1LSH_A       2 FQPGKVYRYSYDAFSISG----LPEPGVNRAGLSGEMKIEIHGHTHNQATLKITQVNLKYFLGPWPS--DSFYPLTGGYD 75   Ichthyomyzon uni...
Q9U572      15 LQPGLEYQYRYSARVASG----IPSINRQFAAAGIQADVTVQMAADYSVVVQFSNIEVGDLNKVLDCdlRAPLPIEYHPL 90   black tiger shrimp
Q9UAR3      16 LHSNLEYQYRYSGRVASG----IPFIKSQYSGAGFQADVFLQITSTKVPFFKISNTMVGEYHDELECdtRAPLPIEYHPL 91   signal crayfish
NP_524634   43 YIPGNYYDYSFDSILTIGassdVPN-DSDDTSLKVSGSAKIFAKGNCGYTLQLSSVKVTNTKES-------------VEK 108 
Q9U943      40 YQKGQTYTYSFEGTTLTS----LPGTQGEPVRLKLKATADLSVADDCNKVLRLRGVTVSGPDSK--------------NY 101  migratory locust
Q25490      39 FAAGQKYNYGVEGTVSVY----LTGADNQETSLKMLGQASVSAISNCELELSVHNMVLSGPDGK--------------KY 100  tobacco hornworm
Q9GSG2      42 YQPGKTYTYEYSGKSRIQ----LKGVEGGLTETDWSAQVELSWITPCDMVITMKDSKTDGAT--VPG------------- 102  Cherax quadricar...
Q9NDS1      42 YQPEKTYTYQYSGKSRVQ----LKGVDDGVSETEWAARVDLTWISPCDVAISFNNMKMDGARGP---------------- 101  Penaeus japonicus
P04114      46 FKHLRKYTYNYEAESSSG----VPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEg-KALLKKTKNSE 120  human
9E9R_A      46 FKHLRKYTYNYEAESSSG----VPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEg-KALLKKTKNSE 120  human

1LSH_A      76 HFIQQLEV-PVRFDYSAGRIG-DIYAPPQVTDTAVNIVRGILNLFQLSLK----------KNQQTFELQETGVEGICQTT 143  Ichthyomyzon uni...
Q9U572      91 EDYVDLLEkPFRVIMNESHVP-SYMEGPEEPIWISNVRKGFVNIFRVPLFwst----elhSTKLNYGAVEETLVGRCQNW 165  black tiger shrimp
Q9UAR3      92 VEGKELLEkPFQAIPGEQRGE-EHLVGPAEPAWITNIKKAIVRAFSIPPImanagrqvdaFKRTTYSHNGTFIHGDCMCW 170  signal crayfish
NP_524634  109 KILNSIQK-PVQFTLVSGILEpQICSDSSDLDYSLNIKRAVVSLLQSGIE----------------AEHEVDVFGMCPTH 171 
Q9U943     102 ANLKDLEAhPVLANFKGSSINkQLCSEDGDNQSSLNIKRAILSLLQTPNT-------------KSSTASEVDVFGICPTN 168  migratory locust
Q25490     101 PCPQGIEK-PVRFSYQDGRVGpEICAAEDDSRRSLNIKRAIISLLQAEQK----------------PSVQVDVFGVCPTE 163  tobacco hornworm
Q9GSG2     103 -ASRFLERyPLVVAVTDGKVH-HVCSHPDDDTWSINLKKGVASAFQNSLPsn-------sTINSGQNITETDVVGKCPTR 173  Cherax quadricar...
Q9NDS1     102 IAARTLERhPLVVAVVDGRVQ-HVCAHPDDEPWAINLKKGVASAFQNSIPsl-------sTVSSGMTVTETDVVGKCPTT 173  Penaeus japonicus
P04114     121 EFAAAMSRyELKLAIPEGKQV-FLYPEKDEPTYILNIKRGIISALLVPPE----------TEEAKQVLFLDTVYGNCSTH 189  human
9E9R_A     121 EFAAAMSRyELKLAIPEGKQV-FLYPEKDEPTYILNIKRGIISALLVPPEt--------eEAKQV--LFLDTVYGNCSTH 189  human

1LSH_A     144 YVVQ---------------------------------------------------------------------------- 147  Ichthyomyzon uni...
Q9U572     166 YTSMklpvnlaeevnvqrehfmeediqrdaysssyttkt------------ksktssktssktssktssktsktgktspg 233  black tiger shrimp
Q9UAR3     171 YSMIhlnkeeaarenrqreaameediqreeqdesdrftsskvpsktsktqtskttkttgtkttgtkttgtkntgfkgapa 250  signal crayfish
NP_524634  172 TSTS---------------------------------------------------------------------------- 175 
Q9U943     169 VRHS---------------------------------------------------------------------------- 172  migratory locust
Q25490     164 VSSS---------------------------------------------------------------------------- 167  tobacco hornworm
Q9GSG2     174 YEVQ---------------------------------------------------------------------------- 177  Cherax quadricar...
Q9NDS1     174 YQIE---------------------------------------------------------------------------- 177  Penaeus japonicus
P04114     190 FTVK---------------------------------------------------------------------------- 193  human
9E9R_A     190 FTVK---------------------------------------------------------------------------- 193  human

