5TVF,1MSV


Conserved Protein Domain Family
SAM_decarbox

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pfam01536: SAM_decarbox (This model is not part of the current CDD release)
Adenosylmethionine decarboxylase
This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes. In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl moiety necessary for spermidine and spermine biosynthesis from putrescine. The Pfam alignment contains both the alpha and beta chains that are cleaved to form the active enzyme.
Statistics
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PSSM-Id: 514336
Aligned: 89 rows
Threshold Bit Score: 286.33
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5TVF_B         1 XSLFVMKDRVILITCGTITLLNC-V--PLIC-EAVSTVCGEVEWVSFMHKNYSFPWEQKGPHLSMAEEFKTLRSHFPSGQ 76  Trypanosoma bru...
XP_002882990   2 tTEFEGVEKRLEIVFRKEED-------SLREvLTEEVWHDILRSIDCWIVDKLLTASVDSYLLSASSLFVFDDRLIIKTC 74 
XP_009115932   4 DERFEGVEKRLEIVFSPTAG-------KLREkLTQNLLEQILTDVKCHIVSHKLEEKVDAYLLSTSSCFVYDDRVIVKTC 76 
XP_024358075  18 sPGFEGFEKRLDIEFHIPPIFSdpagqGLRA-IPRTELDQMLRAAECTIVSHMSNAELDSYVLSESSLFVYPHRLVIKTC 96 
XP_004229470   3 vSGFEGFEKRLELHFSGDDPIIR-Mg-GLRQ-LDFESIEEILNAVQCTVVSAVGNQYFDSYVLSESSLFVYSTKIIIKTC 79 
XP_004241063   3 ASGFEGFEKRLEIHFSGDDPAIE-Mg-GLRQ-LDFDSLEQVLHAVQCTVVSAVSNQYFDSYVLSESSLFVYPTKIIIKTC 79 
XP_002277316   3 vSGFEGFEKRLELHFSGDDPVVG-M--GLRH-LDFESLEQVLHAVQCTVVSAVGNHYFDAYVLSESSLFVYPTKIIIKTC 78 
XP_002516818   3 vSGFEGFEKRLELHFFGDDPVMV-DnmGLRL-LEFESLVNVLNAVQCTVVSAVGNQYFDAYVLSESSLFVYPTKIIIKTC 80 
XP_003542902   5 fsGFEGFEKRLELHFFGDDPTIL-Ql-GLRK-LSFECIQQTLEAVQCTVVSAVGNSYFDAYVLSESSLFVYPTKIIIKTC 81 
XP_003550518   3 vSGFEGFEKRLELHFFGDDPAMF-Pl-GLRK-LEFDSIEQVLEAVQCTVVSAVGNSYFDAYVLSESSLFVYPTKIIIKTC 79  soybean
5TVF_B        77 PFIFGPIDSDHYFLYFHSDVV-QPSCSDDAQLSMTMYGLDRNQTKHWYSD----KMLPTGPE--TA----VIREATGLs- 144 Trypanosoma bru...
XP_002882990  75 GEIKLFQAITKILGLS----KrTPVGVKFTRGTYFWPERQPEPHGNFPSE----VSELRRNF--LElddtVTAEFGTD-- 142
XP_009115932  77 GETEIFKCMESLMGLTDHq---NVVSVVYTRGDFFWPERQPFPHNDVTEEnkefVKLLEKLTklKP----MKALCMGT-- 147
XP_024358075  97 GTTQLLRAIPILLQVT-SRLNlRVSRVKYTRGTFMFPAVQPYPHGSFTEE----VRYLEEYF--GSlgdgGKAFVMGSkg 169
XP_004229470  80 GTTQLLKSILPLIQFT-SELGfMMSECRYTRGNFIFPKSQPYPHTNFNDE----IFYLQQQL--PIhlcyRKASVMPSkf 152
XP_004241063  80 GTTQLLKSIRPFIHFA-CQMGlIITECRYTRGNYIFPKAQPYPHTSFKEE----ISYLQDQL--PNhlcyRKASVMPSkf 152
XP_002277316  79 GTTQLLKSIPPLLHHG-RHLGlAMCGCRYTRGSFIFPKAQPFPHTSFRDE----VIYLEQSL--PStlcyRKASVMPSkm 151
XP_002516818  81 GTTQLLKSIRPLLHYA-CNLGlSLCSCRYTRGNFIFPKSQPFPHTSFKEE----VIYLEETL--PSnlcyRKASVMPSkm 153
XP_003542902  82 GTTQLLKSITPLIFYAQTHLGlTLSLCRYTRGSFIFPLSQPFPHTSFEHE----VTYLETTL--PSdlcfRKASIMPSks 155
XP_003550518  80 GTTQLLKSILPLIHYADHHLGlTLSSCRYTRGSFIFPKAQPFPHTSFKDE----VTYLQDTI--PSslcfRKASIMPSks 153 soybean
5TVF_B       145 EVVDDSWILHDL---------QYEPCG-YSINAIRGSEYQTIHITPEEHC------SFASYetnTCALNYSKCICGVLRV 208 Trypanosoma bru...
