3PGB,3K5T,1N9E


Conserved Protein Domain Family
Cu_amine_oxid

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pfam01179: Cu_amine_oxid (This model is not part of the current CDD release)
Copper amine oxidase, enzyme domain
Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyze the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ). This family corresponds to the catalytic domain of the enzyme.
Statistics
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PSSM-Id: 514064
Aligned: 278 rows
Threshold Bit Score: 336.356
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3PGB_A        328 PVMIAPDGARYSVDAerKYVTWMDFSFYIAFNRDTGLSLFDIKYKGQ----RVLYELGLQEALAHYAANDPVQSSVAYLD 403 Aspergillus ni...
XP_016285941  379 PLQFSPQGPRYSVQG--SQVASPFWTFTFSLGVFSGMRIFDVRFQGE----RVAYEISVQECLSIYGADSPKTMMTHYLD 452
XP_002719458  308 ILRFSPQGAQYSVQG--SLVVSPLWAFTFGHGVFSGLRIFDVRFRGE----RIAYEVSVQECLTLYGADSPKTMTTRYLD 381
31_pfamImport   1 PLQFHPQSPCFNVqS--NRVSSSLW-FSFDLRAFSGPRILTFDYKENdwlmRSAYKWPALFMVWEY----PTAMFTRPVN 73 
XP_003222540  302 PLHYEPCGKRYSVKN--NQVLSMLWSFAYRMDANRGPHIYDIRFRKQ----RIVYELSVQEALSVYGSNSPGGLLTRYMD 375
XP_016847525  310 PLHYEPRGPRYSIkN--NQVNFMSWSFAFGTDAFQGPRVFDIRFKGE----RIIYELSLQDAIAVYGSNSPGLMYNRYMD 383
XP_014350019  331 PIEYEPQGKRYSVkN--NQVIYLSWRFSFGLSATTGLRLFDIRFNGE----RIVYELSVQEALTVYGSNTGTAMLTKYLD 404
XP_003964455  304 PQLFHPEGKRYSISD--NHVLYMDWSFAFGLSSLTGMRVFDVRFKDE----RILYELSVQEAMSVYGSVTPGMGLTKFFD 377
XP_015217386  300 PLQYDVQGKRYSVrN--NQVLYLDWSFAFGLSSLTGMRVFDIRFKGE----RIAYELSVQEAMSVYGSVTPGMMLTKFID 373
XP_006006014  291 PLEYEPQGKRYSVkN--NQVKSLLWSFSFGQNAATGLRLFDIRFNGE----RIIYELSIQEALSVYGSNTAGAMLTRYMD 364 coelacanth
3PGB_A        404 S-YyGFGPYAFELLKGYDCPSYASYLNTSFY-KDEETHTHVDSLCLFEFDADyPMARHSTSEF----VSVTKNVYFTLRS 477 Aspergillus ni...
XP_016285941  453 StY-GIGRHSRGLIRGVDCPYLATMVDAYVLvDQGTAQLLPGALCVFEEAQGmPLRRHHNQAQgr-yFGAVVGSALVIRS 530
XP_002719458  382 SsY-GLGHNSRGLVRGVDCPYQATMVDIHILmGKGTAQLLPGAVCIFEEAQGlPLRRHHNYIGsh-fYGGLASSALVVRS 459
31_pfamImport  74 SgI-GMGYFPTPLIR-VECPYQASYMDWHFVvEsQAPKTPHDAFGVFKQNKGlPLRFSFPl------FWGRCGDSAGLRS 145
XP_003222540  376 GsF-GIGRYSYSLVKGVDCPYSATYLDATYFfDNWEPEVLKNSICVFEQNVEvPFRRHFSNLQsl-yYGGLPATALVLRS 453
XP_016847525  384 IsY-GLGSNLHTLIQGVDCPYLATYLDRHYFvDtSSPVTREASICIFEQNTEvPIRRHYES-GqapfFGGLVDSTLVFRS 461
XP_014350019  405 GsF-GFGRCSYEMVRGVDCPYTATYLDTYYFfDtDGPVRSKNSICIFEQNIGlPLRRHYSAs----hYGGLTNSVLIVRT 479
XP_003964455  378 TsI-GIGRFAHQLVRGVDCPYEAAYITTYRYiDAPNPIKFEDSICIFEHNLGqPLRRHFSDFFhn-sYGGMVNSALVMRT 455
XP_015217386  374 SsI-GIGRFAHELVRGVDCPYTATFVDTYRYiDtNFTQRFRNSICIFEHNTGrPLRRHFSD-FfsnsYGGLANNVLVFRT 451
XP_006006014  365 AsF-GIGKHSYELVRGVDCPYTATYLDSYRFfEaSEPMRFKNSICIFEHNTAvPLRRHYASs----hYGGLTNSVLIIRT 439 coelacanth
3PGB_A        478 VSTIGNXDYMFSYNFHMDGTIGVEVRASGYIQSAYYA-Nn--QDFGYQIHDSLSGSMHDHVLNFKADFDI-LGPnNTIEL 553 Aspergillus ni...
