8WOX,7WPZ


Conserved Protein Domain Family
Peptidase_M2

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pfam01401: Peptidase_M2 (This model is not part of the current CDD release)
Angiotensin-converting enzyme
Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.
Statistics
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PSSM-Id: 514237
Aligned: 46 rows
Threshold Bit Score: 768.695
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8WOX_A          1 STIEELAKTFLEKFNQEAEDLSYQSALASWDYNTNITEENVQKMNDAEAKWSAFYEEQSKLAKTYPSQEVQ-NLTVKRQL 79   rabbit
EFX74557       29 NTNEDEAIAFLEHYDTEYGPIINQYVLASWNYETNLTDENAMAVAEAGGVAGAYYAQASANASTFDTTNF--SEDTKRQF 106 
EEC03271       12 ITDESLASMFMESLADDYKILGCVSANAQWDYVTNLTAENMQTMNVVFGEVSKVHSEISNTLRRFAWRHFQ-NATLKRLF 90  
KAF8353839    307 VKDESEAREWMKGYAEEARKMLHLVTKSGWMYFTDASPTLNRALNEAEEVMARFVRATAQQAKQFDTSAFA-DEALKKQF 385 
WP_025409187   42 TPTAAAARLFVDSVERRLDALSVTVNQAEWVAATYITDDTEALSADAQQRYDAAAQRFALAARRFD--GVTvPPDLRRKL 119  Gemmatirosa k...
WP_023173625   33 VQSVAEAQKFMQRAEGELAELNVKANRASWVGATYITDDTEALSADAQTNLNSAIQRFAIEAKRFD--NLQmPPELARKF 110  Gloeobacter k...
WP_014076685   32 APDSAQADAFVAAAEKEAFDYSVDASRIMWVNATHITDDTDALAAQAGAKGTEMAVRFALEAAKYEQVPGL-SFDTKRKL 110  Sphingobium s...
WP_015456931   30 APTAADADRFVAAAEKELFDLSIPTAQVAWVNATYITDDTDALNTLFGAKNTEASVRLAKEAARYDKVAGF-SFDTRRKL 108  Sphingomonas ...
Q8EE93         43 TPDKAQAIAFIQDAEAQMAQLSIEANRAEWIYSNFITEDTAALSAAVGEKVSAASVKFATEAAKYA--NVElDPANARKL 120  Shewanella on...
WP_013051597   36 SSKTSEAKQFLIQSEQTLSDLSIEINRAEWIYSNFITDDTAALSASAAEKLTATSVRLATQAAQYT--DLAlDDTSLRKL 113  Shewanella vi...
8WOX_A         80 QALQQSGSS-ALSAD-KSKQLNTILSTMSTIYSTGKVCN------QSNP---QECFLLEPGLDEIMAK-STDYNERLWAW 147  rabbit
EFX74557      107 SYLQSV----SLDDA-ESEELYNILSEMGRIYGSYQACR------SNPStglNECMYLEPELTELMAE-NGNYDDHLWAW 174 
EEC03271       91 QESAPLGNG-SFSVE-KSEKMDELNAEMEAIYSETEVRVdf--rgG---------LKIEPGLAAIMRE-VGDYDLLMEAW 156 
KAF8353839    386 GYVTFEGMS-TLNVA-DAEAFSTANSNMNKMAADVTVCD------LDLP---PPCALKKIDLESIART-DKDANRLGHLY 453 
WP_025409187  120 TLLKLAFTApPPSDPaKGAELVRLTTGMEGAYGRGTYCRrgalgqPAATtgdSTCYQIN-DLSRALAE-SHDPAVLLDAW 197  Gemmatirosa k...
WP_023173625  111 KLLKLNLIApPPSDSkEQQELTRLTVGMESEYGKGTYCR-------SPVdgkQECLQLN-DLERILRT-SRDPKELLDVW 181  Gloeobacter k...
WP_014076685  111 DIMRSGIVLpAPTKPgAAAELNEIATRLQSTYGKGRGTL------DGKE------LTGS-DIEAEMANlSHTPAQFSEMW 177  Sphingobium s...
WP_015456931  109 DILRQGIVLpAPATEgAATELNALSTRMSSTYGKGRGTL------AGKE------INGS-DIEEKMGT-VRNPDQLKEMW 174  Sphingomonas ...
Q8EE93        121 NILRSALVLpAPLDPaKNAELAQISSELNGLYGKGKYCF---------Ad--GKCMTQP-ELSSLMAE-SRDPAKLLEAW 187  Shewanella on...
WP_013051597  114 NILRSSLVLpAPLDPeKNAELAGISAQLNGLYGKGKYCF---------Dd--GRCLTQP-ELSAIMAE-SSDPKLLLEVW 180  Shewanella vi...
8WOX_A        148 EGWRSVVGKQLRPLYEEYVVLKNEMARANNYEDYGDYWRADYEaegadgydysRSQLIDDVERTFSEIKPLYEQLHAFVR 227  rabbit
EFX74557      175 QAWHDGVGRQLRPLYLRYVELSNKQAQLNGYADYGDQWRQKYE----------TTEMETIVQDLYSQVEPLYKELHAYIR 244 
EEC03271      157 AAWHNSVGSQERDLFIPYIKLANESAISEGYGNIKEMWLKSYA----------MNNFTEVIDGIFEELSPLYKKLHAYVR 226 
KAF8353839    454 TTFNQNVAA-LKGNYQKIIELTNKGAKMNGFGSGSSMWLSSFDlstk--dtppQFDVMKKLNEVFKQVSPFYKQLHAYMR 530 
WP_025409187  198 RGWHA-IGAPLRPKYERFVALSNEGARELGFADLGAMWRANYDm--------pADQFPREVERLWKQVEPLYVALHAYVR 268  Gemmatirosa k...
WP_023173625  182 QGWHQ-IARPLRPRYERFVQLSNKGARELGFADTGAMWRSNYDm--------sPAQFSAEVERLWQQVRPLYLSLHAYVR 252  Gloeobacter k...
WP_014076685  178 TSWHDRVGAPMKADYVRLVDIANEGAKELGFADAGAMWRSGYDm--------pPDEFAALTEALWQEVKPLYDALHCYTR 249  Sphingobium s...
WP_015456931  175 ASWHDNVGKPMKADYARMVEIANQGAKELGYKDLGAMWRSNYDm--------sPDEFARLTDKLWLQVKPLYDQLHCYTR 246  Sphingomonas ...
Q8EE93        188 KGWRE-IAKPMRPLFQREVELANEGAKDLGYANLSELWRSQYDm--------kPDEFSQELDRLWSQVKPLYESLHCYVR 258  Shewanella on...
WP_013051597  181 QGWRE-IAKPMRPLFQREVELANEGAKDLGYADLSVLWRSQYDm--------kPDEFSNELDRLWGQVKPLYDSLHCYVR 251  Shewanella vi...
8WOX_A        228 TKLMDAY--PSRISPTGCLPAHLLGDMWGRFWTNLYSLTVPFGQ-KP--NIDVTDTMVNQ-------------------- 282  rabbit
EFX74557      245 RKLYNTYg-ANYIDLRGPLPAHLLGDMWGRFWVNLNPIAIPYPD-KP--STDPSPEMIRQ-------------------- 300 
EEC03271      227 MKLRDIY--PGRMPEDGTIPAHLLGDMWSQQWGNLYTTLKN----GT--PIDITREMEFQ-------------------- 278 
KAF8353839    531 RQIAGLYknPEGLTKDLAIPAHLFGTLEGGDWSAHYLDTRPYDD-EDsvPEEILAAFHGQ-------------------- 589 
WP_025409187  269 TRLNQQYg-DAVVAKDGMIPAHLLGNMWAQEWGNVYPIVAPPNA-SP--TYDLTALLKAK-------------------- 324  Gemmatirosa k...
WP_023173625  253 TKLGEQYg-TQLVPADGPIPAHLLGNMWAQEWGNIYPLAAPAND-QR--GYDLTQLLTAK-------------------- 308  Gloeobacter k...
WP_014076685  250 TKLNEKYg-DAVQSPTGPIRADLLGNMWAQEWGNIYPIVAPAGTgDL--GYDIGDLLRAKgfvqttpqtidtpdtpetqr 326  Sphingobium s...
WP_015456931  247 TKLNEKYg-DGVQPRTGPIRADLLGNMWAQEWGNIYDVVAPAGAgDL--GYDTTDLLKAK-------------------- 303  Sphingomonas ...
Q8EE93        259 GELNKEYg-DAIAPKTGPIPAHLLGNMWAQQWGNVYDLVAPENA-DP--GYDVTELLAQK-------------------- 314  Shewanella on...
WP_013051597  252 GELNEEYg-DEVVPANGPIPAHLLGNMWAQSWGNVYDKVSPQDA-DP--GYDLTQLLAEH-------------------- 307  Shewanella vi...
8WOX_A        283 -GWDAERIFKEAEKFFVSVGLPSMTQGFWENSMLTEPGDgRKVVCHP-TAWDL-GKGDFRIKMCTKVTMDNFLTAHHEMG 359  rabbit
EFX74557      301 -NYTVERMFRTGNDFYTSMGLLPVPETFWNLSMLEKPTDgREVACHA-TAWDFyDAKDFRIRMCARVVFEDFQTVHHELG 378 
EEC03271      279 -KWDAQRIFETAEAFFVSLGLSPMTPTFWNKSILSQPAD-RNIVCHP-AAADFsDGDDYRIKMCTEPRLLDLLNAHHEMG 355 
KAF8353839    590 -NITQKEMFVKAYRYFKAVGFPKLPKSFWTNSVFARVWS-KDMICNPpAAIDMrDGEEFRVKMCAQLGDTDFKQAHSLLA 667 
WP_025409187  325 -NVDAKGMAKYAEGFFTSMGFAPLPATFWERSMLVKPRD-REVVCHA-SAWTIdNKNDVRIKACLEPTADDFVTIHHEEG 401  Gemmatirosa k...
WP_023173625  309 -KVDEREMFRYGERFFTSLGFAPLPKTFWERSMLTKPRD-RDVVCHA-SAWDIdNLDDVRIKMCAEVTDSDFVTIHHELG 385  Gloeobacter k...
WP_014076685  327 rGYWEKQMFRIGEGFYSSLGFDPLPETFWQRTQFIAPRD-REVVCHA-SAWDVdNRNDIRVKMCTKVNSDDFVTIHHELG 404  Sphingobium s...
WP_015456931  304 -GYDALKMVKGGENFFSSLGFAPLPDSFWQHSQFTKPAD-REVICHA-SAWDVdNKDDLRIKMCIKVNGDDFTTIHHELG 380  Sphingomonas ...
Q8EE93        315 -GYDEHRMVKQAESFFTSLGFAPLPDSFWSRSLFLQPKD-RDVVCHA-SAWDLdNLDDIRIKMCIQKTAEDFTVIHHELG 391  Shewanella on...
WP_013051597  308 -DYDEVKMVKQAESFFSSLGFDELPDSFWERSLFVQPKD-RDVVCHA-SAWDLdNLDDIRIKMCIQKTAEDFTVIHHELG 384  Shewanella vi...
8WOX_A        360 HIQYDMAYATQPFLLRNGANEGFHEAVGEIMSLSAATPEHLKSIGLLp-YDFHEDNETEINFLLKQALTIVGTLPFTYML 438  rabbit
EFX74557      379 HIQYFMQYAFQPLNYRDGANDGFHEAVGELMSMSFSTTKHLNTLGLL---NVPDDPDVDMNFLLFQALNTISTLPFHLTQ 455 
EEC03271      356 HIVYYMLYSHLHPSFQDGANEAFQEMVGDLIALSVSTVRRYRHLGLLg-FEYIDP----IDALLQTALDKIAFLPYGYAL 430 
KAF8353839    668 QTFYQFLYRKQPFSFREAANPSFNEAIANVFSILSSNTDYLFSQSLIapDSLVPKESQVINRLYKEALTHFVKLPFDLAA 747 
WP_025409187  402 HNFYQRAYSSQPYLFQNGANDGFHEAIGDAIALSI-TPGYLQQAGLL---ATPPSAAADTALLLRQALDKVAFLPFGLMI 477  Gemmatirosa k...
WP_023173625  386 HNFYQRAYKTQPPLFQNSANDGFHEAVGDTIALSV-TPDYLVKVGLL---GKAPGPESDTGFLLKQALDKVAFLPFGLLI 461  Gloeobacter k...
WP_014076685  405 HNYYQRAYQKHGYLYLNGANDGFHEAIGDFIALSI-TPQYLVQIGLLd-PAKVPSADKDIGLLLRQAMDKVAFLPFGLLI 482  Sphingobium s...
WP_015456931  381 HNYYQRAYNKQPYLYLNGANDGFHEAIGDAIALSI-TPDYLVRIGLLd-PAKVPPADKDIGLLLRQAMDKVAFLPFGLLV 458  Sphingomonas ...
Q8EE93        392 HNFYQRAYKQQPFLFKNSANDGFHEAIGDTIALSI-TPSYLKQIGLL---EEVPDASKDIGLLLKQALDKIAFLPFGLMI 467  Shewanella on...
WP_013051597  385 HNYYQRAYKNQPFIFKNSANDGFHEAIGDTIALSI-TPSYLKQIGLL---DEVPDASKDIGLLLKQALDKVAFMPFGLMI 460  Shewanella vi...
8WOX_A        439 EKWRWMVFKGEIPKEQWMQKWWEMKREIVGVVEPMP-HDE-TYCDPAALFHVAN-DYSFIRYYTRTIYQFQFQEALCQAA 515  rabbit
EFX74557      456 DTWRWNMFRGDIPEAELNTQYWADKARVLGVAPPVG-RDPaQDLDITAIFHVCN-NYDMIRYFMRTFFQYQFNEVLCTAA 533 
EEC03271      431 EKWRWSVFTGETPFEDMNKRFWEYRIKYQGVSPPLT-RAE-LHFDPGAKYHVAI-NAPYISYFVSFILQFQVHEYLCSKT 507 
KAF8353839    748 DEWRIEYFNGKTVPSKLNERWWQLRERYEGVRHVSPtVNA-STLDALINTAIVQeHSPATRQMITYVMQFQILKALCPEG 826 
WP_025409187  478 DQWRWGVFSGAIKPSEYNKAWWDLRARYQGVVPPVA-RSE-ADFDPGAKYHVPA-NTPYMRYFLARVLQFQFYRAMCRAA 554  Gemmatirosa k...
WP_023173625  462 DQWRWKVFSGETQPKDYNKSWWELRERYQGIAPPLA-RSE-ADFDPAAKYHVAA-NTPYIRYFLARILQFQFHRALCREA 538  Gloeobacter k...
WP_014076685  483 DRWRWGVFDGSIRPADYNKAWTDMRLRYQGIVPPTD-RPA-DSFDPGAKFHVPG-NTPYTRYFLARILQFQFYEAACRQA 559  Sphingobium s...
WP_015456931  459 DKWRWGVFDGSIAPQDYNKAWTALRLQYQGITPPVE-RGA-DAFDPGAKYHVPA-STPYTRYFLARILQFQFYKAACDQA 535  Sphingomonas ...
Q8EE93        468 DQWRWKVFSGEITPAQYNQAWWELREKYQGVKAPTP-RSE-TDFDPGAKYHVPG-NVPYTRYFLAHILQFQFHKALCETA 544  Shewanella on...
WP_013051597  461 DQWRWKVFSGEITPDQYNQAWWDLREKYQGVKAPIE-RSE-ADFDPGAKYHVPG-NVPYTRYFLAHILQFQFHKSLCETA 537  Shewanella vi...
8WOX_A        516 QH---EGPLHKCDISNSTEAGQKLLNMLRLGRSEPWTLALENVVGAKNMDVRPLLNYFEPLFTWLKEQN--RNSFVGW 588  rabbit
EFX74557      534 GH---VGPLYKCDFYNSTAAGDALAAMLQLGASKPWQDAMEAMTGQRDVLATPLLNYFEPLRVWLEAENakNGEYIGW 608 
EEC03271      508 NKiddENPFHECDIYGHELAGHILKRGLSLGKSKPWPEVLEILAGTSQMSAGSMRRYFRPLEKWLDEQI--KDEMVGW 583 
KAF8353839    827 SI------LSEGCIL-SEDTTGKLREAMEKGSSINWLEALKIVTGKGELDVAPLLEYYEPLINWLQNTNevDQVIVGW 897 
WP_025409187  555 GH---TGPLYRCSFYGSKEAGAKLARMLEAGQSKPWQETLYEMTGERDMDAGAMLEYFAPLKAWLDRQN--AGHPVGW 627  Gemmatirosa kal...
WP_023173625  539 GY---TGPLHRCSIYANRAAGTKLAAMLAAGQSQPWPDTLYAMTGERQMDASAMLDYFAPLKSWLDAQN--QGKKVGW 611  Gloeobacter kil...
WP_014076685  560 GW---KGPLHRCSFYGNKEVGKRLNAMLEMGASKPWPDALEAFTGSRKMSGKAMLAYFAPLGKWLDQQN--KGKQCGW 632  Sphingobium sp....
WP_015456931  536 GW---KGPLHRCSFYGNKEVGANLNKMLEMGMSKPWPDALQAFTGSREMDGTAMIAYFKPLMTWLEQQN--KGKTCGW 608  Sphingomonas sp...
Q8EE93        545 GD---KGPVHRCSIYGNQAAGEKLNRMLELGSSQPWPMALKEVTGTETMDANAVLDYFAPLKTWLDEQNkaANRQCGW 619  Shewanella onei...
WP_013051597  538 GD---TGPVHRCSIYGNKAAGSKLNTMLEMGLSRPWPDALKVVTGSPEMDASAVLDYFAPLQVWLNEQNtqAKRQCGW 612  Shewanella viol...
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