1V5V


Conserved Protein Domain Family
GCV_T
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pfam01571: GCV_T 
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Aminomethyltransferase folate-binding domain
This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.
Links
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Statistics
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PSSM-Id: 426330
Aligned: 62 rows
Threshold Bit Score: 137.332
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1V5V_A        14 HKEHARKIEE--FAGw-eMPIWYS--Si--------------------kEEHLAVRNAVGIFDVS-HMGEIVFRGKDALK 67  Pyrococcus hori...
Q1AVQ1        18 ELLRNSQIGPyaFPG---VPAEFTnwR----------------------DEQRAWRESCVLFDQSyHMTDLYIEGPDVKR 72  Rubrobacter xyl...
Q2JFT9        19 PGAVAGTAEDdaVAAhygDPL----------------------------REQRAVRGGAAVVDRS-HRDVLRVSGPDRLS 69  Frankia casuarinae
Q9HM98         8 HEAHGATFRE--VAGr-aVPVEYGrpD----------------------RTHRAVRNAAGVTEHA--FDVVVATGED--- 57  Halobacterium s...
XP_002940239 485 LKTKCSMGFH---AGw-eQPHWFYkpGddtgykpsfr---rtnwfepvrREYKQVMEKVGVIDLT-PFGKFTVKGKDSIH 556 tropical clawed...
Q16AK6       428 MSAAGCQWGQ---SWdleVPLYFAepGfveapslkr-----snahgivaDECQAVRNGVGLLDIT-GFSRFEVSGPNAEQ 498 Roseobacter den...
Q5LKS1       430 LAAKGAVFGE--IAGw-eRPRYFGdvGeveqigwgh-----qswhenalAEAQATRATAGVIDLC-AFAQFEITGTDAGK 500 Ruegeria pomeroyi
WP_012179628 442 QKALGAQFGQ--VNGw-eRPNYYGplDapdnfdhdarsfrrggwwdyarAEAEAVRSTAGLIDAT-AFAKHRVSGPGATA 517 Dinoroseobacter...
Q5LW00       430 LTRAGAVWGV--AGGw-eRARWFDaeGnrtpetltfr---rsnafeaigAECRAIRNAVGLIDFT-SFAKWEVSGAGAMA 502 Ruegeria pomeroyi
Q4FLB1       432 LKKEGACFG---VSGeyeRPMWYAksNekaeykysfd---yqnwypsveFETKNTITNVGLFELS-PFSKYEIKGENAHS 504 Candidatus Pela...

1V5V_A        68 FLQYVTTNDISKPPa---ISGTYTLVLNERGAIKDETLVFNMGNNEYLMicdSDAFEkl-yaWFTylkrtiEQFTKLD-- 141 Pyrococcus hori...
Q1AVQ1        73 LLSDLGINSFEGFKk---NNAKQFVACNHDGYVIGDAILFGLEDDRVSLvgrPTAHN-----WVQ------YHAESGDyd 138 Rubrobacter xyl...
Q2JFT9        70 WLHSITSQHLSALGa---LRGTEALVLSPHGHVEHHLVLADDGTSTWVDvepGTGgil--lrYLE------SMRFMLR-- 136 Frankia casuarinae
Q9HM98        58 -AHEVVAAGVSGGVptedGRGAYVVVCDD-GRVRADGYVFAT-DDRLLAllpAGEGDgvasrWRE------RAGNRD--- 125 Halobacterium s...
XP_002940239 557 LLDHLFANTIPKV-----GFTNISHILTPRGRVYAELTVSQLSPGEFLLitgSGSELhd-lrWIE------EVTVRGKy- 623 tropical clawed...
Q16AK6       499 WLDQIMASKLPKP-----GRARLAPMLAEDGRLKGDLTVFNWGDGIWWImgsYYLRRwh-mrWFV------DHMMEG--- 563 Roseobacter den...
Q5LKS1       501 LLNRLSANRIPHKD----GRMSLNHLLTEKGRFETEITIWRINENRYFTgspITRANpd-faWIK------SHIRPGEd- 568 Ruegeria pomeroyi
WP_012179628 518 FLDWFTTNTLPRV-----GRINLTYALTGAGTTHTEYTILRTGEDDYTLisaGAWHAyd-qdFLT------KAIEDTEpr 585 Dinoroseobacter...
Q5LW00       503 FLDRALANAMPKRD----GRVTLAHALDENGRFCAEFTVARLAEDRFYIcgpAFSEVhd-dhVLR------SRLRPADa- 570 Ruegeria pomeroyi
Q4FLB1       505 ELQRICTANIKNEI----GRSTYTQMLNEGGGIETDLTVICIDKNHFRIissAATRThd-kaHIL------KHLSPN--- 570 Candidatus Pela...