1LSH_A     148 -----EGYRTNEMAVVKTKDLNNCDHKVYKTMGT-A-YAERCPTCQKMNKNLRSTAVYNYAIFDEPS--GYIIKSAHSEE 218  Ichthyomyzon uni...
Q9U572     234 qlanvPHIEDTLWSVRRTTDFDMCENLVSLQI----------HSSKYTEDIIQRSSVASYLIRGDTH---RRIEQVVVEG 300  black tiger shrimp
Q9UAR3     251 klttpERIDNTLWSMSRTVDFDSCEDLVKWRI----------HGNKKIDKKIQRTSIGTYLLRGNAR--DTRVEYAVIEG 318  signal crayfish
NP_524634  176 -------KVGNANIITKARNLNSCSHREQINSGL---VSGKVNE--KAGITSSLLLQANYIKESRIV--NHLIENVQLTE 241 
Q9U943     173 -------QRGDVTVISKTRNLNRYASRENLIQET---LSTRFTG--QSDLHATPFLDADLHVEQQIK--GGLIVSATSRE 238  migratory locust
Q25490     168 -------QEGGAVLLHRSRDLSRCAHREQGRNDF-V------NSIANPDAGIKDLQVLQSMLNVESKvnNGVPEKVSAIE 233  tobacco hornworm
Q9GSG2     178 -------DHGDTVIMIKEKNHRQCKERYHTPAEN-P--APWL-----RGPFIT--DESTCMCKQETR--NGIYSAITCED 238  Cherax quadricar...
Q9NDS1     178 -------TEGEKVIVVKEKNHRHCQQRYPTPAET-P--APW-----LKAPLPIEESKSEC----KQEitNGIYTSIMCHD 238  Penaeus japonicus
P04114     194 -----TRKGNVATEISTERDLGQCDRFKPIRTGI-SpLALIKGMTRPLSTLISSSQSCQYTLDAKRK--H--VAEAICKE 263  human
9E9R_A     194 -----TRKGNVATEISTERDLGQCDRFKPIRTGIsP-LALIKGMTRPLSTLISSSQSCQYTLDAKRK--H--VAEAICKE 263  human

1LSH_A     219 IQQLSVFDIKEGN-VVI-ESRQKLILEGI-QSA-PAASQAASLQNRGGLMYKFPS-------SAITK---------MSSL 278  Ichthyomyzon uni...
Q9U572     301 TITVLTNKEQHEH-VDT-FTNQTLELKAVrEVG-EPITVTYDVHPHYDWQYDIER-------PQGDQfipleqvltGRPV 370  black tiger shrimp
Q9UAR3     319 SITVFTGTQSHEH-IST-FTNQTLELKRVrRIQ-NLFSFDYETVTHQSFHFEVDKfdvseqePGHDIhpsleqlvtGIRI 395  signal crayfish
NP_524634  242 TYKFIGNTKRNSD-ISA-KVVTILKLKNPsGTK-ANSPGTGS--TVRSLIFQRPEt------------------------ 292 
Q9U943     239 SYLFRPFSNQGNG-AKT-IVETKLTLTSQnAQP---APPLASFTVPKSIVFE-------------------------APH 288  migratory locust
Q25490     234 EYLYKPFSVGENG-ARA-KVHTKLTLSGKgGAG----GGNAHCTESRSIIFD-------------------------VPH 282  tobacco hornworm
Q9GSG2     239 KNVVKPSYGAYKY-VEA-KMMSTLKYLSEsSEH--SSDILEGNMVRKSLLYDYHT------------------------- 289  Cherax quadricar...
Q9NDS1     239 KNIVRPAIGIYKY-VEA-NQESTLHFISEtTDTsAITAIPRGEMHIESLLYNHET------------------------- 291  Penaeus japonicus
P04114     264 QHLFLPFSYKNKYgMVA-QVTQTLKLEDTpKIN-SRFFGEGT--KKMGLAFESTK------------------------- 314  human
9E9R_A     264 QHLFLPFSYKNKY-GMVaQVTQTLKLEDTpKIN-SRFFGEG--TKKMGLAFESTK------------------------- 314  human

