5NIS,2WYN


Conserved Protein Domain Family
Trehalase

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pfam01204: Trehalase 
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Trehalase
Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with pfam07492 in fungi.
Statistics
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PSSM-Id: 395961
Aligned: 19 rows
Threshold Bit Score: 603.553
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NIS_A        68 KSFGRHQIFLDEARINEnpVNRLSRLINTQFWNSlTRRVDLNNVGEIAKDTKIDTPGAKnPRIyVPYDCPEQYEfYVQAS 147 Saccharomyces c...
O43280        46 KLYQDDKQFVDMPLSIA--PEQVLQTFTELSRDH-NHSIPREQLQAFVHEHFQAKGQEL-QPW-TPADWKDSPQ-FLQKI 119 human
P32358        40 RLYPDSKTFVDFQMRKD--ENATLSAFQELLDRT-NHNPTKEDLQEFVVDFFDET-SEL-EEW-KPDDHKENPP-FLAKI 112 domestic silkworm
NP_001293773  20 GLFPDCKTFVDMPLKHD--ADVTLARWNALMALAp---ITNDVLALFLRENFDEPEGEL--EEcAPTDWAPMTDqFGGi- 91 
Q9FWC1        34 PNDFDPKLYVDLPLA----ADASAAAALASLPRAaP---SRGEMEAYISRYFALAGSDL-VAAaDPPDFERDPPgFLPRV 105 Japanese rice
KRH60094      55 hsNFDPKTYVDMPLKS---ALTVTEDAFQKLPRNaNGSVPVEDLKRFIEAYFEGAGDDL-VYR-DPQDFVPEPEgFLPKV 129
Q8SQJ2        78 KFFRSEEDFWNFVGMHSiePGSEFIFAKDNEELEaSMFSGVPEYVSRLEERLLEP---------NPQRESEGFK-----Q 143 Encephalitozoon...
2WYN_D        25 KLFPDQKTFADAVPNSD--PLMILADYRMQQNQ------SGFDLRHFVNVNFTLP----------KEGEKYVPP------ 80  Escherichia col...
Q8XT38        72 QVYPDQKTFVDTVPKAD--PAVILQAYRAQKDV------PGFSLKAFVDQYFT-----------VPFETVITPP------ 126 Ralstonia solan...
Q8P519        72 ELFDDQKHFVDFLPLRD--PALINADYLAQHEH------AGFDLRKFVDANFEE----------SPPVQTDAIR------ 127 Xanthomonas cam...
5NIS_A       148 qMHPSLKLEVEYLPKKITAeYVKSVNDTPGLLALAMEEHFNPStgektligyPYAVPGGRFNELYGWDSYMMALGLLEAN 227 Saccharomyces c...
O43280       120 -SDAKLRAWAGQLHQLWKK-LGKKMKPEVLSHPERFSLIYSEH---------PFIVPGGRFVEFYYWDSYWVMEGLLLSE 188 human
P32358       113 -RDQGFREFAKALNDIWPT-LARRVKPSVLEKPEQSSLVPMTH---------GFIVPGGRFKEIYYWDAYWIIEGLLITD 181 domestic silkworm
NP_001293773  92 -IDEDYRRFAAALHAKWPT-LYRKISKKVRVNPEKYSIIPVPN---------PFVVPGGRFREMYYWDSFFTIKGLIASG 160
Q9FWC1       106 -ERAEARAWALEVHALWKD-LTRRVAPAVAARPDRHTLLPLPG---------RVVVPGSRFREVYYWDSYWVVRGLLVSK 174 Japanese rice
KRH60094     130 -NQPQVRAWALQVHSLWKN-LSRKISGAVKAQPDLHTLLPLPG---------SVVIPGSRFREVYYWDSYWVIRGLLASK 198
Q8SQJ2       144 -SLETLVRVSKELNDAWKN-LYV--KQRDLDKGYYSTMIKVKN---------PFVIPGDRFKECYYWDTYWIIEGLVKSG 210 Encephalitozoon...
2WYN_D        81 -EGQSLR---EHIDGLWPV-LTR----STENTEKWDSLLPLPE---------PYVVPGGRFREVYYWDSYFTMLGLAESG 142 Escherichia col...