1V5V_A       142 ---------LEIELKTYDIAMFAVQGPKARDLAKDLFGIDi-------NE-MWWFQARWVELDGIKM--------LLSRS 196 Pyrococcus hori...
Q1AVQ1       139 vkverderyAANPEKRRRLYRYQIQGPNAAELLEKLNGGP--------LPqVPFFSMYEINIGDRKV--------RALRH 202 Rubrobacter xyl...
Q2JFT9       137 ---------VEPADLGAVTAVLSVLGPRAAQVAAAALGGPgdgapgpgLPePQAPGPVGAPITGPYPvgrtgtgtLVRRM 207 Frankia casuarinae
Q9HM98       126 ---------AAVTLSTGEFGTFGVHGPQATEKVASVLHRAsp-----pEErLRFVRGEmeg-----------gvtVVRDD 180 Halobacterium s...
XP_002940239 624 --------nTDIANVTDEIGVLGIAGPLARKVLQKLTPDDl------gNTsFKFLQSRKLNIAGIPV--------TAIRI 681 tropical clawed...
Q16AK6       564 ---------VTLRDLGDEVSGFSLAGPASLGVIEKLTDGPi--------AdLNFMGCGHFDIGLLRC--------KVGRL 618 Roseobacter den...
Q5LKS1       569 ---------VQMVNRSADWGMLAMSGPASRRILSELTDADl------sNAaFPWLSGQEITVAGVPC--------YALRV 625 Ruegeria pomeroyi
WP_012179628 586 f------grITLQDTTTQTGVFALAGPKARDILKALIRDPdpet-alsNKrFPWLGTREIELGMCPL--------RAVRV 650 Dinoroseobacter...
Q5LW00       571 ---------ATLTNVSMGWGCFTVAGPKSRELLSRIVDAPl------eNDsFKWFDLHEGEVGWATDv-------RLMRV 628 Ruegeria pomeroyi
Q4FLB1       571 ---------LEFKDITDDLVCLGIFGPKSRNLISKISNDDf------sNEtFKFGYGKFVTLGSKKI--------WAQRL 627 Candidatus Pela...

1V5V_A       197 GYTGENGFEVYIedanpyhpdeskrgEPEKALHVWERILEEGKKYGIKPCGLGARDTLRLEAGY-------TLYGNETK 268 Pyrococcus horik...
Q1AVQ1       203 GMSGQPGAEIFG--------------PWEERDEIKGIIVEAGEEYGLRQVGSRTYATNTLESGWipspcpaIYTGEEMK 267 Rubrobacter xyla...
Q2JFT9       208 PH----GVDLLV--------------GRADLTGTVERLRAAGAGL----AGLSAFDAMRIASRR-------PRLSRETD 257 Frankia casuarinae
Q9HM98       181 DLAGEEGYLVVC--------------AAEDADDVFETLLVRG--LNAVPFGRETWETLTLEAGT-------PLFASELA 236 Halobacterium sa...
XP_002940239 682 SYTGELGWELYH--------------KRQDTSALYRALMQAGQEEGIDNFGTYAMNALRLEKGF-------RAWGAEMN 739 tropical clawed ...
Q16AK6       619 SVAGERGYEIHC--------------RAGDHAVLRRILLEAGADAGIREYGFNALLSLRLEKSF-------GIWNAEFT 676 Roseobacter deni...
Q5LKS1       626 SFVGELGWELHA--------------LLNRIPELYDALFDVGSAHGLTDLGSYAFNGMRMEKAY-------RASGE-LT 682 Ruegeria pomeroyi
WP_012179628 651 AYTGALGWELHH--------------PIEMQTYLWDQLMAVGAAHGLKPVGARAQNWLRQEKSY-------RAFGTELG 708 Dinoroseobacter ...
Q5LW00       629 NYCGELGWELHH--------------PIAFQHHILDQLEQAGADLGLRHVGMRALDSLRIEKSY-------RAVAQELT 686 Ruegeria pomeroyi
Q4FLB1       628 SYVGELGFELYI--------------ENKDAKEIYQLIIEEGKNHNLSHCGSHAMDTMRMESGF-------LHWGHDIS 685 Candidatus Pelag...
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