2CP6,1WHG,2CP5,1WHH,2COZ,1TOV,1WHK,4B6M,7OWD,1WHL


Conserved Protein Domain Family
CAP_GLY

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pfam01302: CAP_GLY (This model is not part of the current CDD release)
CAP-Gly domain
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.
Statistics
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PSSM-Id: 514168
Aligned: 544 rows
Threshold Bit Score: 39.7069
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CP6_A         41 IGDR--V-------LVgg-tKA---GVVRFLG-E-TDFAKG----E-WCGVELDE--PLGKNDGAVAGTRYFQCQPKYGL 98   human
XP_004037550    8 VGDY--V-------QLtntqNKdqeGYIKFIG-Q-LEGKEG----I-WVGVELTI--QKGTHNGTFQDKKYFECKELHGI 69  
XP_001031446    8 VNDR--I-------KLtnnaNKdqeGTILYIG-Q-LDGKEG----I-WIGVELDL--PKGSHNGQFNGKQYFQGRDQHCM 69  
EED44627       14 KGDS--V-------Sin-nkYF---GKIQYIG-P-IENKDG----I-WVGIELNK--PVGKNNGTYMGIKYFDCRPNYGI 71  
XP_007605024    5 INDR--I-------Ilk-nnLR---GVVRYIG-P-VEGRSE----E-WVGIELEE--PKGSNNGAIGGTRYFYCPEGHGL 62  
Q4UGG2          6 VNDQvmV-------YG----FR---GVVKYIGkKeYIkkpTgnvvNqLVGVELVKklPq-CTNGNLNGTNVFDTKAETAL 70   Theileria ann...
XP_009022371  222 LGDR--Iiw----yNDnddgEF---GNVRWIG-E-LPDHNG----S-FAGVEFDN--PIGSATGIYKNVKYFTARPKHAL 283 
EFP09438      457 IGDQ--Ci-----wNNsgteER---GVIKYIG-F-LKGHKT----L-YAGVEFRN--NIGAGTGVFNKEQLFQSREGHAG 517 
6_pfamImport    1 IGDP--Cv-----wNNngkeEK---GIVRYIG-F-LKgh----kmL-YAGVEFNN--RIGAGTGVFNKEQLFESRDGHAG 61  
A0CKR3          6 EGDY--VtilkdpiKN----EK---GYIRYLG-E-LEGRPG----T-FYGIHLDN--KVGSHNGTLQGKEYFTCPEGHGL 67   Paramecium te...
2CP6_A         99 FAPVHKV 105  human
XP_004037550   70 FVREKHL 76  
XP_001031446   70 FVKEKHI 76  
EED44627       72 FVKENKI 78  
XP_007605024   63 FVKYERL 69  
Q4UGG2         71 FIPLETL 77   Theileria annulata
XP_009022371  284 FLPMAGL 290 
EFP09438      518 FVELCTL 524 
6_pfamImport   62 FVELASL 68  
A0CKR3         68 FITGNHL 74   Paramecium tetraurelia
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