XP_016285941  531 VSSVGNYDYIWDFVLHPHGALEGRVHATGFINTAFLGggentlHFGNRVGGHVLGTVHTHAFHFKLDLDV-AGLeNWVLT 609
XP_002719458  460 VSTVGNYDYIWDFVLYPNGALEGRVHATGYINTAFLSggaeslLFGNRVGERVLGAVHTHAFHFKLDLDV-AGLkNWVLA 538
31_pfamImport 146 VSTMLNYDYVWDLVFYPNGAIEVKFHATGYISSAFFFgEa--QRCGNQVGEKTLGAIHTHSAHYKVDLDVgEGAaRLGAS 223
XP_003222540  454 VATLGNYDYIWDFIFHPNGAIESKVRATGYITSAFLYgDg--LEYGNRVGDHTLGTIHTHFINYKVDLDV-GGVkNSLIS 530
XP_016847525  462 ISSVTNYDYIWDFIFHQNGAIGVRVQASGYIQSSFFIdDa--TQFGNRVQEWVLGTIHTHSVQFKVDMDVg-GVkNTLMG 538
XP_014350019  480 IATIGNYDYVWDFRFYQNGAIEAKIHATGYISTAYLFgDg--LKYGTKVRTDTLGTIHTHFLHYKVDLDIa-GTeNSFVT 556
XP_003964455  456 ITAIGNYDYMWDFIFYQSGSVEAKVHATGYISSSYMMeg--slNYGHQVAEKVLGNLHTHFINFKVDLDV-AGVkNVFQT 532
XP_015217386  452 ITAIGNYDYMWDFMFYQSGSVEAKVHATGYISSSYKTeDn--LRYGHQVAENTLGNIHTHFINFKVDLDVl-GRkNMFLT 528
XP_006006014  440 IATIGNYDYVWDYMFYQNGAIEAKVHATGYIYAAYLFgDg--LKYGTKVRTNTLGTIHTHFVHYKVDLDIv-GTnNLFVT 516 coelacanth
3PGB_A        554 VSV------VPv-tKQfSwSGNKTRNTMQLGRSFIHSEdeARLNWGFNG-QTQLHVVNQDKPNKFGEPRGYRILPsa--g 623 Aspergillus ni...
