Conserved Protein Domain Family
Frizzled

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pfam01534: Frizzled (This model is not part of the current CDD release)
Frizzled/Smoothened family membrane region
This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.
Statistics
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PSSM-Id: 514334
Aligned: 71 rows
Threshold Bit Score: 268.713
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX86266            241 FFNESEVRFSRVWIVVWGAICMASCLFTVLTFLLDV-RRFRYPERPVVFLSVCYFMVALAYVIGYAM--G-DSVSCNapf 316
24_pfamImport         1 QYSSIEKTFTERWNTGWSWLCFISTLFTLLTFWVDP-RRFRYPERPIVFLALCYNAMSLVYIVRGAV--Gp-SIACVpst 76 
EFN69078            213 YYRAEDKRFAERWMTGWAWLCFLSTLFTLLTFWVEP-SRFRYPERPIVFLALCYNLLSVAYIIRGAV--GgENISCVsqi 289
XP_002422941        160 YYRKEDKLFAEKWMVGWAWLCFLSTSFTLLTFWVEP-SRFRYPERPVIFLALCYCLIGVTYILRGAL--GpSTFSCVhve 236
WGS:AAQB:GK20092-PB 197 FHTSQQKKLTESFILGLSAICFVLTLFALVTFWAEP-RRFGYPERPVLFLCLCYNLFSICYLERIVF--HnQSRSRAiy- 272
XP_001963774        239 FHTTAQKKLTESLILGLSAVCFVLTLFALVTFWAEP-TRFGYPERPVLFLCLCYNLFSVCYLERIVFhnQaRSLAAQmqd 317
XP_002116990         25 LFTSKEKKRMNTYMALLSALTFSFTLIAILTAAIRP-QRFQYPERILIFMSICYNIYALVHLLRVFL--RyETVACGkld 101
EDO40119            175 IFSEEEHTRIHRFVAAFGTLTTVCTLFTVVTFLVGWkSQNRYPSVILFFMNACFCVASVGFLIQFSSd-ArRKVVCRrdd 253
XP_002931911        194 LFTKKEHREMHVYIAIFSSVTIFCTFFTLATFLSDWkNSNRYPAVILFYVNACFFVGSIGWLAQFMDg-ArDEIVCRgdg 272
NP_036939           225 LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWrNSNRYPAVILFYVNACFFVGSIGWLAQFMDg-ArREIVCRadg 303 Norway rat
EFX86266            317 dppqdfsvdkadmvETITQGT-----KRESCTILFMLLYYFEMAANLWWVVLTLTWFLAAGLKWG--HEPIEAKSHYFHL 389
24_pfamImport        77 e---------gyesYVATDGL-----ESASCTVTFLVLYYCGLSGSVWWVILATSWYLSAAKKWS--SEALYGLATYFHM 140
EFN69078            290 d---------gpsyVPIRDAL-----KNIPCTIWWIVRYYLGLASNAWWAILCGCWLLSAKNEWS--SEALHNIAPYLHA 353
XP_002422941        237 n----------gesYIAVDGM-----QSMPCTLAFLSLYYFALASSIWWVILALSWFLSAANKWS--SEALHGLASYFHV 299
WGS:AAQB:GK20092-PB 273 ------------epISTVCTL-----LSPPCLASYISTSYLSLCAATWWLIFALCFYLSSHKKWS--SEALEKHSGLFHV 333
XP_001963774        318 vpr-----------------lrqgclLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWS--SEALEKRSGLFHV 378
XP_002116990        102 -----------ssnRILTKMTnssilSHVPCTVIFIMLYYFDLVASIWLVVLTLLWYLSAKKKWC--SEIITGYAVYYHT 168
EDO40119            254 tmrl----------------geptesDSFLCVLTFVLVYYFSLAGMTWFVMLAYSWCI-CFKTLGstRDNFAGKTGYFHI 316
XP_002931911        273 t-----------mrlgEPTSN-----ETLSCVIIFVIVYYAMMSGVIWFVMLTYAWHT-SFKALGttHQPLSGKTSYFHL 335
NP_036939           304 tmrf----------------geptssETLSCVIIFVIVYYALMAGVVWFVVLTYAWHT-SFKALGttYQPLSGKTSYFHL 366 Norway rat
EFX86266            390 VTWALPAALTIAILAMGKVEGDVLSGVCSVGIWDMS-A---LRLFVLAPLFLFLIVGTIFLLGGFISLFRVRTLMKSGGT 465
24_pfamImport       141 AAWAGPAIAALMALTLHRVAGDELTGLCKVSSDSTI-------WLVVLPHGLMLLAGTVVGVFGAVALVNVRSEILMSG- 212
EFN69078            354 AAWILPILFTGGGLLSHNVVADELTGLCQISDESAL-------WLEVLPHTLLLFLGCIFGGIAGNALIRVRKAVRCAG- 425
