFVELALDHVLVSESEYFQ----TEMPVFDIDCEKYICDNSESCRMLLEQYA--GFCSKITSDVKGNSQLLNANTLAMYK 660 
APU57645      580 QQIELPIDHYVSVKEQFIQ----TSTPKFDVDCERYICDVSSDCRELLVKYG--GYCSKILADIKSSSIQLDYQILGLYK 653 
AQW43023      573 QIVSLPLDHVINVKEQFVQ----TSAPKFDVDCERYICDVSVQCKELLAKYG--GYCPKIVSDIKSSSLQLDYQVQGIYK 646 
AHY61337      745 FVVEIPTNFSFGVTQEYIQ----TTIQKVTVDCKQYVCNGFAKCEQLLREYG--QFCAKINQALHGANLRQDESIANLFA 818 
AGX27799      759 FQVSIPQNFSFGITEEFIE----TSIQKVTVDCKQYVCNGFERCEQLLVQYG--QFCSKINQALHGVNLRQDDATKSLFE 832 
YP_009072440  757 STLQIPINFTIGIEYETIP----VTMPKVTVDCAQYVCGDNSECRTLLVQYG--TFCETINDALRGVALQQDVNQKDVFS 830 
P59594        692 NTIAIPTNFSISITTEVMP----VSMAKTSVDCNMYICGDSTECANLLLQYG--SFCTQLNRALSGIAAEQDRNTREVFA 765  Severe acute ...
AKZ19076      678 NSIAIPTNFSISVTTEVMP----VSMAKTSVDCTMYICGDSAECSNLLLQYG--SFCTQLNRALSGIAVEQDKNTQEVFA 751 
6U7H_B        654 FDKKAFTLANVSSFG-DY-----NLSSVIPS--LPTsgsrvaGRSAIEDILFSKIVTSGLGTVDAdYKNCTK--G-LSIA 722  Human coronav...
ADN95979      767 ------------------------------------------YNSVITDIVESQATLDAL------Y---------TEML 789 
ASF90450      661 NIVPSDSIKPIENFG-DF-----NMSMFIDK--S--------GRSVLEDLLFDKIVTTGPGFYED-YYKCRT----TTVK 719 
APU57645      654 TLAVDFKVP-------DIdfgdfNFSMYMSE--AN-------GRSFIEDLLFDKIVTTGPGFYQD-YYDCKK----MNLQ 712 
AQW43023      647 TLNVDVKVPD-VDFGa------fNFSMFESE--PN-------GRSFIEDILFDKIVTTGPGFYQD-YYDCKK----MNLE 705 
AHY61337      819 NIKTEATQPLDAGLNgDFnltllQVPKVVTS--EYS------YRSAIEDLLFNKVTIADPGYMQG-YDECMKq-GpPSAR 888 
AGX27799      833 DIKVPQSVPLMTSLTgDYnlslfEAPNIGSG--NNN------YRSALEDLLFDKVTLSDPGYMKG-YDECMKkgP-PSAR 902 
YP_009072440  831 SVRRLAKVSSPMNLGnln---gfNFSSILNQeaINGnn--fqARSAIEDLFFDKIETADVGFQKK-YDECTG--G-SVVK 901 
P59594        766 QVKQMYKTPTLKYFGg-F-----NFSQILPD--PLKp----tKRSFIEDLLFNKVTLADAGFMKQ-YGECLG--D-INAR 829  Severe acute ...
AKZ19076      752 QVKQMYKTPTLRDFGg------fNFSQILPD--PLKp----tKRSFIEDLLYNKVTLADAGFMKQ-YADCLG--G-INAR 815 
6U7H_B        723 DLACAQYYNGIMVLPGVADAERMAMYTGSLIGGIALGGLT----SAVSIPFSLAIQARLNYVALQTDVLQE----NQKIL 794  Human coronav...
ADN95979      790 DVAMTKF--------GTVAQTRKKRFVEFIALGVASVALVe---ATVAIGLAVANANDIRELRGDVKNLRDesaaNFKAI 858 
ASF90450      720 DLVCAQYYNGIMIIPPIQDAETIGMYGGIVAAGMTMGLFGg---QATMGTWQIAMSARLNAVGVTQGMIME----DVQKL 792 
APU57645      713 DLTCKQYYNGIMVIPPVMDDTLITFWSSAVAGSMTAGLFGg---QAGMVSWTVALAGRLNALGVMQDALVE----DVNKL 785 
AQW43023      706 DITCKQYYNGIMVIPPVMDDTLITFWSSAVAGSMTAGLFGg---QAGMVSWSIAVAGRLNALGVMQDALVN----DVNKL 778 
AHY61337      889 DLICAQFVAGYKVLPPLYDPNMEAAYTSSLVGSILGAGWTagasSFAAIPFAQSVFFRMNGIGITQQVLSE----NQKQI 964 
AGX27799      903 DLICAQYVSGYKVLPPLYDANMEAMYTASLTGSIAGSFWTgglsSAAALPFAQSMFYRMNGIGITQNVLMK----NQREI 978 
YP_009072440  902 DLGCAQSFNGLMVLPPQMTDAHVAAYTTSAALG-----------SFFSIPNTMQMAYRFNGIAVTQKVLVD----NQKQI 966 
P59594        830 DLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTfgagAALQIPFAMQMAYRFNGIGVTQNVLYE----NQKQI 905  Severe acute ...