XP_016285941  610 EDVm----fEPl-tVP-WsP-EHQLQRPQLTRQTLDTEnkAAFLLGDTL-PRYLYLAS-NHTNTWGHRRGYRVQIhs-pl 679
XP_002719458  539 EDV------VFkpvAApWsP-EYQLQRPQLTRQVLGREdlAAFSWGSPL-PRYLYLAS-NQTNAWGHQRGYRIQIhs-pl 608
31_pfamImport 224 LGErae-kmVPw----sPa---HQTQRLQVTRKQLETEeqAAFPL-GGGsPRYLYLAS-NQSNKWGRPCGYRIQTvsfag 293
XP_003222540  531 NDM------TFe-nIKaPwSPDNEIRQMKMVKNVLDTEdkAAFRLHDNM-PRYVYFAA-NSNNKWGHKRGYRIQLi---s 598
XP_016847525  539 NDMafetvkAPw----sPk---HKINRMKMVRKVLDTEnkAAFRL-HDDmPKHIYFAA-NNTNKWGHKRGYRIQMvsfsg 609
XP_014350019  557 RDMefetitVPw----kSn---QQKQIPKLTEKLLETEnqAAFKL-HSKsPRYLLFAS-NKTNKWGHMRSYRIQTisfag 627
XP_003964455  533 KDM------KFv-nTSvPwQPGHHAMIPQLVEKQLNTEqeAALRYNTKT-PRYLHVASP-KVNRWGHPRSYRLQVf---t 600
XP_015217386  529 KDMefvnvsLPw----iPg---EYAQIPRLVERQLKTEgeAALRY-DTKtARYLHIAS-NLTNRWGHPRSYRLQVasftg 599
XP_006006014  517 RDMdfekinVPw----dSd---QQREIPRLIENLIKTEdqAAFAL-HSNsPRYLLFAS-NKTNDWGHRRSYRIQIvsfag 587 coelacanth
3PGB_A        624 TAHLTVLNSSNLVHAAHWAEYDVQVTRQHDFEPTSAHPYN-SQdIHNppvDFSTFF-NGESLNQTDLVVWLNLGMHHVPH 701 Aspergillus ni...
XP_016285941  680 G--VHLPLETSMEKAFSWGRYQLAVTRRKEEEPQSSSIYNqND-PWTptvVFANFI-DNEVLSGEDLVAWVTTSFLHIPH 755
XP_002719458  609 G--IHVPLESAMERALSWGRYQLAVTRRKEEEPWSSSIYHqND-IWTptvAFADFI-DNETLLGEDLVAWVTASFLHIPH 684
31_pfamImport 294 G--PLP-QNSSMERVVSWGRYQLAVTQRKETEPSSSSVFNqND-PWTptvDFADFI-NNETIAGKDLVAWVTA-FLYIPH 367
XP_003222540  599 FAGDHLPETDPMERSVSWSRYKLAVTKRKENEPFSTSIYNqND-PWTpsvAFADFI-NNESLIEEDLVAWITTGFLHIPH 676
XP_016847525  610 D--HLP-ETDPMERAISWDRYKLAVTKRKENEPSSTSPYNmLD-PWSptvAFSDFI-NNESIVNEDLVAWITTGFLHIPH 684
XP_014350019  628 D--HIP-ENTPEEAGMSWGRYKLAVTTHKDEELTSSSVYNqNG-PWNpavNFASYI-NNENIKNKDLVAWITIGFLHIPH 702
XP_003964455  601 FAGDHLPESEPEERSMSWARYKVAITKQKDLEQTSSSLYNqNN-IWSptvDFSKYIdDNESIVDQDLVAWVTAGFLHIPH 679
XP_015217386  600 D--HLP-EAVPEERAMSWARYKVAITKYKDEEQTSSSLYNqNN-IWSpavDFSQFIeDNENIESEDLVAWVTTGFLHIPH 675
XP_006006014  588 D--HMP-KTTSEEKGMSWGRFKMAVTKHKDEEPSSSSIHNqNN-PWKpavNFADFI-NNENIVEEDLVAWITTGFLHIPH 662 coelacanth
3PGB_A        702 TGDLPntVFTTAHSGVAFTPLNYLPGDPSR 731 Aspergillus nidulans
XP_016285941  756 AEDIPntVTPGNGAGFFLRPYNFFDEDPSA 785
XP_002719458  685 AEDVPntVTVGNGVGFLLRPYNFFDEDPSI 714
31_pfamImport 368 AEDIPnmVTVGNSVSFFLQPRNFFDHEPSV 397
XP_003222540  677 AEDVPntVTLGNAVGFLLRPYNYFDEDPSI 706
XP_016847525  685 AEDIPntLTLGNVLGFFLRPYNFFDEDPSI 714
XP_014350019  703 SEDVPntVTVGNGVGFLLRPYNYFKEDPST 732
XP_003964455  680 AEDIPntVTVGNGGGVLLRPHNYFDEDPSI 709
XP_015217386  676 AEDIPntVAVGNGGGVILRPHNYFDEDPSM 705
XP_006006014  663 SEDIPntVTVGNGVGFLLRPYNYFKEDPSI 692 coelacanth
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