Q8XT38       127 -AGQSLR---AHINWLWPA-LTR----TTATAPDNSSLIPLPK---------PYVVPGGRFREVYYWDTYFTMLGLQASG 188 Ralstonia solan...
Q8P519       128 -QDTALR---EHIDALWPK-LVR----SQTNVPAHSSLLALPH---------PYVVPGGRFREVYYWDSYFTMLGLVKSG 189 Xanthomonas cam...
5NIS_A       228 KTDVARGMVEHFIFEINHYGKILNANRSYYLCRSQPPFLTEMALVVFKKLggrsnpdAVDLLKRAFQASIKEYKTVWTa- 306 Saccharomyces c...
O43280       189 MAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHT-------NDTAFLQENIETLALELDFWT-- 259 human
P32358       182 MTETAKGMIENLIELLYKFGHIPNGSRWYYQERSQPPLLAAMIKLYYEKT-------KDIEFIRKYISALEKELEYWL-- 252 domestic silkworm
NP_001293773 161 MLTTVKGMIENMIYLVETYGFIPNGTRVYYLNRSQPPLLTWCVKAYYEAT-------GDKQFLSDVLPTLRKEFSFFQ-- 231
Q9FWC1       175 MYETAKDIVLNLVYLVEKYGFVLNGARSYYTNRSQPPLLSSMVLDIYMAT-------GDMAFVRRVFPSLLKEHSFWMs- 246 Japanese rice
KRH60094     199 MHDTAKAIVTNLISLIDKYGFVLNGARAYYTNRSQPPLLSAMIYEIYNST-------GDLELVKRSLPALLKEYEFWNs- 270
Q8SQJ2       211 MHKIAVGMVENFILLIEKYGFIPNGTRTYYLNRTQPPYFCMMLFTVYRHVpw---teEVEEIIKRGLKAAVMEYNFFM-- 285 Encephalitozoon...
2WYN_D       143 HWDKVADMVANFAHEIDTYGHIPNGNRSYYLSRSQPPFFALMVELLAQH--------EGDAALKQYLPQMQKEYAYWMdg 214 Escherichia col...
Q8XT38       189 RDDLVDSMLDNFAYQINRFGHIPNGNRTYYLSRSQPPFFALMVELAATK--------EGEAAYTRYLAPLRKEYAYWMrg 260 Ralstonia solan...
Q8P519       190 ETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPLFSYMVELQAGV--------EGEAVYQRYLPQLQKEYAYWMqg 261 Xanthomonas cam...
5NIS_A       307 ------SPRLDPETGLS--RYHPNGLGIPPETESDHFDTVLLPYASKHGvt--ldEFKQLYNDGKIKEPKLDEFFLHDRG 376 Saccharomyces c...
O43280       260 ------KNRTVSVSLEGk-NYLLNRYYVPYGGPRPESYSKDVELADTLP------EGDREALWAELKAGAESGWDFSSRW 326 human
P32358       253 ------DTHLIAFNKDDr-VYTLLRYYIPSAGPRPESYYEDYELAQKLDk-----NTDPNDIYADLKSAAESGWDFSTRW 320 domestic silkworm
NP_001293773 232 ------THKTYNHPDWN---TPLYRFVVETSHPRPESYREDLESAEHLDt-----LEKKCVLWGDLAAAAESGRDFSSRF 297
Q9FWC1       247 ------EVHNVAVMDNHgrVHNLSRYQAMWNKPRPESATIDEEFASKLS------TAAKEKFYHQVASTAETGWDFSSRW 314 Japanese rice
KRH60094     271 ------DIHKLTILDAQgcTHTLNRYYAKWDKPRPESSIMDKASASNFSs-----VSEKQQFYRELASAAESGWDFSTRW 339
Q8SQJ2       286 ------NYRKEEIEKDGk-SYVLNVYRVSDCTPRAESYSEDRKVAENNKskdevyRRREEDIYSNLKAGAESGWDYSSRW 358 Encephalitozoon...
