7CYC


Conserved Protein Domain Family
CoV_S1

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pfam01600: CoV_S1 (This model is not part of the current CDD release)
Coronavirus spike glycoprotein S1
This family represents the spike glycoprotein (S) of coronaviruses. The spike protein is arranged in trimers on the surface of the viral membrane and is essential for viral entry. The spike protein is translated as a large polypeptide that is subsequently cleaved to the distal S1, responsible for receptor binding, and the membrane-anchored S2 responsible for membrane fusion. The coronavirus (SARS-CoV) S1 subunit is composed of two distinct domains: an N-terminal domain (S1 NTD) and a receptor-binding domain (S1 RBD) also referred to as the S1 CTD or domain B. Each of these domains have been implicated in binding to host receptors. However, most coronaviruses are not known to utilize both the S1 NTD and S1 RBD for viral entry. This entry contains spike protein from both alpha and gamma coronaviruses but excludes the spike protein from beta-coronaviruses such as SARS-CoV.
Statistics
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PSSM-Id: 514378
Aligned: 17 rows
Threshold Bit Score: 377.461
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7CYC_C         26 YSVC-N--GCVGYSENVFAVESGGYIPS-DFAFNNWFLLTNTSSVVDGVVRSFQPLLLN---C--LWSVS-----GLRFT 91   Human coronav...
2_pfamImport    1 YSIC-K--NCSGFPDHVFAAGQDGTIPP-SFGFENWFYLTNSSSPVSGRFSSSQPLQLF---C--LWPIP-----ALLGN 66  
YP_008439202  219 YQVL-P--DSGEFSDNLFTVGDDGSIPP-SFGFNNWFVLSNSSSIISGTVVSNQPLRLT---C--LWPIP-----SSTGA 284 
Q0Q466        225 YSVC-Tk-HCTGLADNVFSTDQGGHIPP-IFPYNNWFLLTNTSTLVQGVTRVFQPFLVN---C--LVALP-----KLQGL 291  Scotophilus b...
YP_005352846   40 RMVR-N--IEGGATERCMYVQEGGFIPD-NFTFPQWFVLTNDSTLLQGELTTSQPLIVNghlC--SW--------QSNQQ 105 
YP_005352863   60 SAIC-P---------------ENGYITStSYDLSKIYYLTDGDYPIDGVYKSLQPLKVT---CvpEWHGNs---nFNDTT 117 
YP_005352871   41 YQQP----QVRGWTDDI---GVDGRIPA-TYPLTNTFYLSNTTTPVDGVYTSLQPLLIR---C--KFKYV-----NDTVN 102 
YP_005352881   53 TDQI-I---LDNNLTRNFHVTNQGNIYG-GSYL--LSYITNNSYPIFGVYRSYQPLLVR---C--VFSFSmngniTGNGK 120 
P10033        249 YELCeDyeHCTGYATNVFAPTSGGYIPD-GFSFNNWFLLTNSSTFVSGRFVTNQPLLIN---C--LWPVP-----SFGVA 317  Feline infect...
3_pfamImport    1 VQNCtG--NCEEYANNIFSTEPGGIIPE-GFSFNNWFVLTNDSTVLDGRFLTRQPLLVN---C--LWPVP-----SFSEI 67  
7CYC_C         92 TGFV---YFNGTG----RG---DCK------------GFSS--DVLSDVIRYNLNFEENLrR----GTILFKTSyGVvV- 142  Human coronav...
2_pfamImport   67 TLPV---YFNMSKn---NA---NCN------------GFKA--DGVVDSLRFALNFSDER-AfareGVISLETVgNT-Yn 121 
YP_008439202  285 LATI---YFNGTN----GA---QCN------------GFDS--NAPFDAIRFNLNGTLSGhNfv--sGFVLHAAnGAtLg 338 
Q0Q466        292 TTTL---SFDSPLnv-pGF---SCN------------GANG--SSSAEAFRFNVNDTK---LfvgaGAVTLNTVdGVnVs 347  Scotophilus b...
YP_005352846  106 YRKY---SFNTSCpl-pAD---GCNptwgsgnlklfkGWNNt-KGLTDNIRINVNISQSD-YrtsaGSVGLELEgGGtVn 176 
YP_005352863  118 GWKH---YFDGRIkqnpNTiwcPCSqsg------pggAQHNaaGNSTEYIRFHSNITTSVsN-----LLRLYAVdNQyYy 183 
YP_005352871  103 AGKIltmYFNLTNn---TG---RCD------------GNSEk-VGLVDAIRFQINVTTDI-LqltaGSINFTTPdGElYt 162 
YP_005352881  121 DWVY---TFNPSTt---NG---NCNs-----------PLQNkyNGTVDAIRFVTNFSAFSsE-----ITSFIFRgEHeVs 175 
P10033        318 AQEF---CFEGAQ----FS---QCN------------GVSL--NNTVDVIRFNLNFTADVqSgmgaTVFSLNTTgGViLe 373  Feline infect...