AKZ19076      816 DLICAQKFNGLTVLPPLLTDDMIAAYTAALISGTATAGWTfgagAALQIPFAMQMAYRFNGIGVTQNVLYE----NQKQI 891 
6U7H_B        795 AASFNKAMTNIVdaftgvndaitqtsQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQAISSSIQAIYDRLDPPQA 874  Human coronav...
ADN95979      859 EEKHNAFVKTTA--------------DGFAAQNEVNKGFNSNIDTLQNSLKDMAIVTSQKFKELDQAIQSLVSSINSLQL 924 
ASF90450      793 ANGFNTLATSVS--------------KMASVTADALSRIQGVVNANALQVELLARATMDNFGAISSNFEIIEKRLKQVQA 858 
APU57645      786 ANGFNNLTQYVS--------------DGFKTTSQALSTIQAVVNNNAQQVSQLVQGLSENFGAISNNFALIAERLERIEA 851 
AQW43023      779 ANGFNNLTQYVA--------------DGFKTTSQALSAIQSVVNNNAQQISQLVQGLSENFGAISNNFLVIAERLERLEA 844 
AHY61337      965 ANKFNQALGAMQ--------------TGFTTTNLAFSKVQDAVNANAQALSKLASELSNTFGAISSSISDILKRLDAVEQ 1030
AGX27799      979 ANKFNQALGAMQ--------------TGFTATNQAFQKVQDVVNANAQALSKLASELANTFGAISSSIGDILKRLDVLEQ 1044
YP_009072440  967 ANKFNQAMMSVQ--------------TGFKATSSALEKLQKVVNDNAQALNNLVAQLTNNFGAISSAINDITQRLDKLEA 1032
P59594        906 ANQFNKAISQIQ--------------ESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA 971  Severe acute ...
AKZ19076      892 ANQFNKAITQIQ--------------ESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA 957 
6U7H_B        875 DQQVDRLITGRLAALNVFVSHTLTKYTEVRASRQLAQQKVNECVKS-QSKRYGFCGN-GTHIFSIVNAAPEG-----LVF 947  Human coronav...
ADN95979      925 KLDTEIQLSANSDSALARVLTALSLGHRTNRNLDRHISQVRTCLASiQQNSLAGCVNqGSNSIPLGIRVFNEtgdlkIVF 1004
ASF90450      859 EQQMDRVINGKMNALLNFVSNYKLKVSELTSIQQLVKQKVQECVHA-QSLRNGFCGS-GLHVMSIPQLVPNG-----VMF 931 
APU57645      852 AMQMDRLINGRMNILQNFVTNYKLSISELKSQQALAQSLINECVYA-QSSRNGFCGD-GLHLFSLMQRAPDG-----IMF 924 
AQW43023      845 QMQMDRLINGRMNILQNFVTNYKLSISELKSQQILAQSLVNECVYA-QSNRNGFCGD-GLHLFSLMQRAPDG-----IMF 917 
AHY61337     1031 EAQIDRLINGRLTSLNAFVAQQLVRSETAARSAQLASDKVNECVKS-QSKRNGFCGS-GTHIVSFVINAPNG-----LYF 1103
AGX27799     1045 EVQIDRLINGRLTSLNAFVSQQLVRSEAAARSSQLAKEKINECVKA-QSTRSGFCGQ-GTHIVSFVINAPNG-----FYF 1117
YP_009072440 1033 DAQIDRLINGRLQVLQTFVTQQLIRASEIRASAKLAAQKMSECVQG-QSQRLDFCGR-GMHLMSFPQAAPYG-----MVF 1105
P59594        972 EVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLG-QSKRVDFCGK-GYHLMSFPQAAPHG-----VVF 1044 Severe acute ...
AKZ19076      958 EVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLG-QSKRVDFCGK-GYHLMSFPQAAPHG-----VVF 1030
6U7H_B        948 LHTVLLPTQYKDVEAWSGLCVDGT--NGYVLRQPNLALYKEGn-----yYRITSRIMFEPRIPTMADF--VQIENCNVTF 1018 Human coronav...
