Conserved Protein Domain Family
GDT1

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pfam01169: GDT1 (This model is not part of the current CDD release)
Divalent cation/proton antiporter GDT1
This entry, previously known as UPF0016, represents the budding yeast Divalent cation/proton antiporter GDT1 and its homologue, the human TMEM165 that are functionally related and form a new group of Golgi-localised cation/Ca(2+) exchangers. Budding yeast GDT1 is a Golgi-localised calcium transporter required for stress-induced calcium signalling and protein glycosylation. TMEM165, also a Golgi protein, transports Ca2+ and Mn2+, which are both required for proper protein glycosylation in cells. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions.
Statistics
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PSSM-Id: 514056
Aligned: 548 rows
Threshold Bit Score: 32.7806
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_018635083   256 VSAFLVTIATELGDRTFFLAALLSMKYsk--aiVFVGTCLALFLMTAFSTGL-GrllHWA----PDMPGlrarlgdfpid 328
68_pfamImport    1 VTTFVLFFLMEMGDKTQIATAALAAHYstf-fwVVAGSVSGMMVVNAPTVWF-G---HCYgcriSPRLL----------- 64 
Q0VL27         113 LTALVLFFIAEIGDKTQLATIALAIQFkdqfwpVLSGSTLGMIAANLPVIWL-A---HQFgsqqFETWA----------- 177 Alcanivorax b...
131_pfamImport   1 LTALVLFFIAEIGDKTQLATVALAVRFqef-wpVLLGSTAGMIAANLPVIWV-A---HRLagerlERWA----------- 64 
91_pfamImport    1 IATFLLFFIAEIGDKTQVATVLLGAHYqsi-flVTVGTTLGMMIANVPVVLA-G---QHImnkfNPAKA----------- 64 
Q3IBT3         103 LVAFVLFFIAEIGDKTQIATVLLGAQYqsv-lwVTIGTTVGMLIANVPVIYA-G---NALlkriPLNKV----------- 166 Pseudoalterom...
158_pfamImport   1 AATTVLFFIAEIGDKTQIATVLLAAEFqsm-wwVTAGTTLGMLIANVPVVIW-G---NHLmqrmPLNAA----------- 64 
51_pfamImport    1 VAATVLFFLAEIGDKTQVATVLLGAQFdsi-vwVTLGTTLGMLAANVPVVFA-G---DYLmrrlPLNGA----------- 64 
Q5ZV02         104 GATFITFFLSETGDKTQIATIALAAHYssp-ilVIAGSTLGMLLADLPAVYF-G---NLFshkiPMKII----------- 167 Legionella pn...
62_pfamImport    1 LTSALGLFILGFGDGAQFLILGIAVRTadp-flAAAGGAIGIIAATVLVVLLrG---PTFka-lPLRGI----------- 64 
XP_018635083   329 AWVSCLLLLFFA 340
68_pfamImport   65 HRLSALIFAAIG 76 
Q0VL27         178 HRISAALFVGFG 189 Alcanivorax borkumensis SK2
131_pfamImport  65 HRISAALFIVFG 76 
91_pfamImport   65 HIIACLFFIAIG 76 
Q3IBT3         167 RIIAASVFVLLG 178 Pseudoalteromonas haloplanktis TAC125
158_pfamImport  65 RYITSAVFLALA 76 
51_pfamImport   65 RWTAAAVFIGVG 76 
Q5ZV02         168 HAVAACAFLIIG 179 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
62_pfamImport   65 RLGGGVLVLLAG 76 
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