XP_002882990 143 EKHKFHIFAAA-----------ASGSSvSDGVTVEILMTGIEKSKASVFF------KDSGI-----PGSMTSASGIDQIF 200
XP_009115932 148 GNKKWHVLGGFS---------GDSLTSqGDFVTVEMSMRGLDREKAKVFY------EKENV----TKTTMTEESGICYIF 208
XP_024358075 170 KFPNWHIYTAA-----------DHGATaEPTYTLEMCMTKLDRQAAGNFV------KAPGL---ETGPEMTKVANIDNIL 229
XP_004229470 153 ISHSWHVFTAC----------NE--ESnNDLFTVEVCMTELDRVLARKFF------KHPNM----ASNEMTEVTGISDIN 210
XP_004241063 153 TSHSWHVFSACDk--------FYPIPIpNDQYTVEICMTDLDLVLARKFF------KNPDT----TGKQMTEVTGIGEII 214
XP_002277316 152 SSHSWHVFSASDep------hMVLQHMpDVLYTLEVCMTDLDRVLARKFFlrpgagKAGDV----AGKEMTELTGIGDIN 221
XP_002516818 154 TSHSWHVFTASDq--------NHFISQnHHLYTIEVCMTELDRVLARKFFqpagdgKNGDV----AGKEMTKLTGIGDIN 221
XP_003542902 156 SSHAWHVFTATNiphh--hsrAL--YSeRHAYTMEICMTDLDPVLARKFFrragdgKTGDS----AGKEMTEITGVDEIN 227
XP_003550518 154 SSHSWHVFTANDnthththspMPYDHDnELLFTMEICMTELDPILARKFFrrpddeKSGDS----AGKEMTELTGINEIN 229 soybean
5TVF_B       209 FdPERFSVIVFIDPDSAVGKSYHS-GGTIGVEPEYYPNYEAHHRTVN-EY----TPGHWVLKVNYVKRAVGTVGTSAASG 282 Trypanosoma bru...
XP_002882990 201 P-ESSICDHEFPTCGYSMNGVVGSnSVYTIHVTPEEGFSFASFEVCGcET----HSLEKLVQNVLSCFNPSTFTAVLHTR 275
XP_009115932 209 P-NAIIDAHAFDKCGYSMNGIEGK-GISTIHVSPEDEGSFASFESFGyDFkn-eKKFEHVIPTVLKCFSPKQFTMTVYST 285
XP_024358075 230 P-ESRICDFAFDPCGYSMNGIEGA-AHSTIHVTPEDGLSYASYEAMG--YnprrVDLPMLVERVVASFKPAVLAMSVHVS 305
XP_004229470 211 P-NALICDFVFDPCGYSMNGIDGD-RYSTIHVTPEDGFSYASYECVGsIYdd-pNDIINILKKVVQVFRPGTMSISTTST 287
XP_004241063 215 P-SALICEFAFDPCGYSMNGIDGD-RYSTIHVTPEDGFSYASYECVGsVYd--eDDIDRILKKVVQVFLPGTMSVSISCS 290
XP_002277316 222 P-GALICDFAFDPCGYSMNGIDGD-RYSTIHVTPEDGYSYASFECVGsIYdd-qNDVVQVLKKVVQVFRPATMSVSTTCT 298
XP_002516818 222 P-GAIICDFAFDPCGYSMNGIDSD-RYSTIHVTPEDGYSYASFECVGsIFddsdDDVAEVLKKVVQVFRPATMSVSTTCN 299
XP_003542902 228 P-QALVCDFAFDPCGYSMNGIDGE-WYSTIHVTPEDGYSYASFECVGsVNd--dVDILHVLRKVVQIFRPGTMSVSTTSL 303
XP_003550518 230 P-DALICDFAFDPCGYSMNGMDGD-WYSTIHVTPEDGFSYASFECVGsVDn---GNIGHVLMKVVQIFRPGTMSISTTCN 304 soybean
5TVF_B       283 A------KE 285 Trypanosoma brucei brucei TREU927
XP_002882990 276 Sklelldln 284
XP_009115932 286 Vplegnepe 294
XP_024358075 306 DankathTS 314
XP_004229470 288 T-------N 289
XP_004241063 291 Sss---sSS 296
XP_002277316 299 S-------H 300
XP_002516818 300 S-------H 301
XP_003542902 304 G-------S 305
XP_003550518 305 Gfs---sND 310 soybean
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