Conserved Protein Domain Family
PseudoU_synth_1
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pfam01416: PseudoU_synth_1 
tRNA pseudouridine synthase
Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.
Links
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Statistics
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PSSM-Id: 426254
Aligned: 263 rows
Threshold Bit Score: 47.528
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EHY53673          387 AAKKLEGLHDFRnLcKIDPSKqmPSCERRITYADIVewedTGkmfsshpalnqtgasssgldsasnsnglnvaallgkgd 466 Exophiala ...
CDC35726            6 MIIQYDGTRYKG-W-QGQNST--DMTIEGRIEAVLSamvgY--------------------------------------- 42  Butyrivibr...
CDC23357            6 MIIAYDGSRYKG-W-QRQNLT--NLTIQTILERTVEqivgY--------------------------------------- 42  Clostridiu...
wucgs:EUBREC_1311  32 IIVAYDGTRYKG-W-QVQKST--DDTIQGKLQHVLStlagK--------------------------------------- 68  [Eubacteri...
BAF70217            5 AVISYDGSRFDG-F-QIQKHT--ANTVMHHLYNALQrvgiE--------------------------------------- 41  Nitratirup...
WP_013553835        6 AVIAYDGSAFEG-F-QRQKRT--PRTVQGALERALAsl------------------------------------------ 39  Nitratifra...
CCY35799            5 ASISYNGSGLSG-W--QIQDN--APSVQDEIQKAVSavlgE--------------------------------------- 40  Alistipes ...
CDC25280            5 IFFGYDGTNYHG-W--QIQPN--ANSVQQELQKALStllrR--------------------------------------- 40  Prevotella...
jgi:Haur_4942       7 LCFEYLGTAFCG---SQWQPG--GRAVQTELETAWQrltsET-------------------------------------- 43  Herpetosip...
Q9PP96              6 IIFSYDGSAFLG---SATQPH--KKGVQDALSGALShlgiF--------------------------------------- 41  Campylobac...

EHY53673          467 ayssspsptvagvggasgpkvyAFCVHGSAFLWHQVRCMVAIL-FLV--GQ--GLEQPSIVDDLLDVEKtPTRpMYEMAD 541 Exophiala ...
CDC35726           43 ----------------------PVELTGSGRTDAGVHARGQVAnYHL--DT---PRDTSAMLSYVNQYL-PDDiAVLSIE 94  Butyrivibr...
CDC23357           43 ----------------------PVEIDGSGRTDAGVHANGQVA-NMK--VS--GLLDE-SFVGELNCLL-PEDiCVKEME 93  Clostridiu...
wucgs:EUBREC_1311  69 ----------------------PVEVIGSGRTDAGVHAVGQVAsFHM---P--KHFSKDEIFIWLNEHL-PADiAVTDIS 120 [Eubacteri...
BAF70217           42 -----------------------SKIVGSGRTDKGVHATAQVIhFDL--PP--FWSELERLQNLLNESL-RPYiQIKRVV 93  Nitratirup...
WP_013553835       40 --------------------giGTPIVGSGRTDAGVHATGQVIhFDL--PPhwAKQPLDELQIHLNRRL--DAiRFKHLT 95  Nitratifra...
CCY35799           41 ----------------------KISVVGAGRTDAGVHASDFTAhFDSdsLC--LLEDPAHVIYKINAIL-PKNiVFRSIT 95  Alistipes ...
CDC25280           41 ----------------------DMEVVGAGRTDTGVHARKMAAhFDW--EG--EELDAPQLTYRLNRIL-PRDiAVKDIK 93  Prevotella...
jgi:Haur_4942      44 -----------------------GRWIFAGRTDAGVHALAQVA-HIV--SD--TPRSLDTIAKAINAIT-PPDiSVHEAW 94  Herpetosip...
Q9PP96             42 -----------------------SPLLMASRTDKGVHASYAVAsVEC--GD--YFTNLEYLQKQLNKFS-HPFiHIKKIE 93  Campylobac...

EHY53673          542 DAPLvLWDCIFP 553 Exophiala dermatitidis NIH/UT8656
CDC35726           95 SVDE-RFHSRYN 105 Butyrivibrio sp. CAG:318
CDC23357           94 LVPG-SFHSRYS 104 Clostridium nexile CAG:348
wucgs:EUBREC_1311 121 NVPD-RFHARYN 131 [Eubacterium] rectale ATCC 33656
BAF70217           94 KVPK-EFHARYS 104 Nitratiruptor sp. SB155-2
WP_013553835       96 PVPA-DFHARYD 106 Nitratifractor salsuginis
CCY35799           96 RVRD-DAHARFD 106 Alistipes sp. CAG:831
CDC25280           94 RVAD-DMHARFS 104 Prevotella sp. CAG:386
jgi:Haur_4942      95 EMPT-GFHARFS 105 Herpetosiphon aurantiacus DSM 785
Q9PP96             94 KVKD-DFEVRFD 104 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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