Conserved Protein Domain Family
PHO4
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pfam01384: PHO4 (This model is not part of the current CDD release)
Phosphate transporter family
This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.
Links
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Statistics
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PSSM-Id: 514222
Aligned: 691 rows
Threshold Bit Score: 53.6365
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004995736    24 TGANDVGNAFGTGVGTGAFTYRTAV-IIAAIFELAGASLIgAnVVDFIQSKFIsledfggdeelfaA-------GMFA-A 94  
Q18IJ3          20 IGGSSTGVAFGPAVGSRLVRKTTAG-ALFVGFAFFGAWTVgRnVIATMSSSIV-------------PaiqftpiASVI-V 84   Haloquadratu...
ADE02634        20 IGGSSTGVSFGPAVGSGVLGKLAAA-ALMTGFALLGGWTLgReVVAKMGGEIV-------------PqseftlaASVA-V 84  
Q18ER8          20 IGGSSTGVAFGPAVGSGLVSKLFAA-GLMTTFALIGAWTAgReVIETMGGQIV-------------PrsqftlaASVA-V 84   Haloquadratu...
41_pfamImport    1 IGGSSTGVAFGPAVGSGLVSKLLAA-GLMTAFALLGGWTAgReVIKTMGGQIV-------------PqseftlaASVA-V 65  
WP_015267253    22 MGGSGTAPAFSAAYGASVIRRSLIP-GLFGIMVLAGALLAgKeVSLTLGKGLL-------------Daaf-ftpEATSlI 86   Echinicola v...
56_pfamImport    1 MGGSGTAPAFSASYGANVIRRSLIP-GVFGVVVFLGAIIAgKeTATTMGKGIL-------------Dpsy-msfTVVCiI 65  
WP_015782010    22 MGGSGTAPAFSASYGANVIRKTVIP-GLFGIMVFVGAFLAgKkTAGTMGSGIL-------------Psey-ldfTVVSiA 86   Capnocytopha...
83_pfamImport    1 IGASGAAASMGVAYGSGAVSRKMAAlSLVAVGVFLGAYLGgGeVVKTLGSGII-------------PpklltveLVII-I 66  
WP_179261728    20 IGGSSTGITWGPSVGAGIVTKTMAA-AVMTFFVFFGGWTVgRnVMDTLSEGIIttdl--------------tltAGVA-V 83   Natrinema ha...

XP_004995736    95 AAGTFIWVLTATCFALPVSTTHAIVGAVIAFVIV----QgkannlSGtaIGG---VAAGWFTSPILGGIISAVIYLLVKV 167 
Q18IJ3          85 LFFTGISLLISNLYGVPASTSMTAVGAIIGLGLAtstlN-------QalMFV---ILSAWIVSPLVCLTIGV----VIGR 150  Haloquadratu...
ADE02634        85 LFFVGLALLVSNTFGVPASTSMTAVGAIAGLGLAngslD-------SrvMLE---IISWWIVAPVIAFWICA----VIGR 150 
Q18ER8          85 LFFVGIALLISNTFGVPASTSMTAVGAIAGLGVAsgtlN-------EavMLE---IVSWWIVAPVLAFWICA----VVGR 150  Haloquadratu...
41_pfamImport   66 LFFVGFALLISNTFGVPASTSMTAVGAIAGLGVAtgtlN-------EavMLE---IISWWIVAPVIAFWVCA----VIGR 131 
WP_015267253    87 LLSISLSLLIANLLGVPQSTSQSTVLAIAGAASAmevfD------SHklFYV---ILPTWLILPVVAFGLML----VLSK 153  Echinicola v...
56_pfamImport   66 LFSIAVAMLFANIAGIPQSTSQVAVLAVTAPALYyhvlD------SRklLLE---IIPMWVFLPIISFFAAY----LCGK 132 
WP_015782010    87 LFSIAVTMLISNISGIPQSTSQAAVLALAAPALYfeklD------TNklFLE---IIPAWFILPVIAYFLSY----FAGK 153  Capnocytopha...
83_pfamImport   67 LLSATLTLFGANLLGIPLSTSEVTVGAVVGVGIA----Y------ETvfVQKllvIVSFWVILPVVAFTLAWGMGHVIRR 136 
WP_179261728    84 LFFIGLGMLVANIFGVPVPTSMTTVGAIAGLGLAtgtlN-------YvtIAG---IISWWIVTPIIGLWVGV----LIGR 149  Natrinema ha...