3_pfamImport   68 SQEF---CFASAD----FT---QCN------------GYKL--NSTADVIRFNLNFTHETaAasgtTFFELNTTgGVvLy 123 
7CYC_C        143 FYCTNNTLVSGDAh------IPFGTVLG-NFYCFVNTti---------gnETTSAFVGALPKTVREFVISRTGHFYINGY 206  Human coronav...
2_pfamImport  122 FTCTNSSTPTDGStf----vLPFGVTDQ-AYYCFMTFylnr------tadLRTTVFAGMLPPVVREFVVMRNGDFYLNGF 190 
YP_008439202  339 FSCTNSTDAPYLRq------IPFGIGDT-PYYCYLNVtt---------diNSTMSFVGALPLNLREIVIASNGDVYMNGY 402 
Q0Q466        348 IVCSNNATQPTRSn-----nLQ---EDL-PYYCFTNTss---------gtNHTVKFLSVFPPIIREFVITKYGNVYVNGY 409  Scotophilus b...
YP_005352846  177 ITCTNSSTPVTTYs-----lLPWARSSGePIYCFANVss---------psQSYIDFMGILPPFVSEIAFDRSGSIYINGY 242 
YP_005352863  184 FGCTPTPTPL-TFnltseniTLFTAEEQ-VHYCYANI-------------NGTVSYIGVLPPKITELTVGRYGDIFVNGF 248 
YP_005352871  163 LHCLNTTLGVGQDyyp--sqSRTRQSGV-TYHCYMIYrntsyaysaneytYRVLQYLGPLPASVREIVAFSNGFIYINGI 239 
YP_005352881  176 FSCSNTSNVTAHEhllivnaTTFKSNSN-ILYCYFTSnf---------ngTLSSFYVGPFPPNIADVTIFRSGNIYVNGY 245 
P10033        374 ISCYSDTVSESSSysy--geIPFGITDG-PRYCYVLYn------------GTALKYLGTLPPSVKEIAISKWGHFYINGY 438  Feline infect...
3_pfamImport  124 ISCYNQSRTEAQVse---gfVPFGNHEG-SLYCYVSYn------------ETLQKFLGVLPPSVKEIAISKDGGFYINGY 187 
7CYC_C        207 RYFTLGNVEAVNFNVTTAE--TTDFCTVALASYADVLVNVSQTSIANIIYCN-SVINRLRCDQLSFDVPDGFYSTS--PI 281  Human coronav...
2_pfamImport  191 RVFSVGQVVSARFNISSND--SRDFWTVAFANNAPVLVDINSTNIQRLLYCN-SPLNIIKCQQLRFNLDNGFYSYA--PE 265 
YP_008439202  403 RYFAAGDLSSVDVELPSQQvfGSTFWTIAFTVFETVLLEVDGTSINRMLYCD-NPLNRVKCSHTQFDLVDGFYPLT--DV 479 
Q0Q466        410 IYLRTRPLTAVHLNASSHSqdVAGFWTIAATNFTDVLVEVNNTGIQRLLYCD-TPENSVKCSQLSFELEDGFYSMTadNV 488  Scotophilus b...
YP_005352846  243 RYFKISPLLNVELQLNFNL--TSDHFSVTWSNYTEVHLNTTNGYIHQIKYCY-DPLDKLACEMNTFQLPDGVYPYT--PA 317 
YP_005352863  249 LYFKIPNV-IEYVQLSHTIphNKQFYTVFYANMTQVLLNISMASINRLLYCDkDSYSSIACAVNQFEPANGFYSTS--AI 325 
YP_005352871  240 LLSRIPALHKVDFGLVKSAh-TSDYYVILFADMVDVMVNISATEMQSIFYCI-TPFEQVKCSQKQTTLSDGFYSTS--AI 315 
YP_005352881  246 -YLGYIGMSIHNFSTHHVGltYMSSLRGIFTDQVDVLVNISNSVITNIVYCNhSLVNQIKCQRHLFDLPDGFYSYS--SV 322 
P10033        439 NFFSTFPIGCISFNLTTGV--SGAFWTIAYTSYTEALVQVENTAIKNVTYCN-SHINNIKCSQLTANLNNGFYPVA--SS 513  Feline infect...
3_pfamImport  188 NYFQTFPIDCISFNLTTGN--TGAFWTIAYTSYTDVMVDVENTAIKRVIYCN-SHINDIRCNQLTPSLPDGFYPVS--PK 262 
7CYC_C        282 QSVELPVSIVSLPVYHKHTFIVLYVDFK-PQSG----GGKCFNCYPAGVNITLANFNETkgPLCVDTSHFTT-KY-VAVY 354  Human coronav...