XP_002422941        300 AAWTGPAVLGIVALALRRIAGDELTGLCQVSDSDVL-------AFLVVPQAVLLSAGCVLATIAAAALIRVRRTMQSAG- 371
WGS:AAQB:GK20092-PB 334 LAWVPPLAPPIAALLLEKVHPSELTGMCM------------APGFVEVPALILLLLGLYFTLRASRSLHSLQQQHQLHL- 400
XP_001963774        379 LAWVPPLAPPIAALLLERVRPSELTGMCT------------APGFVELPALVLLLLGLYFTLRASRSLLSLQQQLQPTLA 446
XP_002116990        169 LSWIIPAVPVAVIILWKKVSADELTGLCYISSHLATqKgfyLIGFVILPHSLCLLLASVFMIVFYVSTRKIKAQLAQNTA 248
EDO40119            317 ISWSLPAVLTGCVLLVKQVDANSISGICFVGYKNPS-M---RAGFLLAPLGLDLVIGGMFLAKGLFTLFK----LRKSNP 388
XP_002931911        336 ITWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYH-Y---RAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLS 411
NP_036939           367 LTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYR-Y---RAGFVLAPIGLVLIVGGYFLIRGVMTLFS----IKSNHP 438 Norway rat
EFX86266            466 -----K-TDK--LEKFMLRIGIYSFLYTVPAI-------------IVIACLLHEQAFFDSWMLRWqe--dKCrdpqw--- 519
24_pfamImport       213 -----GsAAK--LERLMTRLAVFTALYVFPAL-------------GSLFCSLYETFHGae---------aICls------ 257
EFN69078            426 -----RsATK--LERLMTRLGIFALLYALPAL-------------GGLACVLHEASVKPRWRKLAllaalDCrt------ 479
XP_002422941        372 -----RcTGK--LERLMTRLGVFAILYVLPAI-------------GYLACLIYEAWHRPRWRSLAllaalDCri------ 425
WGS:AAQB:GK20092-PB 401 -----QhQQR--FSQLRKRFVIFSLLFFIPTA-------------AGLMLGAFYRDLGGAPPTIVp----SCst------ 450
XP_001963774        447 -----LaHHR--FGQIRKRFVLFSLLYFAPTAagviaalceryvdSVPGCSTPE-------------------------- 493
XP_002116990        249 -----AkASMvkLSRFRGRVLTFFIFYWLLAS-------------IIIGCYCYEYTQGPYWQPLHrnqsr---------- 300
EDO40119            389 nflsnRaSIK--IKETIMRVGFFAFVAFAFVF-------------ITFACHVYEYYNQERWERSYra-flMCianhev-- 450
XP_002931911        412 e----KaASK--INETMLRLGIFGFLAFGFVL-------------ITFGCHFYDFFNQAEWERSFre-yvLCeanvtiae 471
NP_036939           439 gllseKaASK--INETMLRLGIFGFLAFGFVL-------------ITFSCHFYDFFNQAEWERSFrd-yvLCqanvtigl 502 Norway rat
EFX86266            520 --ikfvfACpsqslayakgaggypTAPTYPKPEFAVFMIKYLMMLIVGISSGFWVMSSKTLATWSNFYRRL 588
24_pfamImport       258 ------gsC---------------ASASHHDSNVEVSLLRVFLSLVVGISSGMWVWSGKTCRAWKRLF--S 305
EFN69078            480 -----tqNCa--------------PGPIYRAAGLEITLLRLFLSLITGVTSGMWVWSNKTCRAWSKLLSAP 531
XP_002422941        426 -----dpSCe--------------PGPSYRTAGVEMALLRLFLSLVVGVTSGMWVWSGKTCRAWSRLFVSP 477
WGS:AAQB:GK20092-PB 451 -----leDC-----------------SPPDKLSAWPSLMRVFFQLLGGTLTGLWVWSRKTCENYRSRLVGG 499
XP_001963774        494 -------DC-----------------ASPAPLSAWPALVRIFFQLVGGTLTGLWVWSRKTCESYRSRLGAP 540
XP_002116990        301 ---fnqfPCe-------------kRQNIHSDVHISVLAVKLLAQLLRGIVVSFWIASRKTVNEWENIFRLI 355
EDO40119            451 --kgvsnTC-----------------SIKDRANLSVLELSLSSLFGAGIAMSGWTWTSNTFKTWKKLWHRV 502
XP_002931911        472 qtnkpipEC-----------------EIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATIIIWKRAWCRI 525
NP_036939           503 ptkkpipDC-----------------EIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRL 556 Norway rat
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