1LSH_A     279 FVTKGKNLESEIHTVLKHLvENNQL-SVHEDAPAKFL-RLTAFLRNVDAGVLQSIWHKLHQ-----QK-DYRRW--ILDA 348  Ichthyomyzon uni...
Q9U572     371 TDQIVNSIMEYIKKTVDDLsHRMEHyPAKPENLAYIIgRLVEAVANLDYPYIQTLYTHFDG------KgTMQKYi-FVQL 443  black tiger shrimp
Q9UAR3     396 TTQGVTEIKTLIIRLLKMLvKRTTThPYSTDPLVKDMsTLVDAASILSRPEIEALCSQIEH-----EElHAKKLeiFYEL 470  signal crayfish
NP_524634  293 ---yTSKNINALKTILSDLvDSTGD-YVKKETAKKFV-EFIRLLRQSDSETLLELAAFPHP-----NKvLARKV--YLDG 360 
Q9U943     289 ALASVPGGSSAITAALHAAeSSTKD-GVTVDAAEKFR-TLVSVLRQSSTTDILKVYNDVKAgagfsNKhSARNL--LLDA 364  migratory locust
Q25490     283 GTSSASGNLNSVISAVKETaRTVAN-DASSKSAGQFA-QLVRIMRTSSKDDLMRIYSQVKA------HqLEKRV--YLDA 352  tobacco hornworm
Q9GSG2     290 -PKKDPSMVTQLDRIMSQIcRKTRD-NVERDVAALVA-RAIQFLRMVPEEAVEQTLNKIRSgqycqDYkKLEEL--FLDF 364  Cherax quadricar...
Q9NDS1     292 --MKDPELAPELDQLMKEIcEKTKD-TVEAEAAALVA-KALHLLRRVPETVVVEIAQKVRQghycsDSaKLESI--FLDA 365  Penaeus japonicus
P04114     315 -STSPPKQAEAVLKTLQELkKLTIS-EQNIQRANLFN-KLVTELRGLSDEAVTSLLPQLIE----------VSSpiTLQA 381  human
9E9R_A     315 -STSPPKQAEAVLKTLQELkKLTIS-EQNIQRANLFN-KLVTELRGLSDEAVTSLLPQLIE-----VSsp-----iTLQA 381  human

1LSH_A     349 VPAMATSEALLFLKRTLASEQLTSAEATQIVASTLS--NQQATRESLSYARELLNT-SFIRNRPILRKTAVLGYGSLVFR 425  Ichthyomyzon uni...
Q9U572     444 VIHAGTEPAVNFAVDNLSDI-LFYVTFYESIGVSLR--TPAPIPKIMHSLINGEEG--------LHHSLGLMNFATLAHD 512  black tiger shrimp
Q9UAR3     471 LVTAGTEPAIRYLLDKIKDPEFRKTNVASVKTILENfhTSVKNPLLIPDIIDLEQTlTWDEENQQFKMTLLLNLASLAKQ 550  signal crayfish
NP_524634  361 LFRTSTAESARVILKQLSK--FDEKEKLLAILSLNI--VKSVDKETLNQAASQLL--------PNAPKELYIAVGNLVAK 428 
Q9U943     365 LFRTSTGDAVEVIARLLKTKEITANHWYLSLAFIQH-----------ASLKSVVSI-SSLLDQKNLPTEAFLGIGSFIGR 432  migratory locust
Q25490     353 LLRAGTGESIEASIQILKSKDLSQLEQHLVFLSLGN--ARHVNNPALKAAAGLLD-------MPNLPKEVYLGAGALGGA 423  tobacco hornworm
Q9GSG2     365 VSFVDEPGAVKVMVKELLNSRFTRGRYSLYTAAFYL--IPRPCIHAMKALKPLFES-TRPMPYPT------LAASSMVNN 435  Cherax quadricar...
Q9NDS1     366 VAFLHESGAVKVMVQEILNGRATGGRLALYTAALYL--TPRPNIEAVKALTPLFES-------PRPMPSLLLAAASMVNH 436  Penaeus japonicus
P04114     382 LVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVAL--IPEPSAQQLREIFNMARD--------QRSRATLYALSHAVNN 451  human
9E9R_A     382 LVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVAL--IPEPSAQQLREIFNMARD-QRSR-------ATLYALSHAVNN 451  human