2WYN_D       215 venlqaGQQEKRVVKLQd-GTLLNRYWDDRDTPRPESWVEDIATAKSNP------NRPATEIYRDLRSAAASGWDFSSRW 287 Escherichia col...
Q8XT38       261 aagtapGQASGNVVVLPd-GTVLNRYWDDEATPRPESYLQDVATAQQAP------DRPAAEVWRDLRAAAESGWDFSSRW 333 Ralstonia solan...
Q8P519       262 gddlqpGQAARHVVRLAd-GSVLNRYWDERDTPRPEAWLHDTRTAAEAH------DRPAADVYRDLRAGAESGWDYTSRW 334 Xanthomonas cam...
5NIS_A       377 VREs-GHDTTYRFEGVCAYLATIDLNSLLYKYEIDIAdfikeFCDDKYEDpldhsITTSAMWKEMAKIRQEKITKYMWDD 455 Saccharomyces c...
O43280       327 LIG--GPNPNSLSGIRTSKLVPVDLNAFLCQAEELMS-----NFYSRLGN-----DSQATKYRILRSQRLAALNTVLWDE 394 human
P32358       321 FISesGDNSGNLTNLNTKNVIPVDLNAIFAGALQITA-----NFQAILKN-----PRRAAHWGYMAEQWRSSIEQALWDE 390 domestic silkworm
NP_001293773 298 FAVh-GPYAGQLASTRTSQLIPVDLNSIICGNMKTLS-----EMYTVCGD-----LESAKYFDNEYRTLRDTIRQVLWNE 366
Q9FWC1       315 MRD--STD---MTTLTTSCIIPVDLNTFILKMEQDIA-----FFAKLIGE-----STTSEIFSEASKARHNAIDSVLWNA 379 Japanese rice
KRH60094     340 MRN--PPN---FTTLATTSVIPVDLNAFLLGMELNIA-----LFAKVTGD-----NSTAERFLENSDLRKKAMDSIFWNA 404
Q8SQJ2       359 LGV-----RGELDSIRTSKRVPADLNAIMYANELIIMk----LFEVVEGKr----SKNAEDFKKKSEERYRAINAVLWSD 425 Encephalitozoon...
2WYN_D       288 MDN--PQQ---LNTLRTTSIVPVDLNSLMFKMEKILA-----RASKAAGD-----NAMANQYETLANARQKGIEKYLWND 352 Escherichia col...
Q8XT38       334 FGD--SAT---LATIRTTSILPVDLNALMFQLEKTIA-----KGCAVARD-----FACTVEFGNHARKRAVAVERYLWH- 397 Ralstonia solan...
Q8P519       335 LAD--GKT---LSTIRTTAIVPIDLNSLLYHLERTLA-----QACAHTG------TACSQDYAALAQQRKQAIDAHLWN- 397 Xanthomonas cam...
5NIS_A       456 ESGFFFDYNTKIK------------HRTSYESATTFWALWAGLATKEQaq----kMVEKALPKLEMLGGLAActERSRGP 519 Saccharomyces c...
O43280       395 QTGAWFDYDLEKK------------KKNREFYPSNLTPLWAGCFSDPG-------VADKALKYLEDNRILTY--QYGIPT 453 human
P32358       391 EDGVWHDYDILNN------------KPRRYFYTSNLAPLWMNAVEKPFla----kHGARVLEYLHESQALEY--PGGVPV 452 domestic silkworm
NP_001293773 367 EHNCWFDFDVEEG------------NHATSFHDTNFFPMYCDSYHEDLd-------SQVVVDYLTTSGAISF--PGGIPV 425
Q9FWC1       380 DMEQWLDYWLPTDgncqgvyqwksiSQNRAIFASNFVPLWLNAQHSGLeqfvdeaKSVRVMRSLQKSGLLQ---PAGIAT 456 Japanese rice
KRH60094     405 NKKQWLDYWLSSTceevh--vwkneHQNQNVFASNFVPLWMKPFYSDTs------LVSSVVESLKTSGLLR---DAGVAT 473
Q8SQJ2       426 EEGVWNDYDIEKKk-----------HTSPGFYFSNLAPMCYGISPPPD-------KNITVYDILNAFAEEIFghPGGMPA 487 Encephalitozoon...
