3NUA,4FE2,3KRE,2GQS,1OBG,4JA0


Conserved Protein Domain Family
SAICAR_synt

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pfam01259: SAICAR_synt (This model is not part of the current CDD release)
SAICAR synthetase
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6) (SAICAR synthetase) catalyzes the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR. This domain can be found in SAICAR synthetases as a monofunctional protein from the bacteria (purC), fungi (ADE1) and plants (Pur7). In animals, this domain can be found in the N-terminal domain of a multifunctional enzyme (ADE2) possessing both the SAICAR synthetase and the phosphoribosylaminoimidazole carboxylase (AIR carboxylase) activity.
Statistics
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PSSM-Id: 514132
Aligned: 522 rows
Threshold Bit Score: 181.798
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NUA_A        10 MLYEGKAKKIYAtdKE-DMVIVHYKDDATAFNGEKKaQIESKGVLNNEITSLIFEMLN-KegIKTHFVeKlndRDQLCKK 87  Clostridium per...
CBJ28207      61 KRTVGKVRDTYI---CdDAIVLVTTDRQSAFDRQLA-RVPFKGAVLNQTSAWWFEKTRhI--APNHLLgSphpNVCVGKK 134
XP_002903172  41 KQITGKVRDVYV---FeDRVLLVSTDRQSAFDRALA-SVPFKSRVLTLTSVWWFNQTKhI--VANHLLgVphpSAMLCKK 114
XP_002505827  76 QKYEGKVRDTYV---DdELMIAVTTDRQSAFDRHLA-SIPFKGAVLNRTSAWWFNQTKdI--VPNAWIsSpdpNVTVMKK 149
XP_002177592 265 GRLRGKVRDRYP---GtKSLALVTTDRQSGFDRMLA-RVPYKGAVLNLTSAFWFEQTAhI--IPNHLVsVphpYVSVVKP 338
WP_014266801  23 DKYPGKVRDTYD--LGdGRLLLVTTDRQSGFDRMLG-AIPFKGQVLNRTSLHWFAATKhI--VGNHVLrSphaNALLARK 97  Granulicella ma...
XP_002958876  69 NRRQGKVRDTYD---LgDRVVIVTTDRQSAFDRLLA-SVPFKGQVLNQTAAWWFSATShI--VPSALLtLpdpNVAVMKK 142
P38025       108 SRIKGKVRDIYD---AgDYLVLITTDRLSAFDRNLA-SIPFKGQVLNETSLWWFNNTQhI--TPNAIVsSpdrNVVIAKK 181 thale cress
XP_002968039  78 PKRRGKVRDVYE---TkDHLVIVTTDRMSAFDRVLA-SIPFKGQVLNQTSVWWFNNTRhI--TPNAFVsApdpNVTIARK 151
XP_006841255  87 TKTRGKVRDVYD---GgDYLVLVTTDRQSAFDRVLA-SIPFKGQVLNETSTWWFDRTQhI--VQNAVIsVpdeNVTIAKK 160
3NUA_A        88 VEIVPLEVIVRNVAAGSM------------AK----RL--GLEEGYELKT-TVFELSYKDDSlgDPLINDYHAVgiGatT 148 Clostridium per...
CBJ28207     135 CKVFPIEFVMRGYLTGSTstsiwknyekgtRAycghTLpeGMSKNQALPMgNILTPTTKDDLh-DELISAQEIVssNrmS 213
XP_002903172 115 CTVFPVEFVVRGYITGSTstsmwtnykngsRDfcghKLqdGYKQHQKLPQ-NLVTPTTKDDEh-DELISGVEIVssGrmT 192
XP_002505827 150 CTVFPIEFVVRGYLTGSTstslwthyskggRDycgnPLadGMVKNQKLPK-NIVTPTTKEKEh-DRPISLADIVseGwmE 227
XP_002177592 339 CQPFPIEFVVRSYMTGSTstsiwrnyqegvRSycghDLpdGMTKNQKLEC-NILTPTTKEEDh-DRPISLVDIVaeNwmT 416
WP_014266801  98 CRVLPIEFVVRGYLTGSTdtsiwtqyakgvRQycghALpeGMRKNEKLQQ-NIVTPTTKETAh-DRPITAQEIVaeGwmT 175 Granulicella ma...