1LSH_A     426 YCANTVS--------------CPD-----ELLQPLHDLLSQSSDR------AKEE-EIVL-ALKALGNAGQ------PNS 472  Ichthyomyzon uni...
Q9U572     513 ACLSEDRkhfyfdyscgpkttCDPeliitNFIPYLVRELGNQ---------GKDVwQRLI-YLQALSNLGT------PQT 576  black tiger shrimp
Q9UAR3     551 LCLSSDKwesygyntcdpqhtCTPdfiieNFLPTLIQGVQDD---------ESSLwIRLV-YIQALANLGI------PQT 614  signal crayfish
NP_524634  429 YCLKNY---------------CQG-----PEIDAISKKFSDGLKHckpntkREEE-RIVY-ILKGLGNAKSl----sGNT 482 
Q9U943     433 YCREHN---------------CENvaefdEVLNKFSKHLSGSTTS------KAGEnRAIA-ALKALGNIRHl-----NNA 485  migratory locust
Q25490     424 YCREHD---------------CHNvk--pEGIVALSNKLGSKLQNcrpknkPDED-VVVA-ILKGIRNIRHl----eDSL 480  tobacco hornworm
Q9GSG2     436 YCNHNRN--------------CHEe----EPVKSLAETLGNKLQRqcsaseDEQTvQAALtTLKALGNMGVm----tPAV 493  Cherax quadricar...
Q9NDS1     437 YCRHTPH--------------CHQeapveRIAEILAAKVEGHCSPsi---gVEEKeEALA-IFKALGNMGVv----tPAV 494  Penaeus japonicus
P04114     452 YHKTNPT--------------GTQ-----ELLD-IANYLMEQIQDdc---tGDED-YTYL-ILRVIGNMGQtmeqltPEL 506  human
9E9R_A     452 YHKTNPT--------------GTQel--lDIANYLMEQIQDDCT-------GDED-YTYL-ILRVIGNMGQtmeqltPEL 506  human

1LSH_A     473 IKKIQRFL--PGQgkslDEYSTRVQAEAIMALR--NIAKRDPRKVQEIVLPIFLNVAIKSELRIRSCIVFFESKPSVALV 548  Ichthyomyzon uni...
Q9U572     577 INVLKPII--LGV----TETNIFMRTNAIWSLSayNMHKTALSQIYEILMPIIENKGEQFEIRNIAFLTLATWGPGHAWW 650  black tiger shrimp
Q9UAR3     615 IDVLKHFAlgDKP----STNIHVLRTNAILGLSgvYLPETAQSSVFGILMPVFENTGEHNEVRAVAFLAMMTFKPSLAWW 690  signal crayfish
NP_524634  483 VAALSECA----S----TGRSNRIRVAALHAFS----KVKCEETLQSKSLELLKNRNEDSELRIEAYLSAISC-PNAEVA 549 
Q9U943     486 LGEKVKQL--ALD----KSLPPRVRVAALEVIQ----SDPCRKNIKQAALQILRDQVEDSELRIKAYLAVVEC-PCDNVV 554  migratory locust
Q25490     481 IDKLVHCA---VD----NNVKARVRAVALEAFH----ADPCSAKIHKTAMDIMKNRQLDSEIRIKAYLAVIEC-PCSHSA 548  tobacco hornworm
Q9GSG2     494 ATSVLRCM---GT----EGADNRIRVAAAQAFR----KAKCHRASTGRLVGYALDSRKTTEVRIASYIAAVRCAEKWD-F 561  Cherax quadricar...
Q9NDS1     495 TRAAAQCI---EK----EGLETSIRVAAAQAFR----QANCDRPAVQKLVDIATRPTFETEVRIASYLAAIRC-AEKEHL 562  Penaeus japonicus
P04114     507 KSSILKCV---QS----TKPSLMIQKAAIQALR--KMEPKDKD--QEVLLQTFLDDASPGDKRLAAYLMLMRS-PSQADI 574  human
9E9R_A     507 KSSILKCV---QS----TKPSLMIQKAAIQALR--KMEPKDKD--QEVLLQTFLDDASPGDKRLAAYLMLMRS-PSQADI 574  human

1LSH_A     549 SMVAVRLRREPNLQVASFVYSQMR 572  Ichthyomyzon unicuspis
Q9U572     651 QQLAVSTWHDPSPQFANFVTTTIY 674  black tiger shrimp
Q9UAR3     691 ERIAISTWRDPSSQVANYVSTTIT 714  signal crayfish
NP_524634  550 NQISEIVNSETVNQVGGFISSNLK 573 
Q9U943     555 KTISNLLENEPIIQVGSFVVSHLK 578  migratory locust
Q25490     549 SEIKNLLDSEPVHQVGNFITSSLR 572  tobacco hornworm
Q9GSG2     562 EKIVEKISVGQNTQVRGFILSHLR 585  Cherax quadricarinatus
Q9NDS1     563 EQIIEKISEEENTQVRGFVLGHLI 586  Penaeus japonicus
P04114     575 NKIVQILPWEQNEQVKNFVASHIA 598  human
9E9R_A     575 NKIVQILPWEQNEQVKNFVASHIa 598  human