Conserved Protein Domain Family
MAGE

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pfam01454: MAGE 
MAGE family
The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.
Statistics
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PSSM-Id: 426270
Aligned: 98 rows
Threshold Bit Score: 81.9335
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESK91814      68 LVRLA-LFNENRRGPLRRDDISKkVMGGn--------ARIFNRVFEQANATLKKTFGMELVELPSKasleeeatgtvedA 138 Moniliophthora ...
CCK70997      22 VVRFLlSNAEASNGIVTKSRLQV-VVRTvseqlnndrKIPMRVIIEHVNGILWDVYGFRLLGIPPR-------------G 87  Kazachstania na...
Q6FSE8        24 LVGFIlSSTEQGNSVLGRAKLQK-AIKQyasn-envvRCPMSDVLLKVNQILDDTYGFELIGVSTN-------------K 88  [Candida] glabrata
XP_002619647  49 LLRMV-MTRSARNQKIRREHFTA-ILHKhn------vKGNTKAIISQVDAELKEVFGLKLDQS----------------- 103 Clavispora lusi...
XP_007372871  44 VIRLV-LTRESKGQLIRREHINQ-IINDr-------kNRSYDVVLKEVTVALEEAYGLTLVETPII-------------K 101 Spathaspora pas...
XP_002545705  63 VVRLA-LAKELNGKKLRTDHIAK-AIKHnf-----grKVTGNVLIKEANKILQEVYGLSLEDVSSS-------------T 122 Candida tropica...
EMG48242      60 VVRLF-LTRELLGKPSKPDVIRK-FVKHnl-----grKFTTDMLIQQADVVLKDVYGLAIQETPNL-------------N 119 Candida maltosa...
CCE41206      84 IVKLI-LTKDARGQNFQKQHINQyLTNK---------RFKSDSLLDDAIAILENVYGLTLVDAPTA-------------K 140 Candida parapsi...
Q6BHM0        43 VIRYV-MSRELKSQIIRREHITQ-LYSNr--------RINYDALITRVKLTLKEVYGLTLVVVPPK-------------R 99  Debaryomyces ha...
XP_001384110  11 VVRLI-LGRELKSQFIRREKISSeVNTK---------RHGLDLIIKRVNAELEKVYGLTLVETPPE-------------K 67  Scheffersomyces...
ESK91814     139 ELEEARKAVGGKKKa---tTVG-----------------SKQYIIRSILDPGLLdyaslmhesilNQEAEDLPSDDdddd 198 Moniliophthora ...
CCK70997      88 ESSTAQPALADps-------------------------kADHFLLVNKLPWrk----------hfDEFKLSQVSSTydkl 132 Kazachstania na...
Q6FSE8        89 TTSQADQSGRStpiaiads------------tksikssdINYFVLRNKLKPit----------avENFKIELAKEAyetf 146 [Candida] glabrata
XP_002619647 104 ---------------------------------------TNDIVLVSNLQKDTKlllqklvengdGSEFKGNPYdtfyfm 144 Clavispora lusi...
XP_007372871 102 KKGDTSKAKKVLK--------P-----------------KQPYAVVNCLTPEARnllgdiwekslGT-FTKNDDLGqskf 155 Spathaspora pas...
XP_002545705 123 DKQKTKPESDQPATkm-rkTSG-----------------KGPYVMVSTLSVQSRnilgelwnkdlRI-SFKKPDLTskgf 183 Candida tropica...
EMG48242     120 NAKKQDQQQQQPQQtqeqqPKKprka----------ageRNAFIVVSDLSPQARnvlgelwqrdlAR-VTKKTDINtskf 188 Candida maltosa...
CCE41206     141 QEKKFNASHGDQRNvidtsNANggvnggngdkitkktppRNRFFLVSNLSQPAQqvlgdlwmttvNS-SLDKTKIGdtrf 219 Candida parapsi...
Q6BHM0       100 GDKKNKSSHSNG---------------------------KQQLMLTNCLSPEGRivlqeiwltdsEAGIPNNRNSGdnqy 152 Debaryomyces ha...