ADN95979     1005 FYATRQRLGYLQFKATSAFCTNGT--LVTAAPGCIFTANGTQ----------IEHSKIGPLTPCGSSFvsLPIATCPTGS 1072
ASF90450      932 LHFSLVKNNSIIVKQTPGLCKEDKi-NCIVPKSGIFVSKNDSn------WYITPRNKYVPKNITNSD---IIFTTYSENF 1001
APU57645      925 FHYTLKPNNTIIVETTPGLCLSND--VCIAPKDGLFVRLSTArd---tdWHFTTRNRYSPEPITVNNT--LTISG-GVNF 996 
AQW43023      918 FHYTLVPNNTIDVETTPGLCLGNN--VCIAPRDGLFVKTNIRsd----vWHFTTRNLYNPQAITVNNS--VIVNG-GVNF 988 
AHY61337     1104 FHVGFVPTSFVNATAAYGLCNTENppRCIAPIDGYFVLNSTTtraadqeWYYTGSSFFSPEPITMANA--RYVSP-DTKY 1180
AGX27799     1118 IHVGYHPQDYVNQTAAYGLCDSSSs-KCIAAKNGYFVKNDSDsd----sWSYTGSSFYQPEPITSFNS--RFVQP-EFTF 1189
YP_009072440 1106 LHVLYKPTDYINVTTVPAICSNDV---AYFPVDGVFVYYNNS-------LMFTKRNYFEPEIITIDNI--RSAGSCNVDV 1173
P59594       1045 LHVTYVPSQERNFTTAPAICHEGK---AYFPREGVFVFNGTS-------WFITQRNFFSPQIITTDNT--FVSGNCDVVI 1112 Severe acute ...
AKZ19076     1031 LHVTYVPSQEKNFTTAPAICHEGK---AYFPREGVFVFNGTS-------WFITQRNFYSPQTITTDNT--FVAGNCDVVI 1098
6U7H_B       1019 VNISRSE-LQTI-VPE--YIDVNKTLQELSYKLpNYT---V-PDLV---VEQYNQTILNLTSEISTLenksaelnytvQK 1087 Human coronav...
ADN95979     1073 VDIEGVK--PSL-TPN--FEVPQLELKp--------------PKLE------VNLTNVNLSDYIRPItpvd---lskiED 1124
ASF90450     1002 TVINNTIqFPGIeFPQ--DGDFDGQIKNVTLEL---------QSLK---DVVANMSYLDLSNHT--------------AL 1053
APU57645      997 TVVNSTI-DGIE-PPA--NPSFDEEFAELYKNV-TLEleqL-KNIS------FDPEMLNLTYYI--------------DR 1050
AQW43023      989 TSLNQTI-EGIE-PPT--IPSFDEEFEDLYKNI-TLEleqL-KNIT------FDPELLNLTYYI--------------DR 1042
AHY61337     1181 EQLDNKL-PPPL-LSNqtDQDFKEELEEFFKNV-SSQ---G-PNFQe--ISKINATLLDLSGEM--------------KI 1237
AGX27799     1190 QNLTNNL-PPPL-LSNnsDVTFEDELEEFYKNI-TSE---I-PNFGs--ISQINTTMLNLSREM--------------SI 1246
YP_009072440 1174 TYVNHTI-YNPE-MPE--LEDFKQELEEIRKNF-STGlpnR-PNFTlpgLEGINASMVDLSEEV--------------KI 1233
P59594       1113 GIINNTV-YDPL-QPE--LDSFKEELDKYFKNH-------TsPDVDlgdISGINASVVNIQKEI--------------DR 1167 Severe acute ...
AKZ19076     1099 GIINNTV-YDPL-QPE--LDSFKEELDKYFKNH-TS------PDVDlgdISGINASVVNIQKEI--------------DR 1153
6U7H_B       1088 LQTLIDNINSTLVDLKWLNRVETYIK 1113 Human coronavirus 229E
ADN95979     1125 LQARFDKLNLTLTELSHISSSGSGLP 1150
ASF90450     1054 LKNISEEVKKMNITVSQFKQYVKYVK 1079
APU57645     1051 LDELATNVSQLHVDVSEFNKFVQYIK 1076
AQW43023     1043 LDELSTNVSQLHVDISEFNKYVQYIK 1068
AHY61337     1238 LNEVVKQLNESYIDLKELGNYTYYQK 1263
AGX27799     1247 LQQVVKDLNNSYIELKELGNYTYYQK 1272
YP_009072440 1234 LNDVVKELNASLINLQELGVNSQYIK 1259
P59594       1168 LNEVAKNLNESLIDLQELGKYEQYIK 1193 Severe acute respiratory syndrome-related coronavirus
AKZ19076     1154 LNEVAKNLNDSLIDLQELGKYEQYIK 1179
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