6O3I


Conserved Protein Domain Family
IDO

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pfam01231: IDO (This model is not part of the current CDD release)
Indoleamine 2,3-dioxygenase
Statistics
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PSSM-Id: 514108
Aligned: 170 rows
Threshold Bit Score: 408.05
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6O3I_A         29 EYHIDEEVGFA-LPNPQENLPD-F-YNDWMFIAKHLpd----------------lIESGQLRERVEK-LNMLSI---DHL 85   human
XP_003027344   12 DYEVDVNTGFMaPDVPLARLPHp--WDAWEDVLSDAhhrklqvgd-kpgitdaerADSEAWRATVRR-LPILPI---EGM 84  
CCA77747       45 SWDVDGRSGFMpPEPPVARLPAe--WDAWENILQVAigarftvgd-tpditpeetDRALQWREAVQN-MPMLGT---HRL 117 
Q5KJZ4         62 DFEVDVRTGFLpATKNVERLSGe--YEVWEEALDAArgsavggg----vmlggkrEKDQLWRAGVES-LPVVAT---DDL 131  Cryptococcus ...
XP_009266795   50 DFDVDPRSAFLpPEEPLRRLSe-C-YDIWELALDSAqnlplll-------dganneVSNTWRNAICG-MSVLEP---PTI 116 
7_pfamImport    4 DFDVDVRSGFLsPSAPLKRISNpV-YQPWEDALETIsksisqta---dqdqdtklIEIEEWKKFIASeLPVLNI---DPL 76  
XP_007414362   58 DYDVDVDSGFLpPQMPLCRLVGeP-WNVWEEAWDSTsgfrpgi-------gedddqRIRAWRRYIREeMPVIDV---KPL 126 
XP_007414373   58 HPHIDIRSGFLpRLPPIHRIELhP-WSQWEEALDQAkglqlgl-------gesrnaHTATWRKHIREgLPILSVqadDPL 129 
KDE04431      102 DYDVSVATGFLpPDEPVQRLQLgVeWQRFERLLEMAqkevsrl------vgggvgrLSESWRRHLRE-LPQPPI---HEL 171 
XP_011390268  169 DFDVDVRSGFLpPEAPVRRLSApY-AEHWEHALDLAkriplmhggggtkttphqrLLARRWRRSIRE-MPILPLs--DEL 244 
6O3I_A         86 TDH-K-SQRLARLVLGCITMAYVWGk---GhgdvRK--------------------------------------VLPRNI 122  human
XP_003027344   85 EVS-LlMLRRAHVVLGFLEHFYVHSl---Pp---Hep------------------------------------vVIPAPI 121 
CCA77747      118 KNS-ErNLRRAHLVLAWILHFYVHTh---Vp---APtp-----------------------------------iIIPAVL 155 
Q5KJZ4        132 RAS-LpHLRRAHLVLTFLAHFYVHTtplpGps-aQKep-----------------------------------tSIPPCI 174  Cryptococcus ...
XP_009266795  117 LSDgIrSVRRAYTVLSFLAHFFVHSq--pAhk-kQTtqs---------------------------------tqIIPRSI 160 
7_pfamImport   77 RND-IvEMRRAHLVLAFLTHAFVHSl--sSnq-pSLaet---------------------------------qtLIPLSL 119 
XP_007414362  127 QDQgVvELRRAHSLLAFLTHTYVHSe--aRkv-vLQddy---------------------------------qvIIPRAL 170 
XP_007414373  130 ANQ-LpLLRRAHLVLAFLVHFYLHSd--qVnd-dEEeegs------------------------------tktvLVPSSL 175 
KDE04431      172 TS--LpLLRRAHVVLTYLAHFYTHAvyp-------------------------------------------ydtHVPATV 206 
XP_011390268  245 AND-IrYARRGHVVLSFLAHFYIHSq--pRkv--tAalavapqrtwlnmfsrktpddlqdeqdladelagkymrRLPAAI 319 
6O3I_A        123 AVPYCQLSKKLELPPILVYADCVLANWkkk---dpnKPLTYENM--DVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIP 197  human
XP_003027344  122 GVPMLQVSLLLDMPPLLTYPDTTLYNYapiiergapVPH-LDNI--TNQTTFTETTDEVEFYITSARIELRGVAVLNIVK 198 
CCA77747      156 TVPLLAISRELILPPVLTYSDTVLYNWr-------yAEGDPSKL--ESVTTFTQTKDEEHFYLTSAYIELAGVEALGLMQ 226 
Q5KJZ4        175 SIPLLAVSPLLGLPPILTYADTVLWNFlpln--sliAPSAFSNPpnRIITTFTNTRSEEQFYLISALCEIAGAEALGLMR 252  Cryptococcus ...