XP_001384110  68 KSRVTKTTNVKV---------------------------KQPFAIVSCLEPKSKkvlgelwqtstNVNPEADAHgskyfv 120 Scheffersomyces...
ESK91814     199 sgirsygs--------------------ifswstcdqleAYGVLTVILSLILVSGKVMSDADLRNALKHLHLNNSSqirf 258 Moniliophthora ...
CCK70997     133 ivdgeyvggemsl---------sdataagtklgvdedlvCKGLTAVALSIILFSRNNIVQRELLHHLSEFGIPIDGt--- 200 Kazachstania na...
Q6FSE8       147 lskelgenedynsdgeniipqsqinatlssdyeikdnlvLKGILSVMLCIILFSKNNLLERDLYEELKKFGISENN---- 222 [Candida] glabrata
XP_002619647 145 nkekr-----------------------nettvsmsdsiFGGIIMLLIGLVIVNENRIRESDLLDGLSQFGFSENLn--- 198 Clavispora lusi...
XP_007372871 156 yvprysk---------------------sklptsnyelvKNGILLVIVSLIILSENHISESELFRNLRKFGISTNLn--- 211 Spathaspora pas...
XP_002545705 184 flplyek---------------------tpapgshydlvKTGIMLLIISMIILNENHIQETILLTKLKKFGISDNLn--- 239 Candida tropica...
EMG48242     189 flpkynk---------------------scipgshhqlvKDGIMLVIISIIILNENHIQEDALLKSLRKVGLPPSLn--- 244 Candida maltosa...
CCE41206     220 flpkfkq---------------------silpksnsdlvKTGIMMLVTTLVILSENHIMESQLIRSLRKFGISDNNa--- 275 Candida parapsi...
Q6BHM0       153 flpkynk---------------------tsslgsntdmvKTGVTLLIMSLLIISENHMSEYELVNGLKRFGLSDHPn--- 208 Debaryomyces ha...
XP_001384110 121 pkykk-----------------------tegplsnielvRTGIMLYIVSMLILAENYLSEDDLERGMERMGISKDSn--- 174 Scheffersomyces...
ESK91814     259 taLSTTRTMPLDRFLDSLMRQGYIDQQIVgeakkkggpgkrarqaDDDTGVQYEWRWGPRAH 320 Moniliophthora roreri MCA 2997
CCK70997     201 --rIPILEWSIDEFLRWLERREYVVRAQDk---------------TDLEGSSTLYRTGRRTQ 245 Kazachstania naganishii CBS 8797
Q6FSE8       223 --PIPLLDMSIDSVLRIFVNQQYIDKRDQn---------------TETGNVITTYHIGRRTK 267 [Candida] glabrata
XP_002619647 199 -iVVPNLNKTTQEVLTEATKKEYLQKLVAq--------------aHGGEPAIVSYALGKRTL 245 Clavispora lusitaniae ATCC 42720
XP_007372871 212 -vKNSSLNMNIQELLNDLIRREYLNKNITk--------------gRIESENVVEYTLGRRSL 258 Spathaspora passalidarum NRRL Y-2...
XP_002545705 240 -qKNSNINMNSKDLLNDLTDKEYLSRKKLk--------------gRTESEDIHDYSLGKRSL 286 Candida tropicalis MYA-3404
EMG48242     245 -vKNSNLNMNTVELIKELKDHDYLSENVIk--------------gSSESENIIDYSLGKRSL 291 Candida maltosa Xu316
CCE41206     276 -mKNSNINMNWEDVLKELVSREYLTKLQLa---------------DSEKDKIYAISLGRRSL 321 Candida parapsilosis
Q6BHM0       209 -fKNSSFNASLPDLINELVKKEYLDKEVQk---------------DSNNVENVDYKLGRRSL 254 Debaryomyces hansenii
XP_001384110 175 -kRNSNLGMNLQELVSDLIKKDYINKEVSk--------------gTVESENRVIYSLGRRSL 221 Scheffersomyces stipitis CBS 6054
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