3LTL,1BC9,8UCQ,6FNE,1KU1,1XSZ,4D7R,7VMB


Conserved Protein Domain Family
Sec7

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pfam01369: Sec7 (This model is not part of the current CDD release)
Sec7 domain
The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.
Statistics
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PSSM-Id: 514212
Aligned: 359 rows
Threshold Bit Score: 35.5202
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LTL_A         18 QKEIIEQGIDLFNK--KPKRGIQYLQEQGML---------GTT-PED----------IAQFLHQE--------------- 60   human
XP_001016011  788 SQNLLEIGISLFNS--SPLCGLSFLILFDYI---------KPE-SED----------IVKFLMQNpstpvsaqqansleq 845 
A0DVC2        116 DYNTENLAIDLFNH--SYFMGISYMISTQII---------RPT-PQS----------IINWLFHNi-------------- 159  Paramecium te...
XP_001581412   30 KFKHLKGFASNFNK--NP---LEMVKKSIEVn-------nNLDdASA----------LGPFLFYN--------------- 72  
XP_001322120  413 IKENEEEGLSIFKN--NPQQGLEYYIQNKFV---------KDD-KKE----------IGNFIFNR--------------- 455 
EDK47015      135 KQANLETEKEHFSSqtSTSEPASKADSTTQTsk------eDVN-PNLql-------aITLFQDKY--------------- 185 
XP_001567651  938 DKRIFQEAVQRINAg-RWREAKEFLESRGLTtalapsageRAD-PTSvvtgtssyslFARFLFEY--------------- 1000
Q4E275        631 NKRIAQEAMQYINRg-HWRDGMKLLEQRGYIsha----deATR-WSD----------FARFLKTY--------------- 679  Trypanosoma c...
Q381I9        621 SKRTAQLAVGLINKg-QWRQAMSFLKERDYI---------PAE-GEEgw------saFALFLKTY--------------- 668  Trypanosoma b...
XP_653354     352 KKEKDEKIALSFNR--NIQSGLELYKKTYFPd-------qQELtPKQ----------IATFFRNT--------------- 397  Entamoeba his...
3LTL_A         61 ---ERLDSTQVGEFLG----DNDk-fNKe-VMYAYVD--QHDF-SGKDFVSAL-RMFLE--GFRLPG-EAQKIDRLMEKF 124  human
XP_001016011  846 tylLKKSKQAITEILT----DLSlqeNCe-ILYYYST--FFSF-SNSSFCSAL-RYFVQ--DLQLQN-DPEQIDILLSCF 913 
A0DVC2        160 ---EQKNKIQISKLLT----NLNlqeQSq-ILKLFVD--RV-V-TNQNLINSL-HSLFS--KLLVQN-DPYLLDILVKEF 223  Paramecium te...
XP_001581412   73 ---EGVSPIAMTKLVF----GPDfpfDVrtFLFYFFSsiSHEY---TILSKST-YYCLS--RIAFPD-NPQQIQIIFDCF 138 
XP_001322120  456 ---NDLDKQSVTTIL-----ESDa-ySE--CLDEFLE---NNFkLE-KFSDIL-LNILK--RLIIPD-DLTHIDNILTHF 516 
EDK47015      186 ---ATVTPAEVTHFIA----GGDn-eAKq-IRTYYMN--QFKW-SQ-NLLTAT-RQLCA--KLYLKA-ESQELDRILSSF 248 
XP_001567651 1001 ---PGISREALSAIFEkv-nQKDg-aSRm-LLLEYLH--CFDY-KDVPIDVALrDTTCKfmSWERPTfEAKVWETIQECF 1071
Q4E275        680 ---PGIERSALCSIFErvlkDSD---CDr-ILREYMQ--LFPY-KGVTIDVALrDTTCEfmSWERPTfEAQVWAVIQRRF 749  Trypanosoma c...
Q381I9        669 ---EGVERGALCGIFErvlkDKD---CDr-ILREYLQ--HFSY-RNVPIDIALrDTTCEfmSWDRPTfEAQVWVVIQQRF 738  Trypanosoma b...
XP_653354     398 ---KGLDKQFIGDFFE----KRKe-iQIa-TLKEYLY----EFiKDKDILTGF-VAFVQ--SLKLPK-ETNSINHIFEDY 460  Entamoeba his...
3LTL_A        125 AARYLECNQGq----tLF---ASADTAYVLAYSIIMLTTDLHSPQV----KNKMTKEQYIKMNRGIN------D-----S 182  human
XP_001016011  914 AKKFFQQNQQqs---sLF---ESSDSVHMLAFATFMLDIDIH---FhkehDLPKLIQEFQMNIQGIN------G-----G 973 
A0DVC2        224 SRRYYELNFNsksqsfPF---KSEDSLHMFCFALVIFDIDNTKYD------KDYAFKSFFQNIQTIN------N-----G 283  Paramecium te...
XP_001581412  139 ASAYCTCN--------PE---YNYDLASVIAMAKTLLIASGYNIP-----NGKLPLPRFLDLCK-YS------N------ 189 
XP_001322120  517 TQKFYRSHPS------VY---ETAEDVYNMIFASIICYANTHYSD-----HTDFSFEEFLRIC-GKN------T------ 569 
EDK47015      249 TKSYLQQHPN------NVfqtKNFEQIYIIIYSLILLNTSLHNPQLn--kRSRISQTDFIKNTFTTFslqqnnEslkdkT 320 
XP_001567651 1072 GNEYANQNPH------S----ITARDADAMAGVLLFLHSNLHNVLMk---NERMQMSQFVRDANDCL------------E 1126
Q4E275        750 GEAYAAQNPR------S----ITVKDADAMAGVLLFLHTSLHNENMr---NNRMTVEEFVRNGNECV------------- 803  Trypanosoma c...
Q381I9        739 GEVYAAQNPR------S----ISPDDANAMAGVLLFLHTSLHNANVr---SSRMTMKDFVRNGNECV------------- 792  Trypanosoma b...
XP_653354     461 AKYFAEVHPE------LY---SSDDVLFMIS-AMLLLNVELHHPVM----KNKRTKKEFVQAMKEMI------P------ 514  Entamoeba his...
3LTL_A        183 -K-DLPEEY-----LSAIYNEIAGKKI 202  human
XP_001016011  974 -K-NFSQDF-----INNIIENLLDKKI 993 
A0DVC2        284 -D-NFNSKF-----ISEIIEQLQYKPI 303  Paramecium tetraurelia
XP_001581412  190 ----IPDNH-----KMKLYDEINKKPI 207 
XP_001322120  570 -Q-N----------LGEIFETIKNTNI 584 
EDK47015      321 kKlDIRQKIaieneLSSFYEDLLKEEL 347 
XP_001567651 1127 fP--MMVED-----LQAIFNRVLQCKW 1146
Q4E275        804 -DfAFLEQD-----MRDMYYRVAQRKW 824  Trypanosoma cruzi
Q381I9        793 -AvPFPEDV-----MCEMYTRVARSKW 813  Trypanosoma brucei
XP_653354     515 -K--VNEDI-----FNTIYDYIDQNEF 533  Entamoeba histolytica HM-1:IMSS
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