5E3S


Conserved Protein Domain Family
PIP5K

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pfam01504: PIP5K (This model is not part of the current CDD release)
Phosphatidylinositol-4-phosphate 5-Kinase
This family contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyzes the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathway.
Statistics
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PSSM-Id: 514314
Aligned: 308 rows
Threshold Bit Score: 110.778
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5E3S_A          86 SLCNEPLIELSNPGAS-GSLFYVSSDDEFIIKTVQHK-EAEFLQT-LLPGYFMNLNQNMRTLLPKFYGLYCVQadGKNI- 161  zebrafish
17_pfamImport    1 RQREEALKAVGDMGFS-GSTFYSTADQKRLVKSVPRHsEHSYFREdLLDPYVQHMATHPRSLLVRIYDFLAV---SGPSl 76  
Q2H8M1          80 GAEEQSLNAIGDMGFS-GSTFYATANHKYLVKSVPRHsEHSFFHEdLLTPYVQHMAAQPRSLLVHVFDFLAV---SGPSl 155  Chaetomium g...
XP_009156139    70 FQGENPLIPKGDMGYS-GSTFFTTRDNKYLIKSVPRRfEHTFFRDdLLEPYVAHMESHPQSLLVRITDFLGW---KYHSl 145 
XP_001468872   793 ADETTAWRITVSPGKSgTTLLYFSD---FVMKTVRPR-EMEFLLRkFLPAYVRYCERNPHTLLPRFYALATLrwwka--- 865 
Q38BL1         611 LTDRCVWREVPSCGESgKSLIFLGN---FVLKSLKES-EFYLLKEsFLLKYIHYCERNCMTTLPHFYALVTFawvss--- 683  Trypanosoma ...
Q4DKY9         720 LGENAMWRQSISPGKSgTSFIFFGN---FVLKSLKES-EFKFLKNrFLRSYVSFCELNPDTMLPRFYALLSFswlrl--- 792  Trypanosoma ...
Q38BC4         120 LPNERQDLEL-SEGRS-MALFLESKSKYLLCKIIAKV-EVDVLLH-LLPRYAKHFREHSNTLLMRFYMLLRVEf-RGEL- 193  Trypanosoma ...
Q4Q241         113 LPENRLKMEM-GEGRS-QALFLKSKTMLLMCKTISVE-EVHALLH-VLRAYTLHITAHPSSLLMRFYMLLKVSv-RSEE- 186  Leishmania m...
Q4D5N5         120 LPEDRLALEL-GEGRS-MALFLKSKSMDLMCKTIAEE-EVNVLLK-LLPQYTEHLSRNTNTLLMRFSMLLRIEa-GAEV- 193  Trypanosoma ...
5E3S_A         162 ---------RIVVMNN-LLP---RAVP-MH---LKFDLKGSTYKRRASPKERSKGVP----------------------- 201  zebrafish
17_pfamImport   77 grlfrcapsHHIVMDN-ILYgqeEAKkrgElewEHWDLKPTSYF------------------------------------ 119 
Q2H8M1         156 grvlrsapsHHIVMDN-IMYgreEAKkqgEadwESWDLKPTSYF------------------------------------ 198  Chaetomium g...
XP_009156139   146 ggllglapnYHLVMEN-LLHgqdE-----DsnwQTFDLKPMSYF------------------------------------ 183 
XP_001468872   866 -----gvvqHFVLMQN-VFA---TPYY-IH---RIYDVKGSTVNRTAL-QPGKPPPRtaf-------------------- 911 
Q38BL1         684 -----esceHYILTQN-VFR---TPHF-IQ---RIHVAKGARVGLLSK----AKSLSaswrt------------------ 728  Trypanosoma ...
Q4DKY9         793 -----rsckRYVLMQN-VFF---TRYY-IH---RIYDVKGSTVGRSTK---TETAPRtsy-------------------- 836  Trypanosoma ...
Q38BC4         194 ---------GYVLCFGdVFA---PCRT-LN---EKWDLKG----RRPKPGKYKHFAKlfqhpydsttgqsttpgtdttqy 253  Trypanosoma ...
Q4Q241         187 ---------GYILCFNdVFG---TASV-LH---EKWDIKG----RVPKNGKHLHYPHligsgyepdphatkpppkrhvla 246  Leishmania m...
Q4D5N5         194 ---------GFILCFGdVFA---PCRT-LN---EKWDLKG----RIPKPGKYQHFPKliqrpyepnpylietprdtiev- 252  Trypanosoma ...
5E3S_A         202 ----------------------------T-YKDLDFMQDMpEg---------------ILL-ENDHYTALSRTMQRDCRV 236  zebrafish
17_pfamImport  120 ------------------------------YPERDIAGGA-LaseatksrladefhdkIVL-RREQAEDFFASLDADTQL 167 
Q2H8M1         199 ------------------------------YPERDIAGGA-LtseatkdrladdfhdkIIL-SRDQAEDFFASLEVDSKL 246  Chaetomium g...
XP_009156139   184 ------------------------------FPERDIAGGK-LasqatkskladefndkMRL-SQSQADAFLEALQADTEL 231 
XP_001468872   912 --------------------------gaLlLKDNDLPPQ-------------------LIIcGTYQRAIVLAQLRSDVGF 946 
Q38BL1         729 ------------------------rfgeDvFRDDDPPPR-------------------LLTcGKLKRAQLLAQFISDTSF 765  Trypanosoma ...
Q4DKY9         837 --------------------------gaLlLKDNDLPAQ-------------------LIIcGPLQRAHVLAQFRSDVNF 871  Trypanosoma ...
