1LN0


Conserved Protein Domain Family
GIY-YIG

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pfam01541: GIY-YIG 
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GIY-YIG catalytic domain
This domain called GIY-YIG is found in the amino terminal region of excinuclease abc subunit c (uvrC), bacteriophage T4 endonucleases segA, segB, segC, segD and segE; it is also found in putative endonucleases encoded by group I introns of fungi and phage. The structure of I-TevI a GIY-YIG endonuclease, reveals a novel alpha/beta-fold with a central three-stranded antiparallel beta-sheet flanked by three helices. The most conserved and putative catalytic residues are located on a shallow, concave surface and include a metal coordination site.
Statistics
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PSSM-Id: 426314
Aligned: 35 rows
Threshold Bit Score: 39.2455
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1LN0_B           2 KSGIYQIKNTLNNKV-YVGSA-K--DF-EKAW-KRH--FKDLEKGCHSSIklqrsfnkhG-NVFECS-ILEEIPYEKDLi 71  Escherichia v...
Q91G76           3 IGYIYAIENNLNDEV-YIGSTlR--TI-EERF-SEH--KASARRRPTCTFhkfm--slhGiEHFKII-ELKKIEVNSFFe 72  Invertebrate ...
wustl:cce_5131  94 KGYLYFIIDNTLPILlYCGETrL--TV-NKRWsGVH--DCKDYIRNYIQLhr-----ihKvDVGVVSaFWEHIPPDKKVl 163 Crocosphaera ...
Q8YRK7          40 HPGIYAIRHKNDGLL-YIGKT-K--SL-RGRFsGGH--KAFLWAWLDQYq-----------DKDVRI-AWQEISYWENPg 100 Nostoc sp. PC...
WP_001048949    45 KGGIFMFYNINDELL-FVGKA-R--KI-RQRI-KKH--FEDNVSPIKNH----------RdEVYRIDaCIVEDPTEREI- 105 Bacillus
P32286           9 YNYTYVITNLVNNKI-YYGTH-StdDLnDGYM-GSGtlLAQAKKKYGk-------------KNFNLS-ILGFYKDFKSAr 71  Escherichia v...
jgi:Gura_3531  221 EMGVYQIRNKANGRI-YVGSS-K--NLdGTRN-SRL--FQLRMGKIVFNRelqkdlnqyGaDSFEFS-VLAVLDKPEPGd 292 Geobacter ura...
Q36580          85 KGGIYSFINTVNNNQ-YIGSA-K--DF-YLRL-NEH--LENKKSNIALQKaft----kyGlDKFIFC-IYEYFTYESKIi 151 Neurospora cr...
Q02714         280 KGGIYIMEYIHNPHIyYIGRT-T--LF-KRRI-NNH--IKADSNSKFHAflk-----lvGlEHFKFS-IIEISSSSEQG- 345 Podospora ans...
Q12C88         309 AGLIYLVTHVASGKR-YVGLTiQ--TL-ERRW-TYH--LQQARAGHVRGAdslh-aairEhGSNAFT-MVQIDSGTTKVd 379 Polaromonas s...
1LN0_B          72 ------IERENFWIKELNSk-iNGYN 90  Escherichia virus T4
Q91G76          73 -----lQALEESYIRDYGSl--NTIN 91  Invertebrate iridescent virus 6
wustl:cce_5131 164 ------LEWERQLILKYRS----PFN 179 Crocosphaera subtropica ATCC 51142
Q8YRK7         101 l----lLELEAIILRATEP----PYN 118 Nostoc sp. PCC 7120
WP_001048949   106 --------YETYIINEYKA----KYN 119 Bacillus
P32286          72 -----dAERELVTIDVVNDp--MTYN 90  Escherichia virus T4
jgi:Gura_3531  293 tieqslDALELHWLEKLQPfgeRGYN 318 Geobacter uraniireducens Rf4
Q36580         152 sh-kalTDLETSYINRFNFd--NLYN 174 Neurospora crassa OR74A
Q02714         346 -------IRENYYLQKFLPllnttfs 364 Podospora anserina
Q12C88         380 -----lEQKERHWINAYGTlvpAGYN 400 Polaromonas sp. JS666
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