XP_004995736   168 fvmekpahvrrarhalplllavtlvtdvvfilvsgpellrpshlsprdaflrvffpaivitaalayaigryllvpwvarn 247 
Q18IJ3         151 ymypyvdryvafttfdlhfiqldr-------------------------------------------------------- 174  Haloquadratu...
ADE02634       151 yiypyldawlkldqspgalvrldr-------------------------------------------------------- 174 
Q18ER8         151 ylypyldarlklnrspgplitldr-------------------------------------------------------- 174  Haloquadratu...
41_pfamImport  132 yvypyldakleldsspgplvefdn-------------------------------------------------------- 155 
WP_015267253   154 wvlpmaqkkiftsd------------------------------------------------------------------ 167  Echinicola v...
56_pfamImport  133 yiykpmrrrgltll------------------------------------------------------------------ 146 
WP_015782010   154 yiyqpmrrrgltiq------------------------------------------------------------------ 167  Capnocytopha...
83_pfamImport  137 lerrdarwrgeg-------------------------------------------------------------------- 148 
WP_179261728   150 yiyswinrrvkieksegpllrldr-------------------------------------------------------- 173  Natrinema ha...

XP_004995736   248 lhryriefqelhtyeekregrahtdetddngqcgageqqlqaknqahegaeanrdededddveddgehewrfragitpds 327 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   328 sdtlntsvstdamsnhpllaelrtpttakletaadtiarreqrgrtrtrdngdydengygasnedrgedgtgcasdkdqk 407 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   408 lnggrvqtqggltvettrsmyeqraasrrrrhrrsphvllrkllevsgemeeedddsqhrgrsashisrgsersasvsss 487 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   488 ssnddddgsdsdngrkrssssssssssspgsesrtrarsasfsgrksgtcdgaasppsplsystssqqrrssdsrdnnns 567 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   568 srgvpqsvhataaereplmpvdataeadtrgrtntvaggddagggrdesaclrregerhihvsagarspptpedrarver 647 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   648 athadhprrattvverterrirgtvstsklretsfskpkimhsvtppqrrpvpattttatavakpnraavpssvmqptph 727 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   728 atgvatdmkeddttspavasvttatttpttasdwpsrllwksvgsdrtitrtsdiasmrrrllgpeavgradsrsqhaai 807 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   808 gfpartvslggatadptplpigihrppsahafvgaasvsvsghavststsqrpfhllntstassavaagadkkrqrptav 887 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   888 ppritptptptppttptavtldntsigevgstrttttfgahaatqpnadergvgggevsaedeevrkltavlearceeha 967 
Q18IJ3             --------------------------------------------------------------------------------      Haloquadratu...
ADE02634           --------------------------------------------------------------------------------     
Q18ER8             --------------------------------------------------------------------------------      Haloquadratu...
41_pfamImport      --------------------------------------------------------------------------------     
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport      --------------------------------------------------------------------------------     
WP_015782010       --------------------------------------------------------------------------------      Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728       --------------------------------------------------------------------------------      Natrinema ha...

XP_004995736   968 qaqqqfrkkmhfiggidpnarvidvavhdasttgerergrrrsrgdrgrrwspdafdmrrsvspvsidmrtpspdfhhhv 1047
Q18IJ3         175 ----------------------------------------------------------------------sntiprliin 184  Haloquadratu...
ADE02634       175 ----------------------------------------------------------------------dggfprprlg 184 
Q18ER8         175 ----------------------------------------------------------------------sgsipwirrg 184  Haloquadratu...
41_pfamImport  156 ----------------------------------------------------------------------agilpklrlg 165 
WP_015267253       --------------------------------------------------------------------------------      Echinicola v...
56_pfamImport  147 -------------------------------------------------------------------------------r 147 
WP_015782010   168 -------------------------------------------------------------------------------r 168  Capnocytopha...
83_pfamImport      --------------------------------------------------------------------------------     
WP_179261728   174 ----------------------------------------------------------------------qgavptpalg 183  Natrinema ha...

XP_004995736  1048 rfygaaeayfaplTLVSACTVSFAHGGNDVANAVGPYGViadLVapdsldtslP-----------------VMl----nI 1106
Q18IJ3         185 pnaslqdiigsflVVIIGCYMAFSAGASNAANAVAPLVGssgSLtv-----------------------nqGV------I 235  Haloquadratu...
ADE02634       185 pnttyrefgstvlVVVVACYMAFSAGASNVANAVAPLVGn-gALem-----------------------ntGI------L 234 
Q18ER8         185 pntsnrelgsvclVIIIACYMAYSAGASNAANAVAPLVGn-gSVsm-----------------------niGI------I 234  Haloquadratu...
41_pfamImport  166 pnttpreawstvlVIAIACYMAYSAGASNAANAVAPLVGn-gALkl-----------------------neGI------L 215 
WP_015267253   168 ykqlsthpllkglLIFSSLYVAFSIGANNVANAAAPIAS---LT---------AneigkeaienflpiiilSV------L 229  Echinicola v...
56_pfamImport  148 aqnenmkpiwntvLLLMSLYVSFAIGSNNVANAAGPIAS---MT---------InelkmqsesdfllimilST------L 209 
WP_015782010   169 aqnenkkriwdvaLVIMALYVSFAIGSNNVANATGPLYT---MT---------Inelhires-dhivilmlAT------L 229  Capnocytopha...
83_pfamImport  149 --egwwtkglmwlVLAAGFTEAFSAGMNNVANAVGPLVG---AG---------------------------LLgteegiF 196 
WP_179261728   184 pnttwqelvttvaVLVIGCYMAFSAGASNVPNAAAPLVGtasGLep-----------------------dtAI------V 234  Natrinema ha...