XP_009266795  161 AIPWHTTALALGLPPILTYASTVLWNWeyi---dksKGLRRGNL--RAPLTFTQSRDEEHFYLTSAHIEVEGRLCLERMS 235 
7_pfamImport  120 AVPFSAISLALDMPPVLTYADTVLYNWsfk---eprLGFTAENV--EIPTTFTRSDSERHFYKTSVLVEALGPECLKLMR 194 
XP_007414362  171 AIPFCAVSDILDIPPILTYADTVLYNWklk---nqaLGFTVDNV--EIPSTFTRSVSESHFFKTSLLIETIGPQCLRSMR 245 
XP_007414373  176 ALPFCAVSQLLDIPPVLTYSDTVLYNWtli---npaNGFTSENV--KILTTFTGTKDEEHFYKTSVLIESLGPMCLSLMR 250 
KDE04431      207 SVPLVEISESLGLPPILTYADTVLWNWhll---drsRGIQADNI--VITTTFTSSDSEKAFFFLSILCELHGPIILRSMS 281 
XP_011390268  320 AVPWVQLSQKLDLPPVLTYATTVLWNWdyi---dpsRGLEPDNL--SIVETFTATPSEHHFFFTSLLIEARGVEALELMR 394 
6O3I_A        198 TVFKAM---QMq---eRDTLLKALLEIASCLEKALQVFHQI----------HDHVNPKAFFSVLRIYLSG--WKGNPQ-- 257  human
XP_003027344  199 ASMDAVlngD------IQAVAEQLHRLAPVVHELRVLLGSV----------RRGCDPTRYYNVVRPWLRG----QDTGv- 257 
CCA77747      227 RCFDEAfvaDei---aLRRISSYLRKLAVVIKRMTKILDAV----------RDACEPKIFFNDVRPWLRG----EDS--- 286 
Q5KJZ4        253 QSLDELfiaDek---aLRRVTIYLKKLADQIDRISDITMTL----------MNEVDPEEFYHLIRPWFRG----GDADg- 314  Cryptococcus ...
XP_009266795  236 QCLDEAfmaDVspqvsFPRMCRQLTDLAAQINVLTEILVAV----------RAECSPEVFYTSIRRWFNGpnGEGK---- 301 
7_pfamImport  195 SSLDEAfmeDei---sVKRIGNNLGRLAKQIDRISKVLSDV----------RAGCDPRTFYWEIRPWFIG----GR---- 253 
XP_007414362  246 SSLDEAfigDek---sVRRIGEHLVALVINIKCITSFLNDV----------RTACDPREFYWEIRPWFNG----GK---- 304 
XP_007414373  251 SLLDEAllaDql---sFARISANLSLLASIIDQITVLLEKV----------RDDCQPACFYWLIRPWMNG----GT---- 309 
KDE04431      282 STLDEAffaDrt---aLVRIAGHLDNIASALDELALLLHDStrgafgpapvRASISAPVFYWEIRPWFNG---------- 348 
XP_011390268  395 VSLDEAfvaDrv---aRRRIAGYLNRLAVVIKSLTKLLHDV----------RNGCDPKIFYWGIRPWFVG----SDTVdk 457 
6O3I_A        258 -LSDGLVY--EGf------------------wED---P---KEFAGGSAGQSSVFQCFDVLLGIQQT----AGGG----- 301  human
XP_003027344  258 ---RPWTF--EGre-----------------eHGlpvP---TELSGPSAGQSSLVHLLDVFLGVDHApek---------- 302 
CCA77747      287 -GKRRWIFvd--------------------enGEevdFgdrRELSGPSAGQSSLIHALDIFLGVDHTpprrPAHPttttd 345 
Q5KJZ4        315 pGSVGWDY--LGlaadnanv----vagtheaeSAsteGrrgKLFSGPSAGQSSLIHAIDIFLTVDHSpteeERREameaa 388  Cryptococcus ...
XP_009266795  302 -----WHY--EGv-------------------dPlgvY---RDYGGPSAGQSSLIHAIDAFLGVNHA------------- 339 
7_pfamImport  254 -----WIW--EGvqieennkgktaeqareflaESkwkE---TEYGGPSAGQSTLIHAIDVFLGVDHEpn----------- 312 
XP_007414362  305 -----WIM--EGvp----------------alPGpwrV---TEFGGPSAGQSTLIHSLDVFLGVDHS------------- 345 
XP_007414373  310 -----RQMgsDGv------------------------V---VKWGGPSAGQSTLIHSLDVFLGIDHRpr----------- 346 
KDE04431      349 ---GRWMY--ESv--------------------Ge------REYGGPSAGQSSLVHAVDLFLGIDHSprpaSTTStasvp 397 
XP_011390268  458 gEEAGWHF--EGvd-----------------pEGikrV-----FSGPSAGQSSMIHAIDVFLDVDHTrrkqRLHRpa--- 510 
6O3I_A        302 ------HA----------------------------------------------AQFLQDMRRYMPPAHRNFLCSL---- 325  human
XP_003027344  303 ---------------------------------------------------pgaRPFLERMRAYMPAPHRRFLDVV---- 327 
CCA77747      346 qplsnaSGsmhang-----------------------------------askptKGFLDRMLAYMPRHHRAFMNHL---- 386 
Q5KJZ4        389 enrpeqSGvfikmnsspvnastapsaskphghshgsiappvsnsnpsaaapkseATFLQRMLAYMPLPHRSFLIHL---- 464  Cryptococcus ...