Q38BC4         254 ------fpsgtgisglkempkatdknklAtKKDKDLTRY-------------------FWL-DKEQREKLLLTLRDDCKF 307  Trypanosoma ...
Q4Q241         247 npaidasqqhpgresavvvrgtkdaqglPtLHDKDLTRL-------------------FWV-PRTARKRLVEELLRDYDF 306  Leishmania m...
Q4D5N5         253 ------pelvgsqeervvvveaadkdklAtRKDKDLTRL-------------------FWL-ERHERNKLIRALMKDYEF 306  Trypanosoma ...
5E3S_A         237 LQSFKIMDYSLLV--------------------------------------GI-------------HILHRAGEEA---S 262  zebrafish
17_pfamImport  168 LAEHNAVDYSLFLvrirtaqpaavfsgss-------gsqsvsdsssptwrtGV--------------MSA---------- 216 
Q2H8M1         247 LSKYNAVDYSLFLvrmrtpqqaaasvlppaesaavttnpppappsqqswrtGV--------------SSA---------- 302  Chaetomium g...
XP_009156139   232 LARHNAVDYSLMLvriprpstipassd-----------dpfrdpepldwrtGV--------------PSQ---------- 276 
XP_001468872   947 LRQLNVVDYSCMI--------------------------------------GVrsrlfsseegpskTLLLLRRQHHdghV 988 
Q38BL1         766 LASMNIVGYSCLI--------------------------------------GMrmhnsaftdcgyaEATSCNGEGHatgG 807  Trypanosoma ...
Q4DKY9         872 LQSLNIVDYSCLI--------------------------------------GVrsrvfsrkegpskTIVLKERRGSswqQ 913  Trypanosoma ...
Q38BC4         308 LASVGLMDYSLLI--------------------------------------GV-------------AYEEKGISNPtkrL 336  Trypanosoma ...
Q4Q241         307 LKNAGMMDYSLLI--------------------------------------GV-------------AYQDDKTRPSdkhC 335  Leishmania m...
Q4D5N5         307 LGNAGMMDYSLLI--------------------------------------GV-------------AYNETKVSRSgklV 335  Trypanosoma ...
5E3S_A         263 TAVPDTQKKGQGQKPLYCT------------------------------------AIESIQGESKSKTSPQPYESMGGIP 306  zebrafish
17_pfamImport      --------------------------------------------------------------------------------     
Q2H8M1             --------------------------------------------------------------------------------      Chaetomium g...
XP_009156139       --------------------------------------------------------------------------------     
XP_001468872   989 STLGSSAVATQGHIGQTCSevmyatdktaaadgagisvgameptlppfsvdaqrsDCDDDVYVCIHGCDGGLLSLPIHTS 1068
Q38BL1         808 GGGSIFDF-----------------------------------------------------------DGGFLSEPLTAPG 828  Trypanosoma ...
Q4DKY9         914 TVTSEAIGVGTEQLHK-------------------------------------------MDNSCIHGCDGGLLSLPIYSA 950  Trypanosoma ...
Q38BC4         337 RSMRMPYPRCGPPEG---------------------------------------------AMENRPEWTMTCGGECKFSK 371  Trypanosoma ...
Q4Q241         336 GIESTNVTSSSAVAPASTSae--------------------------------arPASLAQDSHPSGTRTMLTTVPEFAN 383  Leishmania m...
Q4D5N5         336 RSMRMTYPMGSERDAD-------------------------------------------LAEVRPASLPRRCPTPHDFRA 372  Trypanosoma ...
5E3S_A         307 AFNSKGERLLVFIGIIDILQSYRLVKKLEHSWKALl--------HDGDTVSVHRPSFYADRFQKFMCS 366  zebrafish
17_pfamImport  217 -----DGKHVFRASILDF--FWAKHKIQPRLMTLLirlwnvlvsKHGHMSITTTPDEYRGRFLKMCRS 277 
Q2H8M1         303 -----DGRYLFRASILDF--FWAKHKAQPKVMTLLiklwntlisKQGHMSITTTPDEYRERFLNMCRG 363  Chaetomium globosum CBS ...
XP_009156139   277 -----DGKWLYRALILDF--FWAKHKVRAKLMTLLvdaw-nlidRKGPMSITTTAPEYRGRFLDMCRE 336 
XP_001468872  1069 GDDTTAREEVYYLGIIDVLQTYNSVKKLESFAKGFvn------dRRA--ISVIAPDKYAERLYKVLER 1128
Q38BL1         829 AEATTPWRYVCYIGLIDVLREYTSGMGLGRLTRGLf--------GDVQEGNEMQPSAYAEWLQGVLCN 888  Trypanosoma brucei
Q4DKY9         951 GDDTTAREDVYYLGIIDVLQEYTPAKRFENFAKGLwn------dRRH--ISVVPPKEFAERLYKVLEN 1010 Trypanosoma cruzi
Q38BC4         372 GIFSLYNQEVYYIGVIDVLTPYTFKKKLAKLFKSFlw------rMDT--LSTIPPLKYCERILQFTED 431  Trypanosoma brucei
Q4Q241         384 GVRSFDGQEMYYIGVIDVLTTYTLKKKSANFFKSLlw------kQKT--LSTIPPDRYAQRIASFTEL 443  Leishmania major
Q4D5N5         373 GITSLQDQEIYYIGIIDMLTKYTWKKKTANFFKKFlw------kPET--LSTIPPVEYRKRISKYTKI 432  Trypanosoma cruzi
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