XP_004995736  1107 VGGVAIVTGLLMYGYRVMETVGSNITKLTLSKAFAAQYGASVSILCATLI-GLPISSTAVLIGCVAGVGLADg------- 1178
Q18IJ3         236 LAVGAFGVGGLTIARRTLEMVGDDITELPILASLIVSVIGGTVITILSSF-GIPASLAVSTTSTIIGLGWGRasrvatla 314  Haloquadratu...
ADE02634       235 IAGGAIGLGAFTIARRTLDTVGNDLTQLPILAALIVETVSASLISFLSAI-GIPASLAVSATMCIVGLGWGRatrtvtlg 313 
Q18ER8         235 LATGAIGFGAFTIARRTLDTVGNDLTELPILAALVVETVSASVIAILSIL-GIPASLAVSATMCIVGLGWGRatrtvtig 313  Haloquadratu...
41_pfamImport  216 LGAGAIGLGAFTIARRTLDTVGNDLTELPILAALIVETVSASLIAFLSYI-GIPASLAVSATMCIVGLGWGRatrtvtlg 294 
WP_015267253   230 IVAPCFAIGSSLMGHKVTKATGKGIVEPTPFHATVIALIVASLLMYASIMqGIPTSLVQLNGAAFIALSISKd------- 302  Echinicola v...
56_pfamImport  210 IVAPCFGIGSSLFGHKIVKNTGKEIVLFGKFEAVIIAFISGSLLLLASLLkGVPSSLVQVNVAAILGIGVAKm------- 282 
WP_015782010   230 VVAPCFGIGASLFGHKILKNTGKEIILFGKFEAVIIAFISGSLLLLASIVkGIPTSLVQVNVAAILGIGVAKm------- 302  Capnocytopha...
83_pfamImport  197 WGGLFVALGALVLGGKVLETNGKKITRMSLLQGTAISGTGGTLVIISSLY-GIPVPLTQITTTAILGMGSAE-------- 267 
WP_179261728   235 VATLAIGLGGFTIARRTMDSVGGELSDIPLLAALFVMVTASTITTVLSWA-GIPISLVMATVMTIVGIGWGRatrpitvr 313  Natrinema ha...

XP_004995736  1179 -----------------------------------------------------------------DPNAVDW---KLLRN 1190
Q18IJ3         315 elvtpspdrpdvavstgalatsraedtpsgptigdvasgeestekldevpgvpdigsegpadideD-SLFNP---AAAKR 390  Haloquadratu...
ADE02634       314 ealsggeapqvsvna----------------------------ltveredevpkmgeeapdelsaQ-DLFDP---GTTGR 361 
Q18ER8         314 daiggekpemsvna-----------------------------ltaetdtsvpdvgeessqeltnQ-TLFDP---GTTGR 360  Haloquadratu...
41_pfamImport  295 ealggkspemsvna-----------------------------laaetqeevpamgqetetdlagS-DLFDP---GTTGR 341 
WP_015267253   303 ----------------------------------------------------------------gAKTTFQK---PTVRK 315  Echinicola v...
56_pfamImport  283 ----------------------------------------------------------------gRKNIFRK---TQVKK 295 
WP_015782010   303 ----------------------------------------------------------------gHKNIFRK---TQVKR 315  Capnocytopha...
83_pfamImport  268 -------------------------------------------------------------------HGFRLwqkGIVLK 280 
WP_179261728   314 eavtrdvenpeielga-------------------------ivaeekagetaprigdpepeevlrGEDLFNP---RAIIK 365  Natrinema ha...

XP_004995736  1191 VVLTWIITLPCSGAIS 1206
Q18IJ3         391 IVTMWLLTPSLAIIGS 406  Haloquadratum walsbyi DSM 16790
ADE02634       362 VIFFWMLTPSLSALAS 377 
Q18ER8         361 VIFFWLLTPSVSAAAS 376  Haloquadratum walsbyi DSM 16790
41_pfamImport  342 VIFFWLLTPSLSALAS 357 
WP_015267253   316 FFLVWAVAPVFAFLVA 331  Echinicola vietnamensis
56_pfamImport  296 FFTMWMIAPIFSFILS 311 
WP_015782010   316 FFAMWMIAPIIAFFLS 331  Capnocytophaga ochracea
83_pfamImport  281 ILKVWLVSPLLSMTVS 296 
WP_179261728   366 YVSMWIIGPSMSTILA 381  Natrinema halophilum
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