6U7G,4Z7I,2XPY


Conserved Protein Domain Family
Peptidase_M1

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pfam01433: Peptidase_M1 
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Peptidase family M1 domain
Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase, this enzyme also has an aminopeptidase activity.
Statistics
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PSSM-Id: 426262
Aligned: 23 rows
Threshold Bit Score: 221.779
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6U7G_B        255 YALNVTGPILNFFAGHYDTPYPLP----KSDQIGL-PDFNA--GAMENWGLVTYRENSLLFDPLS-SSSSNKERVVTVIA 326  human
P40462        257 FTLDTVQKYLPLLESYFKCPYPLP----KLDFVLL-PYLSD--MAMENFGMITIQLNHLLIPPNAlANETVREQAQQLIV 329  Saccharomyces...
AFK85023      268 FAMDFGQKNMVALEAYNEFPYAFP----KLDKAAV-PDFAA--GAMENWGLVIYREVALLVTEGV-TTTATRQNIARIIC 339  domestic silk...
XP_028036135  303 WSLEIGEKLLEAMEAYTQIPYYTMaeniNMKQAAI-PDFSA--GAMENWGLLTYREALILYDPLN-SNHFYKQRVANIVA 378  wild silkworm
Q10836        369 YALHITKRLIEFYEDYFKVPYSLP----KLDLLAV-PKHPY--AAMENWGLSIFVEQRILLDPSV-SSISYLLDVTMVIV 440  Norway rat
Q22531       1242 FALNVTAGTIDFMENYFSYDFPLK----KLDVMAL-PEYTMnaGAMENWGLIIGEYSLFMFDPDY-ATTRDITEVAETTA 1315 Caenorhabditi...
P74527        240 RSMGKTPRMIEFFNQTFGYPYAYP----NYDQVCV-ADFIF--GGMENTSTTLLMDRCLLDE----RAALDNRNTESLVA 308  Synechocystis...
O09175        261 EEYNGVIEEFLATGEKLFGPYVWG----RYDLLFMpPSFPF--GGMENPCLTFVTPCLLAGD----------RSLADVII 324  Norway rat
2XPY_A        237 WEFENDVEKFIQTAEKIIFEYEWG----TYDILVNvDSYPY--GGMESPNMTFATPTLIAHD----------RSNIDVIA 300  baker's yeast
O94544        230 YEFEHDMENFMEAAEQLTLPYCWT----RYDFVILpPSFPY--GGMENPNATFATPTLIAGD----------RSNVNVIA 293  Schizosacchar...
6U7G_B        327 HELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEP--TWNl-----kDLM-VLNDVYRVMAVDALAS-SHPLStp 397  human
P40462        330 HELVHQWMGNYISFDSWESLWFNESFATWLACHILEQ-----NGDlshywtsEPY-LLQQVEPTMCRDAADVnGRSIFqi 403  Saccharomyces...
AFK85023      340 HENVHMWYGNEVGPLSWTYTWLNEGFATFFESFATDLVLP--EWRm-----mEQF--VVTMQNVFQSDAVLT-INPMT-- 407  domestic silk...
XP_028036135  379 HEIAHMWFGNLVTCAWWDNLWLNEGFARFYQYYLTASVAPelGYE-------TRF-IVEQVQMAMFSDSVDT-AHALT-- 447  wild silkworm
Q10836        441 HEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYP--SWNm-----eKQRfLTDVLHEVMLLDGLAS-SHPVS-- 510  Norway rat
Q22531       1316 HEVVHQWFGDIVTLDWWNDIFLNEGFAQYWFANGIDNTFPeqh------aysIDYnRFYMNHIALKYDCIPGvAKPVI-- 1387 Caenorhabditi...
P74527        309 HELAHQWFGDLVVVKHWSHAWLKEGMASYAEVLWTDHEYGqdEAA---------YyLLGEARNYLAEDSSRY-RRPI--- 375  Synechocystis...
O09175        325 HEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGaaYTCleaatgrALL--------RQHMDVSGE-ENPLNkl 395  Norway rat
2XPY_A        301 HELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGepTRHfsaligwSDL--------QNSIDSMKD-PERFStl 371  baker's yeast
O94544        294 HELAHSWSGNLVTNESWQCFWLNEGMTVFLERKILGRLYGepTRQfeaiigwGEL--------EESVKLLGE-DSEYTkl 364  Schizosacchar...
6U7G_B        398 aS-EINTPAQISELFDAISYSKGASVLRMLSSFLS-EDVFKQGLASYLHT---FAYQNTIYLNLWDHLQe-----AVNnr 467  human
P40462        404 aQrNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATG-ESHLQKGLESVFEDtktFHARSVKPMDIWNHIGkfl-------- 474  Saccharomyces...
AFK85023      408 -H-AVYTPSQIMGQFNAIAYQKSGSVIRMLHHFLT-PEIFRRGLVIYIIN---NSRRAAGPSDLYAALQq-----ALDas 476  domestic silk...
XP_028036135  448 -DlNVNDPTTVSAHFSTITYARGAAILRMTQHLLG-VETFVKGLRNYLRE---RQFNVAEPHHLFTALD------AAAve 516  wild silkworm
Q10836        511 -Q-EVLRATDIDKVFDWIAYKKGAALIRMLANFMG-HSVFQRGLQDYLTI---HKYGNAARNDLWNTLSe-----ALKrn 579  Norway rat
Q22531       1388 --------SDTPPVFGIEPYYKGSALLNLLNNVLT-PAVFQEGLSSYLTQ---YGYVNASPRNLWTSLTv-----AAQrh 1450 Caenorhabditi...
P74527        376 ---VTHVYREAIELYDRHLYEKGACVYHMIRAVLG-DELFFRAVHTFVND---HAHGTVETVDLLRAIEk-----ATG-- 441  Synechocystis...
O09175        396 rV-KIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGdQEQFDKFLKAYVDE---FKFQSILAEDFLEFYLeyfp------- 464  Norway rat
2XPY_A        372 vQ-NLNDNTDPDDAFSTVPYEKGFNLLFHLETILGgKAEFDPFIRHYFKK---FAKKSLDTFQFLDTLYef----ypEk- 442  baker's yeast
O94544        365 iQ-NLE-GRDPDDAFSTVPYEKGSNFLYEIERVIGgPSVFEPFLPFYFRK---FAKSTVNEVKFKHALYeyfsplGLA-- 437  Schizosacchar...
6U7G_B        468 si----qlpTTVRDI----MNRW 482  human
P40462        475 -------ksQNITNF----VSSW 486  Saccharomyces cerevisiae S288C
AFK85023      477 dh----sipYSISNV----MNRW 491  domestic silkworm
XP_028036135  517 dgalngyggITIDTY----FRTW 535  wild silkworm
Q10836        580 g------kyVNIQEV----MDQW 592  Norway rat
Q22531       1451 nitdwngqpLDVSSF----MDPY 1469 Caenorhabditis elegans
P74527        442 ---------FNLLWL----FDQY 451  Synechocystis sp. PCC 6803
O09175        465 -----elkkKGVDSIpgfeFNRW 482  Norway rat
2XPY_A        443 --------kEILDSVd---WETW 454  baker's yeast
O94544        438 ---------SKLDSId---WDTW 448  Schizosaccharomyces pombe 972h-
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