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Hantavirus glycoprotein Gc, N-terminal The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins Gn and Gc (also known as G1 and G2, respectively) as a polyprotein precursor. Gn and Gc forms homotetramers at the surface of the virion, which attach the virion to host cell receptors including integrin beta3/ITGB3 and induce internalisation, predominantly through clathrin-dependent endocytosis. Gc protein has a typical class II fusion protein fold consisting of a central beta-sandwich domain (termed domain I) made of eight beta-strands arranged in two antiparallel beta-sheets, domain II which has an elongated shape with two subdomains (central, opened beta-barrel proximal to domain I and a distal beta-sandwich 'tip') and and domain III, which has an Ig-like fold. This entry represents the N-terminal region of Gc containing the central and dimerization domains (which includes domain I and II). This region has a conserved CNP motif, suggested to be an integrin-binding motif. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",