2WYN_D       353 QQGWYADYDLKSH------------KVRNQLTAAALFPLYVNAAAKDR---------ANKMATATKTHLLQ---PGGLNT 408 Escherichia col...
Q8XT38       398 PAGYYADYDWKLG------------KVRDNLSAAATYPLFVQMAPWGR---------ARQTLRQTQTALLQ---VGGLST 453 Ralstonia solan...
Q8P519       398 AAGYYADYDWQTR------------TLSNQVTAAALYPLFAGLASDDH---------AKRTATSVRARLLR---PGGLAT 453 Xanthomonas cam...
5NIS_A       520 ISISr--PIRQWDYPFGWAPHQILAWEGLRSYGY---LTVTNRLAYRWLFMMTKAFVDYn---GIVVEKYDVTRgtdphr 591 Saccharomyces c...
O43280       454 SLQK---TGQQWDFPNAWAPLQDLVIRGLAKAPLrraQEVAFQLAQNWIRTNFDVYSQK----SAMYEKYDVSN------ 520 human
P32358       453 SLVN---SGEQWDFPNAWPPEVSIVVTAIQNIGSeesSKLAKELAQVWVRACKSGFTEK----KQMFEKYDALN------ 519 domestic silkworm
NP_001293773 426 SLVN---SGEQWDFPNSWPPTTWVLLEGLRKVGQ---EELALSLVEKWVQKNFNMWRTSg---GRMFEKYNVVSp----- 491
Q9FWC1       457 SLSN---TGQQWDFPNGWAPLQHLIVEGLLRSGSgeaRELAEDIATRWVRTNYDAYKAT----GAMHEKYDVVT------ 523 Japanese rice
KRH60094     474 SLTD---SGQQWDFPNGWAPLQHMLVEGLLKSGLkeaRLLAEEIAIRWVTTNYIVYKKT----GVMHEKFDVEH------ 540
Q8SQJ2       488 SGSKnknSPEQWDYPNVWPPLVHIMTFFLERIGE---RQMALHLARSLLENISVSTSISdvtrRGIFEKYNCER------ 558 Encephalitozoon...
2WYN_D       409 TSVK---SGQQWDAPNGWAPLQWVATEGLQNYGQ---KEVAMDISWHFLTNVQHTYDRE----KKLVEKYDVS------- 471 Escherichia col...
Q8XT38       454 TTLH---TQQQWDAPNGWAPLQWIALQASQHYGQ---ALLAQTIGERFLGSVERLYAAE----QKLVEKYIVD------- 516 Ralstonia solan...
Q8P519       454 TALK---TGQQWDEPNGWAPLQWVAVDGLRRYGE---DGLARTIGERFLTQVQALFARE----HKLVEKYGLD------- 516 Xanthomonas cam...
5NIS_A       592 vEAEYGnqgADFKGAATEGFGWVNASYILGLKYMN 626 Saccharomyces cerevisiae S288C
O43280       521 -GGQPG---GGGEYEVQEGFGWTNGVVLMLLDRYG 551 human
P32358       520 -AGKYG---GGGEYTVQDGFGWSNGVVLEFLDRYG 550 domestic silkworm
NP_001293773 492 -CFKVK---GGGEYVMQEGFGWTNGVILDFLKNYG 522
Q9FWC1       524 -CGKSG---GGGEYKPQTGFGWSNGVILSFLDEFG 554 Japanese rice
KRH60094     541 -CGEFG---GGGEYVPQTGFGWSNGVVLAFLEEFG 571
Q8SQJ2       559 -VGDSG---YKGEYAPQVGFGWTNGSAIHFLEHFS 589 Encephalitozoon cuniculi
2WYN_D       472 -TTGTGg--GGGEYPLQDGFGWTNGVTLKMLDLIc 503 Escherichia coli K-12
Q8XT38       517 -GSGTGg--GGGEYPLQDGFGWTNGVTLRLLDAYG 548 Ralstonia solanacearum GMI1000
Q8P519       517 -ADAAGg--GGGEYALQDGFGWTNGVTLMLLNLYP 548 Xanthomonas campestris pv. campestris str. ATCC 33913
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