2_pfamImport  266 TANNLPRSFVRLPKYMTHSVINVSVAVSyDVVNktniGLHAWRVSFADRWLDYDKDNRT--AVCADSASFTM-RLiKGSF 342 
YP_008439202  480 DLAVKPFTFVTLPTFADHSFVYFNFSLMf--------DDLNEDFRLQSFNLTINGQL----SYCVQSRQFTTsGSvRTNT 547 
Q0Q466        489 YAVTKPHTFVTLPTFNDHGFVNVTVGGNfDSSY------PPKFT--ANGTLVNNGT-----VVCVTSNQFTL-RHdFMV- 553  Scotophilus b...
YP_005352846  318 QQQALPETFVTTPVYANHTTVVVRTQYTvSSTGi---NGPPSWS-----TVELDGAIND--TLCVNSRQFTV-HLnTTVH 386 
YP_005352863  326 EKISRKFTFVTMPTVQNHSYYSINLTIGgCGHG------------------EYPHLSNK--TGCYRTDASNI-NAkQITF 384 
YP_005352871  316 EVLQRQRTFVGLPMAINITTLNFAISYLnT-------KANPSLGAPQEVNLTINGFAD---QFCVTTSQFMV-TLnVTCL 384 
YP_005352881  323 SDVSVPETVILLPKEVTYSRVKLTAFAEgNIFD----GVSLSSLILSENKTNSNTTFND--TICVDTTYFNF-YLkFACG 395 
P10033        514 EVGFVNKSVVLLPSFFTYTAVNITIDLGmKLSG----YGQPIASTLSNITLPMQDNNTD--VYCIRSNQFSV-YVhSTCK 586  Feline infect...
3_pfamImport  263 AIGFINKTFVTLPANFDHVYVNITGNVNlK-AE----RGRPYNNG-GNATLSFQG--------CIAVSQFTV-NLnHTCT 327 
7CYC_C        355 a------------NVGRWSASINT------GNCPFSFGKVNNFVKFGSVCFSLKDiPGGCAMPIVa--NWAYSKYYTIG- 413  Human coronav...
2_pfamImport  343 -------------SYGDVYVDIWS------GECPFSFAALNNYLSFGSICFSLVP-NGGCAMSIVt--RGSYGEPQKFA- 399 
YP_008439202  548 n-----------hQFGFYTQRAAS------NGCPFTIDTLNNYLTFGRICFSFGEsGAGCGVDVMv-eSQYNMFKVT--- 606 
Q0Q466        554 ----------------GYSADMRKgifeysSTCPFNRETINNYLTFGRICFSTSPaDGACELKYYv--WNTIGAVSHLAg 615  Scotophilus b...
YP_005352846  387 y-----------tAAHLFGTEFVA------GTCPFTLPNINNYLTFGSICFSTVn-NGGCTIHVQkvlRHYRYTFGT--- 445 
YP_005352863  385 vint-----ythdNWIQWAHKP--------GNCPWALNKINNYNTAGTLQVVPEn-QATCCTDNQa-sWLYLASWTSVNv 449 
YP_005352871  385 vhnnt----siipCPQAYTAEISP------GDCPFNFLDVNNYLMFDSICFSPSPsGDSCQMVIN---KVWANNRIPMS- 450 
YP_005352881  396 g------------GSFRCSLSCRS------AGCPFDLQGLNNYLSFDHICFSLLn-NGGCPIQLL---AYWGSSFSRVLa 453 
P10033        587 sslwdnifnqdctDVLEATAVIKT------GTCPFSFDKLNNYLTFNKFCLSLSPvGANCKFDVAa-rTRTNEQVVR--- 656  Feline infect...
3_pfamImport  328 itnag---ssgctNAYEANVYMTS------GSCPFAFDRLNNHMSFSKLCFSTVPlGDDCRLDLTv-qTRYFTGVFA--- 394 
7CYC_C        414 SLYVSWSDGDGITGVPQ 430  Human coronavirus 229E
2_pfamImport  400 ALYVSFSEGDNVIGVPK 416 
YP_008439202  607 TIFVSYSEGDIIAGMPK 623 
Q0Q466        616 TLYVQHTKGDIITGTPK 632  Scotophilus bat coronavirus 512
YP_005352846  446 -IYVSYQPGNQITAMPK 461 
YP_005352863  450 KVCFNYQPGTTISIQPQ 466 
YP_005352871  451 SVYVSYVYGNQIVGVPR 467 
YP_005352881  454 TIYVSYSPGTRITGSKD 470 
P10033        657 SLYVIYEEGDNIVGVPS 673  Feline infectious peritonitis virus (strain 79-1146)
3_pfamImport  395 HVYVSYKFGLDIVGLPT 411 
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