8Q7H,7ONI,6GLC


Conserved Protein Domain Family
IBR
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pfam01485: IBR (This model is not part of the current CDD release)
IBR domain, a half RING-finger domain
The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.
Links
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Statistics
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PSSM-Id: 514302
Aligned: 160 rows
Threshold Bit Score: 32.1468
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8Q7H_A             2143 KYEKALLRGYVES-CSNLTWCTnpqGCDRILCRQGLgcgT---TCSK-----CG-WASCFNCSFPeA-HYPA-SC 2205 human
8_pfamImport          2 KYEYLVLKRGLDI-MPDIVNCPr-aNCETPVILDSEnl----aRCPq-----CK-LSFCPICLQM-Y-H-GVePC 61  
WGS:AAAA:OsI_17210  306 RWERLTLQKTLDS-MSDVAYCP---RCVTACLEDEEnn----aQCSK-----CF-FSFCTRCRYL-R-HIGE-RC 363 
XP_001416228        307 KYEATLLARTLDS-MADLVYCP---RCEHPVIEEEDqnfGr---CPG-----CF-FAFCTLCRAS-W-HAGS-EC 365 
Q8K5C2               26 RYQQYGAEECVLQmGGV--LCPr-pGCGAGLLPEQG---QkkvTCEGgnglgCG-FVFCRDCKEA-Y-HEG--EC 89   Norway rat
Q55CB4              345 RYQDYLKQQ------RGLVKCL---RCPDGWSFVDNltrSt--fCST-----CY-YSFCLFCRNQ-F-HPGV-NC 399  Dictyosteliu...
Q5C0S0               80 RYEEFLLQQ-VMSrEPEARWCPr--GCGYGL-IAHSfqaCpqiVCLHp---eCEgRSFCFKCKRP-W-STDI-KN 144  Schistosoma ...
A0BMN6              179 ENNEREFKK-LVE-NMNCKQCT---NCGAWILKEKG---CnhmKCK------CF-YEFCYRCGRK-YrHPDC-KC 236  Paramecium t...
XP_001329146        412 LFQTEAMNDVIKSgLPNLVKCA---NCGFIVEFLGSsn----mRCPQ-----CQ-KETCSKCGLL-A-HPGK-TC 470 
6GLC_A              316 RYQQYGAEECVLQ-MGGVL-CPr-pGCGAGLLPEPD---CrkvTCEGgnglgCG-FAFCRECKEA-Y-HEGecsa 381  human
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