6EM5,1SQF,3AJD


Conserved Protein Domain Family
Methyltr_RsmB-F

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pfam01189: Methyltr_RsmB-F 
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16S rRNA methyltransferase RsmB/F
This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.
Statistics
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PSSM-Id: 426109
Aligned: 8 rows
Threshold Bit Score: 256.967
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EM5_q 338 VIALDPHENER--ILDMAAAPGGKTTYISAM-MKNTGCVFANDANKSRTKSLIANIHRLGCT--NTIVCNYDAREFpkvi 412 Saccharomyces cerevis...
P72943 245 AQILNPQPEET--IFDVCAAPGGKTTHIAEL-MGDQGQIYAGDRHGWRLQKLAVTQQRLGLT--SIKIWEGDLTQP---- 315 Synechocystis sp. PCC...
P45679 231 AYLLKLENNQT--VLDACAAPGSKTSHILEV-NPHLKTLVAIDNNKQRLNRIKENITRLGLRqeHLQCLLADVSQIdqws 307 Coxiella burnetii RSA...
P44788 251 ATLLEPKNEEW--ILDACAAPGGKTTHILEL--APQANVIALDVESHRLKRVEENLERLNQQ---AIVVCGDASKPdewl 323 Haemophilus influenza...
1SQF_A 239 MTWLAPQNGEH--ILDLCAAPGGKTTHILEV--APEAQVVAVDIDEQRLSRVYDNLKRLGMK---ATVKQGDGRYPsqwc 311 Escherichia coli
P9WGX3 259 ALTLAPVDGDTgrWLDLCAGPGGKTALLAGLgLQCAARVTAVEPSPHRADLVAQNTRGLPVE-----LLRVDGRHTdld- 332 Mycobacterium tubercu...
3AJD_A  76 PIVLNPREDDF--ILDMCAAPGGKTTHLAQL-MKNKGTIVAVEISKTRTKALKSNINRMGVL--NTIIINADMRKYkdyl 150 Methanocaldococcus ja...
P46087 377 VMALAPQEHER--ILDMCCAPGGKTSYMAQL-MKNTGVILANDANAERLKSVVGNLHRLGVT--NTIISHYDGRQFpkvv 451 human
6EM5_q 413 gG-------FDRILLDAPCSGTGVIGKDQSVKVSRTEKDFIQIPHLQKQLLLSAIDSVdcnsKHGGVIVYSTCSVAVEED 485 Saccharomyces cerevis...
P72943 316 -GvkppvelVDRALLDVPCSGLGTLHRNPDLRWRQTPATIATLLPLQQALLKAIAPLV----KSGGTLVYSTCTLNPAEN 390 Synechocystis sp. PCC...
P45679 308 sGe-----lFDRILLDAPCSATGVIRRHPDIKLLRQPGDISQYHQKKLQLLNALWTVL----KAGGFLLYSTCSVLPDEN 378 Coxiella burnetii RSA...
P44788 324 aEigksaakFDRILLDAPCSATGVIRRHPDIKWLRKETDIAQLVELQKKILSALWEKL----KPNGVLLYATCSVLPEEN 399 Haemophilus influenza...
1SQF_A 312 gEq-----qFDRILLDAPCSATGVIRRHPDIKWLRRDRDIPELAQLQSEILDAIWPHL----KTGGTLVYATCSVLPEEN 382 Escherichia coli
P9WGX3 333 -------pgFDRVLVDAPCTGLGALRRRPEARWRRQPADVAALAKLQRELLSAAIALT----RPGGVVLYATCSPHLAET 401 Mycobacterium tubercu...
3AJD_A 151 lKne---ifFDKILLDAPCSGNIIKDKNRNV----SEEDIKYCSLRQKELIDIGIDLL----KKDGELVYSTCSMEVEEN 219 Methanocaldococcus ja...
P46087 452 gG-------FDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVnatsKTGGYLVYCTCSITVEEN 524 human
6EM5_q 486 EAVIDYALRKRPNVKLVDT------GLAIGKEAftsyrgkkfhpsvklARRYYPHTYNVDGFFVAKFQ 547 Saccharomyces cerevisiae S288C
P72943 391 EAQIERFLQDHEDWRSEPFewtspqGQTNSVTSg--------------MLTILPHHHHQDGFFIANLK 444 Synechocystis sp. PCC 6803 substr...
P45679 379 EKVIEEFLSTHDKVELSPTnvhgglQLKYGVQQ-------------------LPGQDNKDGFYYSLLF 427 Coxiella burnetii RSA 493
P44788 400 CEQIQAFLNAHADAELLSLpfs-ddKSAVGFQF-------------------IPQPNSGDGFYYAKLL 447 Haemophilus influenzae Rd KW20
1SQF_A 383 SLQIKAFLQRTADAELCETgt----peQPGKQN-------------------LPGAEEGDGFFYAKLI 427 Escherichia coli
P9WGX3 402 VGAVADALRRHPVHALDTRplfepvIAGLGEGP---------------HVQLWPHRHGTDAMFAAALR 454 Mycobacterium tuberculosis H37Rv
3AJD_A 220 EEVIKYILQKRNDVELIIIkanefkGINIKEGYik------------gTLRVFPPN---EPFFIAKLR 272 Methanocaldococcus jannaschii
P46087 525 EWVVDYALKKR-NVRLVPT------GLDFGQEGftrfrerrfhpslrsTRRFYPHTHNMDGFFIAKFK 585 human
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