XP_002958876 143 CRVFPVEFVCRGFMTGSTdtslwthykagaRQycgnSFpdGMRKNDRLVA-NVITPTTKAEDh-DVPISPKEIVeqGlmT 220
P38025       182 CSVFPIEFVVRGYVTGSTdtslwtvynkgvRNycgnELsdGLVKNQKLPA-NILTPTTKAADh-DVPISPNEIVegGfmT 259 thale cress
XP_002968039 152 CAVFPVEFVVRGYITGSTstslwtvynqgiRYycgnDLpeGLIKNQRLDY-LMLTPTTKSDDh-DRPISGEEIVeqGlmS 229
XP_006841255 161 CSVFPVEFVVRGFVTGSTdtslwmvyskgiRHycgnVLldGLVKNQKLAT-NILTPTTKGIDh-DIPVTPDQIIgqGlmT 238
3NUA_A       149 FEELNKIYEITAKVNEILKEAFKKQNINLIDFKLEFGRY--NGeILLADEI-SPDTCRFWDATTg----------EKMDK 215 Clostridium per...
CBJ28207     214 QQDWDECSRLAHALFRFGQEAAAERGLILVDTKYELGKDa-DGnIILVDEIhTPDSSRYWVKETyegnisqgrepENIDK 292
XP_002903172 193 QEQWDYCEKKTLELFAFGQEQAAKRGLILVDTKYEFGYDeaTGeILLIDEIhTPDSSRYWLADSyeqrmaegkspENIDK 272
XP_002505827 228 KDDLDYCVAKTLEVFEFAQRVAAERGLILVDTKYEFGRDa-DGvIRLIDEInTPDSSRYWLADSyaerhaaglepDMIDK 306
XP_002177592 417 QSDLDVCAAAALKVFALGQQVAAAHGLILVDTKYEFGKDehTGeILLIDEVhTPDSSRYWLASTyeeriaageepDNIDK 496
WP_014266801 176 AEQWEFCSAKALALFAFGQKIAAEHGLILVDTKYEFGVGd-DGeILLIDEIhTPDSSRYWLADSyaerlavgqepDMIDK 254 Granulicella ma...
XP_002958876 221 QEEWDTVSAAALRIFQFGQEEAARRGLLLVDTKYEFGKDa-DGtIRIIDEVhTPDSSRYWLADTyaarhaaglepENIDK 299
P38025       260 QAEFDEASMKALSLFEFGQGVAKKHGLILVDTKYEFGRSs-DGsILLIDEIhTPDSSRYWLAGSyeerfqkglepENVDK 338 thale cress
XP_002968039 230 EADYKSVSSKALALFAYGQEVALKHGLLLVDTKYEFGKMa-DGsICLIDEVhTPDSSRYWIAGSyeermkqglepENIDK 308
XP_006841255 239 KDEFDEASHKALQLFEYGQHVALEHGLILVDTKYEFGKDs-DGsLCLIDEVhTPDSSRYWIAHSyeeriknglepENVDK 317
3NUA_A       216 DRFRRDMGNVINGYREVLNRL 236 Clostridium perfringens ATCC 13124
CBJ28207     293 EFLRRWYTQHCDPYKDETVPD 313
XP_002903172 273 EFLRLWFKERCDPYNDAVLPE 293
XP_002505827 307 EFLRLWFAERCDPYNDETLPA 327
XP_002177592 497 EFLRLWFRSQCDPYNDETLPE 517
WP_014266801 255 EFFRLWFRERCDPYKDAILPV 275 Granulicella mallensis
XP_002958876 300 EFLRLWFRQRCDPYKDAVLPE 320
P38025       339 EFLRLWFKENCNPYEDEVLPA 359 thale cress
XP_002968039 309 EFLRLWFKDNCNPYEDKVLPD 329
XP_006841255 318 EFLRLWFKDHCNPYEDKVLPV 338
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