Conserved Protein Domain Family
DUF21

?
pfam01595: DUF21 
Domain of unknown function DUF21
This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to Brachyspira hyodysenteriae hemolysin C that does not contain this domain. This domain is found in the N-terminus of the proteins adjacent to two intracellular CBS domains pfam00571.
Statistics
?
PSSM-Id: 426337
Aligned: 83 rows
Threshold Bit Score: 42.9746
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
tigr:CLC_2805   9 FLiLILI-IINAFFSSAEMAIISLNKNKLntiidnaeeENSSSRKTKKAKI--LLNLLKEPSKFLATIQVGITLAGFLAS 85  Clostridium bo...
O67884         13 LVfLFLL-FASGFFSSSEVVFFSVSKPVL-----------MKFSGNRFFKL--LMKLLSKPKELLISILIGNELVNVLIA 78  Aquifex aeolicus
WP_012513136    9 LLiLFLI-FLSGFFASSEVVFFGA--------------SNILEEKDKKFYKklIDRIFKDPQALLVSMLIGNEFVNVLIS 73  Hydrogenobacul...
XP_627549      69 LFsIALI-FFGGILSGLTTGLMSLDSVQLrvlieagneHEKRWASI-------ALDLIKRHHLLLVTLLLANSICMEALP 140 Cryptosporidiu...
Q67XQ0         40 GIsCFLV-LFAGIMSGLTLGLMSLGLVELeilqrsgtpNEKKQAAA-------IFPVVQKQHQLLVTLLLCNAMAMEGLP 111 thale cress
Q4DHE1         16 LGfVGLL-IFTGITAGLQVALFSMDRLFLriltttgslRERRQAKR-------LLGILRLGHWTLVALLLSNASAMTGLP 87  Trypanosoma cruzi
CAM71067       21 VIiTALV-VLAGLMAGLIISVFSLDKDRLkvlaqrsetVEGQRARR-------LLLVLQNPHWVLVTLVVVDSAATEMLP 92  Leishmania inf...
Q4UER3         23 LAtIVCS-ALSALFSGLTIGYTSIDLFQLhllsqftptTKEDIANQKRARK--IIPLRSDPNNLMIALIACNAMINSLLV 99  Theileria annu...
Q5LGK7          4 IIyLLITmAFSAFFSGMEIAFVSVDKLR----------FEMDRKGGVSSRI--LSLFFRNPNDFISTMLVGNNIALVIYG 71  Bacteroides fr...
O66507          7 LIgVFFFiILEGFFAGSEIALVNADKGFL---------KAVYKK--KKYSF--LKHFLDSPEEYITLTMLGYTVSIVFAS 73  Aquifex aeolicus
tigr:CLC_2805  86 A-SAATSISKYIeiffkhlnipksSSIALFLTTLLL-SYLTLVFGELLPKRIAL-NNSEKIAL-FSIKPIIIFMKISLPF 161 Clostridium bo...
O67884         79 S-YGTKTFVELF------------GDKGALLAVAVS-STLIFIFGETIPKNVVL-PIADRLAL-VYAPVFYLFHVVITPL 142 Aquifex aeolicus
WP_012513136   74 S-VSSSFVINLV------------GKRWVFLSGIFI-SILIFLIGETIPKNIAL-FLKDRLLK-FYAIIFYPYLVATKPF 137 Hydrogenobacul...
XP_627549     141 L-FLDRIIPSWVa--------------------VICsVTAILIFGEILPQAICTgKHQLRIAA-SCATFVRCLIICLFVF 198 Cryptosporidiu...
Q67XQ0        112 I-YLDKLFNEYVa--------------------IILsVTFVLAFGEVIPQAICT-RYGLAVGA-NFVWLVRILMTLCYPI 168 thale cress
Q4DHE1         88 I-LLEDIFDQLTa--------------------LLVsLTAVLFISDIIPLSIFV-RWSFPICS-FFVPLVWVLLVVTAPV 144 Trypanosoma cruzi
CAM71067       93 L-LFNVLFSPVEa--------------------VIMsVILLVVCGEIIPEAVFT-HHALALGS-ALAYLVLVLMVVTAPI 149 Leishmania inf...
Q4UER3        100 L-FVGELFEFAMg--------------------FIVsSLIVTIFGEIFPQTVFF-RYQLQLCS-FFAPLTFVVKYVLYPI 156 Theileria annu...
Q5LGK7         72 IlMAQIIGDNLLagw-------itNHFVMVLVQTVIsTLIILVTGEFLPKTLF--KINPNLALnVCAVPLFICYVVLYPI 142 Bacteroides fr...
O66507         74 A-LYTLFLMNLSkyvpeik--------gkevllAETlVIFTIILGEIIPKSLFQ-HYADKVVI-PSLYILDKLRIVLKPF 142 Aquifex aeolicus
tigr:CLC_2805 162 VNILTYSTNFLLKVLGi--dYENIEEKISEEEIKKMIDLGEET-----GVF-NS----TE 209 Clostridium botulinum A str. Hall
O67884        143 RIILILPVQTLLKKMGv--eIKEETFELTEEKLLSLIEQGIES-----GEF-EI----QE 190 Aquifex aeolicus
WP_012513136  138 TYIFVAPVKKILKLFGv--eNISLEKKFSLEHIVYIMQSPANA-----QEF-SE----EE 185 Hydrogenobaculum sp. Y04AAS1
XP_627549     199 SWPISKFLDYFIg------eNGKTNNFYARGQLKALIALHRRT-----GEF-DN----AP 242 Cryptosporidium parvum Iowa II
Q67XQ0        169 AFPIGKILDLVL---------GHNDALFRRAQLKALVSIHSQEag-kgGEL-TH----DE 213 thale cress
Q4DHE1        145 SYPVGKLLDRLL---------GEKEDLLRSDELVALFLAQQNE-----RAFlRE----SE 186 Trypanosoma cruzi
CAM71067      150 SWPVGKVLDWCV--------GSRSGVAFKRGQLREVVRYRAAQlygihGDDdDEtappRE 201 Leishmania infantum JPCM5
Q4UER3        157 TKPMSMLLNLII--------GTNTEVIYNKQQWKALVDLQKEC-----GGVlSE----EE 199 Theileria annulata
Q5LGK7        143 SKFSSGVSYLFLRLFGmkvnKEASAKAFGKVDLDYFVQSSIDN-------AeSEetldTE 195 Bacteroides fragilis NCTC 9343
O66507        143 LVLAKAVSRFISs------rFAKGESKVRREDIIKLLREKKSF---------SE----SL 183 Aquifex aeolicus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap