Conserved Protein Domain Family
Synuclein

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pfam01387: Synuclein (This model is not part of the current CDD release)
Synuclein
There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.
Statistics
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PSSM-Id: 514224
Aligned: 12 rows
Threshold Bit Score: 129.661
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002745638   1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGvvhgVTTVAEKTKEQVTNVGGAVVTGVTAVAQK 80 
XP_011602812   1 MDAFMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMFVGTKTKDG----VTVVAGKTVSGVSQVGGAMVTGVTAVAQK 76 
1_pfamImport   1 MDAFKKGFSKARDGVAAVAEKTKQGVTGAAEMTKDGVMFVGNKTKDG----VTTDFPTAVSGVSQVGGAMVTGVTAVAHK 76 
XP_003455005   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VTTVAGKTVSGVSQVGEAVVTGVTAVAQK 76 
XP_005812724   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VSTVAEKTVSGVSHVGGAVVTGVTAVAQK 76 
XP_007478272   1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKEGvvqsVTSVAEKTKEQANLVSDVMVASVNTVANK 80 
O76070         1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENvvqsVTSVAEKTKEQANAVSEAVVSSVNTVATK 80  human
XP_008112683   1 MDVFKKGFSIAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGAKTKEGvvqsVTSVAEKTKEQANLVGESVVASVNTVAKQ 80 
XP_015203361   1 MDVLKKGFSIAKEGVVAAAEKTKQGVEEAAAKTKEGVMYVGTKTKEGvvhsVNTVAQKTTEQANIVGETVVGSANQVSAK 80 
2_pfamImport   1 MDMFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSEIRSK---------DRARGSGSVVRDQSNESTEGITMG 71 
Q16143         1 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGvvqgVASVAEKTKEQASHLGGAVFS-------- 72  human
Q9NZ50         1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKEGvvqsVTSVAEKTKEQANAVSEAVVSSVNTVATK 80  domestic cattle
XP_002745638  81 TVEGAGNIAAATG--FVKKDhl----gKSEEGAPQEGiLEDMPV-DPDNEAYEMPSEE 131
XP_011602812  77 TVESAGSIAAATG--LVKKE-------PGKQGDDAAT-AENMAEsPDVTDPAEATEED 124
1_pfamImport  77 TVEGAGNMVVATG--LVKKD-------PAKQSDEASA-VQDMAEsPVDTDPADAME-- 122
XP_003455005  77 TVEGAGTIAAATG--LVKKD-------PAKQSDDASA-VQDVAEsPVDTDPADVTEED 124
XP_005812724  77 TVEGAGNIAAATG--LVKKD-------PAKQGEDVSA-VPDAVEsPIDTDSTEPTEED 124
XP_007478272  81 TVEEAENIVVTSG--IVRKEdlv-npaQPEHGAP-------------EEQPAEAAEVT 122
O76070        81 TVEEAENIAVTSG--VVRKEdlr-psaPQQEGEAs----------KEKEEVAEEAQSg 125 human
XP_008112683  81 TVEGAETVVSSTG--VVKMEdlh-peqPEEPLAD-----------AEEDAPVEATETS 124
XP_015203361  81 TVEGVENVVASTG--VVNPDda----vNQEDFSR-----------PPEGTVEQATDAV 121
2_pfamImport  72 GIRGDDGSSVGVGrvLVKSSqww-hgiPEEVGQEVGEePMAEPLlDTEGESYEEPPQE 128
Q16143        73 ---GAGNIAAATG--LVKREefptdlkPEEVAQEAAEePLIEPLmEPEGESYEDPPQE 125 human
Q9NZ50        81 TVEEVENIAVTSG--VVHKEalk-qpvPSQEDEAa----------KAEEQVAEETKSG 125 domestic cattle
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