XP_009266795  340 -------Pvdde--------------------------------------adfdDTFMRRMQTYMPDYHRRFLNHL---- 370 
7_pfamImport  313 -----lqElssg--------------------------------------iqdeETFMNRMSTYMPHHHRLFLKQLsrsc 349 
XP_007414362  346 -------Prpge--------------------------------------mskeETFMKRMAAYMPHFHRRFLQHL---- 376 
XP_007414373  347 ------pTeghs--------------------------------------tsheSTFMERMAAYMPHHHRNFLQHLsqtl 382 
KDE04431      398 aslgpePSttlptpva-------------------------------qakglsdDTFMMRMSTYMPGHHRAFLAHLasly 446 
XP_011390268  511 -----atTnada--------------------------------------rgadATFMERMSLYMPGHHRAFLSHLrnis 547 
6O3I_A        326 ------------------------------ES-NPSVREFVlskGDA-G-------LREAYDACVKALVSLRSYHLQIVT 366  human
XP_003027344  328 ------------------------------AAsPIALRAFVmsaGDT-E-------LLDAYNATVLALKGFRDEHMIIVT 369 
CCA77747      387 ------------------------------KVtPRPIRTLVshhTTGaGsep--spITNAYDAAVLALKGLRDAHIRIAT 434 
Q5KJZ4        465 ------------------------------SThPTPLRPLVlhfAAS-Hp-----tLVQAYDGALESLRRFRERHMRVVS 508  Cryptococcus ...
XP_009266795  371 ------------------------------KCvEPSCRDVVgtsHNA-D-------LQSAYNGAIESMKKLRSEHIKIAT 412 
7_pfamImport  350 ---------------------------ltqRGqPNLIRSIVinhQDQ-KfksgpnnLKENYNLCIQSLENLRKTHTQIVS 401 
XP_007414362  377 ------------------------------FSyTGEIRSLVlssGSK-Sl------LATRYNSAVAALEELRNSHSRVAL 419 
XP_007414373  383 spnsh-----------------ltifpqlpNQiTHSVRSLAsiaSPD-Ss------LFSAYNQSVQSLLKLRATHSKIAL 438 
KDE04431      447 qpt--------------------evseagiAEkLPSVRDLVirhPQQ---------LQESYDRAVLSMKKFRDEHMKLAT 497 
XP_011390268  548 fddadqdqdeelqdlepreansdadgeqqlRElPHPIRSLAlkaKSE-Ehd---egLPAAYDNALQELKALRDEHMKVAY 623 
6O3I_A        367 KYILIPASQQPKEN-----------------------------------------------------------------K 381  human
XP_003027344  370 LYIIQPARRARALAdaeraee---------------------------------------------------maraqasA 398 
CCA77747      435 LYIINQMPRsdts------------------------------------------------------------------- 447 
Q5KJZ4        509 KFIVQQARRKPGERirrl----------------------------------------------------------tgmE 530  Cryptococcus ...
XP_009266795  413 LYVVTQSRKAEk-------------------------------------------------------------------E 425 
7_pfamImport  402 LFIICQKNSSPPDQlsalnsterthpssstapcnqsvshvdsldeklkdltnrngntkqqenpnklleerstdnhtqpeP 481 
XP_007414362  420 FYIISQSRTEPPIGsafisewe--------------------------------------------------ekmvaewK 449 
XP_007414373  439 WYVLSQSRIEPPLns---------------------------------------------------------------pF 455 
KDE04431      498 VYIVAQAKKEPGRQtvfwqewed-----------------------------------------------kriekerlrQ 530 
XP_011390268  624 LYIVAQARGSPPDAyaplakgftgepnvd-----------------------------------rrlaakakahadaeaE 668 
6O3I_A        382 Ts------EDPsKLEAKGTGGTDLMNFLKTVRSTTEKS 413  human
XP_003027344  399 VvapapdlSQQrRQPVKGTGGTDIARFLKATRDKTAQT 436 
CCA77747      448 -----laqAAAsAATAKGTGGSDLVPFLKGSRDDTTRA 480 
Q5KJZ4        531 MeddedesTMAnAGELRGTGGTALFKFLKRCRDNTTKA 568  Cryptococcus neoformans
XP_009266795  426 SdsnsanvPESrDTDIKGTGGTSLIKFLKTCRDRTHST 463 
7_pfamImport  482 TavkladhGESqREILKGTGGTDLSKFLKRCKLRTTQA 519 
XP_007414362  450 KqqlalsrEPGnETVHTGTGGTDLAKFLKRCRERTTEA 487 
XP_007414373  456 LkqweksrELKkRSVQLGTGGTDLARFLKRCRERTSEA 493 
KDE04431      531 Eea------rGrRDVLKGTGGTDLIVFLKMCRERTKEA 562 
XP_011390268  669 AraildtnSKDnGGGAKGTGGTDLVTFLRDCRVNTIDA 706 
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