2J5V,2CX1,1Q7H,2Q07,2APO


Conserved Protein Domain Family
PUA

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pfam01472: PUA 
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PUA domain
The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modification, a family of predicted archaeal and bacterial rRNA methylases. Additionally, the PUA domain was detected in a family of eukaryotic proteins that also contain a domain homologous to the translation initiation factor eIF1/SUI1; these proteins may comprise a novel type of translation factors. Unexpectedly, the PUA domain was detected also in bacterial and yeast glutamate kinases; this is compatible with the demonstrated role of these enzymes in the regulation of the expression of other genes. It is predicted that the PUA domain is an RNA binding domain.
Statistics
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PSSM-Id: 426278
Aligned: 89 rows
Threshold Bit Score: 50.1758
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2J5V_B 276 GEITVDEGATAAILErGSSLLPKGIKSVTGNFSRGEVIRICNLeGRDIAHGVSRYNSDALRRIAGHHSQEIDAIL 350 Escherichia coli
Q9YDC3 262 PKVLVRDSAVESLTH-GAQLAAPGVAAVEEGVEKGGMVALMTLkGELIGLGKALASAQEMLEAERGIVVSPTRII 335 Aeropyrum pernix K1
Q8ZYB3 239 PKIWVRDSAVDAICN-GAPLAAPGISKFETPFSKGDLVAMFTLkGELIGIGRALVGSEEVKKMERGLVARTDRVV 312 Pyrobaculum aerophilum str...
O26140 240 PRVVILDSAVDAICH-GADLARGGIAGLDDNIAWGDTVAIMTLkGELVGVGEASMSALDIAAADGGLVIETRKVF 313 Methanothermobacter therma...
Q8SRW0 263 PRIMIKDSCVNAICY-GAKLSITGVLRFDRDIDVGTEVVIMTTkGEAVALGIALVSSPEMSIIDHGLVCRTKRVI 336 Encephalitozoon cuniculi
Q8ILS0 269 PRIVIKDSAVNAICY-GAKLTIPGVLRFDNNIDVNTEIVIMTTkGEAVALAIAQMTSTVIATVDHGVVSLTKRVI 342 Plasmodium falciparum 3D7
O17919 285 KRVVVKDSCINAICY-GAKILIPGILRYDDDIEVGKEIVIMSTkGEAICIAIAQMNTSTIASVDHGVVAKSKRVI 358 Caenorhabditis elegans
O60832 297 KRLVMKDSAVNAICY-GAKIMLPGVLRYEDGIEVNQEIVVITTkGEAICMAIALMTTAVISTCDHGIVAKIKRVI 370 human
O44081 295 KRIIMKDSSVNAVCY-GAKITLPGVLRYEDGIEIDQEIVICTTkGEAICLAIALMTTATMASCDHGVVAKIKRVI 368 fruit fly
Q8H5T5 311 KRLVVKDSAVNAICY-GAKLMIPGLLRFENDIDVGEEVVLMTTkGEAIAIGIAEMTTAVMATCDHGAVAKIKRVV 384 Japanese rice
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