3HTZ_A 1 SLSAHEIRELFLSF---FEKKGHTRVKSA-PLVPENDPTLLFVNAGMVPFKNV----FLGLEKRPYKRATSCQKclrvSG 72 Aquifex aeolicus O28029 64 EMREYYLNFFERRG---HGRIERYPVVAR-WRTDIYLTIASIADFQPFVTSGVa---PPPANPLTISQPCIRLD----DL 132 Archaeoglobus fulgidu... Q8U425 61 EMREKFLSFFEKHEvypHGRVKRYPVLPR-WRDDVLLVGASIMDFQPWVISGEa---DPPANPLTISQPSIRFT----DI 132 Pyrococcus furiosus D... O27718 58 EIQDKFMEFFAERG---HEPIRRYPVLAKrWRDDVFLVGASIYNFQPWVTSGLv---KPPANPLVVAQPSIRLN----DV 127 Methanothermobacter t... O84754 5 TLRSNFLKFYANRN---HTPVASSPVFPH-NDPSILFTNAGMNQFKNIFLGKE----QTSYTRATTSQKCIRAGgkhnDL 76 Chlamydia trachomatis... P75368 7 KVRQTWLDYFTAKG---HLALPSKSLIPV-NDPSLLWINSGVATLKDYFSAKK----TPPSKRLANAQICLRVN----DI 74 Mycoplasmoides pneumo... O34526 8 EVRQMFLDFFKEKG---HAVEPSASLVPH-EDPSLLWINSGVATLKKYFDGRV----VPENPRIVNAQKAIRTN----DI 75 Bacillus subtilis sub... P9WFW7 5 EIRKRFLDHFVKAG---HTEVPSASVIL--DDPNLLFVNAGMVQFVPFFLGQR----TPPYPTATSIQKCIRTP----DI 71 Mycobacterium tubercu... P74423 12 EIRQQFLNFFADRQ---HQILPSASLVP--EDPTVLLTIAGMLPFKPIFLGQK----SAEFPRATTSQKCIRTN----DI 78 Synechocystis sp. PCC... P74941 5 EIREKFLSFFEGKG---HLRLPSFSLIPE-DDPSLLFTSAGMAPLKPYFLGAKpifgGREWRRVTTCQECLRVG----DI 76 Thermus thermophilus HB8
3HTZ_A 73 KHNDLEQVGYTSRHHTFFEMLG-----NFSFGDYFKKEAIEYAw--E-----FVTEVLKLPKEKLYVSV--YKDDEEAYR 138 Aquifex aeolicus O28029 133 DSVGRTGRHLTLFEMMAHHAFNypgkeIYWKNETVAYCTELLN---E-----LGVKKEDIVYKEEPWAGggNAGPCLEAI 204 Archaeoglobus fulgidu... Q8U425 133 DNVGITGRHFTIFEMMAHHAFNypgkhIYWIDETVELAFEFFTk--E-----LKMKPEDITFKENPWAGggNAGPAFEVL 205 Pyrococcus furiosus D... O27718 128 DNVGRTGRHLTCFTMGGHHAFNsedntVYWEEETIKYCHDFLT---H-----IGIDPSEITFIESWWQGggNEGPCYEVC 199 Methanothermobacter t... O84754 77 ENVGHTSRHLTFFEMLGNFSFG-----DYFKQDAISFAWEVSLs--I-----FNFDPDFIYATVHEKDD--EAFALWEKY 142 Chlamydia trachomatis... P75368 75 ENVGFTSRHQTLFEMLGNFSIG-----DYFKEEAIGFANDLLVn--H-----YHLDPKRFYITVYQDDE--LTFNTWLKH 140 Mycoplasmoides pneumo... O34526 76 ENVGKTARHHTFFEMLGNFSIG-----DYFKEEAITWAWEFLTsdkW-----IGFDKELLSVTVHPEDE--EAYEFWAKK 143 Bacillus subtilis sub... P9WFW7 72 DEVGITTRHNTFFQMAGNFSFG-----DYFKRGAIELAWALLTn--SlaaggYGLDPERIWTTVYFDDD--EAVRLWQEV 142 Mycobacterium tubercu... P74423 79 ENVGRTARHHTFFEMLGNFSFG-----DYFKSQAIAWAWELSTq--V-----FKLPAERLVVSVFEEDD--EAFAIWRDE 144 Synechocystis sp. PCC... P74941 77 ENVGRTSRHNTYFEMLGNFSFG-----DYFKKEAILWAWEFLTe--H-----LKLDPGRLWVTVFEDDD--EAYEIWRDL 142 Thermus thermophilus HB8
3HTZ_A 139 IwNEHIGIPSEriwRLGE-----EDNFW-------------QMGDVGPCGPSSEiyvDRG------EE-------YEGDE 187 Aquifex aeolicus O28029 205 VgGLEVATLVF---MNLE-----EHPEGdiei-----kgarYRKMDNYIVDTGYgleRFVwaskgtPTvy---daIFPEV 268 Archaeoglobus fulgidu... Q8U425 206 YkGLEVATLVF---MQYK-----KAPANadpsqvviikgekYVPMETKVVDTGYgleRLVwmsqgtPTay---daVLGYV 274 Pyrococcus furiosus D... O27718 200 VrGVELATLVF---IQYR-----TLPDGg------------REEIPLKIVDTGYgleRFAwisqgtPTay---daCLGPV 256 Methanothermobacter t... O84754 143 --LPTDRIFRLtdkDNFW-----SMADT-------------GPCGFCSELLFDRgekFGKaa--spLEdvd--geRFLEY 198 Chlamydia trachomatis... P75368 141 G-IPASRIIKCdrdRNFW-----DLGL--------------GPCGPCTEIYYDRgerFDPhkvgekLFfediendRYVEV 200 Mycoplasmoides pneumo... O34526 144 IgIPEERIIRLe--GNFW-----DIGE--------------GPSGPNTEIFYDRgeaYGNdpedpeLYpgg-endRYLEV 201 Bacillus subtilis sub... P9WFW7 143 AgLPAERIQRRgmaDNYW-----SMGIP-------------GPCGPSSEIYYDRgpeFGPag--gpIVse----dRYLEV 198 Mycobacterium tubercu... P74423 145 IgIPAHRIQRMgadDNFW-----VSGPT-------------GPCGPCSEIYYDFhpeLGDek--ldLEdd----sRFIEF 200 Synechocystis sp. PCC... P74941 143 VgVPEERIGRFgedENYWpggaiTHGPN-------------GPSGPCSEIFYDRgpaYGTpdetgpNTgs---gdRFVEI 206 Thermus thermophilus HB8
3HTZ_A 188 RYLEIWNLVFMQ------YNRDENGVLTPLPHPNIDTGMGLERIASVLQGKNSNFEIDIIFPLIQFGeevsg-------- 253 Aquifex aeolicus O28029 269 VDTIIDNSNVSFnr--edERVRRIVAESSKLAGIMGELRGERLNQLRKSVADTVGVSVEELEGIVVP------------- 333 Archaeoglobus fulgidu... Q8U425 275 IEPLKRMAGVE-------KIDERILMENSRLAGMFDIEDMGDLRYLREQVAKRVGISVEELERLIRP------------- 334 Pyrococcus furiosus D... O27718 257 IEKLVELTGVK--------IDEEILAENAQVAGMMDIETYADLRELRKRVADKLGISVEELERAAAP------------- 315 Methanothermobacter t... O84754 199 WNLVFMEFNRTS------DGTLLALQKKCVDTGAGLERLVSLLAETETVFEADVLRHLISKIENLSGttysp-------- 264 Chlamydia trachomatis... P75368 201 WNIVFSQFNNDG------NGNYSELAQKNIDTGAGIERLVAILQDAPTNFDTDIFLKLIGIIEQHCKhkydtnlyfkfdq 274 Mycoplasmoides pneumo... O34526 202 WNLVFSEFNHNP------DGTYTPLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGetygk-------- 267 Bacillus subtilis sub... P9WFW7 199 WNLVFMQNERGEgttkedYQILGPLPRKNIDTGMGVERIALVLQDVHNVYETDLLRPVIDTVARVAAraydv-------- 270 Mycobacterium tubercu... P74423 201 YNLVFMQYNRDN------AGNLTPLEKKNIDTGMGLERMAQILQKVPNNYETDLIFPIIQTAANIAGidyaq-------- 266 Synechocystis sp. PCC... P74941 207 WNLVFTQYDRQGpi--pgPGILKPLPQKNIDTGMGLYRVAAILQDVEDFYRTDTFFPIIQEVARMSGrpye--------- 275 Thermus thermophilus HB8
3HTZ_A 254 -kkygEKFETDVALRVIADHLRAITFAISDGVIPSNEGRGYVIRRILRRAMRFGYKLgIENPFLYKGVDLVvdiMKEPYP 332 Aquifex aeolicus O28029 334 -----LEKVYSLADHTRCILFMLGDGLVPSNAGAGYLARLMIRRSLRLAEELELGLD-LYDLVEMHKKILG---FEFDVP 404 Archaeoglobus fulgidu... Q8U425 335 -----YELIYAIADHTKALTFMLADGVVPSNVKAGYLARLLIRKSIRHLRELGLEVP-LAEIVAMHIKELSptfPEFKEM 408 Pyrococcus furiosus D... O27718 316 -----MESVYAIADHTRCLAFMLADGVIPSNVKEGYLARLIIRRTLRLMKDLGMKES-LKDIMNIQVEFLEghyPEIRSH 389 Methanothermobacter t... O84754 265 -teakGAAFRVIADHIRSLSFAIADGLLPGNTERGYVLRKILRRAVNYGKRLGFNRPfLADVVPSLVDVMGeayPELSAS 343 Chlamydia trachomatis... P75368 275 klneaQSAFRIISDHFKAITFTIAEGVLPGPNERSYIVRRLLRRALLACKKLDLDLKfIDPMVDAIISVYGsyyQQLQGK 354 Mycoplasmoides pneumo... O34526 268 -dnvkDTAFKVIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPfMFDLVPVVAEIMAdfyPEVKEK 346 Bacillus subtilis sub... P9WFW7 271 gnhedDVRYRIIADHSRTAAILIGDGVSPGNDGRGYVLRRLLRRVIRSAKLLGIDAAiVGDLMATVRNAMGpsyPELVAD 350 Mycobacterium tubercu... P74423 267 anektKVSLKVIGDHVRSVVHMIADGISASNLGRGYVLRRLIRRVVRHGRLLGINGEfTTKVAATAVQLAQpvyPNVLER 346 Synechocystis sp. PCC... P74941 276 --gktSVSHRVIADHVRAVVAALSDGATFSNTGRGYVIRRLLRRALRHGYLLGLSDPfLHRLAPLVAELLGdfyPEMREN 353 Thermus thermophilus HB8
3HTZ_A 333 ELELSREFVKGIVKGEEKRFIKTLKAGMEYIqeviqKALEEGRKTLSGKEVFTAYDTYGFPVDLIDEIAREKGLGIDLEG 412 Aquifex aeolicus O28029 405 LSTVQEILELEKERYRTTVSKGTRLVERLVE-----RKKKLEKDDLIELYDSHGIPVELAVGIAAEKGAEVEMPKDIYAE 479 Archaeoglobus fulgidu... Q8U425 409 EDIILEMIELEEKKYAETLRRGSDLVKREIAklkkkGANEIPLEKLITFYESHGLTPEIVKEIAEKEGVKVHIPDNFYSL 488 Pyrococcus furiosus D... O27718 390 HEHILNIIDLEEHRYARTVKRGRRIVEKTIKylkrdGKAEMPLEILIKLYDSHGIPPETIGEIAEESGFQVKIPDNFYTL 469 Methanothermobacter t... O84754 344 VTQIQEVLTTEEEHFFKTLQRGGNLLQQVLKss--asSAKISGEDAFKLKDTYGLPIDEIALLAKDYNYAIDMDTFEKLE 421 Chlamydia trachomatis... P75368 355 NQVVQQAIWKEVTAFDKTINLGLMLFEKSIAh------NALQPQVAFQLYETYGFPIEMIKELVDKRQLQVDWKAVEQLM 428 Mycoplasmoides pneumo... O34526 347 ADFIAKVIKTEEERFHETLNEGLAILSEMIKkekdkGSSVISGADVFKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEM 426 Bacillus subtilis sub... P9WFW7 351 FERISRIAVAEETAFNRTLASGSRLFEEVASstkksGATVLSGSDAFTLHDTYGFPIELTLEMAAETGLQVDEIGFRELM 430 Mycobacterium tubercu... P74423 347 QSLIEQELQREEAAFLKTLERGEKLLADLMAd----GVTEIAGADAFTLYDTFGFPLELTQEIAEEQGITVDVEGFEKAM 422 Synechocystis sp. PCC... P74941 354 LPAVEKQIRLEEERFLETLEGGLKRLDALLSgl--kpGEVLPGKEAFRLYDTYGFPLDLTVEIAAERGYGVDTEGFQKAM 431 Thermus thermophilus HB8
3HTZ_A 413 FQCELEEqRERARKHfkveakKVKPVYSHLK---ELgKTSAFvgaaaLEH 459 Aquifex aeolicus O28029 480 LAKRHSKaEKVQEKK------ITLQNEYPAT---EK-LYYDD-----PTL 514 Archaeoglobus fulgidus DSM 4304 Q8U425 489 VAKEAEKqVEEKEEEvv---dFELVKDLPDT---RT-LYYED-----PFM 526 Pyrococcus furiosus DSM 3638 O27718 470 VAERNETeTEMPE--------EDVHLDYPAT---EL-LFYDEpddlefqa 507 Methanothermobacter thermautotrophicus str. Delta H O84754 422 VEAKERSrKNTKKTKnd---sDSVFQDLDPTn-tSEfIGYDTlscdtFIE 467 Chlamydia trachomatis D/UW-3/CX P75368 429 EQHRLISkQNSNTLSfe--kqNEHLVNFKTA---SEfLYEANei-taKVI 472 Mycoplasmoides pneumoniae M129 O34526 427 NQQRERArNARQDVGsmq-vqGGALRDVTVE---STfVGYSQtkadaNII 472 Bacillus subtilis subsp. subtilis str. 168 P9WFW7 431 AEQRRRAkADAAARKhah-adLSAYRELVDAg-aTEfTGFDElrsqaRIL 478 Mycobacterium tuberculosis H37Rv P74423 423 QEQQERSkAAHETIDltvqesLDKLANHIHP---TEfLGYTDlqssaIVK 469 Synechocystis sp. PCC 6803 substr. Kazusa P74941 432 EEQQSRSrAAMAFEReifkkgAQVLEELYAErgaTEfLGYNAleaeaEVL 481 Thermus thermophilus HB8
Jiyao W et al.(2023). "The conserved domain database in 2023.",