Conserved Protein Domain Family
GRIP
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pfam01465: GRIP (This model is not part of the current CDD release)
GRIP domain
The GRIP (golgin-97, RanBP2alpha,Imh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown to be sufficient for targeting to the Golgi. The GRIP domain contains a completely conserved tyrosine residue. At least some of these domains have been shown to bind to GTPase Arl1.
Links
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Statistics
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PSSM-Id: 514286
Aligned: 96 rows
Threshold Bit Score: 35.3943
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ESS33832      850 DAQYLRNVLIRYVQYQRggnEKAAVSLL-PVLATVLKMNEEEKRQI 894 
Q9Y7X7        222 NKEYARNVLLQFLENHE-----HRDKIL-PILSTALDLEEVHQHLI 261  Schizosaccharomyces pombe 972h-
XP_013023034  215 DKEYARNVLIQFLENQE-----HRDQIL-PILAIALDLDDIHQQIL 254 
XP_002171439  634 DKEYTRNILFQFLDQKD-----KRNDIC-TLLATLLDLDRDQQAKL 673 
8_pfamImport    3 DVKYTKAVLLKFLMEKN---KKIQTDLItTILASLLQLEKKDQEDW 45  
XP_008598413 1126 DTVYLKTILLQFLEQKD---ARLRAQLV-PVLGKLLKFDKSEEEKW 1167
ERS99027     1091 DAMYLKTILLQFLEQKD---NKLRAQLV-PVLGKLLRFDQADEKKW 1132
EMR61742     1117 DTMYLKTILLQFLEVKD---EKVRSQLV-PVLGKLLRFDRTDEQKW 1158
XP_003721372 1256 DVNYIKTIMLQFLEQKD---NRLRAALV-PVLAQLLKFDKTDEQKW 1297
XP_007785318 1107 DLVYLKNVLLHFLEQKD---KSLQKQFV-PVLGKILHFDPKEEQKL 1148
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